ITK Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description IL2-inducible T-cell kinase|This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3702)
External Link https://ncbi.nlm.nih.gov/gene/3702
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Genes

499 genes differentially expressed following the ITK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0188057
XIC X chromosome inactivation center 0.0179276
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.0153487
CNTN1 contactin 1 0.0151338
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.0149706
TGM2 transglutaminase 2 0.0147318
HSPB1 heat shock 27kDa protein 1 0.0144989
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0142673
NEBL nebulette 0.0134312
RNF167 ring finger protein 167 0.0132602
IFI27 interferon, alpha-inducible protein 27 0.0130473
MMP7 matrix metallopeptidase 7 0.0128755
CTSZ cathepsin Z 0.0124039
LTF lactotransferrin 0.0124028
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0122644
MMP12 matrix metallopeptidase 12 0.0116405
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0115162
ANXA3 annexin A3 0.0113036
HSPA1A heat shock 70kDa protein 1A 0.0108417
HSPH1 heat shock 105kDa/110kDa protein 1 0.0106116
SFRP1 secreted frizzled-related protein 1 0.0103477
STXBP2 syntaxin binding protein 2 0.0102856
HSPA2 heat shock 70kDa protein 2 0.00997228
CCN2 cellular communication network factor 2 0.00995698
ATF3 activating transcription factor 3 0.00979241
FLNA filamin A, alpha 0.00965865
BAMBI BMP and activin membrane-bound inhibitor 0.00957624
EPS8L2 EPS8-like 2 0.00950368
FAM189A2 family with sequence similarity 189, member A2 0.00923562
ALCAM activated leukocyte cell adhesion molecule 0.00922735
FNDC3B fibronectin type III domain containing 3B 0.00922026
ANXA1 annexin A1 0.00913074
NAV2 neuron navigator 2 0.00911862
FMO2 flavin containing monooxygenase 2 (non-functional) 0.00910279
LAMP3 lysosomal-associated membrane protein 3 0.00907611
FBN2 fibrillin 2 0.00906645
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.00905679
HSPB8 heat shock 22kDa protein 8 0.00904188
VWF von Willebrand factor 0.00895193
FABP4 fatty acid binding protein 4, adipocyte 0.0089252
SIK1 salt-inducible kinase 1 0.00869833
SIRPA signal-regulatory protein alpha 0.00868088
CRABP1 cellular retinoic acid binding protein 1 0.00854523
FAM107A family with sequence similarity 107, member A 0.00850549
FHL1 four and a half LIM domains 1 0.00847648
ASCL1 achaete-scute family bHLH transcription factor 1 0.00836257
TACSTD2 tumor-associated calcium signal transducer 2 0.00827692
BCL2A1 BCL2-related protein A1 0.0082562
CRYAB crystallin, alpha B 0.00820674
ADM adrenomedullin 0.00818812
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.00818445
CXCL8 chemokine (C-X-C motif) ligand 8 0.00818431
S100P S100 calcium binding protein P 0.00815163
TPBG trophoblast glycoprotein 0.00813485
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 0.00809829
SPATS2L spermatogenesis associated, serine-rich 2-like 0.00809202
RRBP1 ribosome binding protein 1 0.0080843
SPRR3 small proline-rich protein 3 0.00806021
RGCC regulator of cell cycle 0.00803445
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.00803124
LTBP1 latent transforming growth factor beta binding protein 1 0.00795788
KRT5 keratin 5, type II 0.0079577
DST dystonin 0.00792871
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.00784493
ELF5 E74-like factor 5 (ets domain transcription factor) 0.00780361
SOX9 SRY (sex determining region Y)-box 9 0.00777145
PLCB4 phospholipase C, beta 4 0.00770483
KLF9 Kruppel-like factor 9 0.00767463
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.00764796
AKAP12 A kinase (PRKA) anchor protein 12 0.00764391
RRAGD Ras-related GTP binding D 0.00762938
IRF6 interferon regulatory factor 6 0.00762897
PLTP phospholipid transfer protein 0.00762676
OLFM4 olfactomedin 4 0.00758056
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00756845
SYNM synemin, intermediate filament protein 0.00754629
ACTG2 actin, gamma 2, smooth muscle, enteric 0.0075206
MGLL monoglyceride lipase 0.00750694
FOXC1 forkhead box C1 0.00743557
KRT7 keratin 7, type II 0.00743304
PALLD palladin, cytoskeletal associated protein 0.00741477
TRIP10 thyroid hormone receptor interactor 10 0.00741248
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00739719
TSPYL5 TSPY-like 5 0.00739049
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.00738487
HBEGF heparin-binding EGF-like growth factor 0.00731556
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.00729284
SAMD4A sterile alpha motif domain containing 4A 0.00728078
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.00724423
ZNF423 zinc finger protein 423 0.00724083
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.00723265
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00721083
IER3 immediate early response 3 0.0071902
MTUS1 microtubule associated tumor suppressor 1 0.00718717
AREG amphiregulin 0.007186
CD83 CD83 molecule 0.00717764
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0071546
BCL3 B-cell CLL/lymphoma 3 0.00714899
ACP5 acid phosphatase 5, tartrate resistant 0.00714066
TUBB2A tubulin, beta 2A class IIa 0.00712324
ABLIM1 actin binding LIM protein 1 0.00711593
CHD7 chromodomain helicase DNA binding protein 7 0.00710113
ITGA6 integrin, alpha 6 0.00702994
KRT18 keratin 18, type I 0.00700238
CXCL2 chemokine (C-X-C motif) ligand 2 0.00698496
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.00695511
PLXNA1 plexin A1 0.00695064
TBX3 T-box 3 0.00693343
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.00692398
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00691724
GOLGA8H golgin A8 family, member H 0.00691238
LCN2 lipocalin 2 0.00690409
ZYX zyxin 0.00689697
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 0.00689236
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 0.00686497
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0068505
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.00677146
SOBP sine oculis binding protein homolog (Drosophila) 0.0067578
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.00675191
ATP9A ATPase, class II, type 9A 0.00673471
C1QA complement component 1, q subcomponent, A chain 0.00672728
TRIM29 tripartite motif containing 29 0.00668682
IL17RB interleukin 17 receptor B 0.0066765
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.00667645
C8ORF4 chromosome 8 open reading frame 4 0.00667065
CDC25B cell division cycle 25B 0.00666157
TPM2 tropomyosin 2 (beta) 0.00664639
CUX1 cut-like homeobox 1 0.00664237
CNN1 calponin 1, basic, smooth muscle 0.00663544
RCAN1 regulator of calcineurin 1 0.00660222
KRT14 keratin 14, type I 0.00658698
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00655573
GOLGB1 golgin B1 0.00653547
CAPN3 calpain 3, (p94) 0.0065331
LAMC2 laminin, gamma 2 0.00653176
PLAUR plasminogen activator, urokinase receptor 0.0065283
KRT81 keratin 81, type II 0.0065251
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.00652118
RBMS1 RNA binding motif, single stranded interacting protein 1 0.00648403
LGMN legumain 0.00648323
ZFAND5 zinc finger, AN1-type domain 5 0.00645592
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.00645501
IL33R interleukin 33 receptor 0.00645185
MSL1 male-specific lethal 1 homolog (Drosophila) 0.00645156
A2M alpha-2-macroglobulin 0.00642561
PTCH1 patched 1 0.0063796
CTSC cathepsin C 0.00637696
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.00637421
ISG20 interferon stimulated exonuclease gene 20kDa 0.00634719
ACTN1 actinin, alpha 1 0.00632738
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.00631921
MYO1C myosin IC 0.00630371
RAB15 RAB15, member RAS oncogene family 0.00630345
TP63 tumor protein p63 0.00629737
SORBS2 sorbin and SH3 domain containing 2 0.00628303
CHGB chromogranin B 0.00628277
FGF9 fibroblast growth factor 9 0.00624834
ADGRL2 adhesion G protein-coupled receptor L2 0.00624127
LMOD1 leiomodin 1 (smooth muscle) 0.00623917
IFITM1 interferon induced transmembrane protein 1 0.00623605
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.00623118
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.00622725
SMC1A structural maintenance of chromosomes 1A 0.00622532
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.00621996
BMP2 bone morphogenetic protein 2 0.00621857
PNMA2 paraneoplastic Ma antigen 2 0.00621806
KLF7 Kruppel-like factor 7 (ubiquitous) 0.00621803
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.00621763
TRIM44 tripartite motif containing 44 0.00619348
EREG epiregulin 0.00618827
TMPRSS11E transmembrane protease, serine 11E 0.0061869
TMEM176B transmembrane protein 176B 0.00617763
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0061258
UPK1B uroplakin 1B 0.0061213
GABARAPL1 GABA(A) receptor-associated protein like 1 0.00611639
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.00608481
TPM4 tropomyosin 4 0.00607272
FAM171A1 family with sequence similarity 171, member A1 0.00607199
MED22 mediator complex subunit 22 0.00606449
BHLHE41 basic helix-loop-helix family, member e41 0.00606238
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.00606005
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00605956
PITX1 paired-like homeodomain 1 0.00604805
MINK1 misshapen-like kinase 1 0.00603238
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.00602286
WARS1 tryptophanyl-tRNA synthetase 1 0.00601916
TNNC1 troponin C type 1 (slow) 0.00601471
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.00600943
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.00600086
PLCG1 phospholipase C, gamma 1 0.00596643
COL4A5 collagen, type IV, alpha 5 0.00595513
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.00595098
MCM2 minichromosome maintenance complex component 2 0.00594905
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.00591569
TARBP1 TAR (HIV-1) RNA binding protein 1 0.00591325
CXCL5 chemokine (C-X-C motif) ligand 5 0.00589364
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.00587746
ARFIP2 ADP-ribosylation factor interacting protein 2 0.00586773
FBLN5 fibulin 5 0.00586744
EMP1 epithelial membrane protein 1 0.00585727
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00585645
ADCY2 adenylate cyclase 2 (brain) 0.0058517
KRT15 keratin 15, type I 0.00584646
MVP major vault protein 0.0058411
ACTA2 actin, alpha 2, smooth muscle, aorta 0.00583656
TRIP6 thyroid hormone receptor interactor 6 0.00583263
EDN3 endothelin 3 0.00582516
PEG3 paternally expressed 3 0.00581547
GBP1 guanylate binding protein 1, interferon-inducible 0.00581049
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.00580685
C1S complement component 1, s subcomponent 0.00580294
WIF1 WNT inhibitory factor 1 0.0057964
MYH11 myosin, heavy chain 11, smooth muscle 0.0057937
WEE1 WEE1 G2 checkpoint kinase 0.00577504
TFRC transferrin receptor 0.00577337
KLF10 Kruppel-like factor 10 0.00576354
WFDC1 WAP four-disulfide core domain 1 0.00576324
AQP1 aquaporin 1 (Colton blood group) 0.00574747
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.00573618
RELN reelin 0.00572707
MEIS2 Meis homeobox 2 0.00572316
JUN jun proto-oncogene 0.00571988
JUNB jun B proto-oncogene 0.0057174
PSCA prostate stem cell antigen 0.00571397
FRMD4B FERM domain containing 4B 0.00570383
MBD2 methyl-CpG binding domain protein 2 0.00570216
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00569425
DIO2 deiodinase, iodothyronine, type II 0.00569091
FBRS fibrosin 0.00568409
USP47 ubiquitin specific peptidase 47 0.00568364
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.00567907
ADA adenosine deaminase 0.00567894
GNAS GNAS complex locus 0.00567118
STOM stomatin 0.005671
NFIL3 nuclear factor, interleukin 3 regulated 0.00566776
PDE8B phosphodiesterase 8B 0.00566705
JAK1 Janus kinase 1 0.0056609
NISCH nischarin 0.00565812
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.00565741
MAP2K6 mitogen-activated protein kinase kinase 6 0.00565365
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.00565338
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.00565276
PRAME preferentially expressed antigen in melanoma 0.0056513
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.00565088
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.00564822
MT1E metallothionein 1E 0.00564639
AHCYL1 adenosylhomocysteinase-like 1 0.00564337
LPP LIM domain containing preferred translocation partner in lipoma 0.00562407
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.00559041
GOLGA8A golgin A8 family, member A 0.00557463

decreased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase -0.0155955
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0145056
CNPY3 canopy FGF signaling regulator 3 -0.0141025
NVL nuclear VCP-like -0.0136324
NPY1R neuropeptide Y receptor Y1 -0.0132865
NPTX2 neuronal pentraxin II -0.0122421
DEGS1 delta(4)-desaturase, sphingolipid 1 -0.0113553
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.0113453
JCHAIN joining chain of multimeric IgA and IgM -0.0108401
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.0104595
KDM5D lysine (K)-specific demethylase 5D -0.0100779
TMSB15A thymosin beta 15a -0.00978041
S100A4 S100 calcium binding protein A4 -0.00937723
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0091972
PDGFC platelet derived growth factor C -0.00905136
ASS1 argininosuccinate synthase 1 -0.00893552
RPS5 ribosomal protein S5 -0.00880046
ZBTB18 zinc finger and BTB domain containing 18 -0.00870672
GNMT glycine N-methyltransferase -0.00869682
HIST1H2BK histone cluster 1, H2bk -0.00865641
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -0.00856765
PLAAT3 phospholipase A and acyltransferase 3 -0.00849453
FBXO28 F-box protein 28 -0.00848761
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -0.00837812
METTL7A methyltransferase like 7A -0.00836761
LRRC15 leucine rich repeat containing 15 -0.00836019
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.00824219
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0081839
VCAM1 vascular cell adhesion molecule 1 -0.00817645
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.00816761
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 -0.0081641
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.00815537
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -0.00810093
SC5D sterol-C5-desaturase -0.00806568
HOMER2 homer scaffolding protein 2 -0.00805744
DHCR24 24-dehydrocholesterol reductase -0.00802027
GSTM3 glutathione S-transferase mu 3 (brain) -0.00789334
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.00788729
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -0.00783751
CRIP2 cysteine-rich protein 2 -0.00781863
SHROOM2 shroom family member 2 -0.00781552
FST follistatin -0.0077879
COL11A1 collagen, type XI, alpha 1 -0.00777497
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.00774128
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -0.0076948
TPSAB1 tryptase alpha/beta 1 -0.00767131
PRDX2 peroxiredoxin 2 -0.00766558
NDUFA4 NDUFA4, mitochondrial complex associated -0.00753197
FGG fibrinogen gamma chain -0.00751365
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -0.00746742
BPHL biphenyl hydrolase-like (serine hydrolase) -0.0074649
DCK deoxycytidine kinase -0.00745573
RPA3 replication protein A3, 14kDa -0.00741749
THY1 Thy-1 cell surface antigen -0.00741436
CPVL carboxypeptidase, vitellogenic-like -0.00736896
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.00733741
HMGN5 high mobility group nucleosome binding domain 5 -0.0072898
CLGN calmegin -0.00724376
CCNE2 cyclin E2 -0.00718061
HOXD1 homeobox D1 -0.00716074
GUSBP3 glucuronidase, beta pseudogene 3 -0.00713298
RWDD1 RWD domain containing 1 -0.00712653
CD99 CD99 molecule -0.00711933
REEP1 receptor accessory protein 1 -0.00710734
PCCB propionyl CoA carboxylase, beta polypeptide -0.00696455
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.00696148
HAL histidine ammonia-lyase -0.00695664
IL7R interleukin 7 receptor -0.00692215
EAPP E2F-associated phosphoprotein -0.00691654
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -0.00689606
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -0.00687251
KRT10 keratin 10, type I -0.00682038
NID2 nidogen 2 (osteonidogen) -0.00677591
STK17A serine/threonine kinase 17a -0.00671059
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.00666346
CD1E CD1e molecule -0.00663116
SSBP2 single-stranded DNA binding protein 2 -0.0066034
ARHGAP29 Rho GTPase activating protein 29 -0.0066032
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.00660216
NMU neuromedin U -0.00659512
HSPA13 heat shock protein 70kDa family, member 13 -0.00656448
NAV3 neuron navigator 3 -0.00652868
SAR1B secretion associated, Ras related GTPase 1B -0.00651919
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -0.0065128
TMEM126B transmembrane protein 126B -0.00650728
TSPAN13 tetraspanin 13 -0.00650232
MCUB mitochondrial calcium uniporter dominant negative subunit beta -0.00648398
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -0.00643474
SOCS5 suppressor of cytokine signaling 5 -0.00641545
TMEM14B transmembrane protein 14B -0.00641484
NTS neurotensin -0.00640379
PQBP1 polyglutamine binding protein 1 -0.00638216
ECI1 enoyl-CoA delta isomerase 1 -0.00631014
DCLK1 doublecortin-like kinase 1 -0.00629797
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00629087
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.00627437
EVI2A ecotropic viral integration site 2A -0.00627371
TMEM106C transmembrane protein 106C -0.00626781
ATP5ME ATP synthase membrane subunit e -0.00622523
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -0.00622218
PSPH phosphoserine phosphatase -0.00620278
FAM162A family with sequence similarity 162, member A -0.00619371
COL10A1 collagen, type X, alpha 1 -0.00619046
FGFR1 fibroblast growth factor receptor 1 -0.00618829
CCR2 chemokine (C-C motif) receptor 2 -0.00617082
ATF1 activating transcription factor 1 -0.00616518
IKZF1 IKAROS family zinc finger 1 (Ikaros) -0.0061625
SPON2 spondin 2, extracellular matrix protein -0.00615069
PRDX4 peroxiredoxin 4 -0.00613593
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.00612969
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -0.00611061
REXO5 RNA exonuclease 5 -0.0060805
MGMT O-6-methylguanine-DNA methyltransferase -0.00606477
UROS uroporphyrinogen III synthase -0.00606
PDE10A phosphodiesterase 10A -0.00604812
ADI1 acireductone dioxygenase 1 -0.00603791
APOA1 apolipoprotein A-I -0.00602083
PLA2G12A phospholipase A2, group XIIA -0.00599433
GAMT guanidinoacetate N-methyltransferase -0.00597037
NUSAP1 nucleolar and spindle associated protein 1 -0.00595194
AHSG alpha-2-HS-glycoprotein -0.0059489
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -0.00594703
GSTT1 glutathione S-transferase theta 1 -0.00594555
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 -0.00593201
APOB apolipoprotein B -0.00593026
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.00591195
ZG16 zymogen granule protein 16 -0.00589506
MARCHF1 membrane associated ring-CH-type finger 1 -0.00588724
ITPRID2 ITPR interacting domain containing 2 -0.00588677
TRAPPC4 trafficking protein particle complex 4 -0.00587842
EPHA4 EPH receptor A4 -0.00586746
ERI2 ERI1 exoribonuclease family member 2 -0.00586127
LDOC1 leucine zipper, down-regulated in cancer 1 -0.0058438
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 -0.00582628
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0058115
LAMP5 lysosomal-associated membrane protein family, member 5 -0.00580317
SLC38A2 solute carrier family 38, member 2 -0.00580157
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.00579713
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -0.00578477
H1-2 H1.2 linker histone, cluster member -0.005783
IVD isovaleryl-CoA dehydrogenase -0.00578168
CASP8 caspase 8, apoptosis-related cysteine peptidase -0.00577168
PECR peroxisomal trans-2-enoyl-CoA reductase -0.00574339
ZNF239 zinc finger protein 239 -0.00572913
LEPROTL1 leptin receptor overlapping transcript-like 1 -0.00572774
CKAP2 cytoskeleton associated protein 2 -0.00571936
SCAND1 SCAN domain containing 1 -0.00571834
PHF20 PHD finger protein 20 -0.00571552
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -0.00569966
CPB1 carboxypeptidase B1 (tissue) -0.00568625
MAGEB2 melanoma antigen family B2 -0.0056806
SPON1 spondin 1, extracellular matrix protein -0.00565286
IPO13 importin 13 -0.00564929
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -0.00563069
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -0.00559455
H2AFV H2A histone family, member V -0.0055921
MZB1 marginal zone B and B1 cell-specific protein -0.00558153
ACOX2 acyl-CoA oxidase 2, branched chain -0.0055752
PBLD phenazine biosynthesis-like protein domain containing -0.00557339
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 -0.00555775
ESR1 estrogen receptor 1 -0.00555749
RAB40B RAB40B, member RAS oncogene family -0.00554602
ZCCHC10 zinc finger, CCHC domain containing 10 -0.00553939
CDC7 cell division cycle 7 -0.00547834
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -0.00546842
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -0.00546562
DCT dopachrome tautomerase -0.00546508
SPTSSA serine palmitoyltransferase, small subunit A -0.00544553
CHN2 chimerin 2 -0.00542565
OSBPL8 oxysterol binding protein-like 8 -0.00540679
ZNF329 zinc finger protein 329 -0.00540525
LOR loricrin -0.00540008
PRDX3 peroxiredoxin 3 -0.00539367
GLUD2 glutamate dehydrogenase 2 -0.00538671
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) -0.00537229
ADIRF adipogenesis regulatory factor -0.00536721
DHCR7 7-dehydrocholesterol reductase -0.00536599
FBXO11 F-box protein 11 -0.00535488
RP2 retinitis pigmentosa 2 (X-linked recessive) -0.00535128
ACAT1 acetyl-CoA acetyltransferase 1 -0.00533491
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.00532329
THBS2 thrombospondin 2 -0.00531078
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00531032
MYL5 myosin, light chain 5, regulatory -0.00530754
WT1 Wilms tumor 1 -0.00530597
MTFR1 mitochondrial fission regulator 1 -0.00530332
NRBF2 nuclear receptor binding factor 2 -0.00530085
SCUBE2 signal peptide, CUB domain, EGF-like 2 -0.00528015
OPN3 opsin 3 -0.00527751
SPC25 SPC25, NDC80 kinetochore complex component -0.00527474
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.00525997
ASGR2 asialoglycoprotein receptor 2 -0.00525806
NELL2 NEL-like 2 (chicken) -0.00525734
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) -0.00524741
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -0.00524587
TGDS TDP-glucose 4,6-dehydratase -0.00522601
CENPU centromere protein U -0.00522509
GMFG glia maturation factor, gamma -0.00521904
ADCY9 adenylate cyclase 9 -0.00521553
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -0.00520705
GAS6 growth arrest-specific 6 -0.00518692
GSPT2 G1 to S phase transition 2 -0.00518013
MOCS2 molybdenum cofactor synthesis 2 -0.00516164
HIST3H2A histone cluster 3, H2a -0.00516097
PHTF2 putative homeodomain transcription factor 2 -0.00514368
HELLS helicase, lymphoid-specific -0.00512351
LY86 lymphocyte antigen 86 -0.00511944
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -0.00511898
SEPTIN10 septin 10 -0.00511666
NINJ2 ninjurin 2 -0.00511279
MPC1 mitochondrial pyruvate carrier 1 -0.0050992
NRGN neurogranin (protein kinase C substrate, RC3) -0.0050874
STMN1 stathmin 1 -0.00506542
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.00505627
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -0.00503698
RMI1 RecQ mediated genome instability 1 -0.00503215
KLK7 kallikrein-related peptidase 7 -0.00502672
ECI2 enoyl-CoA delta isomerase 2 -0.00502381
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -0.005005
DCXR dicarbonyl/L-xylulose reductase -0.00500244
TM7SF2 transmembrane 7 superfamily member 2 -0.00500056
ALB albumin -0.00500011
GET1 guided entry of tail-anchored proteins factor 1 -0.00498756
GET3 guided entry of tail-anchored proteins factor 3, ATPase -0.00498348
TSPAN12 tetraspanin 12 -0.00498047
PPIH peptidylprolyl isomerase H (cyclophilin H) -0.00497185
CA2 carbonic anhydrase II -0.00496423
MRPS30 mitochondrial ribosomal protein S30 -0.00496378
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -0.00494062
FASTKD3 FAST kinase domains 3 -0.00494056
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.00492682
APLP2 amyloid beta (A4) precursor-like protein 2 -0.00492565
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -0.00491921
ZNF217 zinc finger protein 217 -0.0049152
TRAPPC2L trafficking protein particle complex 2-like -0.0049143
PCLAF PCNA clamp associated factor -0.00491358
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant -0.00491082
DSC1 desmocollin 1 -0.00490369
DESI1 desumoylating isopeptidase 1 -0.00490029
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -0.00489257
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00488088
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -0.00487957
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.00487752
RPS27L ribosomal protein S27-like -0.00487715
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -0.00486716
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.00485944
ERLIN1 ER lipid raft associated 1 -0.00485878
MRPS16 mitochondrial ribosomal protein S16 -0.00485453
DCTN3 dynactin 3 (p22) -0.0048454