ISG15 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ISG15 ubiquitin-like modifier|The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012] (NCBI Entrez Gene Database, 9636)
External Link http://www.ncbi.nlm.nih.gov/gene/9636
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Genes

189 interacting proteins for ISG15 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ACLY ATP citrate lyase
ACOT8 acyl-CoA thioesterase 8
ACTA1 actin, alpha 1, skeletal muscle
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
AHNAK AHNAK nucleoprotein
ALDOA aldolase A, fructose-bisphosphate
ANXA2 annexin A2
ANXA3 annexin A3
ANXA5 annexin A5
ARID5B AT rich interactive domain 5B (MRF1-like)
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATXN2 ataxin 2
ATXN2L ataxin 2-like
BAG3 BCL2-associated athanogene 3
CALD1 caldesmon 1
CBX4 chromobox homolog 4
CCNL1 cyclin L1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CFL1 cofilin 1 (non-muscle)
CHD1 chromodomain helicase DNA binding protein 1
CHMP5 charged multivesicular body protein 5
CIRH1A cirrhosis, autosomal recessive 1A (cirhin)
CLIC1 chloride intracellular channel 1
CLK1 CDC-like kinase 1
CLTC clathrin, heavy chain (Hc)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPDC7 DEP domain containing 7
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSTN destrin (actin depolymerizing factor)
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENO1 enolase 1, (alpha)
EPPK1 epiplakin 1
ERCC2 excision repair cross-complementation group 2
EZR ezrin
FAM120C family with sequence similarity 120C
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FASN fatty acid synthase
FLNA filamin A, alpha
FLNB filamin B, beta
FUBP3 far upstream element (FUSE) binding protein 3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GANAB glucosidase, alpha; neutral AB
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBP1 guanylate binding protein 1, interferon-inducible
GDI2 GDP dissociation inhibitor 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPI glucose-6-phosphate isomerase
GSR glutathione reductase
GSTP1 glutathione S-transferase pi 1
HELZ2 helicase with zinc finger 2, transcriptional coactivator
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFNB1 interferon, beta 1, fibroblast
IQGAP1 IQ motif containing GTPase activating protein 1
IRF3 interferon regulatory factor 3
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KPNA5 karyopherin alpha 5 (importin alpha 6)
KPNB1 karyopherin (importin) beta 1
LAP3 leucine aminopeptidase 3
LDHA lactate dehydrogenase A
LGMN legumain
LMAN2 lectin, mannose-binding 2
LMNA lamin A/C
MAP4 microtubule-associated protein 4
MEPCE methylphosphate capping enzyme
MSN moesin
MX1 MX dynamin-like GTPase 1
MYH9 myosin, heavy chain 9, non-muscle
MYOF myoferlin
NACA nascent polypeptide-associated complex alpha subunit
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NUP43 nucleoporin 43kDa
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PALLD palladin, cytoskeletal associated protein
PCNA proliferating cell nuclear antigen
PFN1 profilin 1
PGD phosphogluconate dehydrogenase
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PLEC plectin
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PLS1 plastin 1
PLS3 plastin 3
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRDX1 peroxiredoxin 1
PRDX6 peroxiredoxin 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PTBP1 polypyrimidine tract binding protein 1
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAN RAN, member RAS oncogene family
RBBP4 retinoblastoma binding protein 4
RBM15B RNA binding motif protein 15B
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS3 regulator of G-protein signaling 3
RPL24 ribosomal protein L24
RPL27A ribosomal protein L27a
RPS27A ribosomal protein S27a
SENP1 SUMO1/sentrin specific peptidase 1
SEPT2 septin 2
SERBP1 SERPINE1 mRNA binding protein 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SF3A2 splicing factor 3a, subunit 2, 66kDa
SF3B4 splicing factor 3b, subunit 4, 49kDa
SFN stratifin
SIN3A SIN3 transcription regulator family member A
SMAD4 SMAD family member 4
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38 serine/threonine kinase 38
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAGLN transgelin
TARS threonyl-tRNA synthetase
TKT transketolase
TMOD3 tropomodulin 3 (ubiquitous)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM25 tripartite motif containing 25
TXNRD1 thioredoxin reductase 1
UBA1 ubiquitin-like modifier activating enzyme 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBA7 ubiquitin-like modifier activating enzyme 7
UBAP2L ubiquitin associated protein 2-like
UBB ubiquitin B
UBC ubiquitin C
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E2 ubiquitin-conjugating enzyme E2E 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBE2N ubiquitin-conjugating enzyme E2N
UGP2 UDP-glucose pyrophosphorylase 2
USP18 ubiquitin specific peptidase 18
USP21 ubiquitin specific peptidase 21
VCP valosin containing protein
VIM vimentin
WARS tryptophanyl-tRNA synthetase
WDR1 WD repeat domain 1
WDR33 WD repeat domain 33
WIBG within bgcn homolog (Drosophila)
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YTHDC1 YTH domain containing 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZC3H15 zinc finger CCCH-type containing 15
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZNF281 zinc finger protein 281
ZNF318 zinc finger protein 318