| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | itchy E3 ubiquitin protein ligase|This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 83737) |
| External Link | https://ncbi.nlm.nih.gov/gene/83737 |
| Similar Terms | |
| Downloads & Tools |
497 genes differentially expressed following the ITCH gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0168765 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.015403 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0133951 |
| LCN2 | lipocalin 2 | 0.0131522 |
| KRT7 | keratin 7, type II | 0.0116577 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.011653 |
| ANXA1 | annexin A1 | 0.011576 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0113836 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.0110669 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.0108634 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.0107951 |
| PADI2 | peptidyl arginine deiminase, type II | 0.0107446 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.0105783 |
| SPRR3 | small proline-rich protein 3 | 0.0105609 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.010497 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0104296 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.0103707 |
| SIK1 | salt-inducible kinase 1 | 0.0103586 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0102837 |
| LAMC2 | laminin, gamma 2 | 0.0102785 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0102708 |
| MAL | mal, T-cell differentiation protein | 0.010198 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.0100178 |
| GPM6B | glycoprotein M6B | 0.00997172 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | 0.00987993 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00984203 |
| ATF3 | activating transcription factor 3 | 0.00976864 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.0096896 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00965337 |
| PRAME | preferentially expressed antigen in melanoma | 0.00965142 |
| CTSS | cathepsin S | 0.00958794 |
| ABLIM1 | actin binding LIM protein 1 | 0.00956496 |
| XIC | X chromosome inactivation center | 0.00947435 |
| RCAN1 | regulator of calcineurin 1 | 0.00945976 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.00945722 |
| GUCY2C | guanylate cyclase 2C | 0.00943701 |
| ADD3 | adducin 3 (gamma) | 0.00937678 |
| KLK10 | kallikrein-related peptidase 10 | 0.00933523 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.00933007 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00928395 |
| CAPN3 | calpain 3, (p94) | 0.00917315 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00912283 |
| NLRP2 | NLR family, pyrin domain containing 2 | 0.00908812 |
| UPK1B | uroplakin 1B | 0.00907079 |
| CLCA4 | chloride channel accessory 4 | 0.00899729 |
| KRT13 | keratin 13, type I | 0.00885251 |
| MVP | major vault protein | 0.0087733 |
| RAB29 | RAB29, member RAS oncogene family | 0.00875899 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.00874127 |
| OPTN | optineurin | 0.00871832 |
| MYOF | myoferlin | 0.00870619 |
| ETHE1 | ethylmalonic encephalopathy 1 | 0.00869101 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.0086286 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00856559 |
| RTCA | RNA 3'-terminal phosphate cyclase | 0.00855829 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00853564 |
| FABP7 | fatty acid binding protein 7, brain | 0.00851012 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.00848743 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00848353 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00845665 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00845489 |
| SELL | selectin L | 0.00842567 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.00840809 |
| RNF125 | ring finger protein 125, E3 ubiquitin protein ligase | 0.0084031 |
| FYB1 | FYN binding protein 1 | 0.00839245 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.00837123 |
| COG7 | component of oligomeric golgi complex 7 | 0.00837113 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00835294 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.00835199 |
| FCGBP | Fc fragment of IgG binding protein | 0.00827923 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.00824458 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00824075 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00824039 |
| MAMLD1 | mastermind-like domain containing 1 | 0.00822125 |
| MMP12 | matrix metallopeptidase 12 | 0.00817223 |
| STC2 | stanniocalcin 2 | 0.00814894 |
| SST | somatostatin | 0.00813246 |
| OAT | ornithine aminotransferase | 0.00812578 |
| KIF5C | kinesin family member 5C | 0.00809995 |
| TCTA | T-cell leukemia translocation altered | 0.00809712 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.00805511 |
| CHEK2 | checkpoint kinase 2 | 0.0080134 |
| AK4 | adenylate kinase 4 | 0.0080092 |
| MYO1C | myosin IC | 0.00798429 |
| NRCAM | neuronal cell adhesion molecule | 0.00798206 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.00797132 |
| BEX1 | brain expressed, X-linked 1 | 0.00796614 |
| LITAF | lipopolysaccharide-induced TNF factor | 0.00792355 |
| WIF1 | WNT inhibitory factor 1 | 0.00787885 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.0078728 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | 0.00785005 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00784401 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00784075 |
| PLAUR | plasminogen activator, urokinase receptor | 0.00779357 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.00777725 |
| CRYAB | crystallin, alpha B | 0.00777353 |
| OXTR | oxytocin receptor | 0.00776543 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00775645 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00773445 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00772591 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00772108 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00772009 |
| PMP2 | peripheral myelin protein 2 | 0.00771408 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00769743 |
| GSTP1 | glutathione S-transferase pi 1 | 0.00768307 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00766965 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00760745 |
| SP100 | SP100 nuclear antigen | 0.0075822 |
| CD200 | CD200 molecule | 0.0075609 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00754126 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0075146 |
| LXN | latexin | 0.00749562 |
| PRTN3 | proteinase 3 | 0.0074949 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.00747772 |
| RGS10 | regulator of G-protein signaling 10 | 0.00747426 |
| EDN3 | endothelin 3 | 0.00747257 |
| FNDC3B | fibronectin type III domain containing 3B | 0.00744254 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00741992 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00741476 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 0.00741064 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00740765 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00740496 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00740328 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 0.00740204 |
| BCL2A1 | BCL2-related protein A1 | 0.00738673 |
| IRF1 | interferon regulatory factor 1 | 0.00737812 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.00737447 |
| JUNB | jun B proto-oncogene | 0.00733831 |
| MAGEA3 | melanoma antigen family A3 | 0.00732776 |
| POPDC3 | popeye domain containing 3 | 0.00725621 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00725371 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00722723 |
| TRIM22 | tripartite motif containing 22 | 0.0071993 |
| CLTB | clathrin, light chain B | 0.00719255 |
| CSTA | cystatin A (stefin A) | 0.00718611 |
| NEBL | nebulette | 0.00717409 |
| TSPO | translocator protein (18kDa) | 0.00717211 |
| FAM171A1 | family with sequence similarity 171, member A1 | 0.00717169 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.007171 |
| ZYX | zyxin | 0.00716697 |
| ANXA2P2 | annexin A2 pseudogene 2 | 0.00712857 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0071208 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | 0.00708816 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.007088 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | 0.00708478 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00707169 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.00706109 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00703486 |
| CA2 | carbonic anhydrase II | 0.00703478 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.00702286 |
| TRIM16 | tripartite motif containing 16 | 0.00700212 |
| ANXA3 | annexin A3 | 0.00700005 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00699993 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00699808 |
| GPR137B | G protein-coupled receptor 137B | 0.00699358 |
| DYNC1I1 | dynein, cytoplasmic 1, intermediate chain 1 | 0.00698656 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00697219 |
| WFDC1 | WAP four-disulfide core domain 1 | 0.00697116 |
| RNASET2 | ribonuclease T2 | 0.00696702 |
| TAC1 | tachykinin, precursor 1 | 0.00695913 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00694326 |
| ITM2C | integral membrane protein 2C | 0.00693671 |
| GPX2 | glutathione peroxidase 2 | 0.00692342 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.00692275 |
| LAMA3 | laminin, alpha 3 | 0.00691499 |
| POU4F1 | POU class 4 homeobox 1 | 0.00690878 |
| OFD1 | oral-facial-digital syndrome 1 | 0.00690641 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.0068961 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.00689606 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00686924 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00685672 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00684743 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00683016 |
| CHI3L2 | chitinase 3-like 2 | 0.0068262 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.006818 |
| ADGRE1 | adhesion G protein-coupled receptor E1 | 0.00680554 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00680406 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00679158 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.00679091 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | 0.006784 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00678051 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00677194 |
| GM2A | GM2 ganglioside activator | 0.00673684 |
| FOXG1 | forkhead box G1 | 0.0067355 |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.00670704 |
| PTGES | prostaglandin E synthase | 0.00670471 |
| FAM107A | family with sequence similarity 107, member A | 0.00669639 |
| WFDC2 | WAP four-disulfide core domain 2 | 0.00666645 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | 0.00665977 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.00665867 |
| PTHLH | parathyroid hormone-like hormone | 0.00664277 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 0.00663765 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0066321 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00663026 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.00662466 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | 0.00661271 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.00660234 |
| GALC | galactosylceramidase | 0.00660066 |
| MFSD1 | major facilitator superfamily domain containing 1 | 0.00658632 |
| COBL | cordon-bleu WH2 repeat protein | 0.00658451 |
| TMOD1 | tropomodulin 1 | 0.00658396 |
| LTF | lactotransferrin | 0.0065643 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00656418 |
| CALB1 | calbindin 1, 28kDa | 0.00656224 |
| IL2RG | interleukin 2 receptor, gamma | 0.00653697 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0065339 |
| FZD3 | frizzled class receptor 3 | 0.00653096 |
| FOSL2 | FOS-like antigen 2 | 0.00652051 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00651797 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 0.00651589 |
| HMOX1 | heme oxygenase 1 | 0.00651246 |
| MMP8 | matrix metallopeptidase 8 | 0.00649665 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.0064891 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00648765 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.00647759 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00647034 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.00646714 |
| DOCK10 | dedicator of cytokinesis 10 | 0.00646699 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.00645008 |
| MSMB | microseminoprotein, beta- | 0.00644881 |
| TOX | thymocyte selection-associated high mobility group box | 0.00643515 |
| IL6R | interleukin 6 receptor | 0.00642715 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.00642408 |
| CCNG1 | cyclin G1 | 0.00641081 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.00640818 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.00639173 |
| LBH | limb bud and heart development | 0.00638462 |
| ADM | adrenomedullin | 0.00638094 |
| MID1 | midline 1 | 0.00637814 |
| PLP1 | proteolipid protein 1 | 0.00636497 |
| DOK5 | docking protein 5 | 0.00636209 |
| MT1F | metallothionein 1F | 0.00636049 |
| MAGEA1 | melanoma antigen family A1 | 0.00636023 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | 0.00635865 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.00635734 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.00635312 |
| SLC16A4 | solute carrier family 16, member 4 | 0.00635203 |
| TSPAN31 | tetraspanin 31 | 0.00632833 |
| TFF1 | trefoil factor 1 | 0.00631054 |
| IQCG | IQ motif containing G | 0.0063036 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.00628536 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.00628379 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00627171 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.00627037 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.00624292 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.0062355 |
| NMRK1 | nicotinamide riboside kinase 1 | 0.00622949 |
| CNTN1 | contactin 1 | 0.00620538 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SSBP2 | single-stranded DNA binding protein 2 | -0.0199972 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.0159147 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0152136 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.014232 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.0134804 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | -0.0132935 |
| ASPN | asporin | -0.0132085 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.0127038 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.012473 |
| G0S2 | G0/G1 switch 2 | -0.0123168 |
| HOPX | HOP homeobox | -0.0119211 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.0118899 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0115133 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | -0.0114403 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.011321 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0113077 |
| TMSB15A | thymosin beta 15a | -0.0107496 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.0106633 |
| RAPSN | receptor-associated protein of the synapse | -0.0106418 |
| TSPAN4 | tetraspanin 4 | -0.0106224 |
| RRAGA | Ras-related GTP binding A | -0.0104503 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.010391 |
| TPSAB1 | tryptase alpha/beta 1 | -0.0100094 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00998905 |
| NVL | nuclear VCP-like | -0.00998336 |
| FASN | fatty acid synthase | -0.00957941 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00956359 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -0.0095194 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00950629 |
| MMP1 | matrix metallopeptidase 1 | -0.00944444 |
| CDC20 | cell division cycle 20 | -0.00943855 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00942541 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00925858 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00906548 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00904003 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.00895886 |
| DCN | decorin | -0.00892921 |
| CLGN | calmegin | -0.00892516 |
| COLEC12 | collectin sub-family member 12 | -0.00886713 |
| COL3A1 | collagen, type III, alpha 1 | -0.00879377 |
| APMAP | adipocyte plasma membrane associated protein | -0.00876234 |
| ELN | elastin | -0.00876183 |
| LRRC15 | leucine rich repeat containing 15 | -0.00875974 |
| AEBP1 | AE binding protein 1 | -0.00869086 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00864787 |
| PCOLCE | procollagen C-endopeptidase enhancer | -0.00864589 |
| H1-0 | H1.0 linker histone | -0.00861431 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.00856641 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00854774 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -0.00853332 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00851559 |
| STAB1 | stabilin 1 | -0.00848179 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -0.00843954 |
| CD99 | CD99 molecule | -0.00842224 |
| RXRA | retinoid X receptor, alpha | -0.00840857 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | -0.00840242 |
| MAOA | monoamine oxidase A | -0.00837363 |
| DPT | dermatopontin | -0.00835321 |
| FBLN2 | fibulin 2 | -0.00826236 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00822883 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00820816 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00817478 |
| TMEM106C | transmembrane protein 106C | -0.00815972 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00806597 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.0080595 |
| MAEA | macrophage erythroblast attacher | -0.00800716 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0079926 |
| KIF20A | kinesin family member 20A | -0.00797615 |
| COMP | cartilage oligomeric matrix protein | -0.0079559 |
| TDO2 | tryptophan 2,3-dioxygenase | -0.00782111 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00778981 |
| CD209 | CD209 molecule | -0.00778772 |
| PDGFC | platelet derived growth factor C | -0.00773833 |
| GAS1 | growth arrest-specific 1 | -0.00771958 |
| BGN | biglycan | -0.00770352 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00767911 |
| REEP1 | receptor accessory protein 1 | -0.00763044 |
| NELL1 | NEL-like 1 (chicken) | -0.00762892 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | -0.00749013 |
| PON3 | paraoxonase 3 | -0.00748642 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.0074355 |
| FBLN1 | fibulin 1 | -0.00743008 |
| BMP4 | bone morphogenetic protein 4 | -0.00738044 |
| PDLIM3 | PDZ and LIM domain 3 | -0.00737455 |
| THBS4 | thrombospondin 4 | -0.0073396 |
| IPO9 | importin 9 | -0.00725397 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0072268 |
| RGS5 | regulator of G-protein signaling 5 | -0.00721144 |
| ABHD6 | abhydrolase domain containing 6 | -0.00719056 |
| NAPA | N-ethylmaleimide-sensitive factor attachment protein, alpha | -0.00717534 |
| MXRA8 | matrix-remodelling associated 8 | -0.00716864 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.00716018 |
| INSIG1 | insulin induced gene 1 | -0.00715935 |
| PPA2 | pyrophosphatase (inorganic) 2 | -0.00710493 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00710242 |
| PLIN1 | perilipin 1 | -0.00707159 |
| GUSB | glucuronidase, beta | -0.00706176 |
| TGFB1 | transforming growth factor, beta 1 | -0.00705922 |
| CTSK | cathepsin K | -0.00705846 |
| GAMT | guanidinoacetate N-methyltransferase | -0.00705093 |
| CCL13 | chemokine (C-C motif) ligand 13 | -0.00701684 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0070054 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00694716 |
| PMF1 | polyamine-modulated factor 1 | -0.00692595 |
| SEPTIN10 | septin 10 | -0.00692242 |
| REC8 | REC8 meiotic recombination protein | -0.00691432 |
| GPSM2 | G-protein signaling modulator 2 | -0.0069088 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00690152 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.00689655 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.00685804 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | -0.00685202 |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | -0.00685029 |
| NNMT | nicotinamide N-methyltransferase | -0.00684436 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | -0.00683815 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00677005 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.00676112 |
| CEL | carboxyl ester lipase | -0.00675193 |
| INTS1 | integrator complex subunit 1 | -0.00673557 |
| LOXL1 | lysyl oxidase-like 1 | -0.00671556 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00671342 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00670486 |
| FOXM1 | forkhead box M1 | -0.00669969 |
| C6 | complement component 6 | -0.00668978 |
| FEN1 | flap structure-specific endonuclease 1 | -0.00668511 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.00666311 |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | -0.00666263 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00663049 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | -0.00662696 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | -0.00659947 |
| HMGB1 | high mobility group box 1 | -0.00656542 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00656499 |
| TEX30 | testis expressed 30 | -0.0065621 |
| EVA1B | eva-1 homolog B (C. elegans) | -0.00656167 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -0.00655537 |
| SLC43A3 | solute carrier family 43, member 3 | -0.00655028 |
| TTR | transthyretin | -0.00654751 |
| ACAD8 | acyl-CoA dehydrogenase family, member 8 | -0.0065241 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00649807 |
| PLN | phospholamban | -0.00649027 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | -0.00645528 |
| SLBP | stem-loop binding protein | -0.00643771 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | -0.00643505 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | -0.00642956 |
| POLE | polymerase (DNA directed), epsilon, catalytic subunit | -0.006379 |
| FRZB | frizzled-related protein | -0.00637659 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00635372 |
| TM4SF4 | transmembrane 4 L six family member 4 | -0.00635057 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.00634251 |
| HMGB3 | high mobility group box 3 | -0.00633063 |
| LYZ | lysozyme | -0.00632806 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | -0.00630872 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.00630738 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | -0.0062895 |
| DSE | dermatan sulfate epimerase | -0.00627214 |
| RAD9A | RAD9 homolog A (S. pombe) | -0.00625636 |
| PRC1 | protein regulator of cytokinesis 1 | -0.00625008 |
| HMGB2 | high mobility group box 2 | -0.00621605 |
| NEK2 | NIMA-related kinase 2 | -0.00621462 |
| THOC6 | THO complex 6 | -0.00620129 |
| GSE1 | Gse1 coiled-coil protein | -0.00619474 |
| RPA3 | replication protein A3, 14kDa | -0.00618374 |
| PCGF3 | polycomb group ring finger 3 | -0.00616338 |
| ESRP2 | epithelial splicing regulatory protein 2 | -0.00614093 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | -0.00613978 |
| CP | ceruloplasmin (ferroxidase) | -0.00613679 |
| NDUFB6 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa | -0.00612815 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.00611195 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | -0.00610994 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.00610831 |
| TBC1D16 | TBC1 domain family, member 16 | -0.00608913 |
| BCHE | butyrylcholinesterase | -0.00608833 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.0060645 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -0.0060456 |
| HOXB6 | homeobox B6 | -0.00604252 |
| CLK2 | CDC-like kinase 2 | -0.00603554 |
| BAD | BCL2-associated agonist of cell death | -0.00602771 |
| CD320 | CD320 molecule | -0.00600829 |
| APOD | apolipoprotein D | -0.00600545 |
| MFAP4 | microfibrillar-associated protein 4 | -0.0060038 |
| FASTKD3 | FAST kinase domains 3 | -0.00599876 |
| HPN | hepsin | -0.00598233 |
| CHKB | choline kinase beta | -0.0059745 |
| HOXC6 | homeobox C6 | -0.0059652 |
| LMNB2 | lamin B2 | -0.00596192 |
| SERPINF2 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | -0.00596 |
| SDC2 | syndecan 2 | -0.00594696 |
| AURKB | aurora kinase B | -0.00591251 |
| NAXD | NAD(P)HX dehydratase | -0.00591071 |
| C1R | complement component 1, r subcomponent | -0.00587634 |
| DHCR7 | 7-dehydrocholesterol reductase | -0.00587033 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00585696 |
| COL6A3 | collagen, type VI, alpha 3 | -0.00585172 |
| ANXA5 | annexin A5 | -0.00584578 |
| GLOD4 | glyoxalase domain containing 4 | -0.0058346 |
| CPE | carboxypeptidase E | -0.00583231 |
| THAP12 | THAP domain containing 12 | -0.00582847 |
| SDC1 | syndecan 1 | -0.00582202 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00581708 |
| MACROD1 | MACRO domain containing 1 | -0.00581652 |
| SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | -0.00581505 |
| RGL1 | ral guanine nucleotide dissociation stimulator-like 1 | -0.00581365 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00581063 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.00580459 |
| PON1 | paraoxonase 1 | -0.00579302 |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) | -0.00578049 |
| PRRC2A | proline-rich coiled-coil 2A | -0.00577469 |
| MELK | maternal embryonic leucine zipper kinase | -0.00577048 |
| EML3 | echinoderm microtubule associated protein like 3 | -0.00576858 |
| ACO1 | aconitase 1, soluble | -0.00575644 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00575039 |
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | -0.00574969 |
| CBX5 | chromobox homolog 5 | -0.00573582 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | -0.00573552 |
| TOX3 | TOX high mobility group box family member 3 | -0.00573168 |
| KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 | -0.00572685 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.00570631 |
| CST3 | cystatin C | -0.00570023 |
| SDHAP1 | succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 | -0.00568223 |
| TIMELESS | timeless circadian clock | -0.00567067 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -0.00566145 |
| MAP7 | microtubule-associated protein 7 | -0.00565415 |
| GSTT1 | glutathione S-transferase theta 1 | -0.00565262 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | -0.00565193 |
| CLEC2B | C-type lectin domain family 2, member B | -0.00564952 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00564844 |
| THAP9-AS1 | THAP9 antisense RNA 1 | -0.00564054 |
| LBR | lamin B receptor | -0.00563013 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00562551 |
| PLXNB2 | plexin B2 | -0.00561944 |
| ANPEP | alanyl (membrane) aminopeptidase | -0.00561363 |
| DCXR | dicarbonyl/L-xylulose reductase | -0.00560707 |
| AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | -0.00560297 |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | -0.00559488 |
| CD14 | CD14 molecule | -0.00558319 |
| CPB2 | carboxypeptidase B2 (plasma) | -0.00558225 |
| ECT2 | epithelial cell transforming 2 | -0.00558205 |
| RIN2 | Ras and Rab interactor 2 | -0.00556495 |
| CHN2 | chimerin 2 | -0.00556165 |
| ADSL | adenylosuccinate lyase | -0.00556064 |
| DBF4 | DBF4 zinc finger | -0.00555621 |
| MCOLN1 | mucolipin 1 | -0.00555598 |
| ZBED1 | zinc finger, BED-type containing 1 | -0.00555589 |
| CALML5 | calmodulin-like 5 | -0.0055554 |
| CCDC92 | coiled-coil domain containing 92 | -0.00555098 |
| S100A2 | S100 calcium binding protein A2 | -0.00554836 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.00554409 |
| TFAM | transcription factor A, mitochondrial | -0.00553141 |
| CCL21 | chemokine (C-C motif) ligand 21 | -0.00551732 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00551474 |
