ITGA3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)|The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 3675)
Similar Terms
Downloads & Tools

Genes

344 genes differentially expressed following the ITGA3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CCDC158 coiled-coil domain containing 158 2.76541
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.76541
SMIM41 small integral membrane protein 41 2.76541
ZNF324 zinc finger protein 324 2.76541
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.76541
PLCZ1 phospholipase C, zeta 1 2.76541
ERAS ES cell expressed Ras 2.76541
DHH desert hedgehog 2.76541
PLGLB1 plasminogen-like B1 2.76541
MAB21L3 mab-21-like 3 (C. elegans) 2.76541
LIX1 Lix1 homolog (chicken) 2.76541
SPMAP2L sperm microtubule associated protein 2 like 2.76541
CABP4 calcium binding protein 4 2.76541
SMIM22 small integral membrane protein 22 2.76541
WDR87 WD repeat domain 87 2.76541
FPR2 formyl peptide receptor 2 2.76541
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 2.76541
CRYGA crystallin, gamma A 2.76541
APP-DT APP divergent transcript 2.76541
TTC22 tetratricopeptide repeat domain 22 2.76541
CIMAP2 ciliary microtubule associated protein 2 2.76541
KLK6 kallikrein-related peptidase 6 2.76541
ART1 ADP-ribosyltransferase 1 2.76541
IFITM10 interferon induced transmembrane protein 10 2.76541
SPMIP8 sperm microtubule inner protein 8 2.76541
IFT70A intraflagellar transport 70A 2.76541
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.76541
DMRT1 doublesex and mab-3 related transcription factor 1 2.76541
RABAC1 Rab acceptor 1 (prenylated) 2.71536
SAP18 Sin3A-associated protein, 18kDa 2.70385
FHIP1B FHF complex subunit HOOK interacting protein 1B 2.67276
TDO2 tryptophan 2,3-dioxygenase 2.62082
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.62082
MAGEA3 melanoma antigen family A3 2.62082
FOLR1 folate receptor 1 (adult) 2.62082
ELSPBP1 epididymal sperm binding protein 1 2.62082
RASA4B RAS p21 protein activator 4B 2.62082
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.62082
SELPLG selectin P ligand 2.62082
HGD homogentisate 1,2-dioxygenase 2.62082
NOTO notochord homeobox 2.62082
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2.62082
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.62082
RGPD4 RANBP2-like and GRIP domain containing 4 2.62082
OLIG2 oligodendrocyte lineage transcription factor 2 2.62082
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.62082
CLEC14A C-type lectin domain family 14, member A 2.62082
TOR1B torsin family 1, member B (torsin B) 2.62082
TMEM217 transmembrane protein 217 2.62082
TAFA3 TAFA chemokine like family member 3 2.62082
MYO1A myosin IA 2.62082
OC90 otoconin 90 2.62082
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.62082
PRDM12 PR domain containing 12 2.62082
HES2 hes family bHLH transcription factor 2 2.62082
LRRC10B leucine rich repeat containing 10B 2.62082
TDRD9 tudor domain containing 9 2.62082
RPL3L ribosomal protein L3-like 2.62082
TLX2 T-cell leukemia homeobox 2 2.62082
CIITA class II, major histocompatibility complex, transactivator 2.62082
PLXNB3 plexin B3 2.62082
ADGB androglobin 2.62082
CXCL2 chemokine (C-X-C motif) ligand 2 2.62082
POSTN periostin, osteoblast specific factor 2.62082
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.62082
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.62082
ASGR1 asialoglycoprotein receptor 1 2.62082
ACOT12 acyl-CoA thioesterase 12 2.62082
SIX3 SIX homeobox 3 2.62082
TEX53 testis expressed 53 2.62082
PNLIPRP1 pancreatic lipase-related protein 1 2.62082
ADGRG7 adhesion G protein-coupled receptor G7 2.62082
SPI1 Spi-1 proto-oncogene 2.62082
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.62082
SPRR2F small proline-rich protein 2F 2.62082
ASB5 ankyrin repeat and SOCS box containing 5 2.62082
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.62082
RASD1 RAS, dexamethasone-induced 1 2.62082
F5 coagulation factor V (proaccelerin, labile factor) 2.62082
LTB4R2 leukotriene B4 receptor 2 2.62082
PROP1 PROP paired-like homeobox 1 2.62082
SPAAR small regulatory polypeptide of amino acid response 2.62082
MUCL3 mucin like 3 2.62082
CFAP299 cilia and flagella associated protein 299 2.62082
H1-8 H1.8 linker histone 2.62082
CBY2 chibby family member 2 2.62082
WDR97 WD repeat domain 97 2.62082
SPATA46 spermatogenesis associated 46 2.62082
ENTREP2 endosomal transmembrane epsin interactor 2 2.62082
PLAAT2 phospholipase A and acyltransferase 2 2.62082
NDP Norrie disease (pseudoglioma) 2.62082
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.62082
LRRN4CL LRRN4 C-terminal like 2.62082
EDAR ectodysplasin A receptor 2.62082
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 2.62082
PTPRB protein tyrosine phosphatase, receptor type, B 2.62082
PCDHA3 protocadherin alpha 3 2.62082
RGS9BP regulator of G protein signaling 9 binding protein 2.62082
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.62082
SLC22A10 solute carrier family 22, member 10 2.62082
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.62082
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.62082
MAG myelin associated glycoprotein 2.62082
ANXA13 annexin A13 2.62082
GDF9 growth differentiation factor 9 2.62082
TAS1R1 taste receptor, type 1, member 1 2.62082
FAM131C family with sequence similarity 131, member C 2.62082
C9 complement component 9 2.62082
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.62082
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.62082
TFEC transcription factor EC 2.62082
ULBP1 UL16 binding protein 1 2.62082
CATSPERD catsper channel auxiliary subunit delta 2.62082
NRN1 neuritin 1 2.62082
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.62082
TTC9B tetratricopeptide repeat domain 9B 2.62082
LRRC43 leucine rich repeat containing 43 2.62082
ENDOU endonuclease, polyU-specific 2.62082
SPTBN5 spectrin, beta, non-erythrocytic 5 2.62082
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2.62082
CABP7 calcium binding protein 7 2.62082
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.62082
RHCG Rh family, C glycoprotein 2.62082
C17ORF107 chromosome 17 open reading frame 107 2.62082
UBQLNL ubiquilin-like 2.62082
LRRC15 leucine rich repeat containing 15 2.62082
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.62082
PRPF3 pre-mRNA processing factor 3 2.62082
AZIN2 antizyme inhibitor 2 2.62082
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.62082
IL9R interleukin 9 receptor 2.62082
ARL13A ADP-ribosylation factor-like 13A 2.62082
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.62082
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.62082
C2CD4A C2 calcium-dependent domain containing 4A 2.62082
CLEC4D C-type lectin domain family 4, member D 2.62082
CPA2 carboxypeptidase A2 (pancreatic) 2.62082
TDRD10 tudor domain containing 10 2.62082
CALHM3 calcium homeostasis modulator 3 2.62082
IL1B interleukin 1, beta 2.62082
CAGE1 cancer antigen 1 2.62082
WFDC8 WAP four-disulfide core domain 8 2.62082
CDHR5 cadherin-related family member 5 2.62082
KISS1 KiSS-1 metastasis-suppressor 2.62082
CRYBB3 crystallin, beta B3 2.62082
VNN2 vanin 2 2.62082
AQP7 aquaporin 7 2.62082
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.62082
EDN1 endothelin 1 2.62082
PAGR1 PAXIP1 associated glutamate-rich protein 1 2.62082
ACKR2 atypical chemokine receptor 2 2.62082
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.62082
NUTM2B NUT family member 2B 2.62082
CNGB1 cyclic nucleotide gated channel beta 1 2.62082
DEFB135 defensin, beta 135 2.62082
DSPP dentin sialophosphoprotein 2.62082
MGP matrix Gla protein 2.62082
ARMCX3 armadillo repeat containing, X-linked 3 2.62082
C22ORF31 chromosome 22 open reading frame 31 2.62082
IL17B interleukin 17B 2.62082
LAMB3 laminin, beta 3 2.62082
WNT10B wingless-type MMTV integration site family, member 10B 2.62082
NEUROD1 neuronal differentiation 1 2.62082
AMIGO3 adhesion molecule with Ig-like domain 3 2.62082
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.62082
TTC29 tetratricopeptide repeat domain 29 2.62082
LHX5 LIM homeobox 5 2.62082
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.62082
NELL1 NEL-like 1 (chicken) 2.62082
CARNS1 carnosine synthase 1 2.62082
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.62082
FAM9B family with sequence similarity 9, member B 2.62082
CHRM4 cholinergic receptor, muscarinic 4 2.62082
ZC3H12D zinc finger CCCH-type containing 12D 2.62082
RERGL RERG/RAS-like 2.62082
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.62082
ITPKA inositol-trisphosphate 3-kinase A 2.62082
EMCN endomucin 2.62082
RASL11A RAS-like, family 11, member A 2.62082
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.62082
GOLGA8N golgin A8 family, member N 2.62082
UQCRH ubiquinol-cytochrome c reductase hinge protein 2.62082
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.62082
OAZ1 ornithine decarboxylase antizyme 1 2.61154
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.61154
RGS10 regulator of G-protein signaling 10 2.57479
SYAP1 synapse associated protein 1 2.52862
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 2.52862
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 2.5281
GOLT1A golgi transport 1A 2.47777
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.46701
PCDHGA1 protocadherin gamma subfamily A, 1 2.45669
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.44705
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.42057
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.42057
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 2.40772
MLIP muscular LMNA-interacting protein 2.38898
TBCB tubulin folding cofactor B 2.38898
MRPS23 mitochondrial ribosomal protein S23 2.38481
RGPD3 RANBP2-like and GRIP domain containing 3 2.38052
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.38052
ZNF283 zinc finger protein 283 2.38052
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 2.36776
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 2.36043
KANSL1L KAT8 regulatory NSL complex subunit 1-like 2.35672
ESD esterase D 2.35393
ZNF646 zinc finger protein 646 2.34101
ZNF382 zinc finger protein 382 2.32151
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.31576
PCLAF PCNA clamp associated factor 2.28282
SFT2D2 SFT2 domain containing 2 2.28282
SND1 staphylococcal nuclease and tudor domain containing 1 2.27154
NPAS2 neuronal PAS domain protein 2 2.27154
RNF126 ring finger protein 126 2.2562
LOC122526780 uncharacterized LOC122526780 2.22026
STOML2 stomatin (EPB72)-like 2 2.21063
C14ORF119 chromosome 14 open reading frame 119 2.20137
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.20052
NCAM2 neural cell adhesion molecule 2 2.20052
TAPBPL TAP binding protein-like 2.20052
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.19855
RPL26 ribosomal protein L26 2.19855
C12ORF76 chromosome 12 open reading frame 76 2.19855
NEK6 NIMA-related kinase 6 2.16986
RUSC2 RUN and SH3 domain containing 2 2.14375
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 2.13964
DGUOK deoxyguanosine kinase 2.12707
TRMT61B tRNA methyltransferase 61B 2.12707
KIF7 kinesin family member 7 2.12707
CCDC137 coiled-coil domain containing 137 2.10975
FANCG Fanconi anemia, complementation group G 2.1007
MRPL49 mitochondrial ribosomal protein L49 2.09544
SREBF2 sterol regulatory element binding transcription factor 2 2.09329
NCBP2AS2 NCBP2 antisense 2 (head to head) 2.09329
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.09329
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.08797
ILF2 interleukin enhancer binding factor 2 2.06746
TBL1X transducin (beta)-like 1X-linked 2.06215
CCDC92B coiled-coil domain containing 92B 2.05827
AARD alanine and arginine rich domain containing protein 2.05528
DEDD2 death effector domain containing 2 2.05094
TRIM52 tripartite motif containing 52 2.04228
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2.03574
MB21D2 Mab-21 domain containing 2 2.00192
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 2.00138

decreased expression

Symbol Name Standardized Value
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.76541
H4C1 H4 clustered histone 1 -2.76541
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -2.76541
BEAN1 brain expressed, associated with NEDD4, 1 -2.76541
NLRP2 NLR family, pyrin domain containing 2 -2.62082
PRCD progressive rod-cone degeneration -2.62082
SIAE sialic acid acetylesterase -2.62082
BPIFC BPI fold containing family C -2.62082
FRMPD1 FERM and PDZ domain containing 1 -2.62082
SPMIP4 sperm microtubule inner protein 4 -2.62082
DEFB134 defensin, beta 134 -2.62082
CBLN1 cerebellin 1 precursor -2.62082
IDUA iduronidase, alpha-L- -2.62082
VPREB3 pre-B lymphocyte 3 -2.62082
FXYD2 FXYD domain containing ion transport regulator 2 -2.62082
SUSD4 sushi domain containing 4 -2.62082
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.62082
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.62082
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -2.62082
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) -2.62082
GJB7 gap junction protein, beta 7, 25kDa -2.62082
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 -2.62082
BTBD17 BTB (POZ) domain containing 17 -2.62082
TDRD6 tudor domain containing 6 -2.62082
CFAP45 cilia and flagella associated protein 45 -2.62082
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -2.62082
NPFFR1 neuropeptide FF receptor 1 -2.62082
RPL6 ribosomal protein L6 -2.62082
PCDHGA7 protocadherin gamma subfamily A, 7 -2.62082
TMEM238L transmembrane protein 238 like -2.62082
NMT1 N-myristoyltransferase 1 -2.62082
HEPHL1 hephaestin-like 1 -2.62082
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -2.62082
C10ORF105 chromosome 10 open reading frame 105 -2.62082
DLK1 delta-like 1 homolog (Drosophila) -2.62082
MAGEB17 melanoma antigen family B17 -2.62082
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 -2.62082
MAP1A microtubule-associated protein 1A -2.62082
MAOB monoamine oxidase B -2.58384
LYG1 lysozyme G-like 1 -2.57142
BBS9 Bardet-Biedl syndrome 9 -2.55378
ATP13A3 ATPase type 13A3 -2.53561
ITSN2 intersectin 2 -2.53561
FAM149A family with sequence similarity 149, member A -2.53561
LDOC1 leucine zipper, down-regulated in cancer 1 -2.4988
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -2.49069
GREB1 growth regulation by estrogen in breast cancer 1 -2.47777
ORC4 origin recognition complex, subunit 4 -2.45777
CUEDC1 CUE domain containing 1 -2.45669
RBM34 RNA binding motif protein 34 -2.40772
GRIP2 glutamate receptor interacting protein 2 -2.40573
CIART circadian associated repressor of transcription -2.40064
SLITRK4 SLIT and NTRK-like family, member 4 -2.40064
NPTX2 neuronal pentraxin II -2.3903
QRICH2 glutamine rich 2 -2.36101
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.36101
PTDSS2 phosphatidylserine synthase 2 -2.36043
CREB3 cAMP responsive element binding protein 3 -2.35968
RBM18 RNA binding motif protein 18 -2.35393
NOP9 NOP9 nucleolar protein -2.3033
LMTK1 lemur tail kinase 1 -2.30149
TMEM14B transmembrane protein 14B -2.29273
ZFHX2 zinc finger homeobox 2 -2.29273
DPYSL3 dihydropyrimidinase-like 3 -2.29099
E2F4 E2F transcription factor 4, p107/p130-binding -2.28383
TMLHE trimethyllysine hydroxylase, epsilon -2.28282
INSIG1 insulin induced gene 1 -2.27154
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.2296
PEX2 peroxisomal biogenesis factor 2 -2.20475
JUN jun proto-oncogene -2.20137
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -2.20137
OAF OAF homolog (Drosophila) -2.20137
STPG4 sperm-tail PG-rich repeat containing 4 -2.20052
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.20052
GPER1 G protein-coupled estrogen receptor 1 -2.20052
IDS iduronate 2-sulfatase -2.20052
CLGN calmegin -2.19855
TGFA transforming growth factor, alpha -2.19433
SCLY selenocysteine lyase -2.19101
TMEM35B transmembrane protein 35B -2.16175
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.16175
PRR15 proline rich 15 -2.16111
ZNF550 zinc finger protein 550 -2.11343
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.10628
MED1 mediator complex subunit 1 -2.1007
RBM48 RNA binding motif protein 48 -2.09329
TPD52L1 tumor protein D52-like 1 -2.09329
HACD2 3-hydroxyacyl-CoA dehydratase 2 -2.08464
BECN1 beclin 1, autophagy related -2.08415
INSR insulin receptor -2.0826
TMF1 TATA element modulatory factor 1 -2.07556
UBXN6 UBX domain protein 6 -2.07348
ZSCAN23 zinc finger and SCAN domain containing 23 -2.06941
KYAT3 kynurenine aminotransferase 3 -2.05898
ASL argininosuccinate lyase -2.05528
PIWIL4 piwi-like RNA-mediated gene silencing 4 -2.04782
PRKCZ protein kinase C, zeta -2.04034
OSBPL7 oxysterol binding protein-like 7 -2.02514
GDF5 growth differentiation factor 5 -2.02514