ITCH Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description itchy E3 ubiquitin protein ligase|This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 83737)
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Genes

349 genes differentially expressed following the ITCH gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
EQTN equatorin, sperm acrosome associated 3.42677
ASB12 ankyrin repeat and SOCS box containing 12 3.42677
SPAG8 sperm associated antigen 8 3.42677
C1QTNF1 C1q and tumor necrosis factor related protein 1 3.42677
MID2 midline 2 3.42677
ASIC4 acid sensing (proton gated) ion channel family member 4 3.42677
NLRP10 NLR family, pyrin domain containing 10 3.42677
ITGA10 integrin, alpha 10 3.42677
RGPD8 RANBP2-like and GRIP domain containing 8 3.42677
FOXE3 forkhead box E3 3.42677
MYH15 myosin, heavy chain 15 3.42677
SMIM22 small integral membrane protein 22 3.42677
AOC3 amine oxidase, copper containing 3 3.42677
PCDHB10 protocadherin beta 10 3.42677
GML glycosylphosphatidylinositol anchored molecule like 3.42677
MICALL2 MICAL-like 2 3.42677
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.42677
C3ORF80 chromosome 3 open reading frame 80 3.42677
C6ORF58 chromosome 6 open reading frame 58 3.42677
IL32 interleukin 32 3.42677
SIGLEC15 sialic acid binding Ig-like lectin 15 3.42677
DPPA3 developmental pluripotency associated 3 3.42677
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 3.42677
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.42677
PDCD1LG2 programmed cell death 1 ligand 2 3.42677
NT5DC4 5'-nucleotidase domain containing 4 3.42677
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.42677
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 3.42677
RRAD Ras-related associated with diabetes 3.31202
SP6 Sp6 transcription factor 3.31202
CPLX3 complexin 3 3.31202
FAM181B family with sequence similarity 181, member B 3.31202
HIC1 hypermethylated in cancer 1 3.31202
S100A1 S100 calcium binding protein A1 3.31202
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 3.31202
NANOS3 nanos homolog 3 (Drosophila) 3.31202
CD96 CD96 molecule 3.31202
NKAPL NFKB activating protein-like 3.31202
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.31202
PKP1 plakophilin 1 3.31202
NPPC natriuretic peptide C 3.31202
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.31202
TSHZ1 teashirt zinc finger homeobox 1 3.31202
CAMP cathelicidin antimicrobial peptide 3.31202
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.31202
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 3.31202
CPB2 carboxypeptidase B2 (plasma) 3.31202
MAGED4 melanoma antigen family D4 3.31202
TUBB8 tubulin, beta 8 class VIII 3.31202
RPL3L ribosomal protein L3-like 3.31202
C3ORF22 chromosome 3 open reading frame 22 3.31202
PTGFR prostaglandin F receptor (FP) 3.31202
OTUD6A OTU deubiquitinase 6A 3.31202
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.31202
TRIM74 tripartite motif containing 74 3.31202
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.31202
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.31202
COPZ2 coatomer protein complex, subunit zeta 2 3.31202
HBD hemoglobin, delta 3.31202
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.31202
TAS2R13 taste receptor, type 2, member 13 3.31202
TYRP1 tyrosinase-related protein 1 3.31202
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 3.31202
SIM1 single-minded family bHLH transcription factor 1 3.31202
LRTM3 leucine rich repeat transmembrane protein 3 3.31202
PLCZ1 phospholipase C, zeta 1 3.31202
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.31202
FOXC1 forkhead box C1 3.31202
RASD2 RASD family, member 2 3.31202
ZNF441 zinc finger protein 441 3.31202
REP15 RAB15 effector protein 3.31202
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 3.31202
LAMA4 laminin, alpha 4 3.31202
CNTN6 contactin 6 3.31202
DYNAP dynactin associated protein 3.31202
VN1R1 vomeronasal 1 receptor 1 3.31202
AANAT aralkylamine N-acetyltransferase 3.31202
SPMAP1 sperm microtubule associated protein 1 3.31202
SPMIP9 sperm microtubule inner protein 9 3.31202
ANKRD42-DT ANKRD42 divergent transcript 3.31202
H3-7 H3.7 histone (putative) 3.31202
CFAP141 cilia and flagella associated protein 141 3.31202
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.31202
HAO2 hydroxyacid oxidase 2 (long chain) 3.31202
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.31202
GBP3 guanylate binding protein 3 3.31202
MCHR1 melanin-concentrating hormone receptor 1 3.31202
SMCP sperm mitochondria-associated cysteine-rich protein 3.31202
ASIC3 acid sensing (proton gated) ion channel 3 3.31202
GPR85 G protein-coupled receptor 85 3.31202
MTNR1B melatonin receptor 1B 3.31202
DTHD1 death domain containing 1 3.31202
PCDHA7 protocadherin alpha 7 3.31202
ATP13A5 ATPase type 13A5 3.31202
LOC390937 Ets2 repressor factor-like 3.31202
PVRIG poliovirus receptor related immunoglobulin domain containing 3.31202
CPED1 cadherin-like and PC-esterase domain containing 1 3.31202
FPR3 formyl peptide receptor 3 3.31202
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.31202
KLHL34 kelch-like family member 34 3.31202
GGT5 gamma-glutamyltransferase 5 3.31202
LGALS7B lectin, galactoside-binding, soluble, 7B 3.31202
CLDN22 claudin 22 3.31202
CCR9 chemokine (C-C motif) receptor 9 3.31202
CFAP45 cilia and flagella associated protein 45 3.31202
MIP major intrinsic protein of lens fiber 3.31202
TLR7 toll-like receptor 7 3.31202
C10ORF67 chromosome 10 open reading frame 67 3.31202
CATSPERD catsper channel auxiliary subunit delta 3.31202
SLC22A25 solute carrier family 22, member 25 3.31202
SCN10A sodium channel, voltage gated, type X alpha subunit 3.31202
CHRD chordin 3.31202
GPR75 G protein-coupled receptor 75 3.31202
MLIP muscular LMNA-interacting protein 3.31202
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.31202
LY96 lymphocyte antigen 96 3.31202
IL19 interleukin 19 3.31202
MC5R melanocortin 5 receptor 3.31202
HSPA1L heat shock 70kDa protein 1-like 3.31202
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.31202
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.31202
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.31202
CRYBA4 crystallin, beta A4 3.31202
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.31202
VWA7 von Willebrand factor A domain containing 7 3.31202
TMEM61 transmembrane protein 61 3.31202
WFDC10A WAP four-disulfide core domain 10A 3.31202
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.31202
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.31202
CER1 cerberus 1, DAN family BMP antagonist 3.31202
TRIM50 tripartite motif containing 50 3.31202
LCT lactase 3.31202
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.31202
TEX11 testis expressed 11 3.31202
HCRT hypocretin (orexin) neuropeptide precursor 3.31202
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.31202
RGS11 regulator of G-protein signaling 11 3.31202
IGFBP1 insulin-like growth factor binding protein 1 3.31202
CH25H cholesterol 25-hydroxylase 3.31202
FAM135B family with sequence similarity 135, member B 3.31202
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.31202
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 3.31202
A3GALT2 alpha 1,3-galactosyltransferase 2 3.31202
KLK5 kallikrein-related peptidase 5 3.31202
S100A14 S100 calcium binding protein A14 3.31202
CPZ carboxypeptidase Z 3.31202
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 3.31202
BIN2 bridging integrator 2 3.31202
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.31202
AOC1 amine oxidase, copper containing 1 3.31202
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.31202
NLRP6 NLR family, pyrin domain containing 6 3.31202
VWA3B von Willebrand factor A domain containing 3B 3.31202
MEPE matrix extracellular phosphoglycoprotein 3.31202
NRGN neurogranin (protein kinase C substrate, RC3) 3.31202
COX7B2 cytochrome c oxidase subunit VIIb2 3.31202
APOA1 apolipoprotein A-I 3.31202
ZC2HC1B zinc finger, C2HC-type containing 1B 3.31202
ZNF835 zinc finger protein 835 3.31202
SPDEF SAM pointed domain containing ETS transcription factor 3.31202
NUPR1 nuclear protein, transcriptional regulator, 1 3.31202
EVPLL envoplakin-like 3.31202
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.31202
AZU1 azurocidin 1 3.31202
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.31202
MOG myelin oligodendrocyte glycoprotein 3.31202
NPBWR1 neuropeptides B/W receptor 1 3.31202
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.31202
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.31202
LGALS14 lectin, galactoside-binding, soluble, 14 3.31202
A1CF APOBEC1 complementation factor 3.31202
LMAN1L lectin, mannose-binding, 1 like 3.31202
PADI4 peptidyl arginine deiminase, type IV 3.31202
VWA3A von Willebrand factor A domain containing 3A 3.31202
EMP1 epithelial membrane protein 1 3.31202
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.31202
GSTM2 glutathione S-transferase mu 2 (muscle) 3.31202
ANGPTL5 angiopoietin-like 5 3.31202
MMP10 matrix metallopeptidase 10 3.31202
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.31202
DGKG diacylglycerol kinase, gamma 90kDa 3.27734
SLC38A10 solute carrier family 38, member 10 2.96835
KLC1 kinesin light chain 1 2.94784
MFAP3 microfibrillar-associated protein 3 2.92448
SARS1 seryl-tRNA synthetase 1 2.90309
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.87866
MEX3C mex-3 RNA binding family member C 2.86735
TRIR telomerase RNA component interacting RNase 2.78769
EVI5L ecotropic viral integration site 5-like 2.77025
RAB11B RAB11B, member RAS oncogene family 2.76195
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.76195
KDM2A lysine (K)-specific demethylase 2A 2.66347
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 2.65447
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 2.64229
STRN striatin, calmodulin binding protein 2.63618
TMEM52 transmembrane protein 52 2.63067
TAGLN transgelin 2.53734
CCDC178 coiled-coil domain containing 178 2.50125
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.45471
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.42489
PGM5 phosphoglucomutase 5 2.41066
MBP myelin basic protein 2.41066
SPDYE12 speedy/RINGO cell cycle regulator family member E12 2.39979
GRB10 growth factor receptor-bound protein 10 2.39904
ARMCX2 armadillo repeat containing, X-linked 2 2.37154
NECAB1 N-terminal EF-hand calcium binding protein 1 2.36658
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 2.36658
FHL3 four and a half LIM domains 3 2.35915
DPRX divergent-paired related homeobox 2.34625
MAP2K1 mitogen-activated protein kinase kinase 1 2.33442
USP38 ubiquitin specific peptidase 38 2.30419
CCS copper chaperone for superoxide dismutase 2.30419
CTSK cathepsin K 2.29343
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 2.28837
BNC1 basonuclin 1 2.27823
RORA RAR-related orphan receptor A 2.26256
NOP58 NOP58 ribonucleoprotein 2.2565
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.24767
RPL29 ribosomal protein L29 2.23653
PGBD1 piggyBac transposable element derived 1 2.23333
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.22448
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.21891
WNK1 WNK lysine deficient protein kinase 1 2.21265
RNF19B ring finger protein 19B 2.20294
STRADB STE20-related kinase adaptor beta 2.19286
ZNF793 zinc finger protein 793 2.17941
AGTRAP angiotensin II receptor-associated protein 2.15112
ARL1 ADP-ribosylation factor-like 1 2.14391
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.1352
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.1352
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.1352
TBC1D19 TBC1 domain family, member 19 2.1352
TCP10L t-complex 10-like 2.12487
RTL10 retrotransposon Gag like 10 2.12184
TMX3 thioredoxin-related transmembrane protein 3 2.11734
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.09484
SYCP2L synaptonemal complex protein 2-like 2.08014
PCBP1 poly(rC) binding protein 1 2.07938
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.0741
FAM114A1 family with sequence similarity 114, member A1 2.06405
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 2.05345
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.05345
CASZ1 castor zinc finger 1 2.03849
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 2.03823
FAM217B family with sequence similarity 217, member B 2.03823
USP15 ubiquitin specific peptidase 15 2.02277
PMFBP1 polyamine modulated factor 1 binding protein 1 2.01655
ANKRD40 ankyrin repeat domain 40 2.01586

decreased expression

Symbol Name Standardized Value
NGF nerve growth factor (beta polypeptide) -3.42677
MMP26 matrix metallopeptidase 26 -3.42677
ZSCAN22 zinc finger and SCAN domain containing 22 -3.42677
SLC46A1 solute carrier family 46 (folate transporter), member 1 -3.42677
GUCA1B guanylate cyclase activator 1B (retina) -3.42677
WDR31 WD repeat domain 31 -3.42677
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) -3.42677
NLRP9 NLR family, pyrin domain containing 9 -3.31202
RORC RAR-related orphan receptor C -3.31202
PRDM16 PR domain containing 16 -3.31202
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -3.31202
IFI16 interferon, gamma-inducible protein 16 -3.31202
NPB neuropeptide B -3.31202
ZNF648 zinc finger protein 648 -3.31202
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -3.31202
IDUA iduronidase, alpha-L- -3.31202
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -3.31202
POM121L2 POM121 transmembrane nucleoporin-like 2 -3.31202
PXDC1 PX domain containing 1 -3.31202
SAMD15 sterile alpha motif domain containing 15 -3.31202
CXCL14 chemokine (C-X-C motif) ligand 14 -3.31202
IL6ST-DT IL6ST divergent transcript -3.31202
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -3.31202
LIPH lipase, member H -3.31202
CNTNAP4 contactin associated protein-like 4 -3.31202
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa -3.31202
YY2 YY2 transcription factor -3.31202
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -3.31202
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -3.31202
SVOP SV2 related protein homolog (rat) -3.31202
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -3.31202
TSLP thymic stromal lymphopoietin -3.31202
MOS v-mos Moloney murine sarcoma viral oncogene homolog -3.31202
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.31202
CALY calcyon neuron-specific vesicular protein -3.31202
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -3.24455
FIGNL1 fidgetin-like 1 -3.24455
ZNF365 zinc finger protein 365 -3.24455
CENPH centromere protein H -3.16353
ZSCAN12 zinc finger and SCAN domain containing 12 -3.12048
DCXR dicarbonyl/L-xylulose reductase -3.01273
TM2D3 TM2 domain containing 3 -2.86735
CHEK1 checkpoint kinase 1 -2.79038
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -2.78379
ADM2 adrenomedullin 2 -2.73907
TMEM161A transmembrane protein 161A -2.70954
INO80B INO80 complex subunit B -2.70615
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) -2.69441
SLC35F3 solute carrier family 35, member F3 -2.65382
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.64229
SPARCL1 SPARC-like 1 (hevin) -2.63618
CPXM1 carboxypeptidase X (M14 family), member 1 -2.63618
CCSAP centriole, cilia and spindle-associated protein -2.60502
ANXA2 annexin A2 -2.59717
RPS14 ribosomal protein S14 -2.53888
ATP5MF ATP synthase membrane subunit f -2.48057
H4C9 H4 clustered histone 9 -2.46063
ARMCX4 armadillo repeat containing, X-linked 4 -2.45778
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.4435
ECI1 enoyl-CoA delta isomerase 1 -2.43297
SF3B6 splicing factor 3b, subunit 6, 14kDa -2.41066
SCX scleraxis basic helix-loop-helix transcription factor -2.36658
CDC37L1 cell division cycle 37-like 1 -2.36658
H2AC12 H2A clustered histone 12 -2.35915
OSBP2 oxysterol binding protein 2 -2.34171
SAXO1 stabilizer of axonemal microtubules 1 -2.30389
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -2.3008
COL4A5 collagen, type IV, alpha 5 -2.3008
PYGM phosphorylase, glycogen, muscle -2.28837
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like -2.28837
SCD5 stearoyl-CoA desaturase 5 -2.28837
TMBIM1 transmembrane BAX inhibitor motif containing 1 -2.28837
GAL3ST4 galactose-3-O-sulfotransferase 4 -2.2693
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.24767
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.23677
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -2.23677
DNAI3 dynein axonemal intermediate chain 3 -2.21913
FTCD formimidoyltransferase cyclodeaminase -2.21913
EHBP1L1 EH domain binding protein 1-like 1 -2.21913
CMKLR2 chemerin chemokine-like receptor 2 -2.21913
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 -2.18588
SKAP2 src kinase associated phosphoprotein 2 -2.18321
PCDHB2 protocadherin beta 2 -2.171
CADM4 cell adhesion molecule 4 -2.1513
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -2.15112
WASF2 WAS protein family, member 2 -2.14313
PEX10 peroxisomal biogenesis factor 10 -2.1352
CHMP4B charged multivesicular body protein 4B -2.131
MYO15B myosin XVB -2.12247
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.10942
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -2.08908
EHD3 EH-domain containing 3 -2.08123
ZNHIT3 zinc finger, HIT-type containing 3 -2.0741
TRIM69 tripartite motif containing 69 -2.0741
IQUB IQ motif and ubiquitin domain containing -2.07196
ZNF799 zinc finger protein 799 -2.07196
LGI2 leucine-rich repeat LGI family, member 2 -2.07008
LCOR ligand dependent nuclear receptor corepressor -2.04811
EFCAB10 EF-hand calcium binding domain 10 -2.04677
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.03476
DMXL2 Dmx-like 2 -2.00976