Icatibant Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/6918173
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Genes

199 proteins with high or low expression in Icatibant relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ACTBL2 actin, beta-like 2 1.17
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.96
BBS9 Bardet-Biedl syndrome 9 0.56
ABHD15 abhydrolase domain containing 15 0.49
ZNF557 zinc finger protein 557 0.46
CYBA cytochrome b-245, alpha polypeptide 0.43
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 0.41
MAN2C1 mannosidase, alpha, class 2C, member 1 0.4
REPS2 RALBP1 associated Eps domain containing 2 0.4
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.39
MTUS2 microtubule associated tumor suppressor candidate 2 0.39
EHF ets homologous factor 0.34
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.32
ZBED9 zinc finger, BED-type containing 9 0.32
EEF1AKMT1 EEF1A lysine methyltransferase 1 0.32
CARD10 caspase recruitment domain family, member 10 0.31
KLHL20 kelch-like family member 20 0.31
EFCAB7 EF-hand calcium binding domain 7 0.31
FCHO1 FCH domain only 1 0.3
B9D1 B9 protein domain 1 0.3
PLEKHJ1 pleckstrin homology domain containing, family J member 1 0.3
C17ORF53 chromosome 17 open reading frame 53 0.3
VAMP8 vesicle-associated membrane protein 8 0.3
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.3
CD320 CD320 molecule 0.3
PCLAF PCNA clamp associated factor 0.29
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 0.29
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.29
BHLHE40 basic helix-loop-helix family, member e40 0.29
SP100 SP100 nuclear antigen 0.29
RLIM ring finger protein, LIM domain interacting 0.29
FAM53C family with sequence similarity 53, member C 0.28
CEP55 centrosomal protein 55kDa 0.28
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.28
HOXB9 homeobox B9 0.28
IRF5 interferon regulatory factor 5 0.28
MEX3C mex-3 RNA binding family member C 0.28
ESAM endothelial cell adhesion molecule 0.28
DCAF16 DDB1 and CUL4 associated factor 16 0.28
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta 0.27
TTC9 tetratricopeptide repeat domain 9 0.27
RPUSD4 RNA pseudouridylate synthase domain containing 4 0.27
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.27
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.26
SUMO1 small ubiquitin-like modifier 1 0.26
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.26
NTN1 netrin 1 0.26
ZIC5 Zic family member 5 0.26
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.26
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 0.26
MSANTD4 Myb/SANT-like DNA-binding domain containing 4 with coiled-coils 0.26
RPS26P11 ribosomal protein S26 pseudogene 11 0.25
IFITM3 interferon induced transmembrane protein 3 0.25
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 0.25
TMEM59 transmembrane protein 59 0.25
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 0.25
KDM4D lysine (K)-specific demethylase 4D 0.25
RACK1 receptor for activated C kinase 1 0.24
ELOB elongin B 0.24
ITGB8 integrin, beta 8 0.24
FAM110A family with sequence similarity 110, member A 0.24
UCK1 uridine-cytidine kinase 1 0.23
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.23
LDB1 LIM domain binding 1 0.23
CNIH4 cornichon family AMPA receptor auxiliary protein 4 0.23
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.23
PAQR7 progestin and adipoQ receptor family member VII 0.23
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.23
JPT1 Jupiter microtubule associated homolog 1 0.23
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 0.23
RPA3 replication protein A3, 14kDa 0.23
SPC24 SPC24, NDC80 kinetochore complex component 0.23
ELOC elongin C 0.22
DUSP6 dual specificity phosphatase 6 0.22
DDTL D-dopachrome tautomerase-like 0.22
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.22
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.22
GRHL1 grainyhead-like 1 (Drosophila) 0.22
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.22
TMEM70 transmembrane protein 70 0.22
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.22
NCS1 neuronal calcium sensor 1 0.22
MIEN1 migration and invasion enhancer 1 0.21
FANCC Fanconi anemia, complementation group C 0.21
YBX3 Y box binding protein 3 0.21
C11ORF49 chromosome 11 open reading frame 49 0.21
DONSON downstream neighbor of SON 0.21
RPL30 ribosomal protein L30 0.21
UBE2H ubiquitin-conjugating enzyme E2H 0.21
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 0.21
PTMA prothymosin, alpha 0.21
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.21
LYST lysosomal trafficking regulator 0.21
FASTKD3 FAST kinase domains 3 0.21
RPLP1 ribosomal protein, large, P1 0.21
NTHL1 nth endonuclease III-like 1 (E. coli) 0.21
BLZF1 basic leucine zipper nuclear factor 1 0.2
COPZ1 coatomer protein complex, subunit zeta 1 0.2
CDC25B cell division cycle 25B 0.2
ARID5B AT rich interactive domain 5B (MRF1-like) 0.2

low expression

Symbol Name Standardized Value
IL17RD interleukin 17 receptor D -3.69
ADPRH ADP-ribosylarginine hydrolase -1.83
ZG16B zymogen granule protein 16B -1.72
MDM1 Mdm1 nuclear protein homolog (mouse) -1.66
PIP prolactin-induced protein -1.5
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -1.4
XDH xanthine dehydrogenase -1.38
VIM vimentin -1.32
KIAA1324L KIAA1324-like -1.2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -1.14
HKDC1 hexokinase domain containing 1 -0.96
MED8 mediator complex subunit 8 -0.87
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.8
FGG fibrinogen gamma chain -0.79
PARPBP PARP1 binding protein -0.78
MSLN mesothelin -0.78
DEDD2 death effector domain containing 2 -0.77
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.76
TDRD9 tudor domain containing 9 -0.76
ATXN1L ataxin 1-like -0.73
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -0.7
MAN2A2 mannosidase, alpha, class 2A, member 2 -0.69
TRIM29 tripartite motif containing 29 -0.69
HMOX1 heme oxygenase 1 -0.66
AKR1C2 aldo-keto reductase family 1, member C2 -0.64
ABHD4 abhydrolase domain containing 4 -0.64
ATF6B activating transcription factor 6 beta -0.63
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -0.63
DCHS1 dachsous cadherin-related 1 -0.62
DDIT4 DNA-damage-inducible transcript 4 -0.62
NKX2-8 NK2 homeobox 8 -0.6
SQSTM1 sequestosome 1 -0.6
KSR2 kinase suppressor of ras 2 -0.57
MYBPC1 myosin binding protein C, slow type -0.56
OSGIN1 oxidative stress induced growth inhibitor 1 -0.55
F13A1 coagulation factor XIII, A1 polypeptide -0.53
ZNF611 zinc finger protein 611 -0.53
KLF13 Kruppel-like factor 13 -0.52
BAHCC1 BAH domain and coiled-coil containing 1 -0.51
SERAC1 serine active site containing 1 -0.51
SH2B3 SH2B adaptor protein 3 -0.5
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -0.49
AFG1L AFG1 like ATPase -0.48
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.48
JUN jun proto-oncogene -0.48
OBSL1 obscurin-like 1 -0.47
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -0.46
ZNF652 zinc finger protein 652 -0.46
SIGMAR1 sigma non-opioid intracellular receptor 1 -0.46
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.45
ZNF564 zinc finger protein 564 -0.45
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.45
GFOD1 glucose-fructose oxidoreductase domain containing 1 -0.43
DOCK10 dedicator of cytokinesis 10 -0.43
RAMAC RNA guanine-7 methyltransferase activating subunit -0.42
TANGO2 transport and golgi organization 2 homolog (Drosophila) -0.41
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.4
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.4
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.4
ANKRD22 ankyrin repeat domain 22 -0.39
MAST3 microtubule associated serine/threonine kinase 3 -0.39
GGT1 gamma-glutamyltransferase 1 -0.39
PFN2 profilin 2 -0.39
TMEM120A transmembrane protein 120A -0.38
HBA1 hemoglobin, alpha 1 -0.38
ADCY7 adenylate cyclase 7 -0.37
RAD51D RAD51 paralog D -0.37
B2M beta-2-microglobulin -0.37
C4BPA complement component 4 binding protein, alpha -0.37
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.37
ATF3 activating transcription factor 3 -0.37
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -0.37
CCDC28A coiled-coil domain containing 28A -0.37
JAGN1 jagunal homolog 1 (Drosophila) -0.37
LRRC8B leucine rich repeat containing 8 family, member B -0.36
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit -0.36
HSPG2 heparan sulfate proteoglycan 2 -0.36
FGFBP1 fibroblast growth factor binding protein 1 -0.36
TPM4 tropomyosin 4 -0.36
CD82 CD82 molecule -0.36
TULP4 tubby like protein 4 -0.36
TMC7 transmembrane channel-like 7 -0.36
TTC8 tetratricopeptide repeat domain 8 -0.36
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 -0.36
WWC3 WWC family member 3 -0.35
C1QTNF3 C1q and tumor necrosis factor related protein 3 -0.35
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -0.35
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -0.35
RGN regucalcin -0.35
ZNF808 zinc finger protein 808 -0.35
CBR3 carbonyl reductase 3 -0.34
SERINC5 serine incorporator 5 -0.34
OGG1 8-oxoguanine DNA glycosylase -0.34
SFI1 Sfi1 homolog, spindle assembly associated (yeast) -0.34
FHIT fragile histidine triad -0.34
FAT4 FAT atypical cadherin 4 -0.33
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.33
CLU clusterin -0.33
ACTN2 actinin, alpha 2 -0.33