ITGA2B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)|ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3674)
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Genes

353 genes differentially expressed following the ITGA2B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HDX highly divergent homeobox 3.31226
CD14 CD14 molecule 3.31226
ADRB2 adrenoceptor beta 2, surface 3.31226
CD160 CD160 molecule 3.31226
ZNF662 zinc finger protein 662 3.31226
SLC35G5 solute carrier family 35, member G5 3.31226
HES7 hes family bHLH transcription factor 7 3.31226
PGBDF plakoglobin binding and degradation factor 3.31226
SKOR2 SKI family transcriptional corepressor 2 3.31226
LRRC55 leucine rich repeat containing 55 3.31226
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.31226
ASB15 ankyrin repeat and SOCS box containing 15 3.31226
ZNF99 zinc finger protein 99 3.31226
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 3.31226
COL19A1 collagen, type XIX, alpha 1 3.31226
SIX3 SIX homeobox 3 3.31226
TMPRSS11F transmembrane protease, serine 11F 3.31226
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 3.31226
FOLR1 folate receptor 1 (adult) 3.31226
MYO7B myosin VIIB 3.31226
GOT1L1 glutamic-oxaloacetic transaminase 1-like 1 3.31226
PAX2 paired box 2 3.31226
APOA2 apolipoprotein A-II 3.31226
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.31226
CPB1 carboxypeptidase B1 (tissue) 3.31226
CRIP1 cysteine-rich protein 1 (intestinal) 3.31226
LRRC61 leucine rich repeat containing 61 3.31226
MUC21 mucin 21, cell surface associated 3.31226
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.31226
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 3.31226
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.31226
THEMIS thymocyte selection associated 3.31226
LRRC10B leucine rich repeat containing 10B 3.31226
TMEM71 transmembrane protein 71 3.31226
XCL1 chemokine (C motif) ligand 1 3.31226
TAL2 T-cell acute lymphocytic leukemia 2 3.31226
OTUD6A OTU deubiquitinase 6A 3.31226
ADGB androglobin 3.31226
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.31226
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.31226
HAS1 hyaluronan synthase 1 3.31226
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.31226
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3.31226
HES2 hes family bHLH transcription factor 2 3.31226
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.31226
ANGPTL8 angiopoietin like 8 3.31226
GOLGA6L7 golgin A6 family like 7 3.31226
DEFB108B defensin, beta 108B 3.31226
ERVW-1 endogenous retrovirus group W, member 1 3.31226
YPEL4 yippee-like 4 (Drosophila) 3.31226
MCHR2 melanin-concentrating hormone receptor 2 3.31226
MYH4 myosin, heavy chain 4, skeletal muscle 3.31226
SPEM1 spermatid maturation 1 3.31226
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.31226
HTD2 hydroxyacyl-thioester dehydratase type 2 3.31226
BNIP5 BCL2 interacting protein 5 3.31226
THSD8 thrombospondin type 1 domain containing 8 3.31226
STRIT1 small transmembrane regulator of ion transport 1 3.31226
DPEP2NB DPEP2 neighbor 3.31226
GNG5B G protein subunit gamma 5B 3.31226
CPHXL cytoplasmic polyadenylated homeobox like 3.31226
SEPTIN12 septin 12 3.31226
VXN vexin 3.31226
RNF227 ring finger protein 227 3.31226
SPATA46 spermatogenesis associated 46 3.31226
SMLR1 small leucine-rich protein 1 3.31226
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.31226
C1QL4 complement component 1, q subcomponent-like 4 3.31226
NHLRC4 NHL repeat containing 4 3.31226
C1ORF162 chromosome 1 open reading frame 162 3.31226
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.31226
CBLN2 cerebellin 2 precursor 3.31226
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.31226
ARL5C ADP-ribosylation factor-like 5C 3.31226
PTPRS protein tyrosine phosphatase, receptor type, S 3.31226
PRB2 proline-rich protein BstNI subfamily 2 3.31226
EXOC3L4 exocyst complex component 3-like 4 3.31226
FOXI2 forkhead box I2 3.31226
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.31226
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.31226
DOK7 docking protein 7 3.31226
SPATA25 spermatogenesis associated 25 3.31226
VSIG8 V-set and immunoglobulin domain containing 8 3.31226
GATA3 GATA binding protein 3 3.31226
DLK2 delta-like 2 homolog (Drosophila) 3.31226
IL1R1 interleukin 1 receptor, type I 3.31226
GSC goosecoid homeobox 3.31226
CCIN calicin 3.31226
LRRC24 leucine rich repeat containing 24 3.31226
THBD thrombomodulin 3.31226
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.31226
CLEC18C C-type lectin domain family 18, member C 3.31226
OR52K1 olfactory receptor, family 52, subfamily K, member 1 3.31226
FAM209A family with sequence similarity 209, member A 3.31226
CGB1 chorionic gonadotropin, beta polypeptide 1 3.31226
TREH trehalase (brush-border membrane glycoprotein) 3.31226
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 3.31226
TDRD10 tudor domain containing 10 3.31226
KLHL41 kelch-like family member 41 3.31226
KLF2 Kruppel-like factor 2 3.31226
CDHR4 cadherin-related family member 4 3.31226
CDHR5 cadherin-related family member 5 3.31226
KRT222 keratin 222, type II 3.31226
RGSL1 regulator of G-protein signaling like 1 3.31226
MYF6 myogenic factor 6 (herculin) 3.31226
GAL3ST2 galactose-3-O-sulfotransferase 2 3.31226
LRRK2 leucine-rich repeat kinase 2 3.31226
KLK11 kallikrein-related peptidase 11 3.31226
COL6A5 collagen, type VI, alpha 5 3.31226
STRC stereocilin 3.31226
ZNF831 zinc finger protein 831 3.31226
LAMB3 laminin, beta 3 3.31226
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.31226
RAB6C RAB6C, member RAS oncogene family 3.31226
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 3.31226
ORM2 orosomucoid 2 3.31226
PGR progesterone receptor 3.31226
CTSE cathepsin E 3.31226
VAV1 vav 1 guanine nucleotide exchange factor 3.31226
DMRT1 doublesex and mab-3 related transcription factor 1 3.31226
PLA2G12B phospholipase A2, group XIIB 3.31226
TPPP3 tubulin polymerization-promoting protein family member 3 3.31226
CEL carboxyl ester lipase 3.31226
RGS11 regulator of G-protein signaling 11 3.31226
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 3.31226
SPRR2F small proline-rich protein 2F 3.31226
PCDHGB5 protocadherin gamma subfamily B, 5 3.31226
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.31226
GRAPL GRB2-related adaptor protein-like 3.31226
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.31226
PRAP1 proline-rich acidic protein 1 3.31226
ASCL2 achaete-scute family bHLH transcription factor 2 3.31226
RHOJ ras homolog family member J 3.31226
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.31226
ZC2HC1B zinc finger, C2HC-type containing 1B 3.31226
ICAM2 intercellular adhesion molecule 2 3.31226
GALP galanin-like peptide 3.31226
EPX eosinophil peroxidase 3.31226
MAGEB17 melanoma antigen family B17 3.31226
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.31226
TMPRSS15 transmembrane protease, serine 15 3.31226
STEAP4 STEAP family member 4 3.31226
TGM4 transglutaminase 4 3.31226
ST18 suppression of tumorigenicity 18, zinc finger 3.31226
SPRN shadow of prion protein homolog (zebrafish) 3.31226
PFN4 profilin family, member 4 3.31226
HJV hemojuvelin BMP co-receptor 3.25572
PTX3 pentraxin 3, long 3.25572
MAK male germ cell-associated kinase 3.18877
CDC27 cell division cycle 27 2.95106
CAPN7 calpain 7 2.90654
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 2.83917
POU5F1B POU class 5 homeobox 1B 2.83575
MYO1C myosin IC 2.82463
TOR3A torsin family 3, member A 2.79064
ATRX alpha thalassemia/mental retardation syndrome X-linked 2.78717
ANLN anillin, actin binding protein 2.70723
RTBDN retbindin 2.69238
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.67546
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.67546
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.65937
SMAD3 SMAD family member 3 2.61748
GJA1 gap junction protein, alpha 1, 43kDa 2.61268
BRMS1 breast cancer metastasis suppressor 1 2.61268
ZNF213 zinc finger protein 213 2.59249
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.55124
KDM4C lysine (K)-specific demethylase 4C 2.55095
HMCN1 hemicentin 1 2.53629
MLKL mixed lineage kinase domain-like 2.53147
FRMD8 FERM domain containing 8 2.52069
WNT4 wingless-type MMTV integration site family, member 4 2.50563
SRD5A3 steroid 5 alpha-reductase 3 2.50563
PAGE4 P antigen family, member 4 (prostate associated) 2.50563
LTF lactotransferrin 2.50563
FBXL22 F-box and leucine-rich repeat protein 22 2.50563
ZNF217 zinc finger protein 217 2.45787
TBCD tubulin folding cofactor D 2.44547
PRKN parkin RBR E3 ubiquitin protein ligase 2.44158
ZNF629 zinc finger protein 629 2.43722
MAK16 MAK16 homolog (S. cerevisiae) 2.43707
FXYD1 FXYD domain containing ion transport regulator 1 2.43453
ZDHHC4 zinc finger, DHHC-type containing 4 2.43232
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.42811
DYNC2I2 dynein 2 intermediate chain 2 2.41457
NRG4 neuregulin 4 2.39437
IFI35 interferon-induced protein 35 2.39437
ZNF324B zinc finger protein 324B 2.39437
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2.39437
CLPSL1 colipase-like 1 2.39437
MANSC4 MANSC domain containing 4 2.39437
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 2.39437
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.39437
OSBPL7 oxysterol binding protein-like 7 2.39437
SENP6 SUMO1/sentrin specific peptidase 6 2.36405
TPRKB TP53RK binding protein 2.35384
TOR1AIP1 torsin A interacting protein 1 2.34588
RFT1 RFT1 homolog (S. cerevisiae) 2.31654
SYCP2 synaptonemal complex protein 2 2.30737
NANOS2 nanos homolog 2 (Drosophila) 2.30737
ARFIP1 ADP-ribosylation factor interacting protein 1 2.305
BRSK1 BR serine/threonine kinase 1 2.29155
TAC3 tachykinin 3 2.29155
DNAH17 dynein, axonemal, heavy chain 17 2.2869
SSR1 signal sequence receptor, alpha 2.28268
MED14 mediator complex subunit 14 2.27058
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 2.22701
RILPL1 Rab interacting lysosomal protein-like 1 2.21042
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 2.17926
HIGD1B HIG1 hypoxia inducible domain family, member 1B 2.16124
BMAL2 basic helix-loop-helix ARNT like 2 2.1538
RTTN rotatin 2.15376
MID1 midline 1 2.1365
ZNF888 zinc finger protein 888 2.10669
TMEM178B transmembrane protein 178B 2.09614
NARS1 asparaginyl-tRNA synthetase 1 2.05129
SCART1 scavenger receptor protein family member 2.04247
ZNF219 zinc finger protein 219 2.02243
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.00729
RNF217 ring finger protein 217 2.00729

decreased expression

Symbol Name Standardized Value
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -3.31226
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -3.31226
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 -3.31226
TAS2R30 taste receptor, type 2, member 30 -3.31226
CASR calcium-sensing receptor -3.31226
POU5F2 POU domain class 5, transcription factor 2 -3.31226
NCBP1 nuclear cap binding protein subunit 1, 80kDa -3.31226
FLNC filamin C, gamma -3.31226
ZNF554 zinc finger protein 554 -3.31226
TASOR transcription activation suppressor -3.31226
H4C1 H4 clustered histone 1 -3.31226
CCDC163 CCDC163 homolog -3.31226
SERF1B small EDRK-rich factor 1B (centromeric) -3.25572
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 -3.25572
RNF39 ring finger protein 39 -3.25572
ANXA13 annexin A13 -3.25572
MAEL maelstrom spermatogenic transposon silencer -3.25572
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -3.25572
PRSS53 protease, serine, 53 -3.25572
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) -3.25572
TMEM82 transmembrane protein 82 -3.25572
DCST1 DC-STAMP domain containing 1 -3.25572
CD101 CD101 molecule -3.25572
ASCL5 achaete-scute family bHLH transcription factor 5 -3.25572
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -3.25572
GMFG glia maturation factor, gamma -3.25572
CLCF1 cardiotrophin-like cytokine factor 1 -3.25572
GNRHR gonadotropin-releasing hormone receptor -3.25572
C6ORF58 chromosome 6 open reading frame 58 -3.25572
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -3.25572
ASIC4 acid sensing (proton gated) ion channel family member 4 -3.25572
LRRC3 leucine rich repeat containing 3 -3.25572
KLK4 kallikrein-related peptidase 4 -3.25572
PCDHA13 protocadherin alpha 13 -3.25572
CLEC6A C-type lectin domain family 6, member A -3.25572
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -3.25572
RAB36 RAB36, member RAS oncogene family -3.25572
NMBR neuromedin B receptor -3.25572
KLF4 Kruppel-like factor 4 (gut) -3.25572
FRG2C FSHD region gene 2 family, member C -3.25572
ALDOB aldolase B, fructose-bisphosphate -3.25572
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -3.25572
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -3.25572
SQOR sulfide quinone oxidoreductase -3.25572
NXPE1 neurexophilin and PC-esterase domain family, member 1 -3.25572
RAB44 RAB44, member RAS oncogene family -3.25572
SPACDR sperm acrosome developmental regulator -3.25572
IP6K3 inositol hexakisphosphate kinase 3 -3.25572
DOC2B double C2-like domains, beta -3.1255
HSPB8 heat shock 22kDa protein 8 -3.1255
RUNDC3B RUN domain containing 3B -3.11378
TPGS1 tubulin polyglutamylase complex subunit 1 -3.00312
ZNF621 zinc finger protein 621 -2.95106
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -2.94553
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.91353
YIPF4 Yip1 domain family, member 4 -2.80909
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.80572
H2AC20 H2A clustered histone 20 -2.79045
MRI1 methylthioribose-1-phosphate isomerase 1 -2.78362
FAM194C family with sequence similarity 149 member C -2.72722
NBEAL1 neurobeachin-like 1 -2.68598
ZSWIM3 zinc finger, SWIM-type containing 3 -2.65835
TFDP1 transcription factor Dp-1 -2.65563
ABR active BCR-related -2.61268
NCOA4 nuclear receptor coactivator 4 -2.61268
LIMD1 LIM domains containing 1 -2.61042
LOC107985101 uncharacterized LOC107985101 -2.61042
U2AF1 U2 small nuclear RNA auxiliary factor 1 -2.61042
TMEM258 transmembrane protein 258 -2.53502
IRS2 insulin receptor substrate 2 -2.53502
JUNB jun B proto-oncogene -2.53147
MBD3 methyl-CpG binding domain protein 3 -2.50563
EMILIN2 elastin microfibril interfacer 2 -2.4966
SAT1 spermidine/spermine N1-acetyltransferase 1 -2.457
MEGF10 multiple EGF-like-domains 10 -2.45079
KLHL5 kelch-like family member 5 -2.43363
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.42989
CLDN10 claudin 10 -2.41457
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 -2.39437
ORC6 origin recognition complex, subunit 6 -2.39437
FKBP2 FK506 binding protein 2, 13kDa -2.3879
CCNP cyclin P -2.3879
STARD10 StAR-related lipid transfer (START) domain containing 10 -2.37804
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -2.33217
SGF29 SAGA complex associated factor 29 -2.3305
GSTCD glutathione S-transferase, C-terminal domain containing -2.32123
HSPA8 heat shock 70kDa protein 8 -2.29581
EBF3 early B-cell factor 3 -2.29155
C3 complement component 3 -2.29155
SPATA12 spermatogenesis associated 12 -2.29155
ATP7A ATPase, Cu++ transporting, alpha polypeptide -2.29155
PELI3 pellino E3 ubiquitin protein ligase family member 3 -2.29155
ASRGL1 asparaginase like 1 -2.27786
NKIRAS2 NFKB inhibitor interacting Ras-like 2 -2.27058
PA2G4 proliferation-associated 2G4, 38kDa -2.26889
ENTREP2 endosomal transmembrane epsin interactor 2 -2.26865
TSPAN6 tetraspanin 6 -2.26379
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.25542
AKAP3 A kinase (PRKA) anchor protein 3 -2.25542
ROGDI rogdi homolog (Drosophila) -2.22701
GHR growth hormone receptor -2.20899
PAPPA2 pappalysin 2 -2.20899
ZNF611 zinc finger protein 611 -2.20172
FEM1C fem-1 homolog c (C. elegans) -2.19542
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -2.19542
MAMLD1 mastermind-like domain containing 1 -2.19542
GLI3 GLI family zinc finger 3 -2.19542
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -2.18116
UBE3B ubiquitin protein ligase E3B -2.18116
EXOC3 exocyst complex component 3 -2.17926
SPICP3 Spi-C transcription factor pseudogene 3 -2.17372
TRDN triadin -2.16792
FLACC1 flagellum associated containing coiled-coil domains 1 -2.16124
C19ORF73 chromosome 19 open reading frame 73 -2.16124
IL17C interleukin 17C -2.16124
AHNAK2 AHNAK nucleoprotein 2 -2.16124
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.16124
SMC3 structural maintenance of chromosomes 3 -2.16124
BHLHE40 basic helix-loop-helix family, member e40 -2.16124
CDK5 cyclin-dependent kinase 5 -2.14053
MRNIP MRN complex interacting protein -2.1365
PLD5 phospholipase D family, member 5 -2.1365
SPPL2A signal peptide peptidase like 2A -2.1365
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.13383
CCDC174 coiled-coil domain containing 174 -2.10669
CIC capicua transcriptional repressor -2.10669
TP53 tumor protein p53 -2.08006
ZNF133 zinc finger protein 133 -2.07083
TESC tescalcin -2.06176
EPDR1 ependymin related 1 -2.06176
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -2.05876
PRSS35 protease, serine, 35 -2.05608
SBK1 SH3 domain binding kinase 1 -2.04977
FGF2 fibroblast growth factor 2 (basic) -2.04028