| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Idarubicin (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Idarubicin (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.178897 |
| TUBA1B | tubulin, alpha 1b | 0.0633112 |
| EGR1 | early growth response 1 | 0.0608387 |
| EZR | ezrin | 0.0587684 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0567716 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0550879 |
| MKI67 | marker of proliferation Ki-67 | 0.0544777 |
| YBX3 | Y box binding protein 3 | 0.0519976 |
| RTN4 | reticulon 4 | 0.0513227 |
| TMEM41B | transmembrane protein 41B | 0.0495406 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0493906 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0479423 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0473839 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0457348 |
| TPM3 | tropomyosin 3 | 0.0426155 |
| RPS6 | ribosomal protein S6 | 0.042244 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0412208 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.040801 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0388375 |
| DIAPH3 | diaphanous-related formin 3 | 0.0376667 |
| TPI1 | triosephosphate isomerase 1 | 0.0374965 |
| IPO7 | importin 7 | 0.0339427 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0337015 |
| JMJD1C | jumonji domain containing 1C | 0.0334286 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0333808 |
| CALR | calreticulin | 0.0333296 |
| RASAL2 | RAS protein activator like 2 | 0.0318406 |
| VMP1 | vacuole membrane protein 1 | 0.0312761 |
| VIM | vimentin | 0.0304943 |
| EDARADD | EDAR-associated death domain | 0.0300279 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0299509 |
| CMIP | c-Maf inducing protein | 0.0296801 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0295434 |
| RPL4 | ribosomal protein L4 | 0.0291942 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0291527 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0287444 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0283865 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0280667 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0278022 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.027773 |
| SSH2 | slingshot protein phosphatase 2 | 0.027361 |
| GCG | glucagon | 0.0268075 |
| POLH | polymerase (DNA directed), eta | 0.0267631 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0266179 |
| MYO10 | myosin X | 0.0265801 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.026229 |
| PTMA | prothymosin, alpha | 0.0260991 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0260837 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0260682 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0259087 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0257709 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0255137 |
| CALD1 | caldesmon 1 | 0.0254261 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0242964 |
| HELLS | helicase, lymphoid-specific | 0.0239297 |
| ANKRD26 | ankyrin repeat domain 26 | 0.0237252 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0237222 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0236916 |
| BRCA1 | breast cancer 1, early onset | 0.0235781 |
| TUBB6 | tubulin, beta 6 class V | 0.0235622 |
| DTNB | dystrobrevin, beta | 0.0231777 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0230399 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0227197 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0222201 |
| BRD2 | bromodomain containing 2 | 0.022212 |
| ASPH | aspartate beta-hydroxylase | 0.0219776 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0219595 |
| RAD51B | RAD51 paralog B | 0.0218981 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0218056 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0216179 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.0215328 |
| E2F7 | E2F transcription factor 7 | 0.0215088 |
| FOXP1 | forkhead box P1 | 0.0213259 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0212925 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0212838 |
| MMS22L | MMS22-like, DNA repair protein | 0.0211993 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0211428 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0208711 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0208666 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0208322 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0207948 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0200004 |
| RAD51AP1 | RAD51 associated protein 1 | 0.0199758 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0199752 |
| NTN1 | netrin 1 | 0.0198303 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0196587 |
| CEP112 | centrosomal protein 112kDa | 0.019565 |
| POLA2 | polymerase (DNA directed), alpha 2, accessory subunit | 0.0192907 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0192722 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0192265 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0190574 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0190026 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0189229 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0187023 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0186348 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0184108 |
| EGFR | epidermal growth factor receptor | 0.0183046 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0182926 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0182691 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0181393 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.389246 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.169579 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.105347 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.104609 |
| MGAT4C | MGAT4 family, member C | -0.104592 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.103578 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0915272 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.088313 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0876528 |
| TENM3 | teneurin transmembrane protein 3 | -0.0864676 |
| MMP12 | matrix metallopeptidase 12 | -0.0830571 |
| TMSB10 | thymosin beta 10 | -0.0791928 |
| ZNF804A | zinc finger protein 804A | -0.0781441 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0781384 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0664732 |
| PCDH7 | protocadherin 7 | -0.0661642 |
| BCHE | butyrylcholinesterase | -0.060618 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0594156 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0576803 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0576392 |
| RPL23 | ribosomal protein L23 | -0.0569436 |
| EPHA6 | EPH receptor A6 | -0.0537896 |
| ANXA1 | annexin A1 | -0.0536908 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0529164 |
| POTEF | POTE ankyrin domain family, member F | -0.0526081 |
| DST | dystonin | -0.0497007 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0496605 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0495119 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0491298 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0489934 |
| FBXO11 | F-box protein 11 | -0.0478628 |
| DPYD | dihydropyrimidine dehydrogenase | -0.047503 |
| HDAC9 | histone deacetylase 9 | -0.0467921 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0440389 |
| USP34 | ubiquitin specific peptidase 34 | -0.0439446 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0438905 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0436986 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0436522 |
| ZNF292 | zinc finger protein 292 | -0.043643 |
| ECT2 | epithelial cell transforming 2 | -0.0434058 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0421418 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0417792 |
| PGK1 | phosphoglycerate kinase 1 | -0.0417158 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0413979 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0409071 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.040786 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0407492 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0404892 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0386248 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0376469 |
| RPL35A | ribosomal protein L35a | -0.0374155 |
| CPOX | coproporphyrinogen oxidase | -0.0373406 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0373142 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.037028 |
| INTS6 | integrator complex subunit 6 | -0.0364875 |
| HMGA1 | high mobility group AT-hook 1 | -0.0363921 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0357408 |
| PCDH9 | protocadherin 9 | -0.0356886 |
| LDHA | lactate dehydrogenase A | -0.0356835 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0355934 |
| KIF5B | kinesin family member 5B | -0.0353205 |
| EHBP1 | EH domain binding protein 1 | -0.0344109 |
| GSK3B | glycogen synthase kinase 3 beta | -0.033656 |
| RPS24 | ribosomal protein S24 | -0.033447 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0331149 |
| SYT1 | synaptotagmin I | -0.0330734 |
| OXR1 | oxidation resistance 1 | -0.0329102 |
| AHNAK | AHNAK nucleoprotein | -0.0328733 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0328448 |
| RYK | receptor-like tyrosine kinase | -0.0328279 |
| RPL19 | ribosomal protein L19 | -0.0326353 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0325833 |
| CDK6 | cyclin-dependent kinase 6 | -0.0322801 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0321053 |
| KLHL24 | kelch-like family member 24 | -0.0315365 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0315203 |
| MED13 | mediator complex subunit 13 | -0.031386 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0311877 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0303649 |
| MED13L | mediator complex subunit 13-like | -0.030001 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0297635 |
| GASK1B | golgi associated kinase 1B | -0.0296457 |
| RPL8 | ribosomal protein L8 | -0.0295884 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0293654 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0292217 |
| ZNF217 | zinc finger protein 217 | -0.0291249 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0289375 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0287494 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0286069 |
| RC3H1 | ring finger and CCCH-type domains 1 | -0.0284731 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0278529 |
| HELZ | helicase with zinc finger | -0.0278215 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0277508 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0276209 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0276023 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0274973 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0272 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0269732 |
| EFNA5 | ephrin-A5 | -0.0265797 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0265746 |
