ITK Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description IL2-inducible T-cell kinase|This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3702)
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Genes

100 substrates of the kinase ITK from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 100.0
SIPA1L1 signal-induced proliferation-associated 1 like 1 99.87
RPS29 ribosomal protein S29 99.83
RFTN1 raftlin, lipid raft linker 1 99.82
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 99.8
NFYA nuclear transcription factor Y, alpha 99.78
LOC102725035 leukocyte immunoglobulin-like receptor subfamily B member 3 99.76
UBE2E1 ubiquitin-conjugating enzyme E2E 1 99.67
UBE2E3 ubiquitin-conjugating enzyme E2E 3 99.67
UBE2E2 ubiquitin-conjugating enzyme E2E 2 99.67
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 99.56
CEP89 centrosomal protein 89kDa 99.45
FCMR Fc fragment of IgM receptor 99.43
FHIT fragile histidine triad 99.28
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 99.28
KAT2B K(lysine) acetyltransferase 2B 99.21
MX2 MX dynamin-like GTPase 2 99.19
CD300LB CD300 molecule-like family member b 99.13
TCHP trichoplein, keratin filament binding 99.13
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 99.08
KAT2A K(lysine) acetyltransferase 2A 99.04
TCF25 transcription factor 25 (basic helix-loop-helix) 98.86
UNG uracil-DNA glycosylase 98.82
EGR1 early growth response 1 98.8
DOK3 docking protein 3 98.78
RPS16 ribosomal protein S16 98.77
RPL36AL ribosomal protein L36a-like 98.75
GIMAP4 GTPase, IMAP family member 4 98.49
CKAP4 cytoskeleton-associated protein 4 98.32
PBX2 pre-B-cell leukemia homeobox 2 98.29
KAZN kazrin, periplakin interacting protein 98.25
MIS18BP1 MIS18 binding protein 1 98.18
KMT5A lysine methyltransferase 5A 98.16
GCHFR GTP cyclohydrolase I feedback regulator 98.09
N4BP2 NEDD4 binding protein 2 98.07
ELP3 elongator acetyltransferase complex subunit 3 97.985
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 97.96
PTBP3 polypyrimidine tract binding protein 3 97.92
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 97.88
AP1AR adaptor-related protein complex 1 associated regulatory protein 97.85
WDR1 WD repeat domain 1 97.77
TGFB1I1 transforming growth factor beta 1 induced transcript 1 97.77
THOC2 THO complex 2 97.7
IL7R interleukin 7 receptor 97.7
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 97.61
PCYOX1 prenylcysteine oxidase 1 97.57
CSNK2A2 casein kinase 2, alpha prime polypeptide 97.51
DGKK diacylglycerol kinase, kappa 97.51
CCSER1 coiled-coil serine-rich protein 1 97.39
RGS10 regulator of G-protein signaling 10 97.35
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 97.31
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 97.22
SCAF8 SR-related CTD-associated factor 8 97.18
NCKAP5 NCK-associated protein 5 97.16
VCP valosin containing protein 97.07
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 97.05
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 96.93
SMG8 SMG8 nonsense mediated mRNA decay factor 96.87
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 96.74
SRCIN1 SRC kinase signaling inhibitor 1 96.72
JUN jun proto-oncogene 96.7
SON SON DNA binding protein 96.63
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 96.63
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 96.54
LY9 lymphocyte antigen 9 96.53
GEMIN8 gem (nuclear organelle) associated protein 8 96.45
STARD13 StAR-related lipid transfer (START) domain containing 13 96.34
MFAP3L microfibrillar-associated protein 3-like 96.28
UBASH3A ubiquitin associated and SH3 domain containing A 96.26
SBF1 SET binding factor 1 96.23
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 96.21
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 96.15
ZNF169 zinc finger protein 169 96.0
FCRL6 Fc receptor-like 6 95.99
F5 coagulation factor V (proaccelerin, labile factor) 95.95
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 95.89
SLC39A3 solute carrier family 39 (zinc transporter), member 3 95.89
FNBP1 formin binding protein 1 95.86
PCDH7 protocadherin 7 95.65
BCAS2 breast carcinoma amplified sequence 2 95.64
U2SURP U2 snRNP-associated SURP domain containing 95.61
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 95.58
NOSIP nitric oxide synthase interacting protein 95.54
HAVCR1 hepatitis A virus cellular receptor 1 95.51
RTN3 reticulon 3 95.51
RAB34 RAB34, member RAS oncogene family 95.43
FKBP6 FK506 binding protein 6, 36kDa 95.36
RABGAP1L RAB GTPase activating protein 1-like 95.25
CHERP calcium homeostasis endoplasmic reticulum protein 95.205
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 95.19
MVB12A multivesicular body subunit 12A 95.185
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 95.18
FHOD1 formin homology 2 domain containing 1 95.18
EPHA7 EPH receptor A7 95.14
GPR19 G protein-coupled receptor 19 95.08
PARD6B par-6 family cell polarity regulator beta 95.01
SVBP small vasohibin binding protein 94.99
PTPRH protein tyrosine phosphatase, receptor type, H 94.94
STAMBPL1 STAM binding protein-like 1 94.9
EXPH5 exophilin 5 94.88