| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Idarubicin (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Idarubicin (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.134946 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0653284 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0540339 |
| RPS6 | ribosomal protein S6 | 0.0517781 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0449187 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0385237 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0384434 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0315327 |
| BCL2L1 | BCL2-like 1 | 0.0269136 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0266876 |
| RPS2 | ribosomal protein S2 | 0.026266 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0260493 |
| EGR1 | early growth response 1 | 0.0253826 |
| PCBP2 | poly(rC) binding protein 2 | 0.0249283 |
| ASTN2 | astrotactin 2 | 0.0243256 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0236996 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0234048 |
| AXL | AXL receptor tyrosine kinase | 0.0224414 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0220979 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0211338 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0209416 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0208345 |
| LAMA5 | laminin, alpha 5 | 0.0200278 |
| MSN | moesin | 0.0192236 |
| RPL4 | ribosomal protein L4 | 0.0191597 |
| ZFP36 | ZFP36 ring finger protein | 0.0189176 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0188375 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.018692 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0179371 |
| RTN4 | reticulon 4 | 0.0176901 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.016889 |
| STOM | stomatin | 0.016414 |
| ATF3 | activating transcription factor 3 | 0.0163622 |
| RND3 | Rho family GTPase 3 | 0.0162851 |
| NPHS1 | nephrosis 1, congenital, Finnish type (nephrin) | 0.0161081 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0157607 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0156893 |
| WWC1 | WW and C2 domain containing 1 | 0.0156799 |
| GPHN | gephyrin | 0.0156267 |
| PTEN | phosphatase and tensin homolog | 0.0154741 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.015453 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0153368 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.015315 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0152624 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0148055 |
| KLHL29 | kelch-like family member 29 | 0.0147649 |
| MED29 | mediator complex subunit 29 | 0.0145808 |
| SIK3 | SIK family kinase 3 | 0.0144798 |
| EPHA4 | EPH receptor A4 | 0.013776 |
| TPM3 | tropomyosin 3 | 0.0135451 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0133341 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0131506 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0131149 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 0.0131073 |
| DHFR | dihydrofolate reductase | 0.0128372 |
| UBTF | upstream binding transcription factor, RNA polymerase I | 0.0127693 |
| SULF2 | sulfatase 2 | 0.0127658 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.0127635 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0127073 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0124963 |
| TLN1 | talin 1 | 0.0123584 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0123486 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0123416 |
| TOB2 | transducer of ERBB2, 2 | 0.0122269 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0121049 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0119101 |
| IRF3 | interferon regulatory factor 3 | 0.0117664 |
| FAT1 | FAT atypical cadherin 1 | 0.0116481 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0114106 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0114021 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0113848 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa | 0.0112997 |
| GSE1 | Gse1 coiled-coil protein | 0.0111747 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.011153 |
| USP47 | ubiquitin specific peptidase 47 | 0.0109712 |
| PNN | pinin, desmosome associated protein | 0.0109211 |
| SETD1B | SET domain containing 1B | 0.0108918 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0108461 |
| VMP1 | vacuole membrane protein 1 | 0.0107421 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.0107052 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0106188 |
| SERINC5 | serine incorporator 5 | 0.0106173 |
| PEG10 | paternally expressed 10 | 0.0105824 |
| NCOR2 | nuclear receptor corepressor 2 | 0.010456 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.0104095 |
| PER1 | period circadian clock 1 | 0.0103916 |
| POU2F2 | POU class 2 homeobox 2 | 0.0103837 |
| GIT1 | G protein-coupled receptor kinase interacting ArfGAP 1 | 0.0103754 |
| PER2 | period circadian clock 2 | 0.0103409 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0103386 |
| RPL35 | ribosomal protein L35 | 0.0103314 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0102993 |
| INHBB | inhibin, beta B | 0.010261 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0101773 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 0.0101479 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0100964 |
| RFX7 | regulatory factor X, 7 | 0.0100903 |
| YBX3 | Y box binding protein 3 | 0.0100887 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.010087 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0100849 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.188837 |
| NDRG1 | N-myc downstream regulated 1 | -0.163125 |
| ACTG1 | actin gamma 1 | -0.14616 |
| LDHA | lactate dehydrogenase A | -0.127557 |
| ANXA2 | annexin A2 | -0.123526 |
| VIM | vimentin | -0.120771 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.117389 |
| TMSB10 | thymosin beta 10 | -0.113925 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100945 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0922762 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.091903 |
| CA12 | carbonic anhydrase XII | -0.0915843 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0879237 |
| RNF213 | ring finger protein 213 | -0.0878956 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.085287 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0817509 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0779873 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0755394 |
| PGK1 | phosphoglycerate kinase 1 | -0.0748892 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0725658 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0717802 |
| FTL | ferritin, light polypeptide | -0.0713154 |
| EFNA5 | ephrin-A5 | -0.067518 |
| RPS19 | ribosomal protein S19 | -0.0671597 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0640862 |
| STC1 | stanniocalcin 1 | -0.0623958 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0600022 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0598597 |
| RRBP1 | ribosome binding protein 1 | -0.0596849 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0585096 |
| RIGI | RNA sensor RIG-I | -0.058398 |
| SQSTM1 | sequestosome 1 | -0.0577451 |
| EGFR | epidermal growth factor receptor | -0.05772 |
| RAI14 | retinoic acid induced 14 | -0.0575025 |
| S100A6 | S100 calcium binding protein A6 | -0.0562073 |
| LOXL2 | lysyl oxidase-like 2 | -0.0553518 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0553232 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0551024 |
| MT2A | metallothionein 2A | -0.0541366 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.052662 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0522728 |
| FLNB | filamin B, beta | -0.0513359 |
| PDE10A | phosphodiesterase 10A | -0.0508767 |
| MYO1E | myosin IE | -0.0480682 |
| TNS3 | tensin 3 | -0.0468702 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0468089 |
| RIN2 | Ras and Rab interactor 2 | -0.0467984 |
| FAM107B | family with sequence similarity 107, member B | -0.0460792 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.045863 |
| ASPH | aspartate beta-hydroxylase | -0.0454365 |
| OSMR | oncostatin M receptor | -0.0452545 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0449541 |
| UBC | ubiquitin C | -0.0445933 |
| RPS24 | ribosomal protein S24 | -0.044176 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.042509 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0424932 |
| ENO1 | enolase 1, (alpha) | -0.0424842 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0418793 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0416804 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0414332 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0414027 |
| FMNL2 | formin-like 2 | -0.0409511 |
| RPLP1 | ribosomal protein, large, P1 | -0.0409369 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0408205 |
| PTMA | prothymosin, alpha | -0.0407281 |
| TXNRD1 | thioredoxin reductase 1 | -0.0407229 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0406944 |
| MT1X | metallothionein 1X | -0.0405389 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0404659 |
| RPL19 | ribosomal protein L19 | -0.0402224 |
| SMAD3 | SMAD family member 3 | -0.0399419 |
| RPL12 | ribosomal protein L12 | -0.0398297 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0383127 |
| EHBP1 | EH domain binding protein 1 | -0.0374417 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0370089 |
| RPS27A | ribosomal protein S27a | -0.0368587 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0362305 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0361325 |
| ANXA4 | annexin A4 | -0.0358273 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.035807 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0357917 |
| PYGL | phosphorylase, glycogen, liver | -0.035185 |
| B2M | beta-2-microglobulin | -0.0350599 |
| AUTS2 | autism susceptibility candidate 2 | -0.0350159 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0344086 |
| KLF6 | Kruppel-like factor 6 | -0.0342382 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0341689 |
| AHNAK | AHNAK nucleoprotein | -0.0340762 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0338549 |
| GPC6 | glypican 6 | -0.0337212 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0336513 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0335498 |
| TPM4 | tropomyosin 4 | -0.0334548 |
| CANX | calnexin | -0.0333252 |
| CALU | calumenin | -0.0331346 |
| SP100 | SP100 nuclear antigen | -0.0330659 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0330443 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.03242 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0323785 |
| AOPEP | aminopeptidase O (putative) | -0.0320209 |
