Ibutamoren Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/178024
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Genes

200 proteins with high or low expression in Ibutamoren relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.96
TSPAN3 tetraspanin 3 0.92
IRX4 iroquois homeobox 4 0.72
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.65
NCOA4 nuclear receptor coactivator 4 0.61
ARSG arylsulfatase G 0.55
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.54
MBNL2 muscleblind-like splicing regulator 2 0.51
ZFP1 ZFP1 zinc finger protein 0.49
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.48
INPP5J inositol polyphosphate-5-phosphatase J 0.47
SPPL3 signal peptide peptidase like 3 0.47
NIPSNAP3A nipsnap homolog 3A (C. elegans) 0.47
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) 0.46
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 0.45
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.44
KIF27 kinesin family member 27 0.43
LPIN1 lipin 1 0.42
FSTL1 follistatin-like 1 0.41
CCDC66 coiled-coil domain containing 66 0.4
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 0.4
NFE2L2 nuclear factor, erythroid 2-like 2 0.4
CABLES1 Cdk5 and Abl enzyme substrate 1 0.4
CD63 CD63 molecule 0.39
ZBTB44 zinc finger and BTB domain containing 44 0.39
DDTL D-dopachrome tautomerase-like 0.38
PMF1 polyamine-modulated factor 1 0.37
LCORL ligand dependent nuclear receptor corepressor-like 0.36
TULP4 tubby like protein 4 0.36
OTC ornithine carbamoyltransferase 0.36
PRRX2 paired related homeobox 2 0.36
CTSA cathepsin A 0.35
ECHDC3 enoyl CoA hydratase domain containing 3 0.35
SEPTIN4 septin 4 0.35
SLC25A39 solute carrier family 25, member 39 0.34
ZNRD1 zinc ribbon domain containing 1 0.34
TXNDC16 thioredoxin domain containing 16 0.33
COX5B cytochrome c oxidase subunit Vb 0.33
KDM4D lysine (K)-specific demethylase 4D 0.33
FKBPL FK506 binding protein like 0.33
BORCS5 BLOC-1 related complex subunit 5 0.33
DHFR dihydrofolate reductase 0.33
ZNF335 zinc finger protein 335 0.32
NBR1 neighbor of BRCA1 gene 1 0.32
PTPRB protein tyrosine phosphatase, receptor type, B 0.32
RMDN2 regulator of microtubule dynamics 2 0.32
ZNF639 zinc finger protein 639 0.32
GRHL1 grainyhead-like 1 (Drosophila) 0.31
PRKCB protein kinase C, beta 0.31
TLE5 TLE family member 5, transcriptional modulator 0.31
KIF1B kinesin family member 1B 0.31
GUK1 guanylate kinase 1 0.31
GINS3 GINS complex subunit 3 (Psf3 homolog) 0.31
TLL2 tolloid-like 2 0.3
PES1 pescadillo ribosomal biogenesis factor 1 0.3
DCAF7 DDB1 and CUL4 associated factor 7 0.3
BSPRY B-box and SPRY domain containing 0.3
PFDN1 prefoldin subunit 1 0.3
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.3
ZFYVE28 zinc finger, FYVE domain containing 28 0.3
MALRD1 MAM and LDL receptor class A domain containing 1 0.29
IER2 immediate early response 2 0.29
LASP1 LIM and SH3 protein 1 0.29
AUNIP aurora kinase A and ninein interacting protein 0.29
ZNF888 zinc finger protein 888 0.29
TTYH2 tweety family member 2 0.29
ALAS1 5'-aminolevulinate synthase 1 0.29
TMEM59 transmembrane protein 59 0.29
RBM23 RNA binding motif protein 23 0.29
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.29
SGSH N-sulfoglucosamine sulfohydrolase 0.28
SYTL2 synaptotagmin-like 2 0.28
GLRX glutaredoxin (thioltransferase) 0.28
TRIM62 tripartite motif containing 62 0.28
CCDC82 coiled-coil domain containing 82 0.28
KIAA1143 KIAA1143 0.28
NMU neuromedin U 0.28
FBXL2 F-box and leucine-rich repeat protein 2 0.28
SH3RF2 SH3 domain containing ring finger 2 0.28
PER2 period circadian clock 2 0.28
FZD1 frizzled class receptor 1 0.28
GPX1 glutathione peroxidase 1 0.27
ZNF729 zinc finger protein 729 0.27
PRKD1 protein kinase D1 0.27
PROSER1 proline and serine rich 1 0.27
SH3YL1 SH3 and SYLF domain containing 1 0.27
SUMF2 sulfatase modifying factor 2 0.27
BICRAL BICRA like chromatin remodeling complex associated protein 0.27
FBXW4 F-box and WD repeat domain containing 4 0.27
ATMIN ATM interactor 0.27
TC2N tandem C2 domains, nuclear 0.26
MYO15B myosin XVB 0.26
C12ORF73 chromosome 12 open reading frame 73 0.26
KANK3 KN motif and ankyrin repeat domains 3 0.26
RGS12 regulator of G-protein signaling 12 0.26
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.26
BAIAP2 BAI1-associated protein 2 0.26
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.26
CREBZF CREB/ATF bZIP transcription factor 0.26
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.26

low expression

Symbol Name Standardized Value
KMT5C lysine methyltransferase 5C -1.57
ACTBL2 actin, beta-like 2 -0.85
TIGD1 tigger transposable element derived 1 -0.8
PIP prolactin-induced protein -0.76
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -0.71
AMACR alpha-methylacyl-CoA racemase -0.63
ZDHHC2 zinc finger, DHHC-type containing 2 -0.6
NAAA N-acylethanolamine acid amidase -0.56
METTL22 methyltransferase like 22 -0.54
LIPA lipase A, lysosomal acid, cholesterol esterase -0.52
IFITM3 interferon induced transmembrane protein 3 -0.5
C19ORF54 chromosome 19 open reading frame 54 -0.47
PPT1 palmitoyl-protein thioesterase 1 -0.46
NRP1 neuropilin 1 -0.45
GPATCH2L G patch domain containing 2-like -0.45
ENO1 enolase 1, (alpha) -0.44
MYCBP MYC binding protein -0.44
RPE ribulose-5-phosphate-3-epimerase -0.42
ZNF600 zinc finger protein 600 -0.41
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.41
AKR1C3 aldo-keto reductase family 1, member C3 -0.4
ANTXR2 anthrax toxin receptor 2 -0.39
ZCCHC10 zinc finger, CCHC domain containing 10 -0.37
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 -0.37
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) -0.37
COX5A cytochrome c oxidase subunit Va -0.36
MT-ND5 NADH dehydrogenase, subunit 5 (complex I) -0.35
TJP1 tight junction protein 1 -0.35
IGF1R insulin-like growth factor 1 receptor -0.34
EED embryonic ectoderm development -0.34
PTBP2 polypyrimidine tract binding protein 2 -0.34
KCTD17 potassium channel tetramerization domain containing 17 -0.33
HSBP1 heat shock factor binding protein 1 -0.32
TMEM14C transmembrane protein 14C -0.32
SDF2 stromal cell-derived factor 2 -0.32
SF1 splicing factor 1 -0.32
DNLZ DNL-type zinc finger -0.32
ULBP1 UL16 binding protein 1 -0.31
ZNF267 zinc finger protein 267 -0.31
PEX12 peroxisomal biogenesis factor 12 -0.31
ZNF558 zinc finger protein 558 -0.3
LSM1 LSM1, U6 small nuclear RNA associated -0.3
SPAG5 sperm associated antigen 5 -0.3
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.3
AKIRIN2 akirin 2 -0.3
TRIM29 tripartite motif containing 29 -0.3
YPEL5 yippee-like 5 (Drosophila) -0.3
MTUS2 microtubule associated tumor suppressor candidate 2 -0.29
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.29
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -0.29
MTRES1 mitochondrial transcription rescue factor 1 -0.28
WDFY2 WD repeat and FYVE domain containing 2 -0.28
B2M beta-2-microglobulin -0.28
MLXIPL MLX interacting protein-like -0.28
MRC2 mannose receptor, C type 2 -0.27
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.27
NHSL1 NHS-like 1 -0.27
GLT8D1 glycosyltransferase 8 domain containing 1 -0.26
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.26
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.26
STC2 stanniocalcin 2 -0.26
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.26
CIC capicua transcriptional repressor -0.25
SCAND1 SCAN domain containing 1 -0.25
COA5 cytochrome c oxidase assembly factor 5 -0.25
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -0.25
FAM53B family with sequence similarity 53, member B -0.25
CEBPZOS CEBPZ opposite strand -0.24
FAM241B family with sequence similarity 241 member B -0.24
TMEM222 transmembrane protein 222 -0.24
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -0.24
ANKRD54 ankyrin repeat domain 54 -0.24
RNF13 ring finger protein 13 -0.24
USP12 ubiquitin specific peptidase 12 -0.24
DBF4 DBF4 zinc finger -0.24
CLCN2 chloride channel, voltage-sensitive 2 -0.24
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -0.23
HYAL2 hyaluronoglucosaminidase 2 -0.23
RPLP1 ribosomal protein, large, P1 -0.23
CNTRL centriolin -0.23
MAPK14 mitogen-activated protein kinase 14 -0.23
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -0.23
TIPE1 TNF alpha induced protein 8 like 1 -0.23
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.23
WRB tryptophan rich basic protein -0.23
SSNA1 Sjogren syndrome nuclear autoantigen 1 -0.23
LARP6 La ribonucleoprotein domain family, member 6 -0.23
RAD51B RAD51 paralog B -0.22
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.22
CCDC167 coiled-coil domain containing 167 -0.22
RUFY3 RUN and FYVE domain containing 3 -0.22
VAMP4 vesicle-associated membrane protein 4 -0.22
XIRP2 xin actin binding repeat containing 2 -0.22
HMGB2 high mobility group box 2 -0.22
FEM1C fem-1 homolog c (C. elegans) -0.22
KLC1 kinesin light chain 1 -0.22
HYLS1 hydrolethalus syndrome 1 -0.22
MRPL33 mitochondrial ribosomal protein L33 -0.21
GRAMD2B GRAM domain containing 2B -0.21
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 -0.21