ITGB1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)|Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3688)
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Genes

348 genes differentially expressed following the ITGB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AGTR1 angiotensin II receptor, type 1 3.43173
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.43173
PCDHGB3 protocadherin gamma subfamily B, 3 3.43173
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.43173
GJB5 gap junction protein, beta 5, 31.1kDa 3.43173
PAX6 paired box 6 3.43173
CD300A CD300a molecule 3.43173
DMRTC1B DMRT-like family C1B 3.43173
ASB17 ankyrin repeat and SOCS box containing 17 3.43173
MT1HL1 metallothionein 1H-like 1 3.43173
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.43173
SHCBP1L SHC SH2-domain binding protein 1-like 3.43173
HES3 hes family bHLH transcription factor 3 3.43173
WNT3A wingless-type MMTV integration site family, member 3A 3.43173
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.43173
PROKR1 prokineticin receptor 1 3.43173
OR1I1 olfactory receptor, family 1, subfamily I, member 1 3.43173
COLEC10 collectin sub-family member 10 (C-type lectin) 3.43173
RXFP3 relaxin/insulin-like family peptide receptor 3 3.43173
CD14 CD14 molecule 3.43173
CELF6 CUGBP, Elav-like family member 6 3.43173
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.43173
SLC16A11 solute carrier family 16, member 11 3.43173
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.43173
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.43173
HCRTR2 hypocretin (orexin) receptor 2 3.43173
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 3.43173
FAM221B family with sequence similarity 221, member B 3.43173
GYS2 glycogen synthase 2 (liver) 3.43173
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 3.43173
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 3.43173
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 3.43173
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.43173
THEMIS thymocyte selection associated 3.43173
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.43173
TPRX1 tetra-peptide repeat homeobox 1 3.43173
BTBD19 BTB (POZ) domain containing 19 3.43173
SOST sclerostin 3.43173
HOXB3 homeobox B3 3.43173
ETV7 ets variant 7 3.43173
CLCN1 chloride channel, voltage-sensitive 1 3.43173
BIRC3 baculoviral IAP repeat containing 3 3.43173
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 3.43173
PTGFR prostaglandin F receptor (FP) 3.43173
OR1L6 olfactory receptor, family 1, subfamily L, member 6 3.43173
UBA7 ubiquitin-like modifier activating enzyme 7 3.43173
RGPD4 RANBP2-like and GRIP domain containing 4 3.43173
ANKK1 ankyrin repeat and kinase domain containing 1 3.43173
SHE Src homology 2 domain containing E 3.43173
CRYGN crystallin, gamma N 3.43173
OXT oxytocin/neurophysin I prepropeptide 3.43173
CHD5 chromodomain helicase DNA binding protein 5 3.43173
HIGD1B HIG1 hypoxia inducible domain family, member 1B 3.43173
CD5 CD5 molecule 3.43173
CATSPERH catsper channel auxiliary subunit eta 3.43173
FIMP1 fertilization-influencing membrane protein 1 3.43173
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.43173
LMNTD1 lamin tail domain containing 1 3.43173
TMPRSS7 transmembrane protease, serine 7 3.43173
TMEM40 transmembrane protein 40 3.43173
MYPN myopalladin 3.43173
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.43173
SYT15 synaptotagmin XV 3.43173
MROH5 maestro heat-like repeat family member 5 3.43173
GPR84 G protein-coupled receptor 84 3.43173
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.43173
FRG2C FSHD region gene 2 family, member C 3.43173
UNC93A unc-93 homolog A (C. elegans) 3.43173
TEX53 testis expressed 53 3.43173
TBC1D3I TBC1 domain family member 3I 3.43173
IL6ST-DT IL6ST divergent transcript 3.43173
SPMIP8 sperm microtubule inner protein 8 3.43173
SMIM35 small integral membrane protein 35 3.43173
SERTM2 serine rich and transmembrane domain containing 2 3.43173
MINDY4B MINDY family member 4B 3.43173
RNF227 ring finger protein 227 3.43173
MSANTD5 Myb/SANT DNA binding domain containing 5 3.43173
MINAR2 membrane integral NOTCH2 associated receptor 2 3.43173
CFAP65 cilia and flagella associated protein 65 3.43173
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.43173
TAS1R2 taste receptor, type 1, member 2 3.43173
ARMC12 armadillo repeat containing 12 3.43173
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.43173
GDA guanine deaminase 3.43173
KLHL33 kelch-like family member 33 3.43173
ACTL10 actin-like 10 3.43173
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 3.43173
TBX22 T-box 22 3.43173
ACR acrosin 3.43173
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.43173
TAS2R5 taste receptor, type 2, member 5 3.43173
FER1L6 fer-1-like family member 6 3.43173
TPBGL trophoblast glycoprotein-like 3.43173
SLC22A25 solute carrier family 22, member 25 3.43173
IL5 interleukin 5 3.43173
GTSF1 gametocyte specific factor 1 3.43173
SASH3 SAM and SH3 domain containing 3 3.43173
SBSN suprabasin 3.43173
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.43173
S100G S100 calcium binding protein G 3.43173
MYOT myotilin 3.43173
OR2L8 olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene) 3.43173
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.43173
HSPB6 heat shock protein, alpha-crystallin-related, B6 3.43173
ADGRG1 adhesion G protein-coupled receptor G1 3.43173
TLR7 toll-like receptor 7 3.43173
TMPRSS11F transmembrane protease, serine 11F 3.43173
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.43173
KLK2 kallikrein-related peptidase 2 3.43173
FSHR follicle stimulating hormone receptor 3.43173
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.43173
TUBA8 tubulin, alpha 8 3.43173
SPHKAP SPHK1 interactor, AKAP domain containing 3.43173
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.43173
ACOX2 acyl-CoA oxidase 2, branched chain 3.43173
PCDHGB5 protocadherin gamma subfamily B, 5 3.43173
APOH apolipoprotein H (beta-2-glycoprotein I) 3.43173
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.43173
GPR62 G protein-coupled receptor 62 3.43173
PGR progesterone receptor 3.43173
CPZ carboxypeptidase Z 3.43173
CYBB cytochrome b-245, beta polypeptide 3.43173
ZMYND10 zinc finger, MYND-type containing 10 3.43173
SLC38A8 solute carrier family 38, member 8 3.43173
CTRB1 chymotrypsinogen B1 3.43173
PLA1A phospholipase A1 member A 3.43173
CERKL ceramide kinase-like 3.43173
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.43173
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.43173
PCDHGA4 protocadherin gamma subfamily A, 4 3.43173
HPX hemopexin 3.43173
BPIFB4 BPI fold containing family B, member 4 3.43173
PCDHGA2 protocadherin gamma subfamily A, 2 3.43173
LCN1 lipocalin 1 3.43173
FOXE1 forkhead box E1 3.43173
DUOX2 dual oxidase 2 3.43173
HSPA1L heat shock 70kDa protein 1-like 3.43173
CXCR4 chemokine (C-X-C motif) receptor 4 3.43173
VWA3A von Willebrand factor A domain containing 3A 3.43173
C11ORF96 chromosome 11 open reading frame 96 3.43173
C11ORF91 chromosome 11 open reading frame 91 3.43173
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.43173
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 3.43173
IL19 interleukin 19 3.43173
EFCAB9 EF-hand calcium binding domain 9 3.43173
ABHD1 abhydrolase domain containing 1 3.43173
EPO erythropoietin 3.43173
IFITM10 interferon induced transmembrane protein 10 3.43173
ZNF835 zinc finger protein 835 3.43173
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.43173
GOLGA8M golgin A8 family, member M 3.43173
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.43173
OR4M2 olfactory receptor, family 4, subfamily M, member 2 3.43173
DLEC1 deleted in lung and esophageal cancer 1 3.43173
NLRP8 NLR family, pyrin domain containing 8 3.43173
ZFP36 ZFP36 ring finger protein 3.43173
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.43173
CRTAM cytotoxic and regulatory T cell molecule 3.43173
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.43173
PITX3 paired-like homeodomain 3 3.43173
ART1 ADP-ribosyltransferase 1 3.43173
KRTAP13-4 keratin associated protein 13-4 3.43173
OR51A4 olfactory receptor, family 51, subfamily A, member 4 3.43173
TCEA3 transcription elongation factor A (SII), 3 3.43173
CIB4 calcium and integrin binding family member 4 3.43173
FOXP3 forkhead box P3 3.43173
PTGDR prostaglandin D2 receptor (DP) 3.43173
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.43173
IFI35 interferon-induced protein 35 3.43173
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.43173
ORM2 orosomucoid 2 3.43173
EFCC1 EF-hand and coiled-coil domain containing 1 3.43173
LRRC74A leucine rich repeat containing 74A 3.43173
APOL4 apolipoprotein L, 4 3.43173
ERVV-2 endogenous retrovirus group V, member 2 3.43173
TSPAN19 tetraspanin 19 3.43173
AHSG alpha-2-HS-glycoprotein 3.43173
BIN2 bridging integrator 2 3.43173
SLC51B solute carrier family 51, beta subunit 3.43173
OPTC opticin 3.43173
TDRD3 tudor domain containing 3 3.39387
MCOLN3 mucolipin 3 3.19044
ZBTB7B zinc finger and BTB domain containing 7B 3.19044
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.92887
EXOC4 exocyst complex component 4 2.90916
ZBBX zinc finger, B-box domain containing 2.89008
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.89008
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.86478
TSC2 tuberous sclerosis 2 2.80483
IRS1 insulin receptor substrate 1 2.75366
TSLIG2 tRNA splicing ligase complex subunit 2 2.70538
MMP16 matrix metallopeptidase 16 (membrane-inserted) 2.68822
RECQL5 RecQ protein-like 5 2.65425
HSPB1 heat shock 27kDa protein 1 2.65229
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.61574
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.584
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2.58005
UBE2J1 ubiquitin-conjugating enzyme E2, J1 2.553
DERPC DERPC proline and glycine rich nuclear protein 2.54795
LIPT2-AS1 LIPT2 antisense RNA 1 2.54795
PCDHGA7 protocadherin gamma subfamily A, 7 2.54795
SLC61A1 solute carrier family 61 member 1 2.5346
NOTCH1 notch 1 2.53088
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.51615
SPMAP2L sperm microtubule associated protein 2 like 2.51615
RSPO4 R-spondin 4 2.50094
COL18A1 collagen, type XVIII, alpha 1 2.41876
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.40392
QRFPR pyroglutamylated RFamide peptide receptor 2.40392
RASA4 RAS p21 protein activator 4 2.40392
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing 2.40392
SIT1 signaling threshold regulating transmembrane adaptor 1 2.40392
PROKR2 prokineticin receptor 2 2.40392
CNGB3 cyclic nucleotide gated channel beta 3 2.40392
RABAC1 Rab acceptor 1 (prenylated) 2.39252
CHD2 chromodomain helicase DNA binding protein 2 2.38424
SHKBP1 SH3KBP1 binding protein 1 2.35775
MICOS13 mitochondrial contact site and cristae organizing system subunit 13 2.32623
CDK5 cyclin-dependent kinase 5 2.29786
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.29378
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.28923
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 2.28643
SLC35D4 solute carrier family 35 member D4 2.23486
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 2.2335
ANAPC5 anaphase promoting complex subunit 5 2.23073
CHRDL1 chordin-like 1 2.23073
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.22558
PABIR3 PABIR family member 3 2.2254
BKGD beta-keto-L-gulonate decarboxylase 2.22473
PLEKHA5 pleckstrin homology domain containing, family A member 5 2.21741
MBIP MAP3K12 binding inhibitory protein 1 2.21137
SDC4 syndecan 4 2.20299
N4BP2L1 NEDD4 binding protein 2-like 1 2.19546
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.16362
SLC30A8 solute carrier family 30 (zinc transporter), member 8 2.15095
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 2.14255
GRM7 glutamate receptor, metabotropic 7 2.13349
MVB12B multivesicular body subunit 12B 2.1323
PPP1R8 protein phosphatase 1, regulatory subunit 8 2.13157
KIF26A kinesin family member 26A 2.12958
ZDHHC15 zinc finger, DHHC-type containing 15 2.11815
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 2.10885
TGIF2 TGFB-induced factor homeobox 2 2.10828
NTNG1 netrin G1 2.10828
TMSB15A thymosin beta 15a 2.10825
UXS1 UDP-glucuronate decarboxylase 1 2.10825
WDR88 WD repeat domain 88 2.10825
TUG1 taurine up-regulated 1 (non-protein coding) 2.10144
FAAH2 fatty acid amide hydrolase 2 2.10144
VCF2 VCP nuclear cofactor family member 2 2.09757
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.09087
ARMC9 armadillo repeat containing 9 2.07662
NPFFR2 neuropeptide FF receptor 2 2.06367
MAP3K21 mitogen-activated protein kinase kinase kinase 21 2.02639
HYI hydroxypyruvate isomerase (putative) 2.02486
PIGO phosphatidylinositol glycan anchor biosynthesis, class O 2.02486
DCTN5 dynactin 5 (p25) 2.0197

decreased expression

Symbol Name Standardized Value
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -3.43173
TUFT1 tuftelin 1 -3.43173
HPCA hippocalcin -3.43173
PCDHB3 protocadherin beta 3 -3.43173
AOC2 amine oxidase, copper containing 2 (retina-specific) -3.43173
C1ORF116 chromosome 1 open reading frame 116 -3.40816
SLC16A6 solute carrier family 16, member 6 -3.40816
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -3.40816
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 -3.40816
C11ORF87 chromosome 11 open reading frame 87 -3.40816
CCDC177 coiled-coil domain containing 177 -3.40816
SFTPD surfactant protein D -3.40816
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -3.40816
SMCO3 single-pass membrane protein with coiled-coil domains 3 -3.40816
ANXA1 annexin A1 -3.40816
MMP19 matrix metallopeptidase 19 -3.40816
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -3.40816
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.40816
FAM209A family with sequence similarity 209, member A -3.40816
ZNF99 zinc finger protein 99 -3.40816
ZNG1F Zn regulated GTPase metalloprotein activator 1F -3.40816
NSG2 neuronal vesicle trafficking associated 2 -3.40816
MOG myelin oligodendrocyte glycoprotein -3.40816
LTB4R2 leukotriene B4 receptor 2 -3.40816
AANAT aralkylamine N-acetyltransferase -3.40816
PODN podocan -3.40816
NTN5 netrin 5 -3.40816
LOC124906010 uncharacterized LOC124906010 -3.40816
PROZ protein Z, vitamin K-dependent plasma glycoprotein -3.40816
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 -3.40816
TPTE transmembrane phosphatase with tensin homology -3.40816
ZNF572 zinc finger protein 572 -3.40816
SEC14L4 SEC14-like 4 (S. cerevisiae) -3.40816
PYCR3 pyrroline-5-carboxylate reductase 3 -3.28279
INSC inscuteable homolog (Drosophila) -3.28279
MFSD6L major facilitator superfamily domain containing 6-like -3.28279
HELZ helicase with zinc finger -3.27222
HMGB2 high mobility group box 2 -3.16021
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -3.04486
GTPBP2 GTP binding protein 2 -3.01016
ZNF488 zinc finger protein 488 -2.92887
TCTN3 tectonic family member 3 -2.88393
LMTK1 lemur tail kinase 1 -2.8226
EMC4 ER membrane protein complex subunit 4 -2.81723
LAMA2 laminin, alpha 2 -2.60894
BZW1 basic leucine zipper and W2 domains 1 -2.59662
UBA2 ubiquitin-like modifier activating enzyme 2 -2.54795
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -2.51615
PRSS35 protease, serine, 35 -2.51565
GRID1 glutamate receptor, ionotropic, delta 1 -2.49624
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -2.4432
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.4432
PKP3 plakophilin 3 -2.42205
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.42205
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.42205
CFAP58 cilia and flagella associated protein 58 -2.40476
CSF1 colony stimulating factor 1 (macrophage) -2.40392
GPN1 GPN-loop GTPase 1 -2.34827
PCDH17 protocadherin 17 -2.30042
SLCO5A1 solute carrier organic anion transporter family, member 5A1 -2.29788
ECHDC3 enoyl CoA hydratase domain containing 3 -2.29788
EIF3I eukaryotic translation initiation factor 3, subunit I -2.28864
OVGP1 oviductal glycoprotein 1, 120kDa -2.28213
ZNF852 zinc finger protein 852 -2.25499
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -2.23409
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.23409
RAB5IF RAB5 interacting factor -2.23409
TMEM143 transmembrane protein 143 -2.2335
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -2.2335
EMILIN3 elastin microfibril interfacer 3 -2.2335
H2BC17 H2B clustered histone 17 -2.2335
MAGEL2 melanoma antigen family L2 -2.2335
SAMD14 sterile alpha motif domain containing 14 -2.22251
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.2018
MRPL51 mitochondrial ribosomal protein L51 -2.17319
UFL1 UFM1-specific ligase 1 -2.15703
AUP1 ancient ubiquitous protein 1 -2.15095
GPX7 glutathione peroxidase 7 -2.13866
RPRML reprimo-like -2.1323
CENPVL3 centromere protein V like 3 -2.13157
DHRS3 dehydrogenase/reductase (SDR family) member 3 -2.13157
FBXO33 F-box protein 33 -2.12962
TPGS1 tubulin polyglutamylase complex subunit 1 -2.12437
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.10885
CENPX centromere protein X -2.10828
CDC5L cell division cycle 5-like -2.10828
BEST4 bestrophin 4 -2.10144
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.06817
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.05335
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.03919
HAPLN3 hyaluronan and proteoglycan link protein 3 -2.03598