| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Idarubicin (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Idarubicin (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TPI1 | triosephosphate isomerase 1 | 0.0761456 |
| MKI67 | marker of proliferation Ki-67 | 0.0751299 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0681595 |
| EGR1 | early growth response 1 | 0.066491 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.061702 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0594021 |
| TLN1 | talin 1 | 0.0504644 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0470859 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0460867 |
| TPM3 | tropomyosin 3 | 0.0441592 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.043581 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0427712 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.041862 |
| HLA-B | major histocompatibility complex, class I, B | 0.041077 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0398823 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0382675 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0379346 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.036982 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0359692 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0343596 |
| CENPF | centromere protein F, 350/400kDa | 0.0340799 |
| R3HDM2 | R3H domain containing 2 | 0.0335232 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0327036 |
| RPS2 | ribosomal protein S2 | 0.0320062 |
| GRAMD1B | GRAM domain containing 1B | 0.0313228 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0309204 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0306257 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0301969 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0298952 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0298222 |
| CTTN | cortactin | 0.0293925 |
| TOP1 | topoisomerase (DNA) I | 0.0291874 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0290019 |
| SSH2 | slingshot protein phosphatase 2 | 0.0289663 |
| RPS3 | ribosomal protein S3 | 0.0285891 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0284411 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0280432 |
| GPHN | gephyrin | 0.02772 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0274853 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0272014 |
| HOMER1 | homer scaffolding protein 1 | 0.0266424 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 0.0261575 |
| TUBA1C | tubulin, alpha 1c | 0.0257585 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0248022 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0243322 |
| RPL4 | ribosomal protein L4 | 0.024294 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0241991 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0241881 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0241548 |
| ETV6 | ets variant 6 | 0.0239649 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | 0.023394 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0230104 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0226734 |
| CAVIN1 | caveolae associated protein 1 | 0.0224402 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.02208 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0218735 |
| PKP4 | plakophilin 4 | 0.0218175 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0217034 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0216519 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0215335 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0210758 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0209205 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0208743 |
| BRD4 | bromodomain containing 4 | 0.0207703 |
| REST | RE1-silencing transcription factor | 0.020765 |
| DST | dystonin | 0.020606 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0201977 |
| KLHL29 | kelch-like family member 29 | 0.0201345 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0199988 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0198303 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0197654 |
| PRKCE | protein kinase C, epsilon | 0.0197434 |
| FLNA | filamin A, alpha | 0.0197075 |
| THADA | thyroid adenoma associated | 0.0195138 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.019498 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0193719 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0193457 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0192853 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0192679 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0192623 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0192479 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0190325 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0189772 |
| RCOR1 | REST corepressor 1 | 0.0189291 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.018919 |
| NHSL1 | NHS-like 1 | 0.0186756 |
| NABP1 | nucleic acid binding protein 1 | 0.0183372 |
| FUS | FUS RNA binding protein | 0.0182163 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0181318 |
| TUBA1B | tubulin, alpha 1b | 0.017785 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0175414 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0173945 |
| AHI1 | Abelson helper integration site 1 | 0.0173742 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.017231 |
| AFG2A | AFG2 AAA ATPase homolog A | 0.017165 |
| IL6ST | interleukin 6 signal transducer | 0.0171586 |
| GSE1 | Gse1 coiled-coil protein | 0.0171241 |
| AOPEP | aminopeptidase O (putative) | 0.0170098 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0169354 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0169203 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.140717 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.111596 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.106968 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.106341 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.08402 |
| POTEF | POTE ankyrin domain family, member F | -0.0835919 |
| VIM | vimentin | -0.0827474 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0826557 |
| TMSB10 | thymosin beta 10 | -0.0808485 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0736345 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0724616 |
| PTMA | prothymosin, alpha | -0.0692372 |
| BBX | bobby sox homolog (Drosophila) | -0.0663687 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0662737 |
| USP34 | ubiquitin specific peptidase 34 | -0.0662433 |
| RSF1 | remodeling and spacing factor 1 | -0.0642651 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0616702 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0614657 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0571282 |
| RAD51B | RAD51 paralog B | -0.0536834 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0520448 |
| ENO1 | enolase 1, (alpha) | -0.0515598 |
| RBM39 | RNA binding motif protein 39 | -0.0511224 |
| COPA | coatomer protein complex, subunit alpha | -0.0507639 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0505902 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0476711 |
| PFN1 | profilin 1 | -0.0468722 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0467669 |
| PGK1 | phosphoglycerate kinase 1 | -0.0459315 |
| RPL35A | ribosomal protein L35a | -0.0454151 |
| PRELID2 | PRELI domain containing 2 | -0.0444522 |
| LDHB | lactate dehydrogenase B | -0.0443143 |
| SETD5 | SET domain containing 5 | -0.0441695 |
| OGA | O-GlcNAcase | -0.0435958 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0435754 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.043521 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0434106 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0431666 |
| PHIP | pleckstrin homology domain interacting protein | -0.0429793 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0426687 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0425666 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0422142 |
| RPLP0 | ribosomal protein, large, P0 | -0.0420486 |
| TFG | TRK-fused gene | -0.0414136 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0413943 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0413318 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0411393 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.040834 |
| ATXN1 | ataxin 1 | -0.0407768 |
| MORF4L2 | mortality factor 4 like 2 | -0.0406024 |
| TMEM165 | transmembrane protein 165 | -0.0405681 |
| ZNF207 | zinc finger protein 207 | -0.0405267 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0398636 |
| SBF2 | SET binding factor 2 | -0.0387713 |
| ZNF292 | zinc finger protein 292 | -0.0382585 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0377435 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0376705 |
| ACTG1 | actin gamma 1 | -0.0367959 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0366669 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0361962 |
| XPO1 | exportin 1 | -0.0361811 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0361044 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0360264 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0355776 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0352507 |
| GOLGA4 | golgin A4 | -0.0347277 |
| CANX | calnexin | -0.0346515 |
| WASF2 | WAS protein family, member 2 | -0.0340959 |
| WDR45B | WD repeat domain 45B | -0.03388 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0332835 |
| PHF21A | PHD finger protein 21A | -0.0332419 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0331129 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0330496 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.032881 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0328755 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0327859 |
| HELZ | helicase with zinc finger | -0.0322999 |
| TPM4 | tropomyosin 4 | -0.0322572 |
| HMGA1 | high mobility group AT-hook 1 | -0.0320312 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0318645 |
| KRT18 | keratin 18, type I | -0.0318059 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0316928 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0315623 |
| RPL19 | ribosomal protein L19 | -0.0315398 |
| COG5 | component of oligomeric golgi complex 5 | -0.0314526 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0313805 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0313079 |
| SEPTIN7 | septin 7 | -0.031096 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0307118 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0301716 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0300589 |
| LDHA | lactate dehydrogenase A | -0.0299334 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0298463 |
| MYOF | myoferlin | -0.0288923 |
| TBK1 | TANK-binding kinase 1 | -0.028828 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0287658 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0283541 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0281839 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0281223 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0279902 |
