ITGA5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description integrin, alpha 5 (fibronectin receptor, alpha polypeptide)|The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015] (NCBI Entrez Gene Database, 3678)
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Genes

322 genes differentially expressed following the ITGA5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD8B CD8b molecule 3.03441
ANKRD53 ankyrin repeat domain 53 3.03441
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.03441
INHBB inhibin, beta B 3.03441
IZUMO3 IZUMO family member 3 3.03441
DNAH1 dynein, axonemal, heavy chain 1 3.03441
SMIM23 small integral membrane protein 23 3.03441
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.03441
GREM2 gremlin 2, DAN family BMP antagonist 3.03441
ZNF575 zinc finger protein 575 3.03441
CLEC4G C-type lectin domain family 4, member G 3.03441
NOS2 nitric oxide synthase 2, inducible 3.03441
CPA2 carboxypeptidase A2 (pancreatic) 3.03441
PEX12 peroxisomal biogenesis factor 12 3.03441
AQP3 aquaporin 3 (Gill blood group) 3.03441
CTRL chymotrypsin-like 3.03441
MRLN myoregulin 3.03441
OR4D1 olfactory receptor, family 4, subfamily D, member 1 3.03441
LOC124902436 talanin 3.03441
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.03441
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.03441
LBHD1 LBH domain containing 1 3.03441
DNAH12 dynein, axonemal, heavy chain 12 3.03441
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.97667
ZEB2 zinc finger E-box binding homeobox 2 2.97667
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.97667
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.97667
AKR1C2 aldo-keto reductase family 1, member C2 2.97667
MAP3K7CL MAP3K7 C-terminal like 2.97667
SLC46A3 solute carrier family 46, member 3 2.97667
FAM180A family with sequence similarity 180, member A 2.97667
WDR87 WD repeat domain 87 2.97667
RAB7B RAB7B, member RAS oncogene family 2.97667
SCN2B sodium channel, voltage gated, type II beta subunit 2.97667
TNNI1 troponin I type 1 (skeletal, slow) 2.97667
GCKR glucokinase (hexokinase 4) regulator 2.97667
THRSP thyroid hormone responsive 2.97667
ARSI arylsulfatase family, member I 2.97667
HAS1 hyaluronan synthase 1 2.97667
ADAMTSL5 ADAMTS-like 5 2.97667
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.97667
TTLL8 tubulin tyrosine ligase-like family member 8 2.97667
COPZ2 coatomer protein complex, subunit zeta 2 2.97667
PNOC prepronociceptin 2.97667
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.97667
CIITA class II, major histocompatibility complex, transactivator 2.97667
ZNF467 zinc finger protein 467 2.97667
HES4 hes family bHLH transcription factor 4 2.97667
SSTR1 somatostatin receptor 1 2.97667
PKD1L1 polycystic kidney disease 1 like 1 2.97667
PAX8 paired box 8 2.97667
APOA2 apolipoprotein A-II 2.97667
FETUB fetuin B 2.97667
NFAM1 NFAT activating protein with ITAM motif 1 2.97667
RPE65 retinal pigment epithelium-specific protein 65kDa 2.97667
KRT78 keratin 78, type II 2.97667
WASL-DT WASL divergent transcript 2.97667
VSIR V-set immunoregulatory receptor 2.97667
SPATS1 spermatogenesis associated, serine-rich 1 2.97667
AVPR1A arginine vasopressin receptor 1A 2.97667
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.97667
SIM1 single-minded family bHLH transcription factor 1 2.97667
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.97667
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.97667
WNT16 wingless-type MMTV integration site family, member 16 2.97667
SPACA9 sperm acrosome associated 9 2.97667
MINAR2 membrane integral NOTCH2 associated receptor 2 2.97667
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.97667
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.97667
MDFIC2 MyoD family inhibitor domain containing 2 2.97667
GREP1 glycine rich extracellular protein 1 2.97667
FYB2 FYN binding protein 2 2.97667
LHFPL7 LHFPL tetraspan subfamily member 7 2.97667
LY6L lymphocyte antigen 6 family member L 2.97667
CFAP299 cilia and flagella associated protein 299 2.97667
TMEM225B transmembrane protein 225B 2.97667
GRAP GRB2-related adaptor protein 2.97667
KRTAP7-1 keratin associated protein 7-1 (gene/pseudogene) 2.97667
CLEC6A C-type lectin domain family 6, member A 2.97667
CD79A CD79a molecule, immunoglobulin-associated alpha 2.97667
PCDHB12 protocadherin beta 12 2.97667
SCARA5 scavenger receptor class A, member 5 2.97667
SYCP2 synaptonemal complex protein 2 2.97667
GJA4 gap junction protein, alpha 4, 37kDa 2.97667
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.97667
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.97667
RYR3 ryanodine receptor 3 2.97667
C10ORF67 chromosome 10 open reading frame 67 2.97667
FIMP1 fertilization-influencing membrane protein 1 2.97667
SIM2 single-minded family bHLH transcription factor 2 2.97667
MSGN1 mesogenin 1 2.97667
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.97667
MPPED1 metallophosphoesterase domain containing 1 2.97667
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.97667
CLDN22 claudin 22 2.97667
NPFF neuropeptide FF-amide peptide precursor 2.97667
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.97667
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.97667
CD6 CD6 molecule 2.97667
ATOH1 atonal homolog 1 (Drosophila) 2.97667
MUC17 mucin 17, cell surface associated 2.97667
PIH1D2 PIH1 domain containing 2 2.97667
S100A14 S100 calcium binding protein A14 2.97667
TPPP2 tubulin polymerization-promoting protein family member 2 2.97667
DQX1 DEAQ box RNA-dependent ATPase 1 2.97667
TNR tenascin R 2.97667
GPR12 G protein-coupled receptor 12 2.97667
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.97667
GSTA1 glutathione S-transferase alpha 1 2.97667
BRDT bromodomain, testis-specific 2.97667
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.97667
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.97667
SYNGR4 synaptogyrin 4 2.97667
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 2.97667
RORC RAR-related orphan receptor C 2.97667
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.97667
PRRX1 paired related homeobox 1 2.97667
CRYBA1 crystallin, beta A1 2.97667
AQP7 aquaporin 7 2.97667
IL19 interleukin 19 2.97667
CLIC5 chloride intracellular channel 5 2.97667
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.97667
IRGM immunity-related GTPase family, M 2.97667
KLK7 kallikrein-related peptidase 7 2.97667
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 2.97667
CLEC4C C-type lectin domain family 4, member C 2.97667
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.97667
HAVCR1 hepatitis A virus cellular receptor 1 2.97667
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.97667
WFDC8 WAP four-disulfide core domain 8 2.97667
GOLGA6C golgin A6 family, member C 2.97667
WFDC1 WAP four-disulfide core domain 1 2.97667
CPSF4L cleavage and polyadenylation specific factor 4-like 2.97667
KLK3 kallikrein-related peptidase 3 2.97667
SVOP SV2 related protein homolog (rat) 2.97667
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.97667
ACOT12 acyl-CoA thioesterase 12 2.97667
KLHL25 kelch-like family member 25 2.97667
CD38 CD38 molecule 2.97667
RBP4 retinol binding protein 4, plasma 2.97667
KLLN killin, p53-regulated DNA replication inhibitor 2.97667
IFI35 interferon-induced protein 35 2.97667
PLA2G5 phospholipase A2, group V 2.97667
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.97667
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.97667
EVPL envoplakin 2.97667
GYS2 glycogen synthase 2 (liver) 2.97667
SPHK1 sphingosine kinase 1 2.97667
GOLGA8K golgin A8 family, member K 2.97667
NKPD1 NTPase, KAP family P-loop domain containing 1 2.97667
IL37 interleukin 37 2.97667
MAEL maelstrom spermatogenic transposon silencer 2.97667
TSN translin 2.97667
DAW1 dynein assembly factor with WDR repeat domains 1 2.97667
PLAC1 placenta-specific 1 2.97667
TGM4 transglutaminase 4 2.97667
AMDHD1 amidohydrolase domain containing 1 2.97667
CARNS1 carnosine synthase 1 2.97667
NUTM2B NUT family member 2B 2.97667
MMP10 matrix metallopeptidase 10 2.97667
PSG3 pregnancy specific beta-1-glycoprotein 3 2.97667
AQP1 aquaporin 1 (Colton blood group) 2.97667
MAGEH1 melanoma antigen family H1 2.94736
TTI2 TELO2 interacting protein 2 2.93186
CDK20 cyclin-dependent kinase 20 2.9278
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 2.9278
ASPG asparaginase 2.9278
DGUOK deoxyguanosine kinase 2.81817
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 2.792
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 2.78899
CREB3 cAMP responsive element binding protein 3 2.70692
FGFBP3 fibroblast growth factor binding protein 3 2.66724
N4BP2L2 NEDD4 binding protein 2-like 2 2.65544
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 2.61068
PARD6A par-6 family cell polarity regulator alpha 2.59346
NQO2 NAD(P)H dehydrogenase, quinone 2 2.58176
ARID5A AT rich interactive domain 5A (MRF1-like) 2.56825
SRSF11 serine/arginine-rich splicing factor 11 2.53756
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.5192
TGFB2 transforming growth factor, beta 2 2.43066
OPN3 opsin 3 2.42143
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 2.41745
COPS7A COP9 signalosome subunit 7A 2.41722
DUSP4 dual specificity phosphatase 4 2.41272
DCPH1 damage control phosphatase 1 2.39649
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.38419
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 2.35566
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 2.35566
POU2F3 POU class 2 homeobox 3 2.35564
MELTF melanotransferrin 2.34836
RNF115 ring finger protein 115 2.33867
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.32003
LAYN layilin 2.31339
ZNF358 zinc finger protein 358 2.28892
MRPL28 mitochondrial ribosomal protein L28 2.28064
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 2.27007
BORCS5 BLOC-1 related complex subunit 5 2.26094
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.25736
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 2.23707
SNUPN snurportin 1 2.22646
LRRTM3 leucine rich repeat transmembrane neuronal 3 2.18859
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.18137
EBNA1BP2 EBNA1 binding protein 2 2.14501
KIAA0040 KIAA0040 2.09673
ZIC3 Zic family member 3 2.08556
JPH4 junctophilin 4 2.08338
INSIG2 insulin induced gene 2 2.08338
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 2.0797
ESD esterase D 2.07654
NOMO2 NODAL modulator 2 2.07524
HAUS1 HAUS augmin-like complex, subunit 1 2.07126
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III 2.02516
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 2.01262
CCHCR1 coiled-coil alpha-helical rod protein 1 2.01262
STUM stum, mechanosensory transduction mediator homolog 2.01003
ZNF761 zinc finger protein 761 2.00907

decreased expression

Symbol Name Standardized Value
PTPRN protein tyrosine phosphatase, receptor type, N -3.03441
SH2D3C SH2 domain containing 3C -3.03441
ALX1 ALX homeobox 1 -3.03441
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -3.02304
GLB1L2 galactosidase, beta 1-like 2 -3.02304
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.02304
GFY golgi-associated, olfactory signaling regulator -3.02304
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.97667
GRM2 glutamate receptor, metabotropic 2 -2.97667
CFAP52 cilia and flagella associated protein 52 -2.97667
ARR3 arrestin 3, retinal (X-arrestin) -2.97667
SPINT4 serine peptidase inhibitor, Kunitz type 4 -2.97667
LIN28B lin-28 homolog B (C. elegans) -2.97667
LPA lipoprotein, Lp(a) -2.97667
CDCP2 CUB domain containing protein 2 -2.97667
DMP1 dentin matrix acidic phosphoprotein 1 -2.97667
NWD1 NACHT and WD repeat domain containing 1 -2.97667
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.97667
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.97667
SPNS2 spinster homolog 2 (Drosophila) -2.97667
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.97667
ALOX15 arachidonate 15-lipoxygenase -2.97667
CARD18 caspase recruitment domain family, member 18 -2.97667
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.97667
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -2.97667
KLF10 Kruppel-like factor 10 -2.97667
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.97667
PRB2 proline-rich protein BstNI subfamily 2 -2.97667
ANKRD33 ankyrin repeat domain 33 -2.97667
STX11 syntaxin 11 -2.97667
FIBIN fin bud initiation factor homolog (zebrafish) -2.97667
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.97667
NPTXR neuronal pentraxin receptor -2.97667
IL18 interleukin 18 -2.97667
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.97667
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.97667
SLC22A24 solute carrier family 22, member 24 -2.97667
H3C13 H3 clustered histone 13 -2.97667
SEZ6L seizure related 6 homolog (mouse)-like -2.97667
CYS1 cystin 1 -2.97667
GYG1 glycogenin 1 -2.97667
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 -2.97667
SMAD9 SMAD family member 9 -2.97667
PLN phospholamban -2.97667
LMX1B LIM homeobox transcription factor 1, beta -2.97667
DCLK3 doublecortin-like kinase 3 -2.97667
TMEM265 transmembrane protein 265 -2.97667
MRAP melanocortin 2 receptor accessory protein -2.97667
TMEM131L transmembrane 131 like -2.96818
PCIF1 PDX1 C-terminal inhibiting factor 1 -2.87403
ILDR2 immunoglobulin-like domain containing receptor 2 -2.83734
CLVS2 clavesin 2 -2.83734
RWDD4 RWD domain containing 4 -2.71676
KLC3 kinesin light chain 3 -2.70692
CCK cholecystokinin -2.69639
MEF2C myocyte enhancer factor 2C -2.69265
ATP9A ATPase, class II, type 9A -2.68726
MCU mitochondrial calcium uniporter -2.53484
MMP23B matrix metallopeptidase 23B -2.52013
DCBLD1 discoidin, CUB and LCCL domain containing 1 -2.48318
XKR5 XK, Kell blood group complex subunit-related family, member 5 -2.46069
WWC3 WWC family member 3 -2.44136
SEC14L6 SEC14-like 6 (S. cerevisiae) -2.44136
PDE8B phosphodiesterase 8B -2.42278
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -2.41782
KDR kinase insert domain receptor -2.41745
ACAD10 acyl-CoA dehydrogenase family, member 10 -2.41722
KLF6 Kruppel-like factor 6 -2.41272
SYVN1 synovial apoptosis inhibitor 1, synoviolin -2.37434
GPR183 G protein-coupled receptor 183 -2.36687
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.36687
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.36666
PARP10 poly (ADP-ribose) polymerase family, member 10 -2.36496
LMTK1 lemur tail kinase 1 -2.36496
SLC44A4 solute carrier family 44, member 4 -2.36496
CBR4 carbonyl reductase 4 -2.35566
PHF6 PHD finger protein 6 -2.34211
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -2.32802
FAN1 FANCD2/FANCI-associated nuclease 1 -2.32003
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.2772
TALDO1 transaldolase 1 -2.26916
BCAP29 B-cell receptor-associated protein 29 -2.26526
PIKFYVE phosphoinositide kinase, FYVE finger containing -2.23719
TRAPPC2 trafficking protein particle complex 2 -2.22841
MTFMT mitochondrial methionyl-tRNA formyltransferase -2.22126
SPDYE5 speedy/RINGO cell cycle regulator family member E5 -2.16226
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.13364
SYCE3 synaptonemal complex central element protein 3 -2.13364
CCNE2 cyclin E2 -2.13364
CFAP96 cilia and flagella associated protein 96 -2.13222
TMEM8B transmembrane protein 8B -2.12541
TBC1D4 TBC1 domain family, member 4 -2.11807
MRM3 mitochondrial rRNA methyltransferase 3 -2.09673
BCAS3 breast carcinoma amplified sequence 3 -2.08732
COL6A2 collagen, type VI, alpha 2 -2.08732
STXBP5 syntaxin binding protein 5 (tomosyn) -2.05876
BICC1 BicC family RNA binding protein 1 -2.04882
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 -2.03948
KIF7 kinesin family member 7 -2.03008
OSBPL1A oxysterol binding protein-like 1A -2.01003
MRPL50 mitochondrial ribosomal protein L50 -2.01003
COX15 cytochrome c oxidase assembly homolog 15 (yeast) -2.0093
AFG2A AFG2 AAA ATPase homolog A -2.0093
RAB29 RAB29, member RAS oncogene family -2.00907
ELOVL6 ELOVL fatty acid elongase 6 -2.00839
RAB2A RAB2A, member RAS oncogene family -2.00129