ITGA7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description integrin, alpha 7|The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 3679)
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Genes

320 genes differentially expressed following the ITGA7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KCNU1 potassium channel, subfamily U, member 1 3.25997
C3AR1 complement component 3a receptor 1 3.25997
CALHM2 calcium homeostasis modulator 2 3.25997
FGR FGR proto-oncogene, Src family tyrosine kinase 3.25997
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.25997
CALR3 calreticulin 3 3.25997
SHCBP1L SHC SH2-domain binding protein 1-like 3.25997
ZNF467 zinc finger protein 467 3.25997
HES7 hes family bHLH transcription factor 7 3.25997
SRPK3 SRSF protein kinase 3 3.25997
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.25997
FOXR1 forkhead box R1 3.25997
HOPX HOP homeobox 3.25997
CSAG1 chondrosarcoma associated gene 1 3.25997
CHRM4 cholinergic receptor, muscarinic 4 3.25997
PNMA5 paraneoplastic Ma antigen family member 5 3.25997
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.25997
QRFP pyroglutamylated RFamide peptide 3.25997
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.25997
HES2 hes family bHLH transcription factor 2 3.25997
ARL5C ADP-ribosylation factor-like 5C 3.25997
SP9 Sp9 transcription factor 3.25997
SMIM41 small integral membrane protein 41 3.25997
CSP2 CS pseudogene 2 3.25997
TMEM255A transmembrane protein 255A 3.25997
GOLGA8K golgin A8 family, member K 3.25997
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.25997
ASB15 ankyrin repeat and SOCS box containing 15 3.25997
FKBP9 FK506 binding protein 9, 63 kDa 3.25932
ANKRD26 ankyrin repeat domain 26 3.20576
SRPX2 sushi-repeat containing protein, X-linked 2 3.12587
TMPRSS11F transmembrane protease, serine 11F 3.12587
SLFN11 schlafen family member 11 3.12587
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 3.12587
TSHB thyroid stimulating hormone, beta 3.12587
VCX2 variable charge, X-linked 2 3.12587
NR1H4 nuclear receptor subfamily 1, group H, member 4 3.12587
DUXB double homeobox B 3.12587
ATOH1 atonal homolog 1 (Drosophila) 3.12587
CDH5 cadherin 5, type 2 (vascular endothelium) 3.12587
PEAR1 platelet endothelial aggregation receptor 1 3.12587
C8ORF48 chromosome 8 open reading frame 48 3.12587
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 3.12587
CRYGB crystallin, gamma B 3.12587
MUC20 mucin 20, cell surface associated 3.12587
S100A5 S100 calcium binding protein A5 3.12587
COPZ2 coatomer protein complex, subunit zeta 2 3.12587
CLEC5A C-type lectin domain family 5, member A 3.12587
FABP12 fatty acid binding protein 12 3.12587
TSGA13 testis specific, 13 3.12587
TMEM72 transmembrane protein 72 3.12587
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.12587
C1ORF141 chromosome 1 open reading frame 141 3.12587
UNC45B unc-45 homolog B (C. elegans) 3.12587
SLC30A3 solute carrier family 30 (zinc transporter), member 3 3.12587
SSMEM1 serine-rich single-pass membrane protein 1 3.12587
GFAP glial fibrillary acidic protein 3.12587
VEZF1 vascular endothelial zinc finger 1 3.12587
GSTM5 glutathione S-transferase mu 5 3.12587
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 3.12587
TBX20 T-box 20 3.12587
LOC114841035 uncharacterized LOC114841035 3.12587
MT4 metallothionein 4 3.12587
GBP1 guanylate binding protein 1, interferon-inducible 3.12587
ACER1 alkaline ceramidase 1 3.12587
SIM1 single-minded family bHLH transcription factor 1 3.12587
MLN motilin 3.12587
PDF peptide deformylase (mitochondrial) 3.12587
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.12587
SPMIP1 sperm microtubule inner protein 1 3.12587
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 3.12587
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.12587
VSIR V-set immunoregulatory receptor 3.12587
ZNF606-AS1 ZNF606 antisense RNA 1 3.12587
NOTCH2NLB notch 2 N-terminal like B 3.12587
SPMIP3 sperm microtubule inner protein 3 3.12587
CFAP97D2 CFAP97 domain containing 2 3.12587
RHEX regulator of hemoglobinization and erythroid cell expansion 3.12587
LHFPL7 LHFPL tetraspan subfamily member 7 3.12587
AKR1C8 aldo-keto reductase family 1 member C8 3.12587
ACOD1 aconitate decarboxylase 1 3.12587
CCN3 cellular communication network factor 3 3.12587
SAG S-antigen; retina and pineal gland (arrestin) 3.12587
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.12587
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.12587
GLP2R glucagon-like peptide 2 receptor 3.12587
SLC45A2 solute carrier family 45, member 2 3.12587
HNF1B HNF1 homeobox B 3.12587
OR11A1 olfactory receptor, family 11, subfamily A, member 1 3.12587
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 3.12587
MAGEB3 melanoma antigen family B3 3.12587
PCDHA7 protocadherin alpha 7 3.12587
RAB44 RAB44, member RAS oncogene family 3.12587
OR2L5 olfactory receptor, family 2, subfamily L, member 5 3.12587
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.12587
GATA5 GATA binding protein 5 3.12587
RNF183 ring finger protein 183 3.12587
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 3.12587
IL16 interleukin 16 3.12587
LGSN lengsin, lens protein with glutamine synthetase domain 3.12587
TARM1 T cell-interacting, activating receptor on myeloid cells 1 3.12587
C7 complement component 7 3.12587
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.12587
CELA2A chymotrypsin-like elastase family, member 2A 3.12587
ZZZ3 zinc finger, ZZ-type containing 3 3.12587
BMP3 bone morphogenetic protein 3 3.12587
OR52N1 olfactory receptor, family 52, subfamily N, member 1 3.12587
CGB7 chorionic gonadotropin, beta polypeptide 7 3.12587
EHF ets homologous factor 3.12587
PCP2 Purkinje cell protein 2 3.12587
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.12587
TCP11X2 t-complex 11 family, X-linked 2 3.12587
POU6F2 POU class 6 homeobox 2 3.12587
DRD5 dopamine receptor D5 3.12587
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 3.12587
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.12587
CSTA cystatin A (stefin A) 3.12587
SPRN shadow of prion protein homolog (zebrafish) 3.12587
SMIM22 small integral membrane protein 22 3.12587
MORC1 MORC family CW-type zinc finger 1 3.12587
PCDHGB1 protocadherin gamma subfamily B, 1 3.12587
FNDC9 fibronectin type III domain containing 9 3.12587
FNDC8 fibronectin type III domain containing 8 3.12587
ZNF132 zinc finger protein 132 3.12587
CTLA4 cytotoxic T-lymphocyte-associated protein 4 3.12587
IFITM5 interferon induced transmembrane protein 5 3.12587
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.12587
HMGB4 high mobility group box 4 3.12587
LOXHD1 lipoxygenase homology domains 1 3.12587
LMAN1L lectin, mannose-binding, 1 like 3.12587
GPR149 G protein-coupled receptor 149 3.12587
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.12587
REG1A regenerating islet-derived 1 alpha 3.12587
IL25 interleukin 25 3.12587
ADSL adenylosuccinate lyase 3.12587
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.12587
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.12587
CFAP47 cilia and flagella associated protein 47 3.12587
ZC3H11D zinc finger CCCH-type containing 11D 3.12587
UTS2B urotensin 2B 3.12587
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.12587
PRR35 proline rich 35 3.12587
NT5DC4 5'-nucleotidase domain containing 4 3.12587
SIGLEC11 sialic acid binding Ig-like lectin 11 3.12587
SYNGR4 synaptogyrin 4 3.12587
TRIM29 tripartite motif containing 29 3.12587
OR51F2 olfactory receptor, family 51, subfamily F, member 2 3.12587
CCDC83 coiled-coil domain containing 83 3.12587
LRRC74A leucine rich repeat containing 74A 3.12587
MYADML2 myeloid-associated differentiation marker-like 2 3.12587
COL22A1 collagen, type XXII, alpha 1 3.12587
LVRN laeverin 3.12587
ERAP2 endoplasmic reticulum aminopeptidase 2 3.12587
TGM3 transglutaminase 3 3.12587
CCNO cyclin O 3.12587
ZC2HC1B zinc finger, C2HC-type containing 1B 3.12587
SPNS3 spinster homolog 3 (Drosophila) 3.12587
WFDC11 WAP four-disulfide core domain 11 3.12587
NPR3 natriuretic peptide receptor 3 3.12587
CPLX3 complexin 3 3.12587
PITX2 paired-like homeodomain 2 3.12587
SLITRK1 SLIT and NTRK-like family, member 1 3.12587
IRX5 iroquois homeobox 5 3.12587
BANF2 barrier to autointegration factor 2 3.12587
PLGLB2 plasminogen-like B2 3.12587
SCN3A sodium channel, voltage gated, type III alpha subunit 3.12587
NUTM2A NUT family member 2A 3.12587
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.12587
TTC13 tetratricopeptide repeat domain 13 3.10753
RELN reelin 3.02496
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 2.98132
MFSD8 major facilitator superfamily domain containing 8 2.94358
TSHZ3 teashirt zinc finger homeobox 3 2.91037
CCT4 chaperonin containing TCP1, subunit 4 (delta) 2.90022
CDR2 cerebellar degeneration-related protein 2, 62kDa 2.84673
AUH AU RNA binding protein/enoyl-CoA hydratase 2.80866
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 2.80866
XK X-linked Kx blood group 2.74527
FKBP11 FK506 binding protein 11, 19 kDa 2.63618
SIT1 signaling threshold regulating transmembrane adaptor 1 2.63048
DENND2B DENN domain containing 2B 2.62676
AGK acylglycerol kinase 2.57838
KSR2 kinase suppressor of ras 2 2.56095
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 2.51331
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.49985
SELENOO selenoprotein O 2.47885
C8ORF33 chromosome 8 open reading frame 33 2.40989
NEK2 NIMA-related kinase 2 2.40989
EXOSC8 exosome component 8 2.40772
SVIL supervillin 2.40772
PCDHA3 protocadherin alpha 3 2.35945
IDO2 indoleamine 2,3-dioxygenase 2 2.35363
TTC23 tetratricopeptide repeat domain 23 2.35363
BTBD10 BTB (POZ) domain containing 10 2.35083
HNRNPK heterogeneous nuclear ribonucleoprotein K 2.30134
COPS7A COP9 signalosome subunit 7A 2.26079
ZNF551 zinc finger protein 551 2.23438
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.21385
ADPRH ADP-ribosylarginine hydrolase 2.20572
FBXO8 F-box protein 8 2.18303
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.17957
TRPC5OS TRPC5 opposite strand 2.16842
KIAA1143 KIAA1143 2.16708
LIN28B lin-28 homolog B (C. elegans) 2.13486
ZNF793 zinc finger protein 793 2.13459
CRNKL1 crooked neck pre-mRNA splicing factor 1 2.12867
SPARCL1 SPARC-like 1 (hevin) 2.10348
SPAG17 sperm associated antigen 17 2.09876
HDAC9 histone deacetylase 9 2.08923
EEF2K eukaryotic elongation factor 2 kinase 2.05543
EID1 EP300 interacting inhibitor of differentiation 1 2.03797
MYOCD myocardin 2.03701
MRC2 mannose receptor, C type 2 2.03701
RTCA RNA 3'-terminal phosphate cyclase 2.03701
TAOK1 TAO kinase 1 2.03381
GCNA germ cell nuclear acidic peptidase 2.03241
LEP leptin 2.03241
TMEM139 transmembrane protein 139 2.03241
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 2.03241
POMC proopiomelanocortin 2.03241
NME5 NME/NM23 family member 5 2.03241
AJM1 apical junction component 1 homolog 2.03241
NASP nuclear autoantigenic sperm protein (histone-binding) 2.02056
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 2.01718
AXIN2 axin 2 2.01718
RUBCN rubicon autophagy regulator 2.00581
ANXA3 annexin A3 2.00581
ARL15 ADP-ribosylation factor-like 15 2.00581
SKA3 spindle and kinetochore associated complex subunit 3 2.00581
COX20 COX20 cytochrome c oxidase assembly factor 2.00179
EMG1 EMG1 N1-specific pseudouridine methyltransferase 2.00179
EBF3 early B-cell factor 3 2.00161
FRMD1 FERM domain containing 1 2.00161

decreased expression

Symbol Name Standardized Value
PHOX2A paired-like homeobox 2a -3.25997
VSTM1 V-set and transmembrane domain containing 1 -3.25997
FAM43B family with sequence similarity 43, member B -3.25997
C17ORF113 chromosome 17 open reading frame 113 -3.12587
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -3.12587
SIX2 SIX homeobox 2 -3.12587
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -3.12587
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -3.12587
CCL27 chemokine (C-C motif) ligand 27 -3.12587
ICMT isoprenylcysteine carboxyl methyltransferase -3.12587
APOB apolipoprotein B -3.12587
HSPB2 heat shock 27kDa protein 2 -3.12587
GGN gametogenetin -3.12587
LRRK2 leucine-rich repeat kinase 2 -3.12587
CLDN2 claudin 2 -3.12587
UBE2L5 ubiquitin conjugating enzyme E2 L5 -3.12587
ALDOB aldolase B, fructose-bisphosphate -3.12587
ADAP1 ArfGAP with dual PH domains 1 -3.12587
MROH5 maestro heat-like repeat family member 5 -3.12587
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -3.12587
CCR9 chemokine (C-C motif) receptor 9 -3.12587
PGC progastricsin (pepsinogen C) -3.12587
SHC4 SHC (Src homology 2 domain containing) family, member 4 -3.12587
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -2.92897
ZNF496 zinc finger protein 496 -2.81048
LRRIQ1 leucine-rich repeats and IQ motif containing 1 -2.77866
SHLD3 shieldin complex subunit 3 -2.77612
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.77612
PCYOX1L prenylcysteine oxidase 1 like -2.75076
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) -2.75076
KIF4A kinesin family member 4A -2.75076
SVOPL SVOP-like -2.70116
PTPN23 protein tyrosine phosphatase, non-receptor type 23 -2.60571
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -2.56652
MCM4 minichromosome maintenance complex component 4 -2.51303
SPC24 SPC24, NDC80 kinetochore complex component -2.4334
UTP4 UTP4 small subunit processome component -2.4334
DTX3 deltex 3, E3 ubiquitin ligase -2.421
TTLL10 tubulin tyrosine ligase-like family member 10 -2.41836
AGER advanced glycosylation end product-specific receptor -2.40772
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -2.39359
TSEN15 TSEN15 tRNA splicing endonuclease subunit -2.38051
NUTM2E NUT family member 2E -2.35945
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.30401
KLHDC3 kelch domain containing 3 -2.29665
ADIPOR1 adiponectin receptor 1 -2.28726
PCDHB9 protocadherin beta 9 -2.28726
ADIRF adipogenesis regulatory factor -2.28726
APLN apelin -2.26079
RHOU ras homolog family member U -2.26079
POU5F2 POU domain class 5, transcription factor 2 -2.26079
ATG2B autophagy related 2B -2.26079
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.26079
ADGRL1 adhesion G protein-coupled receptor L1 -2.26079
SYBU syntabulin (syntaxin-interacting) -2.2426
C2CD2L C2CD2-like -2.2426
PHF6 PHD finger protein 6 -2.22405
NSUN5 NOP2/Sun domain family, member 5 -2.21719
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.20572
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.1826
CNTFR ciliary neurotrophic factor receptor -2.18122
OXCT2 3-oxoacid CoA transferase 2 -2.18122
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.17957
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.17847
ZBED5 zinc finger, BED-type containing 5 -2.16721
ZNF655 zinc finger protein 655 -2.16708
RHOXF1 Rhox homeobox family, member 1 -2.16173
ZFP36L2 ZFP36 ring finger protein-like 2 -2.13564
ZFYVE27 zinc finger, FYVE domain containing 27 -2.13486
NMT2 N-myristoyltransferase 2 -2.12792
NOL4L nucleolar protein 4-like -2.10422
MOB4 MOB family member 4, phocein -2.09876
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.08525
TEX261 testis expressed 261 -2.08523
TMEM253 transmembrane protein 253 -2.06437
SNX15 sorting nexin 15 -2.04811
OTUD1 OTU deubiquitinase 1 -2.03797
CD200 CD200 molecule -2.03701
DPYSL4 dihydropyrimidinase-like 4 -2.03701
POFUT2 protein O-fucosyltransferase 2 -2.03701
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.03381
STAMBPL1 STAM binding protein-like 1 -2.03381
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.03029
FOXK1 forkhead box K1 -2.0206
MDP1 magnesium-dependent phosphatase 1 -2.01718
RALB v-ral simian leukemia viral oncogene homolog B -2.00581
NADK2 NAD kinase 2, mitochondrial -2.00581