ISX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description intestine-specific homeobox|Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 91464)
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Genes

293 genes differentially expressed following the ISX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 3.81371
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.81371
TLX2 T-cell leukemia homeobox 2 3.81371
ADAD2 adenosine deaminase domain containing 2 3.81371
TNIP3 TNFAIP3 interacting protein 3 3.81371
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 3.81371
FAM221B family with sequence similarity 221, member B 3.81371
BIRC3 baculoviral IAP repeat containing 3 3.81371
CA3 carbonic anhydrase III 3.81371
GFAP glial fibrillary acidic protein 3.81371
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 3.81371
GRXCR2 glutaredoxin, cysteine rich 2 3.81371
MYO7B myosin VIIB 3.81371
FGF23 fibroblast growth factor 23 3.81371
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.81371
SLC16A11 solute carrier family 16, member 11 3.81371
FABP1 fatty acid binding protein 1, liver 3.81371
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.81371
CELA3B chymotrypsin-like elastase family, member 3B 3.81371
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 3.81371
GSG1 germ cell associated 1 3.81371
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.81371
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 3.81371
SERTM1 serine-rich and transmembrane domain containing 1 3.81371
NR4A2 nuclear receptor subfamily 4, group A, member 2 3.81371
ARSH arylsulfatase family, member H 3.81371
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.81371
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.81371
CD22 CD22 molecule 3.81371
CD38 CD38 molecule 3.81371
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.81371
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.81371
IKZF3 IKAROS family zinc finger 3 (Aiolos) 3.81371
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.81371
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.81371
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 3.81371
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 3.81371
AVP arginine vasopressin 3.81371
BMP5 bone morphogenetic protein 5 3.81371
MYO1G myosin IG 3.81371
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 3.81371
NEUROD4 neuronal differentiation 4 3.81371
CATSPERT catsper channel auxiliary subunit tau 3.81371
SPATS1 spermatogenesis associated, serine-rich 1 3.81371
ZNF728 zinc finger protein 728 3.81371
KY kyphoscoliosis peptidase 3.81371
AVPR1A arginine vasopressin receptor 1A 3.81371
CLDN14 claudin 14 3.81371
AANAT aralkylamine N-acetyltransferase 3.81371
AMY1A amylase, alpha 1A (salivary) 3.81371
FMO3 flavin containing monooxygenase 3 3.81371
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.81371
STING1 stimulator of interferon response cGAMP interactor 1 3.81371
ANKRD40CL ANKRD40 C-terminal like 3.81371
CATSPERH catsper channel auxiliary subunit eta 3.81371
EXOC1L exocyst complex component 1 like 3.81371
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.81371
CHD9NB CHD9 neighbor 3.81371
ACP7 acid phosphatase 7, tartrate resistant (putative) 3.81371
INSYN2B inhibitory synaptic factor family member 2B 3.81371
TERB1 telomere repeat binding bouquet formation protein 1 3.81371
AJM1 apical junction component 1 homolog 3.81371
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.81371
GRAP GRB2-related adaptor protein 3.81371
SCN10A sodium channel, voltage gated, type X alpha subunit 3.81371
DSG1 desmoglein 1 3.81371
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.81371
CFAP99 cilia and flagella associated protein 99 3.81371
PCDHA7 protocadherin alpha 7 3.81371
CAPN11 calpain 11 3.81371
PTTG2 pituitary tumor-transforming 2 3.81371
ZACN zinc activated ligand-gated ion channel 3.81371
ARMS2 age-related maculopathy susceptibility 2 3.81371
CDKN2A cyclin-dependent kinase inhibitor 2A 3.81371
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.81371
IMPG1 interphotoreceptor matrix proteoglycan 1 3.81371
MAGIX MAGI family member, X-linked 3.81371
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.81371
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.81371
SYT15 synaptotagmin XV 3.81371
CSF1 colony stimulating factor 1 (macrophage) 3.81371
GPR83 G protein-coupled receptor 83 3.81371
ABHD15 abhydrolase domain containing 15 3.81371
RASL10A RAS-like, family 10, member A 3.81371
GPR171 G protein-coupled receptor 171 3.81371
CFB complement factor B 3.81371
CALR3 calreticulin 3 3.81371
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.81371
COL17A1 collagen, type XVII, alpha 1 3.81371
PCDHGA7 protocadherin gamma subfamily A, 7 3.81371
NLRP14 NLR family, pyrin domain containing 14 3.81371
MAB21L2 mab-21-like 2 (C. elegans) 3.81371
MAMLD1 mastermind-like domain containing 1 3.81371
CREG2 cellular repressor of E1A-stimulated genes 2 3.81371
NPFFR1 neuropeptide FF receptor 1 3.81371
CALHM1 calcium homeostasis modulator 1 3.81371
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.81371
SMIM23 small integral membrane protein 23 3.81371
ANKRD63 ankyrin repeat domain 63 3.81371
CLRN1 clarin 1 3.81371
AQP7 aquaporin 7 3.81371
RGSL1 regulator of G-protein signaling like 1 3.81371
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.81371
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.81371
CCDC170 coiled-coil domain containing 170 3.81371
GOLGA8K golgin A8 family, member K 3.81371
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.81371
EOMES eomesodermin 3.81371
C10ORF105 chromosome 10 open reading frame 105 3.81371
ARHGAP40 Rho GTPase activating protein 40 3.81371
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.81371
NYX nyctalopin 3.81371
LRRC25 leucine rich repeat containing 25 3.81371
DCN decorin 3.81371
MOG myelin oligodendrocyte glycoprotein 3.81371
BCL2L15 BCL2-like 15 3.81371
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.81371
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.81371
TF transferrin 3.81371
FATE1 fetal and adult testis expressed 1 3.81371
GAL3ST2 galactose-3-O-sulfotransferase 2 3.81371
DEFB119 defensin, beta 119 3.81371
ANKRD62 ankyrin repeat domain 62 3.81371
FGF10 fibroblast growth factor 10 3.81371
LAMP3 lysosomal-associated membrane protein 3 3.81371
TGM1 transglutaminase 1 3.81371
FBXO39 F-box protein 39 3.81371
CETP cholesteryl ester transfer protein, plasma 3.81371
SNTN sentan, cilia apical structure protein 3.81371
GRAPL GRB2-related adaptor protein-like 3.81371
LY6G5C lymphocyte antigen 6 complex, locus G5C 3.81371
ALLC allantoicase 3.81371
SOX14 SRY (sex determining region Y)-box 14 3.81371
BPIFC BPI fold containing family C 3.81371
PPP1R3D protein phosphatase 1, regulatory subunit 3D 3.81371
HSF4 heat shock transcription factor 4 3.81371
TRIM29 tripartite motif containing 29 3.81371
PKP3 plakophilin 3 3.72948
HHAT hedgehog acyltransferase 3.29878
PYGB phosphorylase, glycogen; brain 3.03642
CENPO centromere protein O 3.01896
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 3.00873
CHEK2 checkpoint kinase 2 3.00352
TMC5 transmembrane channel-like 5 2.93446
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.89889
FBXL22 F-box and leucine-rich repeat protein 22 2.87855
ZNF214 zinc finger protein 214 2.87855
SAXO4 stabilizer of axonemal microtubules 4 2.87855
HSF5 heat shock transcription factor family member 5 2.87855
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.87855
C5AR2 complement component 5a receptor 2 2.87855
TGFB3 transforming growth factor, beta 3 2.87855
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.87855
TMEM171 transmembrane protein 171 2.87855
RP1L1 retinitis pigmentosa 1-like 1 2.87855
IFIH1 interferon induced with helicase C domain 1 2.87855
CCDC124 coiled-coil domain containing 124 2.84258
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2.81441
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.80336
NES nestin 2.77825
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.68228
SCN5A sodium channel, voltage gated, type V alpha subunit 2.68107
TMEM200A transmembrane protein 200A 2.66542
TSEN54 TSEN54 tRNA splicing endonuclease subunit 2.66542
TTLL9 tubulin tyrosine ligase-like family member 9 2.51584
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.47274
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.46778
ZNF460 zinc finger protein 460 2.45484
IGSF6 immunoglobulin superfamily, member 6 2.43298
AMY2B amylase, alpha 2B (pancreatic) 2.43298
PM20D1 peptidase M20 domain containing 1 2.43298
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 2.42567
LNX2 ligand of numb-protein X 2 2.40698
ADRA2B adrenoceptor alpha 2B 2.3223
STRIT1 small transmembrane regulator of ion transport 1 2.3223
GFY golgi-associated, olfactory signaling regulator 2.3223
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.30737
YARS1 tyrosyl-tRNA synthetase 1 2.3042
NBAS neuroblastoma amplified sequence 2.3013
YIPF4 Yip1 domain family, member 4 2.3013
CHRDL2 chordin-like 2 2.3013
PTEN phosphatase and tensin homolog 2.3013
SOBP sine oculis binding protein homolog (Drosophila) 2.28936
TOP1MT topoisomerase (DNA) I, mitochondrial 2.28936
BCAS4 breast carcinoma amplified sequence 4 2.25232
APOOL apolipoprotein O-like 2.24715
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2.2291
IRF2BP1 interferon regulatory factor 2 binding protein 1 2.22896
DNAH17 dynein, axonemal, heavy chain 17 2.22896
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 2.21645
XXYLT1 xyloside xylosyltransferase 1 2.21645
DYNLL2 dynein, light chain, LC8-type 2 2.1831
ZNF138 zinc finger protein 138 2.18224
RBPMS RNA binding protein with multiple splicing 2.14614
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2.12378
SCARA3 scavenger receptor class A, member 3 2.10641
MCM5 minichromosome maintenance complex component 5 2.08533
CAMTA1 calmodulin binding transcription activator 1 2.08533
NDC80 NDC80 kinetochore complex component 2.08091
MCM3AP minichromosome maintenance complex component 3 associated protein 2.07175
FXR1 fragile X mental retardation, autosomal homolog 1 2.06286
TMEM158 transmembrane protein 158 (gene/pseudogene) 2.06286
ADCY1 adenylate cyclase 1 (brain) 2.05839
SGO2 shugoshin 2 2.05491
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.05201
CAPS2 calcyphosine 2 2.04057
CXADR coxsackie virus and adenovirus receptor 2.03569
ZNF83 zinc finger protein 83 2.02004
BBIP1 BBSome interacting protein 1 2.01983

decreased expression

Symbol Name Standardized Value
CPN1 carboxypeptidase N, polypeptide 1 -3.81371
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -3.81371
PCDHA4 protocadherin alpha 4 -3.81371
LTB4R leukotriene B4 receptor -3.81371
C1ORF116 chromosome 1 open reading frame 116 -3.81371
GLIS1 GLIS family zinc finger 1 -3.81371
PRPH2 peripherin 2 (retinal degeneration, slow) -3.81371
ICOSLG inducible T-cell co-stimulator ligand -3.81371
LCN10 lipocalin 10 -3.81371
KRTAP13-4 keratin associated protein 13-4 -3.55328
GPR162 G protein-coupled receptor 162 -3.55328
GLT6D1 glycosyltransferase 6 domain containing 1 -3.55328
CD8B CD8b molecule -3.55328
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -3.55328
CTRL chymotrypsin-like -3.55328
NLRP10 NLR family, pyrin domain containing 10 -3.55328
MUC20 mucin 20, cell surface associated -3.55328
SPON2 spondin 2, extracellular matrix protein -3.55328
PROB1 proline-rich basic protein 1 -3.55328
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -3.55328
NDRG1 N-myc downstream regulated 1 -3.55328
MEP1B meprin A, beta -3.55328
PNLIPRP2 pancreatic lipase-related protein 2 -3.55328
FIMP1 fertilization-influencing membrane protein 1 -3.55328
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -3.55328
CNGB1 cyclic nucleotide gated channel beta 1 -3.55328
DNAI7 dynein axonemal intermediate chain 7 -3.55328
LHX8 LIM homeobox 8 -3.55328
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -3.55328
IFI27 interferon, alpha-inducible protein 27 -3.55328
CCDC184 coiled-coil domain containing 184 -3.55328
DRD3 dopamine receptor D3 -3.55328
ANKRD65 ankyrin repeat domain 65 -3.55328
DGCR6 DiGeorge syndrome critical region gene 6 -3.55328
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -3.55328
ACOT1 acyl-CoA thioesterase 1 -3.55328
RNASE4 ribonuclease, RNase A family, 4 -3.55328
SP1 Sp1 transcription factor -3.47845
VEGFC vascular endothelial growth factor C -3.37502
SLFNL1 schlafen-like 1 -3.37502
CHP2 calcineurin-like EF-hand protein 2 -3.37502
SLC41A3 solute carrier family 41, member 3 -3.29878
GPRASP2 G protein-coupled receptor associated sorting protein 2 -3.26737
CLDN3 claudin 3 -3.13081
MROH9 maestro heat-like repeat family member 9 -2.89889
ESRRB estrogen-related receptor beta -2.81815
MADD MAP-kinase activating death domain -2.75127
SLC75A1 solute carrier family 75 member 1 -2.72609
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.70196
MAF1 MAF1 homolog (S. cerevisiae) -2.61501
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.52621
CLGN calmegin -2.41623
CPEB3 cytoplasmic polyadenylation element binding protein 3 -2.40774
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.35101
MAPK14 mitogen-activated protein kinase 14 -2.33059
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -2.31954
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.31954
GPR34 G protein-coupled receptor 34 -2.3013
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.3013
C19ORF85 chromosome 19 open reading frame 85 -2.29921
NME5 NME/NM23 family member 5 -2.29921
BTBD2 BTB (POZ) domain containing 2 -2.28682
ZNF442 zinc finger protein 442 -2.28154
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.25143
CALB2 calbindin 2 -2.25143
ZNF233 zinc finger protein 233 -2.25143
PCGF1 polycomb group ring finger 1 -2.25143
CHMP1B charged multivesicular body protein 1B -2.22158
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 -2.21645
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.21528
HPDL 4-hydroxyphenylpyruvate dioxygenase-like -2.20778
ANAPC2 anaphase promoting complex subunit 2 -2.18681
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.18446
UBQLN1 ubiquilin 1 -2.1831
HK2 hexokinase 2 -2.1831
JAK2 Janus kinase 2 -2.18067
EVI2B ecotropic viral integration site 2B -2.13474
XKR9 XK, Kell blood group complex subunit-related family, member 9 -2.13474
SYNGR3 synaptogyrin 3 -2.08533
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -2.08109
STPG1 sperm-tail PG-rich repeat containing 1 -2.06286
TSSC4 tumor suppressing subtransferable candidate 4 -2.05203
GIPC2 GIPC PDZ domain containing family, member 2 -2.04347
TMEM131 transmembrane protein 131 -2.03165