Idarubicin (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idarubicin (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idarubicin (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.175113
GDF15 growth differentiation factor 15 0.0697231
PTPRR protein tyrosine phosphatase, receptor type, R 0.0670779
RNF213 ring finger protein 213 0.0575672
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0566012
YBX3 Y box binding protein 3 0.0547563
RPS2 ribosomal protein S2 0.053367
TXNRD1 thioredoxin reductase 1 0.0521413
RPL4 ribosomal protein L4 0.0513515
MUC13 mucin 13, cell surface associated 0.0510846
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0485531
FAT1 FAT atypical cadherin 1 0.0472063
TPI1 triosephosphate isomerase 1 0.044034
HSPA8 heat shock 70kDa protein 8 0.0431306
HLA-E major histocompatibility complex, class I, E 0.0421573
PRRC2C proline-rich coiled-coil 2C 0.0396719
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0376327
HLA-B major histocompatibility complex, class I, B 0.0349932
FTH1 ferritin, heavy polypeptide 1 0.0345529
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0337589
ARL15 ADP-ribosylation factor-like 15 0.0320818
NAP1L1 nucleosome assembly protein 1-like 1 0.0316948
SHROOM3 shroom family member 3 0.0305407
GCC2 GRIP and coiled-coil domain containing 2 0.0298025
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0295215
PTPRG protein tyrosine phosphatase, receptor type, G 0.0288173
RESF1 retroelement silencing factor 1 0.0285898
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0275336
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0274811
NAMPT nicotinamide phosphoribosyltransferase 0.0272028
CANX calnexin 0.0268625
SLC38A1 solute carrier family 38, member 1 0.0261069
RPS12 ribosomal protein S12 0.0258247
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0253299
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0251929
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0249221
TENT5A terminal nucleotidyltransferase 5A 0.0242007
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0236802
TRIM56 tripartite motif containing 56 0.0235766
MLEC malectin 0.0228813
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0224126
HLA-A major histocompatibility complex, class I, A 0.0223404
H1-0 H1.0 linker histone 0.0216989
RBBP6 retinoblastoma binding protein 6 0.0212981
TPM3 tropomyosin 3 0.0207299
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0206517
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0205383
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0204746
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0204643
RPS27L ribosomal protein S27-like 0.0199774
PRRC2B proline-rich coiled-coil 2B 0.0199666
SOX4 SRY (sex determining region Y)-box 4 0.0198928
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0194903
XPC xeroderma pigmentosum, complementation group C 0.0192326
POLH polymerase (DNA directed), eta 0.0189782
CCNG1 cyclin G1 0.0184532
EEA1 early endosome antigen 1 0.0183313
NFE2L1 nuclear factor, erythroid 2-like 1 0.0183126
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0180835
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0179185
SINHCAF SIN3-HDAC complex associated factor 0.0179151
WWC1 WW and C2 domain containing 1 0.0178815
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0174065
FOXC1 forkhead box C1 0.0173539
KIF5B kinesin family member 5B 0.0172562
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0170901
CLIP1 CAP-GLY domain containing linker protein 1 0.0170851
SOX9 SRY (sex determining region Y)-box 9 0.0169798
FBXO32 F-box protein 32 0.0169542
BCL6 B-cell CLL/lymphoma 6 0.0168912
IKBIP IKBKB interacting protein 0.0168526
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0166241
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0166089
GSTP1 glutathione S-transferase pi 1 0.0165881
IL6ST interleukin 6 signal transducer 0.0163527
RB1CC1 RB1-inducible coiled-coil 1 0.0162507
TMF1 TATA element modulatory factor 1 0.0158634
BZW1 basic leucine zipper and W2 domains 1 0.0158463
CREBRF CREB3 regulatory factor 0.0155522
BHLHE40 basic helix-loop-helix family, member e40 0.0154858
KDM3A lysine (K)-specific demethylase 3A 0.0153165
TIGAR TP53 induced glycolysis regulatory phosphatase 0.0153021
CCND2 cyclin D2 0.015189
RRBP1 ribosome binding protein 1 0.0151656
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0151152
SQSTM1 sequestosome 1 0.0149653
GOLM2 golgi membrane protein 2 0.0149463
IRF3 interferon regulatory factor 3 0.0148007
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 0.0147824
SYAP1 synapse associated protein 1 0.014724
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0145771
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0145718
RPL14 ribosomal protein L14 0.0143801
HSPA4 heat shock 70kDa protein 4 0.0143381
EFCAB14 EF-hand calcium binding domain 14 0.0142868
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.01416
ARID1A AT rich interactive domain 1A (SWI-like) 0.0141173
PTEN phosphatase and tensin homolog 0.0139266
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0137419
KDM5B lysine (K)-specific demethylase 5B 0.0137067

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.188276
RPLP1 ribosomal protein, large, P1 -0.142954
RPL35A ribosomal protein L35a -0.132753
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.112223
FLNB filamin B, beta -0.111129
INTS6 integrator complex subunit 6 -0.104309
ACTG1 actin gamma 1 -0.0939876
RPL31 ribosomal protein L31 -0.0902796
RPL37A ribosomal protein L37a -0.0899468
F3 coagulation factor III (thromboplastin, tissue factor) -0.0894184
RPS23 ribosomal protein S23 -0.0870911
PDE4D phosphodiesterase 4D, cAMP-specific -0.0837697
GMDS GDP-mannose 4,6-dehydratase -0.0810158
RPL34 ribosomal protein L34 -0.0748979
RPS25 ribosomal protein S25 -0.0741889
ANXA2 annexin A2 -0.0738415
RPL23 ribosomal protein L23 -0.07082
PTMA prothymosin, alpha -0.0680222
RPLP2 ribosomal protein, large, P2 -0.0676165
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0667319
TPT1 tumor protein, translationally-controlled 1 -0.0658677
CALB1 calbindin 1, 28kDa -0.0634104
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0628257
AKAP13 A kinase (PRKA) anchor protein 13 -0.0628109
RPS13 ribosomal protein S13 -0.0621892
RPL9 ribosomal protein L9 -0.0614434
RPS14 ribosomal protein S14 -0.06034
ACTN4 actinin, alpha 4 -0.0590814
RPLP0 ribosomal protein, large, P0 -0.0585289
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0585172
POTEF POTE ankyrin domain family, member F -0.0580979
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0566675
RPL11 ribosomal protein L11 -0.05629
EPS8 epidermal growth factor receptor pathway substrate 8 -0.056135
RPS27A ribosomal protein S27a -0.0559053
RPS17 ribosomal protein S17 -0.0558585
LMO7 LIM domain 7 -0.0538357
DIAPH1 diaphanous-related formin 1 -0.0537642
RPS8 ribosomal protein S8 -0.052538
PKM pyruvate kinase, muscle -0.0518082
RPS5 ribosomal protein S5 -0.0512087
CLDN4 claudin 4 -0.050761
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0488368
FBXO11 F-box protein 11 -0.0484861
MYO1E myosin IE -0.0484667
MYO5B myosin VB -0.0482569
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0479891
FNDC3B fibronectin type III domain containing 3B -0.0471076
RPS11 ribosomal protein S11 -0.046304
S100A6 S100 calcium binding protein A6 -0.045607
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0446068
RPS24 ribosomal protein S24 -0.0443912
HMGA1 high mobility group AT-hook 1 -0.0442959
NPSR1 neuropeptide S receptor 1 -0.044159
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0439965
PDLIM5 PDZ and LIM domain 5 -0.0435492
RPL27A ribosomal protein L27a -0.0428114
SVIL supervillin -0.0423248
ITGA6 integrin, alpha 6 -0.0419332
LAMA4 laminin, alpha 4 -0.0412384
SECISBP2 SECIS binding protein 2 -0.0403317
RPS29 ribosomal protein S29 -0.039928
S100P S100 calcium binding protein P -0.0395886
TPM1 tropomyosin 1 (alpha) -0.0394841
RPS21 ribosomal protein S21 -0.0383181
RPL8 ribosomal protein L8 -0.0378911
MYH14 myosin, heavy chain 14, non-muscle -0.0373664
RPS16 ribosomal protein S16 -0.0372157
CTBP2 C-terminal binding protein 2 -0.0365926
TPM4 tropomyosin 4 -0.0365238
MPRIP myosin phosphatase Rho interacting protein -0.0352935
TSPAN8 tetraspanin 8 -0.0350348
RPL7A ribosomal protein L7a -0.0349217
CATSPERB catsper channel auxiliary subunit beta -0.0348886
MSI2 musashi RNA-binding protein 2 -0.0348373
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0345406
UBE2H ubiquitin-conjugating enzyme E2H -0.034496
S100A10 S100 calcium binding protein A10 -0.0342552
ARHGAP26 Rho GTPase activating protein 26 -0.0341746
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0341281
ANXA11 annexin A11 -0.0341207
LDHA lactate dehydrogenase A -0.0338029
MCU mitochondrial calcium uniporter -0.0334978
RPS20 ribosomal protein S20 -0.0334107
RPL36 ribosomal protein L36 -0.0333632
PTPRK protein tyrosine phosphatase, receptor type, K -0.0329966
RPS10 ribosomal protein S10 -0.0328396
PSD3 pleckstrin and Sec7 domain containing 3 -0.0327356
TBCA tubulin folding cofactor A -0.0325239
RABGAP1L RAB GTPase activating protein 1-like -0.032285
PALLD palladin, cytoskeletal associated protein -0.0322619
PERP PERP, TP53 apoptosis effector -0.0322561
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0322208
VCL vinculin -0.0318097
ESYT2 extended synaptotagmin-like protein 2 -0.0316568
RPL19 ribosomal protein L19 -0.0315404
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0313718
NCOR2 nuclear receptor corepressor 2 -0.0309689
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0308531
ATP5F1B ATP synthase F1 subunit beta -0.0307024