| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Idarubicin (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Idarubicin (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0942139 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.056387 |
| KLHL29 | kelch-like family member 29 | 0.0399724 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0397019 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0378708 |
| PRKCA | protein kinase C, alpha | 0.0316036 |
| HDAC4 | histone deacetylase 4 | 0.031079 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0304696 |
| SERINC5 | serine incorporator 5 | 0.0287872 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0276089 |
| TPM3 | tropomyosin 3 | 0.0272667 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0265902 |
| GPHN | gephyrin | 0.025852 |
| SFTPA2 | surfactant protein A2 | 0.0257337 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0255258 |
| NTN1 | netrin 1 | 0.025015 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0249788 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0247293 |
| HLA-A | major histocompatibility complex, class I, A | 0.0240215 |
| FLNA | filamin A, alpha | 0.0237971 |
| TMEM117 | transmembrane protein 117 | 0.0235768 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.02342 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0229224 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0227972 |
| RPS6 | ribosomal protein S6 | 0.0223936 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0223803 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0217542 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0213448 |
| MLEC | malectin | 0.0212807 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0212066 |
| FSTL4 | follistatin-like 4 | 0.0211566 |
| GPC5 | glypican 5 | 0.020757 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0203747 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0203653 |
| TNRC6C | trinucleotide repeat containing 6C | 0.0200215 |
| SEPTIN9 | septin 9 | 0.019943 |
| NOPCHAP1 | NOP protein chaperone 1 | 0.0197276 |
| PCDH9 | protocadherin 9 | 0.0195547 |
| HLA-E | major histocompatibility complex, class I, E | 0.0189515 |
| HLA-B | major histocompatibility complex, class I, B | 0.0188969 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0186171 |
| GPATCH2L | G patch domain containing 2-like | 0.0185934 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0183507 |
| POLH | polymerase (DNA directed), eta | 0.018249 |
| XYLT1 | xylosyltransferase I | 0.0181662 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.0181181 |
| STC1 | stanniocalcin 1 | 0.0178939 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0177306 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0174267 |
| ANXA4 | annexin A4 | 0.0172203 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0171098 |
| EGR1 | early growth response 1 | 0.0169458 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0169439 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0169318 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0169104 |
| SECISBP2 | SECIS binding protein 2 | 0.0168106 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0167343 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.016707 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0166741 |
| RPS12 | ribosomal protein S12 | 0.0166088 |
| AUTS2 | autism susceptibility candidate 2 | 0.0161719 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0159555 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0159548 |
| KALRN | kalirin, RhoGEF kinase | 0.0159274 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0157741 |
| PKP4 | plakophilin 4 | 0.0157186 |
| FNIP1 | folliculin interacting protein 1 | 0.0155118 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0154913 |
| LRRC23 | leucine rich repeat containing 23 | 0.0154882 |
| LMNA | lamin A/C | 0.0153742 |
| KIF26B | kinesin family member 26B | 0.0151354 |
| INTS6 | integrator complex subunit 6 | 0.0151071 |
| CASZ1 | castor zinc finger 1 | 0.0150986 |
| ACLY | ATP citrate lyase | 0.0150212 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0149351 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0147813 |
| EPHA4 | EPH receptor A4 | 0.0147696 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0147638 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0145503 |
| DGKH | diacylglycerol kinase, eta | 0.0143611 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0143479 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0143246 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.014072 |
| CUX1 | cut-like homeobox 1 | 0.0139026 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0138215 |
| USP36 | ubiquitin specific peptidase 36 | 0.0137979 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0137656 |
| FAM219A | family with sequence similarity 219, member A | 0.0137354 |
| SYAP1 | synapse associated protein 1 | 0.0137269 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 0.0136365 |
| FGF13 | fibroblast growth factor 13 | 0.0135564 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0135458 |
| RANBP17 | RAN binding protein 17 | 0.01352 |
| COL27A1 | collagen, type XXVII, alpha 1 | 0.0135091 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.013446 |
| NCOA1 | nuclear receptor coactivator 1 | 0.0134449 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.013383 |
| TLN1 | talin 1 | 0.0133005 |
| SVIL | supervillin | 0.0132469 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0132418 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.252975 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.173186 |
| ASPH | aspartate beta-hydroxylase | -0.165643 |
| EFNA5 | ephrin-A5 | -0.151804 |
| GDA | guanine deaminase | -0.131168 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.121644 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.109471 |
| TXNRD1 | thioredoxin reductase 1 | -0.103644 |
| COL5A2 | collagen, type V, alpha 2 | -0.100778 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0915225 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0864781 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0856348 |
| NEK7 | NIMA-related kinase 7 | -0.0831461 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0802524 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0795932 |
| MYOF | myoferlin | -0.0788855 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0752263 |
| NRCAM | neuronal cell adhesion molecule | -0.0715096 |
| KYNU | kynureninase | -0.0676221 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0666597 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.065901 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0635345 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0628528 |
| SMYD3 | SET and MYND domain containing 3 | -0.0623602 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0619638 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.05892 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0567101 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0559305 |
| DST | dystonin | -0.0558431 |
| PTMA | prothymosin, alpha | -0.0554155 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0548889 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0535231 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0524109 |
| PDE10A | phosphodiesterase 10A | -0.0521422 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0520965 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.051919 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0493883 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0487222 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0486816 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.047914 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0465575 |
| RTN4 | reticulon 4 | -0.0462815 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0461219 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0452554 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0448754 |
| CTSC | cathepsin C | -0.0443073 |
| CD109 | CD109 molecule | -0.0428587 |
| TNPO1 | transportin 1 | -0.0425166 |
| FTL | ferritin, light polypeptide | -0.0417871 |
| CDH13 | cadherin 13 | -0.0409558 |
| TMSB10 | thymosin beta 10 | -0.0406456 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0403578 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0398008 |
| PALLD | palladin, cytoskeletal associated protein | -0.0387923 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0386141 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0378624 |
| SPAG9 | sperm associated antigen 9 | -0.0375538 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0373998 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0371802 |
| GRAMD1B | GRAM domain containing 1B | -0.0365217 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0363675 |
| LDHA | lactate dehydrogenase A | -0.0361591 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.036106 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0360327 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0358965 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0353578 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.0347362 |
| RTN1 | reticulon 1 | -0.0347161 |
| PGK1 | phosphoglycerate kinase 1 | -0.0342243 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0341417 |
| MFF | mitochondrial fission factor | -0.0333555 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0331377 |
| FLNB | filamin B, beta | -0.0325236 |
| ACTG1 | actin gamma 1 | -0.0324726 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0320573 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0310144 |
| RPS24 | ribosomal protein S24 | -0.0304071 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0300275 |
| CENPF | centromere protein F, 350/400kDa | -0.0296038 |
| PCBP3 | poly(rC) binding protein 3 | -0.0288148 |
| RBM39 | RNA binding motif protein 39 | -0.0286586 |
| ENAH | enabled homolog (Drosophila) | -0.0285412 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0284715 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0276952 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0276446 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0273351 |
| RAB3B | RAB3B, member RAS oncogene family | -0.0271567 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0270823 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0270387 |
| NF1 | neurofibromin 1 | -0.0269625 |
| RPL23 | ribosomal protein L23 | -0.02686 |
| ANXA2 | annexin A2 | -0.0255728 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0253674 |
| ANXA1 | annexin A1 | -0.0252845 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0250688 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0249144 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.02483 |
| MATR3 | matrin 3 | -0.0247677 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0247467 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0247014 |
