Idarubicin (hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idarubicin (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idarubicin (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.214312
FTH1 ferritin, heavy polypeptide 1 0.121255
IGFBP3 insulin-like growth factor binding protein 3 0.118754
AKAP12 A kinase (PRKA) anchor protein 12 0.105011
BASP1 brain abundant, membrane attached signal protein 1 0.0822126
STC1 stanniocalcin 1 0.0639895
PYGL phosphorylase, glycogen, liver 0.0586826
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0462359
NDRG1 N-myc downstream regulated 1 0.0455326
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0401817
ARHGAP26 Rho GTPase activating protein 26 0.0397906
HLA-B major histocompatibility complex, class I, B 0.0385138
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0374223
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.037178
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0371712
EPAS1 endothelial PAS domain protein 1 0.0369636
FLNB filamin B, beta 0.0361732
IL6 interleukin 6 0.035692
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0351209
INHBA inhibin, beta A 0.0347508
MT1X metallothionein 1X 0.0340739
NUMB numb homolog (Drosophila) 0.0334242
HLA-A major histocompatibility complex, class I, A 0.0322128
SAMD4A sterile alpha motif domain containing 4A 0.032019
SMOC1 SPARC related modular calcium binding 1 0.0319589
ANGPTL4 angiopoietin-like 4 0.0311713
IGF2 insulin-like growth factor 2 0.0308767
WAC WW domain containing adaptor with coiled-coil 0.0302801
IGFBP4 insulin-like growth factor binding protein 4 0.0300783
RPS6 ribosomal protein S6 0.0294913
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0294754
BRD2 bromodomain containing 2 0.0294387
PRRC2C proline-rich coiled-coil 2C 0.0293022
CYTH1 cytohesin 1 0.0291254
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0276033
GOLGA4 golgin A4 0.0268497
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0266298
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0258681
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.024518
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0234674
MYO1E myosin IE 0.0230865
ATXN1 ataxin 1 0.0228449
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0228401
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0227489
TIMP2 TIMP metallopeptidase inhibitor 2 0.0225064
MYADM myeloid-associated differentiation marker 0.0224672
LAMC2 laminin, gamma 2 0.021949
GOLGB1 golgin B1 0.0215082
FMNL2 formin-like 2 0.0214573
PRKCA protein kinase C, alpha 0.0214228
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0212516
LAMA5 laminin, alpha 5 0.0211929
EGFR epidermal growth factor receptor 0.0211024
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0208516
CUX1 cut-like homeobox 1 0.0207717
PCBP2 poly(rC) binding protein 2 0.0206501
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0200793
RBM25 RNA binding motif protein 25 0.0195836
MSN moesin 0.0194253
NPAS2 neuronal PAS domain protein 2 0.0190547
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0187222
CCL5 chemokine (C-C motif) ligand 5 0.0186621
SSH2 slingshot protein phosphatase 2 0.0183065
DOCK5 dedicator of cytokinesis 5 0.0182753
IRAK2 interleukin-1 receptor-associated kinase 2 0.0180747
AXL AXL receptor tyrosine kinase 0.0176971
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0175905
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0174464
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0173903
C15ORF48 chromosome 15 open reading frame 48 0.017338
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0172824
SLMAP sarcolemma associated protein 0.0170701
LOC102724023 ES1 protein homolog, mitochondrial 0.0170476
ITCH itchy E3 ubiquitin protein ligase 0.0169477
PLAUR plasminogen activator, urokinase receptor 0.0168875
LAMB3 laminin, beta 3 0.0167756
NHSL1 NHS-like 1 0.0167732
EGR1 early growth response 1 0.0166466
TMF1 TATA element modulatory factor 1 0.0165956
PHF21A PHD finger protein 21A 0.0165739
ZMYND8 zinc finger, MYND-type containing 8 0.0162741
RPS2 ribosomal protein S2 0.0162464
RAD51B RAD51 paralog B 0.0162429
GGNBP2 gametogenetin binding protein 2 0.0161879
CD99 CD99 molecule 0.0160868
SLC22A23 solute carrier family 22, member 23 0.0160491
TGFBI transforming growth factor, beta-induced, 68kDa 0.0159772
TGM2 transglutaminase 2 0.0157567
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0156564
FLNA filamin A, alpha 0.0155784
ZFHX3 zinc finger homeobox 3 0.0154373
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0153373
CD44 CD44 molecule (Indian blood group) 0.0153073
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0152935
SRSF4 serine/arginine-rich splicing factor 4 0.0152663
HMGA2 high mobility group AT-hook 2 0.0152339
JUN jun proto-oncogene 0.0152232
SOD2 superoxide dismutase 2, mitochondrial 0.0151596
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0149745
TAOK3 TAO kinase 3 0.0149026

decreased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 -0.198702
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.172376
TXNRD1 thioredoxin reductase 1 -0.171773
GRAMD1B GRAM domain containing 1B -0.16989
TFPI2 tissue factor pathway inhibitor 2 -0.128376
PDE4D phosphodiesterase 4D, cAMP-specific -0.117729
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.106483
FTL ferritin, light polypeptide -0.0995571
TMSB10 thymosin beta 10 -0.0983862
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0963573
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0860486
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0857327
ERBIN erbb2 interacting protein -0.0816215
RPL19 ribosomal protein L19 -0.080588
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.079228
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.077392
WDR43 WD repeat domain 43 -0.0710498
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0667704
RPL23 ribosomal protein L23 -0.0642862
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0634684
SLC38A2 solute carrier family 38, member 2 -0.0618904
RAD21 RAD21 homolog (S. pombe) -0.061664
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0599692
PDLIM5 PDZ and LIM domain 5 -0.0591574
FGB fibrinogen beta chain -0.0585363
RASAL2 RAS protein activator like 2 -0.0581699
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0573942
THSD4 thrombospondin, type I, domain containing 4 -0.0573525
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0556805
ADGRG6 adhesion G protein-coupled receptor G6 -0.0546485
BICC1 BicC family RNA binding protein 1 -0.0530327
TM4SF1 transmembrane 4 L six family member 1 -0.0523616
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0519619
DENND4A DENN/MADD domain containing 4A -0.0518296
HDAC9 histone deacetylase 9 -0.0506394
ASPH aspartate beta-hydroxylase -0.0490564
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.047982
KYNU kynureninase -0.0462405
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0455428
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0451949
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.043582
CYRIB CYFIP related Rac1 interactor B -0.0435478
RPL7 ribosomal protein L7 -0.0433099
PTK2 protein tyrosine kinase 2 -0.0432615
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0429998
RHEB Ras homolog enriched in brain -0.0428844
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0427065
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0424098
DST dystonin -0.0418877
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0416996
RTN4 reticulon 4 -0.0415568
BIRC3 baculoviral IAP repeat containing 3 -0.041287
AHR aryl hydrocarbon receptor -0.0404724
AK1 adenylate kinase 1 -0.0402384
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0397892
ECT2 epithelial cell transforming 2 -0.0392794
LPP LIM domain containing preferred translocation partner in lipoma -0.0392201
YBX1 Y box binding protein 1 -0.0391679
ANKRD28 ankyrin repeat domain 28 -0.0390985
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0385285
ANXA2 annexin A2 -0.0383161
RAB10 RAB10, member RAS oncogene family -0.03829
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0382795
USP3 ubiquitin specific peptidase 3 -0.0374933
BABAM2 BRISC and BRCA1 A complex member 2 -0.036986
USP34 ubiquitin specific peptidase 34 -0.0369232
GLIS3 GLIS family zinc finger 3 -0.0364765
OSMR oncostatin M receptor -0.0364303
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.035481
MBNL1 muscleblind-like splicing regulator 1 -0.0346668
OLA1 Obg-like ATPase 1 -0.0344527
TMEM123 transmembrane protein 123 -0.0344521
AGO2 argonaute RISC catalytic component 2 -0.0344407
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0343533
NEGR1 neuronal growth regulator 1 -0.034185
CHN1 chimerin 1 -0.0340563
SLC38A1 solute carrier family 38, member 1 -0.0340335
KLF6 Kruppel-like factor 6 -0.033933
PTMA prothymosin, alpha -0.0338622
ACACA acetyl-CoA carboxylase alpha -0.0332472
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0332466
IGF1R insulin-like growth factor 1 receptor -0.0329193
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0324756
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0322033
SPAG9 sperm associated antigen 9 -0.0321338
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0317574
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0312022
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0311603
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0311235
ACTG1 actin gamma 1 -0.031062
RPS19 ribosomal protein S19 -0.0310602
SMAD2 SMAD family member 2 -0.0310024
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0309517
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0306409
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0306358
APP amyloid beta (A4) precursor protein -0.0305981
LDHA lactate dehydrogenase A -0.0304669
RPL8 ribosomal protein L8 -0.0300977
NAV3 neuron navigator 3 -0.0299304
RPLP1 ribosomal protein, large, P1 -0.0297668