Ichthyosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization. (Human Phenotype Ontology, HP_0008064)
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Genes

744 genes co-occuring with the disease Ichthyosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 3.694
TGM1 transglutaminase 1 3.622
PNPLA1 patatin-like phospholipase domain containing 1 3.47
FLG filaggrin 3.399
ALOXE3 arachidonate lipoxygenase 3 3.396
ALOX12B arachidonate 12-lipoxygenase, 12R type 3.394
KRT1 keratin 1, type II 3.377
NIPAL4 NIPA-like domain containing 4 3.373
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 3.362
FLG2 filaggrin family member 2 3.338
KRT10 keratin 10, type I 3.334
SPINK5 serine peptidase inhibitor, Kazal type 5 3.258
GJB2 gap junction protein, beta 2, 26kDa 3.244
ABHD5 abhydrolase domain containing 5 3.162
CERS3 ceramide synthase 3 3.105
STS steroid sulfatase (microsomal), isozyme S 3.099
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 3.098
KRT2 keratin 2, type II 3.06
MBTPS2 membrane-bound transcription factor peptidase, site 2 3.013
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.978
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 2.832
IVL involucrin 2.8
CDSN corneodesmosin 2.746
ELOVL4 ELOVL fatty acid elongase 4 2.734
GJB6 gap junction protein, beta 6, 30kDa 2.699
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 2.679
SNAP29 synaptosomal-associated protein, 29kDa 2.65
VCX3A variable charge, X-linked 3A 2.646
CASP14 caspase 14, apoptosis-related cysteine peptidase 2.637
PUDP pseudouridine 5'-phosphatase 2.636
VPS33B vacuolar protein sorting 33 homolog B (yeast) 2.614
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.608
GTF2H5 general transcription factor IIH, polypeptide 5 2.578
GJB4 gap junction protein, beta 4, 30.3kDa 2.561
KRT9 keratin 9, type I 2.561
ASPRV1 aspartic peptidase, retroviral-like 1 2.557
KLK5 kallikrein-related peptidase 5 2.552
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.545
PNPLA2 patatin-like phospholipase domain containing 2 2.541
TGM5 transglutaminase 5 2.533
PNPLA4 patatin-like phospholipase domain containing 4 2.523
GJB3 gap junction protein, beta 3, 31kDa 2.504
TGM3 transglutaminase 3 2.49
EBP emopamil binding protein (sterol isomerase) 2.485
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.474
SUMF1 sulfatase modifying factor 1 2.448
KLK7 kallikrein-related peptidase 7 2.437
CLDN1 claudin 1 2.423
DSG1 desmoglein 1 2.416
ELOVL1 ELOVL fatty acid elongase 1 2.407
MPLKIP M-phase specific PLK1 interacting protein 2.402
LIPN lipase, family member N 2.36
KRT14 keratin 14, type I 2.355
NISCH nischarin 2.338
KRT6A keratin 6A, type II 2.248
KRT16 keratin 16, type I 2.24
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.239
KRT6B keratin 6B, type II 2.235
SGPL1 sphingosine-1-phosphate lyase 1 2.229
DOLK dolichol kinase 2.225
PRSS8 protease, serine, 8 2.22
HRNR hornerin 2.202
DSC1 desmocollin 1 2.198
SRD5A3 steroid 5 alpha-reductase 3 2.183
VCX2 variable charge, X-linked 2 2.179
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.172
TMEM79 transmembrane protein 79 2.163
CSTA cystatin A (stefin A) 2.162
ERCC3 excision repair cross-complementation group 3 2.148
KLK6 kallikrein-related peptidase 6 2.147
TCHH trichohyalin 2.142
KDSR 3-ketodihydrosphingosine reductase 2.141
CLDN7 claudin 7 2.134
COL7A1 collagen, type VII, alpha 1 2.114
ERCC2 excision repair cross-complementation group 2 2.108
RPTN repetin 2.108
DSP desmoplakin 2.077
KRT5 keratin 5, type II 2.075
ANOS1 anosmin 1 2.075
CLDN16 claudin 16 2.065
PHYH phytanoyl-CoA 2-hydroxylase 2.054
GJB1 gap junction protein, beta 1, 32kDa 2.051
PPL periplakin 2.05
CLDN19 claudin 19 2.032
GJB5 gap junction protein, beta 5, 31.1kDa 2.015
GJA8 gap junction protein, alpha 8, 50kDa 2.015
STIM1 stromal interaction molecule 1 2.014
MPDU1 mannose-P-dolichol utilization defect 1 2.012
CLDN10 claudin 10 1.995
KLK14 kallikrein-related peptidase 14 1.994
GJA1 gap junction protein, alpha 1, 43kDa 1.979
TCHHL1 trichohyalin-like 1 1.972
UGCG UDP-glucose ceramide glucosyltransferase 1.962
TSLP thymic stromal lymphopoietin 1.953
GJA3 gap junction protein, alpha 3, 46kDa 1.952
CLDN14 claudin 14 1.952
ALOX12 arachidonate 12-lipoxygenase 1.933
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 1.933
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 1.895
CARD14 caspase recruitment domain family, member 14 1.884
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.873
SPINT1 serine peptidase inhibitor, Kunitz type 1 1.865
NLGN4X neuroligin 4, X-linked 1.862
IL13 interleukin 13 1.837
IL17A interleukin 17A 1.833
KRT83 keratin 83, type II 1.825
ARSL arylsulfatase L 1.822
SHOX short stature homeobox 1.821
LBR lamin B receptor 1.82
SPRR2B small proline-rich protein 2B 1.813
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.812
PEX7 peroxisomal biogenesis factor 7 1.811
KRT17 keratin 17, type I 1.806
GJC1 gap junction protein, gamma 1, 45kDa 1.804
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 1.802
VCX3B variable charge, X-linked 3B 1.798
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 1.795
RNF113A ring finger protein 113A 1.791
ALOX15B arachidonate 15-lipoxygenase, type B 1.787
CNFN cornifelin 1.785
LAMB3 laminin, beta 3 1.769
VCX variable charge, X-linked 1.762
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 1.759
KPRP keratinocyte proline-rich protein 1.754
LCE3D late cornified envelope 3D 1.753
IL31 interleukin 31 1.752
PLIN1 perilipin 1 1.751
LCE3C late cornified envelope 3C 1.75
KRT77 keratin 77, type II 1.749
PLEC plectin 1.741
IL4 interleukin 4 1.74
ELOVL3 ELOVL fatty acid elongase 3 1.74
KRT4 keratin 4, type II 1.735
FA2H fatty acid 2-hydroxylase 1.734
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 1.723
EVPL envoplakin 1.723
ZNF750 zinc finger protein 750 1.72
WFDC12 WAP four-disulfide core domain 12 1.716
GJC3 gap junction protein, gamma 3, 30.2kDa 1.714
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 1.713
TLCD3B TLC domain containing 3B 1.71
GRHL3 grainyhead-like 3 (Drosophila) 1.704
CLDN4 claudin 4 1.704
DSG4 desmoglein 4 1.703
TNF tumor necrosis factor 1.703
PKP1 plakophilin 1 1.701
TRPV3 transient receptor potential cation channel, subfamily V, member 3 1.701
GJC2 gap junction protein, gamma 2, 47kDa 1.697
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 1.696
IL22 interleukin 22 1.695
COL17A1 collagen, type XVII, alpha 1 1.684
ETFDH electron-transferring-flavoprotein dehydrogenase 1.673
ARSB arylsulfatase B 1.671
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 1.669
CLDN23 claudin 23 1.669
DEFB4A defensin, beta 4A 1.667
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.664
GJA5 gap junction protein, alpha 5, 40kDa 1.664
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.658
GJA4 gap junction protein, alpha 4, 37kDa 1.654
MARVELD2 MARVEL domain containing 2 1.644
TJP2 tight junction protein 2 1.643
OCLN occludin 1.642
BLMH bleomycin hydrolase 1.642
CD4 CD4 molecule 1.638
LOX lysyl oxidase 1.634
CLDN2 claudin 2 1.634
IL1B interleukin 1, beta 1.632
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.631
PPARD peroxisome proliferator-activated receptor delta 1.626
KRT72 keratin 72, type II 1.626
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 1.626
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 1.625
KRT15 keratin 15, type I 1.623
POMP proteasome maturation protein 1.622
IL1A interleukin 1, alpha 1.622
ELOVL7 ELOVL fatty acid elongase 7 1.615
KRT86 keratin 86, type II 1.614
SPRR3 small proline-rich protein 3 1.614
SPRR2D small proline-rich protein 2D 1.613
SPRR2A small proline-rich protein 2A 1.612
EPHX3 epoxide hydrolase 3 1.611
SCARF2 scavenger receptor class F, member 2 1.609
S100A7 S100 calcium binding protein A7 1.606
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.602
CRNN cornulin 1.599
LIPE lipase, hormone-sensitive 1.597
TJP1 tight junction protein 1 1.596
CERS1 ceramide synthase 1 1.594
CLDN3 claudin 3 1.59
ADRB2 adrenoceptor beta 2, surface 1.589
KRT85 keratin 85, type II 1.585
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 1.584
CLDN6 claudin 6 1.578
RARS1 arginyl-tRNA synthetase 1 1.578
IL36R interleukin 36 receptor 1.576
ACER1 alkaline ceramidase 1 1.575
IL36A interleukin 36, alpha 1.574
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 1.573
LCE3B late cornified envelope 3B 1.571
PLIN5 perilipin 5 1.569
CAMP cathelicidin antimicrobial peptide 1.569
ARSA arylsulfatase A 1.569
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 1.567
PI3 peptidase inhibitor 3, skin-derived 1.559
SPRR1A small proline-rich protein 1A 1.557
ALB albumin 1.555
LYSMD4 LysM, putative peptidoglycan-binding, domain containing 4 1.555
CLDN15 claudin 15 1.55
IL6 interleukin 6 1.549
LCE3A late cornified envelope 3A 1.548
CKM creatine kinase, muscle 1.547
DNAH8 dynein, axonemal, heavy chain 8 1.545
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 1.542
CERS2 ceramide synthase 2 1.539
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.539
CKMT1B creatine kinase, mitochondrial 1B 1.538
CKB creatine kinase, brain 1.535
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 1.533
EGF epidermal growth factor 1.532
SLURP1 secreted LY6/PLAUR domain containing 1 1.531
ELOVL5 ELOVL fatty acid elongase 5 1.53
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 1.523
LCE1B late cornified envelope 1B 1.519
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 1.515
IL36G interleukin 36, gamma 1.514
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 1.512
IFNG interferon, gamma 1.511
IL36RN interleukin 36 receptor antagonist 1.51
ORAI1 ORAI calcium release-activated calcium modulator 1 1.51
DOCK8 dedicator of cytokinesis 8 1.51
ACTB actin, beta 1.509
IL36B interleukin 36, beta 1.509
PLA2G2F phospholipase A2, group IIF 1.507
LCE1A late cornified envelope 1A 1.506
SPRR1B small proline-rich protein 1B 1.506
DGAT2 diacylglycerol O-acyltransferase 2 1.502
DHCR7 7-dehydrocholesterol reductase 1.501
MGLL monoglyceride lipase 1.497
CCL17 chemokine (C-C motif) ligand 17 1.496
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.496
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.493
ATP7A ATPase, Cu++ transporting, alpha polypeptide 1.492
DEGS2 delta(4)-desaturase, sphingolipid 2 1.491
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 1.489
PPARA peroxisome proliferator-activated receptor alpha 1.489
PSAT1 phosphoserine aminotransferase 1 1.488
PSPH phosphoserine phosphatase 1.487
ARSF arylsulfatase F 1.484
DEFB4B defensin, beta 4B 1.484
GDF1 growth differentiation factor 1 1.483
COG6 component of oligomeric golgi complex 6 1.482
ABHD4 abhydrolase domain containing 4 1.482
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 1.478
GP1BB glycoprotein Ib (platelet), beta polypeptide 1.471
DMKN dermokine 1.471
FERMT1 fermitin family member 1 1.47
XPR1 xenotropic and polytropic retrovirus receptor 1 1.466
CD8A CD8a molecule 1.464
PXDN peroxidasin 1.463
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 1.463
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 1.461
AASDH aminoadipate-semialdehyde dehydrogenase 1.458
DSG3 desmoglein 3 1.457
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 1.456
EPHX4 epoxide hydrolase 4 1.456
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 1.455
SUMF2 sulfatase modifying factor 2 1.454
SAT1 spermidine/spermine N1-acetyltransferase 1 1.453
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.449
PSAP prosaposin 1.445
KRTDAP keratinocyte differentiation-associated protein 1.443
CAPN1 calpain 1, (mu/I) large subunit 1.443
OVOL1 ovo-like zinc finger 1 1.442
DSC3 desmocollin 3 1.441
ETFA electron-transfer-flavoprotein, alpha polypeptide 1.44
GJB7 gap junction protein, beta 7, 25kDa 1.44
FITM2 fat storage-inducing transmembrane protein 2 1.439
CTSD cathepsin D 1.438
DEGS1 delta(4)-desaturase, sphingolipid 1 1.437
PXDNL peroxidasin-like 1.435
EXPH5 exophilin 5 1.434
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 1.433
ELN elastin 1.432
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.426
SPTSSB serine palmitoyltransferase, small subunit B 1.422
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 1.419
AWAT1 acyl-CoA wax alcohol acyltransferase 1 1.418
JUP junction plakoglobin 1.417
ALG6 ALG6, alpha-1,3-glucosyltransferase 1.416
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.414
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 1.414
TGM6 transglutaminase 6 1.413
CTSS cathepsin S 1.411
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase 1.408
FGF2 fibroblast growth factor 2 (basic) 1.408
COG1 component of oligomeric golgi complex 1 1.407
HGFAC HGF activator 1.405
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.403
TTC7A tetratricopeptide repeat domain 7A 1.403
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.401
DHCR24 24-dehydrocholesterol reductase 1.401
VCY variable charge, Y-linked 1.4
VCY1B variable charge, Y-linked 1B 1.399
IFNA1 interferon, alpha 1 1.398
PLIN3 perilipin 3 1.395
IFNA2 interferon, alpha 2 1.395
SPTSSA serine palmitoyltransferase, small subunit A 1.394
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 1.394
IL33 interleukin 33 1.393
KRT13 keratin 13, type I 1.391
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 1.39
SNAP47 synaptosomal-associated protein, 47kDa 1.39
SLC39A4 solute carrier family 39 (zinc transporter), member 4 1.39
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 1.389
KLK13 kallikrein-related peptidase 13 1.389
PGM3 phosphoglucomutase 3 1.389
HAL histidine ammonia-lyase 1.384
KRT79 keratin 79, type II 1.384
IL5 interleukin 5 1.382
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 1.381
CLDN9 claudin 9 1.379
ARSK arylsulfatase family, member K 1.379
S100A7A S100 calcium binding protein A7A 1.379
IFNA16 interferon, alpha 16 1.377
IFNA7 interferon, alpha 7 1.377
TGFB1 transforming growth factor, beta 1 1.377
IFNA10 interferon, alpha 10 1.376
MBTPS1 membrane-bound transcription factor peptidase, site 1 1.376
IFNA21 interferon, alpha 21 1.376
IFNA8 interferon, alpha 8 1.376
IFNA14 interferon, alpha 14 1.376
IFNA6 interferon, alpha 6 1.375
IFNA5 interferon, alpha 5 1.374
SGSH N-sulfoglucosamine sulfohydrolase 1.373
KRT33A keratin 33A, type I 1.373
IFNA13 interferon, alpha 13 1.373
IFNA4 interferon, alpha 4 1.371
IFNA17 interferon, alpha 17 1.369
PLA2G4D phospholipase A2, group IVD (cytosolic) 1.369
IL4R interleukin 4 receptor 1.366
XPA xeroderma pigmentosum, complementation group A 1.366
INS insulin 1.366
CHKB choline kinase beta 1.363
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 1.36
CERS4 ceramide synthase 4 1.359
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.359
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 1.358
TGM2 transglutaminase 2 1.356
SPINT2 serine peptidase inhibitor, Kunitz type, 2 1.356
GJD2 gap junction protein, delta 2, 36kDa 1.355
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.351
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.35
C4BPA complement component 4 binding protein, alpha 1.348
PPARG peroxisome proliferator-activated receptor gamma 1.347
SPINK6 serine peptidase inhibitor, Kazal type 6 1.346
SPINK9 serine peptidase inhibitor, Kazal type 9 1.345
PLIN2 perilipin 2 1.343
ETFB electron-transfer-flavoprotein, beta polypeptide 1.342
SPAST spastin 1.34
PNPLA3 patatin-like phospholipase domain containing 3 1.337
KLF4 Kruppel-like factor 4 (gut) 1.337
LAMA2 laminin, alpha 2 1.337
RAB11A RAB11A, member RAS oncogene family 1.336
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae) 1.336
TP53 tumor protein p53 1.334
SMAD9 SMAD family member 9 1.334
KRT40 keratin 40, type I 1.332
KRT81 keratin 81, type II 1.332
DSC2 desmocollin 2 1.331
PLA2G4E phospholipase A2, group IVE 1.331
PSORS1C2 psoriasis susceptibility 1 candidate 2 1.33
CLDN11 claudin 11 1.328
ELOVL6 ELOVL fatty acid elongase 6 1.324
MYO7A myosin VIIA 1.324
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 1.323
LCE6A late cornified envelope 6A 1.322
DEFB103A defensin, beta 103A 1.32
GPR143 G protein-coupled receptor 143 1.318
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 1.318
POMC proopiomelanocortin 1.314
GALNS galactosamine (N-acetyl)-6-sulfatase 1.308
ITGB4 integrin, beta 4 1.307
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.306
CLDN5 claudin 5 1.305
KRTAP3-1 keratin associated protein 3-1 1.305
FGF7 fibroblast growth factor 7 1.298
PNPLA6 patatin-like phospholipase domain containing 6 1.298
RARG retinoic acid receptor, gamma 1.297
AP1M2 adaptor-related protein complex 1, mu 2 subunit 1.295
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.293
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.291
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.29
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 1.29
PECAM1 platelet/endothelial cell adhesion molecule 1 1.289
KRT80 keratin 80, type II 1.286
PADI3 peptidyl arginine deiminase, type III 1.285
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.284
TYR tyrosinase 1.283
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.279
MMP9 matrix metallopeptidase 9 1.279
FN1 fibronectin 1 1.277
CAPN12 calpain 12 1.276
TSPAN16 tetraspanin 16 1.276
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.275
LAMA3 laminin, alpha 3 1.271
LAMC2 laminin, gamma 2 1.27
KRT25 keratin 25, type I 1.269
PNPLA5 patatin-like phospholipase domain containing 5 1.268
PLIN4 perilipin 4 1.266
UTP25 UTP25 small subunit processome component 1.266
CLDN8 claudin 8 1.266
KRTAP13-1 keratin associated protein 13-1 1.265
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 1.262
LCE2C late cornified envelope 2C 1.261
PCNA proliferating cell nuclear antigen 1.259
FITM1 fat storage-inducing transmembrane protein 1 1.258
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 1.258
WNT10A wingless-type MMTV integration site family, member 10A 1.257
KRT3 keratin 3, type II 1.257
CHD7 chromodomain helicase DNA binding protein 7 1.257
GJE1 gap junction protein, epsilon 1, 23kDa 1.256
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.255
PHGDH phosphoglycerate dehydrogenase 1.255
KDR kinase insert domain receptor 1.252
PADI1 peptidyl arginine deiminase, type I 1.252
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.251
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.251
S100A1 S100 calcium binding protein A1 1.25
KRT75 keratin 75, type II 1.25
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.249
ALOX15 arachidonate 15-lipoxygenase 1.248
TGM4 transglutaminase 4 1.247
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 1.246
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 1.242
KRT35 keratin 35, type I 1.241
TBX1 T-box 1 1.239
LCE5A late cornified envelope 5A 1.237
CXCL8 chemokine (C-X-C motif) ligand 8 1.236
GJA10 gap junction protein, alpha 10, 62kDa 1.236
LCE2A late cornified envelope 2A 1.235
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.233
MAPK3 mitogen-activated protein kinase 3 1.232
KRT71 keratin 71, type II 1.23
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.229
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.225
TMEM86B transmembrane protein 86B 1.224
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 1.222
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 1.22
NF1 neurofibromin 1 1.218
ZMPSTE24 zinc metallopeptidase STE24 1.218
HBEGF heparin-binding EGF-like growth factor 1.216
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.215
PLA2G4B phospholipase A2, group IVB (cytosolic) 1.213
EDAR ectodysplasin A receptor 1.213
CTSC cathepsin C 1.21
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 1.21
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.209
LMNB2 lamin B2 1.209
CERS6 ceramide synthase 6 1.207
ABHD16B abhydrolase domain containing 16B 1.207
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 1.206
VAMP7 vesicle-associated membrane protein 7 1.206
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 1.203
EREG epiregulin 1.203
MVK mevalonate kinase 1.202
KRTAP4-12 keratin associated protein 4-12 1.202
NOD2 nucleotide-binding oligomerization domain containing 2 1.2
CCL20 chemokine (C-C motif) ligand 20 1.199
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.198
PROM1 prominin 1 1.196
KRT82 keratin 82, type II 1.193
HACD1 3-hydroxyacyl-CoA dehydratase 1 1.192
HAO2 hydroxyacid oxidase 2 (long chain) 1.191
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 1.191
LMNB1 lamin B1 1.19
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 1.19
ABHD12B abhydrolase domain containing 12B 1.189
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 1.187
KLK1 kallikrein 1 1.186
SACK1G scaffolding CK1 anchoring protein G 1.186
KRT12 keratin 12, type I 1.185
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 1.181
DGAT1 diacylglycerol O-acyltransferase 1 1.181
AAGAB alpha- and gamma-adaptin binding protein 1.18
DEFB1 defensin, beta 1 1.176
JUN jun proto-oncogene 1.176
JAK1 Janus kinase 1 1.175
MPDZ multiple PDZ domain protein 1.173
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.173
EGFR epidermal growth factor receptor 1.172
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 1.17
MSMO1 methylsterol monooxygenase 1 1.169
TGFA transforming growth factor, alpha 1.169
CERS5 ceramide synthase 5 1.169
KRT33B keratin 33B, type I 1.168
F11R F11 receptor 1.168
CARMIL2 capping protein regulator and myosin 1 linker 2 1.168
TLR2 toll-like receptor 2 1.168
LPIN1 lipin 1 1.168
TMPRSS11F transmembrane protease, serine 11F 1.166
EPB41 erythrocyte membrane protein band 4.1 1.166
SLPI secretory leukocyte peptidase inhibitor 1.165
TMPRSS3 transmembrane protease, serine 3 1.164
LCE2B late cornified envelope 2B 1.164
IL19 interleukin 19 1.164
KRT39 keratin 39, type I 1.162
GLB1 galactosidase, beta 1 1.161
GALC galactosylceramidase 1.16
ALG8 ALG8, alpha-1,3-glucosyltransferase 1.16
ITGA6 integrin, alpha 6 1.16
ALG3 ALG3, alpha-1,3- mannosyltransferase 1.16
STRC stereocilin 1.159
LAMA4 laminin, alpha 4 1.159
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 1.158
AQP3 aquaporin 3 (Gill blood group) 1.158
HOXC13 homeobox C13 1.157
IL10 interleukin 10 1.157
RNASE7 ribonuclease, RNase A family, 7 1.156
SOX10 SRY (sex determining region Y)-box 10 1.155
SPG11 spastic paraplegia 11 (autosomal recessive) 1.155
IL31RA interleukin 31 receptor A 1.154
ACTL9 actin-like 9 1.153
CST6 cystatin E/M 1.152
ERCC6L excision repair cross-complementation group 6-like 1.152
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.152
DST dystonin 1.152
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 1.151
KRT8 keratin 8, type II 1.15
DEFB103B defensin, beta 103B 1.148
MAP2K1 mitogen-activated protein kinase kinase 1 1.148
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.147
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 1.147
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.147
IL18 interleukin 18 1.147
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 1.146
LIPK lipase, family member K 1.146
CPT2 carnitine palmitoyltransferase 2 1.146
SREBF1 sterol regulatory element binding transcription factor 1 1.145
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.145
FAM9A family with sequence similarity 9, member A 1.144
REN renin 1.144
PMM2 phosphomannomutase 2 1.142
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 1.141
LCE1D late cornified envelope 1D 1.14
CDH3 cadherin 3, type 1, P-cadherin (placental) 1.14
CP ceruloplasmin (ferroxidase) 1.14
ZNF341 zinc finger protein 341 1.139
BTD biotinidase 1.138
KRT84 keratin 84, type II 1.137
TRIM8 tripartite motif containing 8 1.134
G0S2 G0/G1 switch 2 1.132
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.131
NPC1 Niemann-Pick disease, type C1 1.131
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.131
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.131
PIGO phosphatidylinositol glycan anchor biosynthesis, class O 1.13
MAP2K2 mitogen-activated protein kinase kinase 2 1.129
ALG11 ALG11, alpha-1,2-mannosyltransferase 1.129
ABHD6 abhydrolase domain containing 6 1.128
SNAP23 synaptosomal-associated protein, 23kDa 1.128
IL2 interleukin 2 1.127
ACADVL acyl-CoA dehydrogenase, very long chain 1.127
FGF8 fibroblast growth factor 8 (androgen-induced) 1.127
ELANE elastase, neutrophil expressed 1.126
ALG12 ALG12, alpha-1,6-mannosyltransferase 1.126
RBP2 retinol binding protein 2, cellular 1.126
POFUT1 protein O-fucosyltransferase 1 1.126
DCD dermcidin 1.125
CERK ceramide kinase 1.125
EDARADD EDAR-associated death domain 1.123
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 1.121
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 1.12
IL17F interleukin 17F 1.119
TMPRSS15 transmembrane protease, serine 15 1.119
RHO rhodopsin 1.118
IGF1 insulin-like growth factor 1 (somatomedin C) 1.118
ZNF431 zinc finger protein 431 1.117
EHD1 EH-domain containing 1 1.117
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 1.116
EPRS1 glutamyl-prolyl-tRNA synthetase 1 1.114
FABP5 fatty acid binding protein 5 (psoriasis-associated) 1.114
DOLPP1 dolichyldiphosphatase 1 1.114
STAT1 signal transducer and activator of transcription 1, 91kDa 1.113
COL1A1 collagen, type I, alpha 1 1.113
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.112
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.112
RARA retinoic acid receptor, alpha 1.111
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 1.11
CLDN12 claudin 12 1.11
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.11
GOSR2 golgi SNAP receptor complex member 2 1.109
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 1.107
KRT31 keratin 31, type I 1.106
KRTAP12-1 keratin associated protein 12-1 1.106
SAMD9 sterile alpha motif domain containing 9 1.103
CRABP2 cellular retinoic acid binding protein 2 1.102
PLA2G15 phospholipase A2, group XV 1.102
ABHD14A abhydrolase domain containing 14A 1.102
KLHL24 kelch-like family member 24 1.102
CD1B CD1b molecule 1.102
FOXP3 forkhead box P3 1.102
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 1.102
LDLR low density lipoprotein receptor 1.1
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.099
ACER2 alkaline ceramidase 2 1.097
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 1.096
F13A1 coagulation factor XIII, A1 polypeptide 1.096
TGM7 transglutaminase 7 1.095
KLK8 kallikrein-related peptidase 8 1.095
EMSY EMSY transcriptional repressor, BRCA2 interacting 1.093
FGF5 fibroblast growth factor 5 1.092
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.092
DDHD2 DDHD domain containing 2 1.091
LPIN2 lipin 2 1.09
TGOLN2 trans-golgi network protein 2 1.089
LCE1F late cornified envelope 1F 1.088
POGLUT1 protein O-glucosyltransferase 1 1.087
SPHK2 sphingosine kinase 2 1.087
FGF17 fibroblast growth factor 17 1.085
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.083
ATL1 atlastin GTPase 1 1.083
CREB3L1 cAMP responsive element binding protein 3-like 1 1.083
OCA2 oculocutaneous albinism II 1.082
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 1.082
CTSL cathepsin L 1.081
FAR2 fatty acyl CoA reductase 2 1.079
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 1.079
POF1B premature ovarian failure, 1B 1.079
STIM2 stromal interaction molecule 2 1.076
VPS13B vacuolar protein sorting 13 homolog B (yeast) 1.074
ORAI3 ORAI calcium release-activated calcium modulator 3 1.074
ADAM33 ADAM metallopeptidase domain 33 1.073
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.072
MAGT1 magnesium transporter 1 1.069
TMPRSS4 transmembrane protease, serine 4 1.069
JAG1 jagged 1 1.069
CCL22 chemokine (C-C motif) ligand 22 1.068
EPHX2 epoxide hydrolase 2, cytoplasmic 1.068
CLDN22 claudin 22 1.068
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.067
PTPRC protein tyrosine phosphatase, receptor type, C 1.067
ERCC8 excision repair cross-complementation group 8 1.066
LCE2D late cornified envelope 2D 1.065
WASHC5 WASH complex subunit 5 1.064
MYO15A myosin XVA 1.064
LMNA lamin A/C 1.063
FGF9 fibroblast growth factor 9 1.062
KRTAP10-2 keratin associated protein 10-2 1.062
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.061
SHH sonic hedgehog 1.061
FGF18 fibroblast growth factor 18 1.06
PCDH15 protocadherin-related 15 1.058
SPRR2E small proline-rich protein 2E 1.057
CHIT1 chitinase 1 (chitotriosidase) 1.057
COG7 component of oligomeric golgi complex 7 1.057
STRA6 stimulated by retinoic acid 6 1.056
CGN cingulin 1.055
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 1.055
PLA2G2E phospholipase A2, group IIE 1.054
ICAM1 intercellular adhesion molecule 1 1.053
HAS2 hyaluronan synthase 2 1.052
CDH23 cadherin-related 23 1.052
KRTAP7-1 keratin associated protein 7-1 (gene/pseudogene) 1.05
SPRR4 small proline-rich protein 4 1.05
CD34 CD34 molecule 1.049
KRTAP3-3 keratin associated protein 3-3 1.048
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 1.047
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 1.046
AKNAD1 AKNA domain containing 1 1.046
AHR aryl hydrocarbon receptor 1.045
FGF4 fibroblast growth factor 4 1.045
ALOX5 arachidonate 5-lipoxygenase 1.045
WAS Wiskott-Aldrich syndrome 1.044
LCA5 Leber congenital amaurosis 5 1.042
FGF10 fibroblast growth factor 10 1.041
TBL1X transducin (beta)-like 1X-linked 1.04
PTH parathyroid hormone 1.04
PRSS53 protease, serine, 53 1.039
CD1C CD1c molecule 1.037
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1.037
APOB apolipoprotein B 1.036
FGF6 fibroblast growth factor 6 1.035
ZFYVE26 zinc finger, FYVE domain containing 26 1.035
CD36 CD36 molecule (thrombospondin receptor) 1.034
DSG2 desmoglein 2 1.034
SERAC1 serine active site containing 1 1.034
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.034
TMPRSS13 transmembrane protease, serine 13 1.033
NKPD1 NTPase, KAP family P-loop domain containing 1 1.033
BCL2 B-cell CLL/lymphoma 2 1.031
CALML5 calmodulin-like 5 1.03
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 1.03
APOE apolipoprotein E 1.03
TMIE transmembrane inner ear 1.03
SOX18 SRY (sex determining region Y)-box 18 1.029
PGAP2 post-GPI attachment to proteins 2 1.029
CIDEC cell death-inducing DFFA-like effector c 1.028
USH1C Usher syndrome 1C (autosomal recessive, severe) 1.026
ERBIN erbb2 interacting protein 1.025
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 1.025
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 1.025
FGF22 fibroblast growth factor 22 1.025
PLA2G3 phospholipase A2, group III 1.024
FGF16 fibroblast growth factor 16 1.024
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 1.023
FGF3 fibroblast growth factor 3 1.022
ARSD arylsulfatase D 1.022
FGF20 fibroblast growth factor 20 1.021
DHDDS dehydrodolichyl diphosphate synthase 1.02
KRT74 keratin 74, type II 1.02
CD1E CD1e molecule 1.019
OTOA otoancorin 1.019
PMVK phosphomevalonate kinase 1.019
CRABP1 cellular retinoic acid binding protein 1 1.019
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 1.019
KRT78 keratin 78, type II 1.017
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 1.017
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 1.017
CCL5 chemokine (C-C motif) ligand 5 1.016
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 1.015
SOX9 SRY (sex determining region Y)-box 9 1.013
PERP PERP, TP53 apoptosis effector 1.013
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 1.013
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.013
SARAF store-operated calcium entry-associated regulatory factor 1.013
ERCC6 excision repair cross-complementation group 6 1.011
DDB2 damage-specific DNA binding protein 2, 48kDa 1.01
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.009
PRCD progressive rod-cone degeneration 1.008
GBA2 glucosidase, beta (bile acid) 2 1.008
LIPA lipase A, lysosomal acid, cholesterol esterase 1.007
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 1.006
MITF microphthalmia-associated transcription factor 1.005
PLP1 proteolipid protein 1 1.005
CARD11 caspase recruitment domain family, member 11 1.005
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.003
CYB5A cytochrome b5 type A (microsomal) 1.002
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.002
HRAS Harvey rat sarcoma viral oncogene homolog 1.002
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.002
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.001
OTOF otoferlin 1.0
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 1.0