ITGA6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description integrin, alpha 6|The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3655)
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Genes

344 genes differentially expressed following the ITGA6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.7327
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.7327
OSR2 odd-skipped related transciption factor 2 2.7327
SH2D7 SH2 domain containing 7 2.7327
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.7327
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.7327
SIGLEC9 sialic acid binding Ig-like lectin 9 2.7327
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.7327
TLX2 T-cell leukemia homeobox 2 2.7327
MFAP4 microfibrillar-associated protein 4 2.7327
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.7327
ANKRD34A ankyrin repeat domain 34A 2.7327
ADTRP androgen-dependent TFPI-regulating protein 2.7327
PEAR1 platelet endothelial aggregation receptor 1 2.7327
RPL41 ribosomal protein L41 2.7327
IGFL2 IGF-like family member 2 2.7327
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.7327
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.7327
HCRTR1 hypocretin (orexin) receptor 1 2.7327
DNASE1L2 deoxyribonuclease I-like 2 2.7327
SEC23B Sec23 homolog B (S. cerevisiae) 2.7327
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.7327
HORMAD1 HORMA domain containing 1 2.7327
DPEP2 dipeptidase 2 2.7327
PCDHGB3 protocadherin gamma subfamily B, 3 2.7327
NRROS negative regulator of reactive oxygen species 2.7327
RPL23A ribosomal protein L23a 2.7327
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.7327
CAPG capping protein (actin filament), gelsolin-like 2.7327
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.7327
TMC6 transmembrane channel-like 6 2.7327
SERTM1 serine-rich and transmembrane domain containing 1 2.7327
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.7327
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.7327
LHX6 LIM homeobox 6 2.7327
FAM81B family with sequence similarity 81, member B 2.7327
TPH1 tryptophan hydroxylase 1 2.7327
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.7327
NLRP6 NLR family, pyrin domain containing 6 2.7327
TAS2R10 taste receptor, type 2, member 10 2.7327
ATOH1 atonal homolog 1 (Drosophila) 2.7327
USP50 ubiquitin specific peptidase 50 2.7327
TMEM72 transmembrane protein 72 2.7327
TMEM79 transmembrane protein 79 2.7327
ZNF324B zinc finger protein 324B 2.7327
ACVRL1 activin A receptor type II-like 1 2.7327
ATP8B4 ATPase, class I, type 8B, member 4 2.7327
OC90 otoconin 90 2.7327
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.7327
BRICD5 BRICHOS domain containing 5 2.7327
PTK6 protein tyrosine kinase 6 2.7327
FAM216B family with sequence similarity 216, member B 2.7327
POPDC2 popeye domain containing 2 2.7327
CIMIP2B ciliary microtubule inner protein 2B 2.7327
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.7327
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.7327
IQCF3 IQ motif containing F3 2.7327
TMEM40 transmembrane protein 40 2.7327
RASD1 RAS, dexamethasone-induced 1 2.7327
GATA2 GATA binding protein 2 2.7327
DLK2 delta-like 2 homolog (Drosophila) 2.7327
ZNF683 zinc finger protein 683 2.7327
STARD6 StAR-related lipid transfer (START) domain containing 6 2.7327
SAMD11 sterile alpha motif domain containing 11 2.7327
SAA4 serum amyloid A4, constitutive 2.7327
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.7327
TBC1D3L TBC1 domain family, member 3L 2.7327
CIMAP2 ciliary microtubule associated protein 2 2.7327
SHLD3 shieldin complex subunit 3 2.7327
PEAK3 PEAK family member 3 2.7327
CFAP276 cilia and flagella associated protein 276 2.7327
TENT5D terminal nucleotidyltransferase 5D 2.7327
KASH5 KASH domain containing 5 2.7327
FAM237B family with sequence similarity 237 member B 2.7327
STING1 stimulator of interferon response cGAMP interactor 1 2.7327
PUM3 pumilio RNA binding family member 3 2.7327
AANAT aralkylamine N-acetyltransferase 2.7327
DNAAF1 dynein, axonemal, assembly factor 1 2.7327
TSPO2 translocator protein 2 2.7327
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.7327
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.7327
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.7327
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.7327
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.7327
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 2.7327
CES1 carboxylesterase 1 2.7327
SYCP2 synaptonemal complex protein 2 2.7327
CCDC116 coiled-coil domain containing 116 2.7327
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.7327
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.7327
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.7327
CD5 CD5 molecule 2.7327
RLBP1 retinaldehyde binding protein 1 2.7327
CD300LG CD300 molecule-like family member g 2.7327
FOXI2 forkhead box I2 2.7327
FAM186A family with sequence similarity 186, member A 2.7327
BARHL1 BarH-like homeobox 1 2.7327
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.7327
ACTA1 actin, alpha 1, skeletal muscle 2.7327
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.7327
NXPE2 neurexophilin and PC-esterase domain family, member 2 2.7327
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.7327
TEX101 testis expressed 101 2.7327
PRB2 proline-rich protein BstNI subfamily 2 2.7327
CAPN11 calpain 11 2.7327
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 2.7327
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.7327
APOC2 apolipoprotein C-II 2.7327
TRIM50 tripartite motif containing 50 2.7327
TRIM55 tripartite motif containing 55 2.7327
DRD2 dopamine receptor D2 2.7327
HCLS1 hematopoietic cell-specific Lyn substrate 1 2.7327
CCL15 chemokine (C-C motif) ligand 15 2.7327
BCO1 beta-carotene oxygenase 1 2.7327
RRH retinal pigment epithelium-derived rhodopsin homolog 2.7327
SLC22A24 solute carrier family 22, member 24 2.7327
LRRK2 leucine-rich repeat kinase 2 2.7327
SH2D4B SH2 domain containing 4B 2.7327
CD53 CD53 molecule 2.7327
TRADD TNFRSF1A-associated via death domain 2.7327
LCNL1 lipocalin-like 1 2.7327
HCRT hypocretin (orexin) neuropeptide precursor 2.7327
ARR3 arrestin 3, retinal (X-arrestin) 2.7327
ICAM3 intercellular adhesion molecule 3 2.7327
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.7327
ERICH6B glutamate-rich 6B 2.7327
TYR tyrosinase 2.7327
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.7327
PLET1 placenta expressed transcript 1 2.7327
DCAF6 DDB1 and CUL4 associated factor 6 2.7327
SFRP4 secreted frizzled-related protein 4 2.7327
TEX12 testis expressed 12 2.7327
ZNF843 zinc finger protein 843 2.7327
NYX nyctalopin 2.7327
ERVV-2 endogenous retrovirus group V, member 2 2.7327
GPR142 G protein-coupled receptor 142 2.7327
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.7327
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.7327
TEX29 testis expressed 29 2.7327
ADRA2A adrenoceptor alpha 2A 2.7327
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.7327
OR52N1 olfactory receptor, family 52, subfamily N, member 1 2.7327
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.7327
ORM2 orosomucoid 2 2.7327
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.7327
PAH phenylalanine hydroxylase 2.7327
SAMD9 sterile alpha motif domain containing 9 2.7327
ZC3H11D zinc finger CCCH-type containing 11D 2.7327
UTS2B urotensin 2B 2.7327
ANKRD55 ankyrin repeat domain 55 2.7327
TPPP2 tubulin polymerization-promoting protein family member 2 2.7327
TPPP3 tubulin polymerization-promoting protein family member 3 2.7327
MORN5 MORN repeat containing 5 2.7327
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.7327
OTOP3 otopetrin 3 2.7327
GNMT glycine N-methyltransferase 2.7327
NLRP14 NLR family, pyrin domain containing 14 2.7327
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.7327
ECM1 extracellular matrix protein 1 2.7327
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2.7327
TCF21 transcription factor 21 2.7327
AQP1 aquaporin 1 (Colton blood group) 2.7327
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.7327
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 2.7327
SNTN sentan, cilia apical structure protein 2.7327
FOXP3 forkhead box P3 2.7327
PRR15L proline rich 15-like 2.7327
LPAR5 lysophosphatidic acid receptor 5 2.7327
GH1 growth hormone 1 2.7327
CARNS1 carnosine synthase 1 2.7327
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.7327
POTEF POTE ankyrin domain family, member F 2.7327
CHRM1 cholinergic receptor, muscarinic 1 2.7327
ADIRF adipogenesis regulatory factor 2.7327
WFDC10B WAP four-disulfide core domain 10B 2.7327
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.7327
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.7327
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.7327
MYF6 myogenic factor 6 (herculin) 2.7327
IL33 interleukin 33 2.7327
ANGPTL6 angiopoietin-like 6 2.7327
RAD21L1 RAD21-like 1 (S. pombe) 2.7327
ADAM20 ADAM metallopeptidase domain 20 2.7327
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.7327
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.7327
PRSS55 protease, serine, 55 2.7327
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.7327
CASS4 Cas scaffolding protein family member 4 2.7327
FNDC5 fibronectin type III domain containing 5 2.7327
SEPTIN5 septin 5 2.72769
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 2.62231
IGFBP3 insulin-like growth factor binding protein 3 2.57851
ZNF225 zinc finger protein 225 2.57851
SDS serine dehydratase 2.54146
SPIN1 spindlin 1 2.53367
MYO16 myosin XVI 2.48032
BOLL boule-like RNA-binding protein 2.36325
LCN2 lipocalin 2 2.36325
CFAP299 cilia and flagella associated protein 299 2.3538
PALB2 partner and localizer of BRCA2 2.34358
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 2.34109
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 2.33269
EMC7 ER membrane protein complex subunit 7 2.31382
KIF15 kinesin family member 15 2.30847
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.30847
RBM46 RNA binding motif protein 46 2.30695
PAIP2 poly(A) binding protein interacting protein 2 2.29562
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.29462
TAOK1 TAO kinase 1 2.26295
CKAP4 cytoskeleton-associated protein 4 2.26295
CDH7 cadherin 7, type 2 2.22106
MCAM melanoma cell adhesion molecule 2.21305
TYMP thymidine phosphorylase 2.21305
GLG1 golgi glycoprotein 1 2.21193
DENND4B DENN/MADD domain containing 4B 2.20082
HDAC5 histone deacetylase 5 2.18762
BRD2 bromodomain containing 2 2.18733
BCAS3 breast carcinoma amplified sequence 3 2.18733
SPRTN SprT-like N-terminal domain 2.1843
SRRT serrate, RNA effector molecule 2.18365
SH2D2A SH2 domain containing 2A 2.17118
MRPL38 mitochondrial ribosomal protein L38 2.16789
CTPS2 CTP synthase 2 2.16251
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 2.14833
TMEM134 transmembrane protein 134 2.13701
FANCD2 Fanconi anemia, complementation group D2 2.08847
CARD11 caspase recruitment domain family, member 11 2.08817
PRKD3 protein kinase D3 2.08622
KRT7 keratin 7, type II 2.07559
CLC Charcot-Leyden crystal galectin 2.04721
PEPD peptidase D 2.04625
BOK BCL2-related ovarian killer 2.04545
IL7 interleukin 7 2.03611
TMEM181 transmembrane protein 181 2.03352
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 2.02392
HYAL3 hyaluronoglucosaminidase 3 2.02316
SIK2 salt-inducible kinase 2 2.02197
NES nestin 2.01294
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.01085
UVSSA UV-stimulated scaffold protein A 2.0055

decreased expression

Symbol Name Standardized Value
TMEM272 transmembrane protein 272 -2.7327
PON3 paraoxonase 3 -2.7327
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -2.7327
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.7327
SPATA31H1 SPATA31 subfamily H member 1 -2.7327
S100A2 S100 calcium binding protein A2 -2.7327
TPPP tubulin polymerization promoting protein -2.7327
ARID5A AT rich interactive domain 5A (MRF1-like) -2.7327
NPY neuropeptide Y -2.7327
LXN latexin -2.7327
LKAAEAR1 LKAAEAR motif containing 1 -2.7327
PGM5 phosphoglucomutase 5 -2.7327
RAI2 retinoic acid induced 2 -2.7327
ALK anaplastic lymphoma receptor tyrosine kinase -2.7327
HHEX hematopoietically expressed homeobox -2.7327
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -2.7327
COX8C cytochrome c oxidase subunit VIIIC -2.7327
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.7327
EGF epidermal growth factor -2.7327
LECT2 leukocyte cell-derived chemotaxin 2 -2.7327
ESR1 estrogen receptor 1 -2.7327
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.7327
MEX3D mex-3 RNA binding family member D -2.7327
RRAGC Ras-related GTP binding C -2.7327
GDA guanine deaminase -2.7327
ATP13A4 ATPase type 13A4 -2.7327
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.7327
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.7327
VSTM5 V-set and transmembrane domain containing 5 -2.7327
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.7327
DYDC1 DPY30 domain containing 1 -2.7327
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -2.7327
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) -2.7327
THTPA thiamine triphosphatase -2.7327
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.7327
ZCCHC12 zinc finger, CCHC domain containing 12 -2.7327
CXCR2 chemokine (C-X-C motif) receptor 2 -2.7327
FAM163A family with sequence similarity 163, member A -2.7327
LIPA lipase A, lysosomal acid, cholesterol esterase -2.68652
ZNF768 zinc finger protein 768 -2.66804
BCAT2 branched chain amino-acid transaminase 2, mitochondrial -2.6337
ITGA6 integrin, alpha 6 -2.59245
BARX1 BARX homeobox 1 -2.58883
SMOC1 SPARC related modular calcium binding 1 -2.58883
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -2.56604
THEM4 thioesterase superfamily member 4 -2.56192
EFCAB5 EF-hand calcium binding domain 5 -2.52707
FAM24B family with sequence similarity 24, member B -2.52707
CCDC39 coiled-coil domain containing 39 -2.52707
IGSF22 immunoglobulin superfamily, member 22 -2.52707
DIABLO diablo, IAP-binding mitochondrial protein -2.52707
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.52707
SLCO6A1 solute carrier organic anion transporter family, member 6A1 -2.48032
CD63 CD63 molecule -2.47444
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.42897
BEX1 brain expressed, X-linked 1 -2.42401
DOCK8 dedicator of cytokinesis 8 -2.39659
TRIM39 tripartite motif containing 39 -2.37736
PHB1 prohibitin 1 -2.37309
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -2.37224
PIERCE1 piercer of microtubule wall 1 -2.34429
ZNF205 zinc finger protein 205 -2.32584
EML5 echinoderm microtubule associated protein like 5 -2.32584
GOLPH3 golgi phosphoprotein 3 (coat-protein) -2.31382
PDZD7 PDZ domain containing 7 -2.27947
PLAC8L1 PLAC8-like 1 -2.27947
OXCT1 3-oxoacid CoA transferase 1 -2.23995
CTBP2 C-terminal binding protein 2 -2.22618
LAMB2 laminin, beta 2 (laminin S) -2.22618
CEP120 centrosomal protein 120kDa -2.22106
TBC1D2B TBC1 domain family, member 2B -2.21305
IFT70B intraflagellar transport 70B -2.20277
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase -2.18131
GEMIN8 gem (nuclear organelle) associated protein 8 -2.18127
FAM133B family with sequence similarity 133, member B -2.17003
SAP130 Sin3A-associated protein, 130kDa -2.16971
MYL12B myosin, light chain 12B, regulatory -2.16971
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -2.14886
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.13414
PLPPR1 phospholipid phosphatase related 1 -2.12817
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.12817
ZNF350 zinc finger protein 350 -2.12789
CSF1 colony stimulating factor 1 (macrophage) -2.12789
MAST2 microtubule associated serine/threonine kinase 2 -2.12253
HTT huntingtin -2.10784
LIMD2 LIM domain containing 2 -2.10777
WNT2B wingless-type MMTV integration site family, member 2B -2.10644
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) -2.09291
USP1 ubiquitin specific peptidase 1 -2.09249
HEATR4 HEAT repeat containing 4 -2.08622
SCO1 SCO1 cytochrome c oxidase assembly protein -2.08611
SNX2 sorting nexin 2 -2.08611
LYPLA2 lysophospholipase II -2.07991
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -2.07963
ZNF74 zinc finger protein 74 -2.07963
NPIPB11 nuclear pore complex interacting protein family, member B11 -2.07909
OARD1 O-acyl-ADP-ribose deacylase 1 -2.07795
FUT2 fucosyltransferase 2 (secretor status included) -2.07496
TRIP4 thyroid hormone receptor interactor 4 -2.05615
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -2.05402
CDK18 cyclin-dependent kinase 18 -2.04721
TTN titin -2.01028
ZFTRAF1 zinc finger TRAF-type containing 1 -2.00247
SCTR secretin receptor -2.00247