ITGAL Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)|ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3683)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_ITGAL
Similar Terms
Downloads & Tools

Genes

55 co-expressed genes for ITGAL from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABHD17A abhydrolase domain containing 17A
ADCY7 adenylate cyclase 7
ADGRE5 adhesion G protein-coupled receptor E5
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
BIN2 bridging integrator 2
BTN3A1 butyrophilin, subfamily 3, member A1
BTN3A2 butyrophilin, subfamily 3, member A2
BTN3A3 butyrophilin, subfamily 3, member A3
C11ORF21 chromosome 11 open reading frame 21
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD247 CD247 molecule
CD7 CD7 molecule
CD96 CD96 molecule
CLEC2B C-type lectin domain family 2, member B
CTSW cathepsin W
CYTH1 cytohesin 1
CYTIP cytohesin 1 interacting protein
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DUSP2 dual specificity phosphatase 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GIMAP6 GTPase, IMAP family member 6
GPR65 G protein-coupled receptor 65
GZMM granzyme M (lymphocyte met-ase 1)
HLA-F major histocompatibility complex, class I, F
HMHA1 histocompatibility (minor) HA-1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAK1 Janus kinase 1
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MBNL1 muscleblind-like splicing regulator 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PARP8 poly (ADP-ribose) polymerase family, member 8
PRKCH protein kinase C, eta
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPRC protein tyrosine phosphatase, receptor type, C
RAP1B RAP1B, member of RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIPA1 signal-induced proliferation-associated 1
SNRK SNF related kinase
STK10 serine/threonine kinase 10
STK38 serine/threonine kinase 38
SUN2 Sad1 and UNC84 domain containing 2
SYNRG synergin, gamma
TMC6 transmembrane channel-like 6
TRAF3IP3 TRAF3 interacting protein 3
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa