| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Idarubicin (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Idarubicin (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.180154 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.17524 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.101391 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0991782 |
| ENO1 | enolase 1, (alpha) | 0.0935877 |
| AXL | AXL receptor tyrosine kinase | 0.0928508 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0915766 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0849643 |
| SMAD3 | SMAD family member 3 | 0.0833822 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0812679 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0767001 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.076454 |
| COL5A1 | collagen, type V, alpha 1 | 0.0733721 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.072974 |
| UBC | ubiquitin C | 0.0715924 |
| HMGA2 | high mobility group AT-hook 2 | 0.0703195 |
| SEPTIN9 | septin 9 | 0.0688124 |
| RUNX1 | runt-related transcription factor 1 | 0.0679819 |
| CDCP1 | CUB domain containing protein 1 | 0.0673895 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0656197 |
| INHBA | inhibin, beta A | 0.0647392 |
| AHNAK | AHNAK nucleoprotein | 0.0647063 |
| LAMB3 | laminin, beta 3 | 0.0638297 |
| FAM13A | family with sequence similarity 13, member A | 0.0612597 |
| TXNIP | thioredoxin interacting protein | 0.0607753 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0581108 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0576795 |
| ASPH | aspartate beta-hydroxylase | 0.0562207 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0558523 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0544579 |
| JUN | jun proto-oncogene | 0.0541608 |
| MLPH | melanophilin | 0.0539303 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0523076 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.051887 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0504383 |
| MT2A | metallothionein 2A | 0.0498754 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0491489 |
| PCBP2 | poly(rC) binding protein 2 | 0.0455495 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0444115 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.043679 |
| FLNA | filamin A, alpha | 0.042864 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0421955 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0420654 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0406955 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0405389 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0404844 |
| EMP1 | epithelial membrane protein 1 | 0.0403502 |
| PTK2 | protein tyrosine kinase 2 | 0.0402762 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0396173 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0385104 |
| DTNA | dystrobrevin, alpha | 0.0375924 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0374035 |
| DST | dystonin | 0.0371973 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0369198 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0368526 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0368302 |
| SYAP1 | synapse associated protein 1 | 0.036471 |
| RPS27A | ribosomal protein S27a | 0.0361814 |
| TNS1 | tensin 1 | 0.035887 |
| TPM3 | tropomyosin 3 | 0.0353563 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0344769 |
| SET | SET nuclear proto-oncogene | 0.0343334 |
| WWOX | WW domain containing oxidoreductase | 0.033859 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0338401 |
| FLNB | filamin B, beta | 0.033804 |
| G0S2 | G0/G1 switch 2 | 0.0337881 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.033189 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0330737 |
| STC1 | stanniocalcin 1 | 0.0326839 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0326455 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0321323 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.032041 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0318418 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.031759 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0312965 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0311745 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0311275 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0306606 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.0306093 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0304847 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0298278 |
| YBX3 | Y box binding protein 3 | 0.0297438 |
| ZNF638 | zinc finger protein 638 | 0.029183 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0290612 |
| HMGB2 | high mobility group box 2 | 0.0289247 |
| MYO10 | myosin X | 0.0288392 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0287703 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0287191 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0286608 |
| TXNRD1 | thioredoxin reductase 1 | 0.0283606 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0282548 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0280734 |
| TPI1 | triosephosphate isomerase 1 | 0.0279978 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0279177 |
| MKI67 | marker of proliferation Ki-67 | 0.027367 |
| EZR | ezrin | 0.0272161 |
| SMYD3 | SET and MYND domain containing 3 | 0.0272095 |
| RPL4 | ribosomal protein L4 | 0.0270684 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0266593 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0266489 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.283145 |
| FN1 | fibronectin 1 | -0.282586 |
| IGF2 | insulin-like growth factor 2 | -0.133909 |
| VCL | vinculin | -0.128039 |
| CDH13 | cadherin 13 | -0.11799 |
| TMSB10 | thymosin beta 10 | -0.112396 |
| ACTG1 | actin gamma 1 | -0.10058 |
| RPL35A | ribosomal protein L35a | -0.0785802 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0713395 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0641527 |
| FTL | ferritin, light polypeptide | -0.0558386 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0557713 |
| GLIS3 | GLIS family zinc finger 3 | -0.0556028 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0553905 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.050533 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0479196 |
| SBF2 | SET binding factor 2 | -0.0466126 |
| INTS6 | integrator complex subunit 6 | -0.0463291 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0462313 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0447757 |
| RPLP1 | ribosomal protein, large, P1 | -0.0425608 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0415068 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0408848 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0405839 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0399222 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.039897 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0391225 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0388517 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0379603 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0377042 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0374302 |
| FBXO11 | F-box protein 11 | -0.0370397 |
| TNNC1 | troponin C type 1 (slow) | -0.0369247 |
| TPM4 | tropomyosin 4 | -0.0362897 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0359676 |
| TENM2 | teneurin transmembrane protein 2 | -0.0346781 |
| PGK1 | phosphoglycerate kinase 1 | -0.0324027 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0319627 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0318352 |
| MORF4L2 | mortality factor 4 like 2 | -0.0313473 |
| LRRC23 | leucine rich repeat containing 23 | -0.0299591 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0295661 |
| CALD1 | caldesmon 1 | -0.0291296 |
| TMEM165 | transmembrane protein 165 | -0.0288582 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0287832 |
| VASP | vasodilator-stimulated phosphoprotein | -0.0285378 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0282606 |
| HM13 | histocompatibility (minor) 13 | -0.0281219 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0279788 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0277505 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0275094 |
| OSMR | oncostatin M receptor | -0.0262038 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0261027 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0259984 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0259171 |
| S100A10 | S100 calcium binding protein A10 | -0.0256201 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.025427 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0252856 |
| RPL34 | ribosomal protein L34 | -0.0249235 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0248377 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0247964 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0246906 |
| PCNX4 | pecanex 4 | -0.0244538 |
| GNAS | GNAS complex locus | -0.0242982 |
| CLIC4 | chloride intracellular channel 4 | -0.0242746 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0241003 |
| RAB31 | RAB31, member RAS oncogene family | -0.0240535 |
| SEC24D | SEC24 family member D | -0.0239326 |
| NABP1 | nucleic acid binding protein 1 | -0.0236929 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0236516 |
| RPS13 | ribosomal protein S13 | -0.023577 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0234234 |
| COPA | coatomer protein complex, subunit alpha | -0.0233333 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0233259 |
| RPS24 | ribosomal protein S24 | -0.0232328 |
| PTMA | prothymosin, alpha | -0.0231978 |
| TBCA | tubulin folding cofactor A | -0.023019 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0228866 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0225841 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0224165 |
| SEPTIN2 | septin 2 | -0.0224126 |
| RPL37A | ribosomal protein L37a | -0.0222211 |
| RPS19 | ribosomal protein S19 | -0.022166 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0220543 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.022027 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0219574 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0218957 |
| RPS29 | ribosomal protein S29 | -0.0211303 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0210316 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0210231 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0205825 |
| FERMT2 | fermitin family member 2 | -0.0205667 |
| NLK | nemo-like kinase | -0.0205137 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0204485 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0204253 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0201567 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0201469 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0200064 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.019931 |
| RPLP2 | ribosomal protein, large, P2 | -0.0198106 |
