Idarubicin (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idarubicin (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

174 genes differentially expressed following the Idarubicin (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.174444
LMO7 LIM domain 7 0.135118
CEMIP cell migration inducing protein, hyaluronan binding 0.105625
COL6A3 collagen, type VI, alpha 3 0.0957127
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0934441
DSCAM Down syndrome cell adhesion molecule 0.0859757
APP amyloid beta (A4) precursor protein 0.0854641
MAML2 mastermind-like 2 (Drosophila) 0.0841861
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0831578
MACF1 microtubule-actin crosslinking factor 1 0.0830659
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0819684
JMJD1C jumonji domain containing 1C 0.0816287
NALF1 NALCN channel auxiliary factor 1 0.0814929
MYO1E myosin IE 0.081093
USP34 ubiquitin specific peptidase 34 0.0808211
ALCAM activated leukocyte cell adhesion molecule 0.0767614
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0723258
STK24 serine/threonine kinase 24 0.0721841
COL6A1 collagen, type VI, alpha 1 0.0682229
TPI1 triosephosphate isomerase 1 0.0680072
WDFY3 WD repeat and FYVE domain containing 3 0.0654218
EEF2 eukaryotic translation elongation factor 2 0.0649703
RNF213 ring finger protein 213 0.0638524
PTK2 protein tyrosine kinase 2 0.0635454
SLTM SAFB-like, transcription modulator 0.0630008
INHBA inhibin, beta A 0.0623726
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0618361
DSPP dentin sialophosphoprotein 0.0595085
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0566327
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.055369
AKAP12 A kinase (PRKA) anchor protein 12 0.0515336
PCDH9 protocadherin 9 0.0513578
LIMS1 LIM and senescent cell antigen-like domains 1 0.0503288
CERS6 ceramide synthase 6 0.0502118
ELOVL5 ELOVL fatty acid elongase 5 0.0488362
TAS2R14 taste receptor, type 2, member 14 0.0481001
HSPH1 heat shock 105kDa/110kDa protein 1 0.0479896
SLC38A1 solute carrier family 38, member 1 0.0463877
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.046187
DOCK5 dedicator of cytokinesis 5 0.046147
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.045701
RPL12 ribosomal protein L12 0.0451808
MARCHF7 membrane associated ring-CH-type finger 7 0.0448045
STC1 stanniocalcin 1 0.0445859
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0424326
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0405428
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.03989
CD44 CD44 molecule (Indian blood group) 0.0394322
RPS12 ribosomal protein S12 0.0390975
ERRFI1 ERBB receptor feedback inhibitor 1 0.0355245
KDM2A lysine (K)-specific demethylase 2A 0.0343708
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0326362
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0318419
GRB10 growth factor receptor-bound protein 10 0.0289125
NHSL1 NHS-like 1 0.0285591
DLG1 discs, large homolog 1 (Drosophila) 0.028451
HLA-B major histocompatibility complex, class I, B 0.0277596
VMP1 vacuole membrane protein 1 0.0260421
PRRC2C proline-rich coiled-coil 2C 0.025586
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.025541
GMDS GDP-mannose 4,6-dehydratase 0.0233394
NDRG1 N-myc downstream regulated 1 0.0231027
TRIO trio Rho guanine nucleotide exchange factor 0.0221343
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.020891
TCF12 transcription factor 12 0.0205962
ANXA2 annexin A2 0.0205324
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.019782
MED13L mediator complex subunit 13-like 0.0189944
GPHN gephyrin 0.0186415
AOPEP aminopeptidase O (putative) 0.0181021
RPS8 ribosomal protein S8 0.0180388
RPL37A ribosomal protein L37a 0.0176455
RIGI RNA sensor RIG-I 0.0173538
TXNRD1 thioredoxin reductase 1 0.0157776
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.015764
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0149778
RORA RAR-related orphan receptor A 0.0133542
APLP2 amyloid beta (A4) precursor-like protein 2 0.0127491
SRPK2 SRSF protein kinase 2 0.0114651
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.011185
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0110335
NBEAL1 neurobeachin-like 1 0.0105411
GOLGA4 golgin A4 0.00919579
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0073516
SMYD3 SET and MYND domain containing 3 0.00727526
BBX bobby sox homolog (Drosophila) 0.00700816
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00695121
ESYT2 extended synaptotagmin-like protein 2 0.00692664
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.00548541
AKAP13 A kinase (PRKA) anchor protein 13 0.0050862
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.00397106
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00352031
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.00275041
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.00206014
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.00179868
BIRC6 baculoviral IAP repeat containing 6 6.38053E-4

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.388347
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162332
EFNA5 ephrin-A5 -0.147507
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127916
TMSB10 thymosin beta 10 -0.126206
FTL ferritin, light polypeptide -0.124693
NKD1 naked cuticle homolog 1 (Drosophila) -0.0931731
ASPH aspartate beta-hydroxylase -0.091803
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0876276
FNDC3B fibronectin type III domain containing 3B -0.0872805
FAM13A family with sequence similarity 13, member A -0.0836383
EGFR epidermal growth factor receptor -0.07868
ELL2 elongation factor, RNA polymerase II, 2 -0.0775805
GPC6 glypican 6 -0.0761989
IGFBP3 insulin-like growth factor binding protein 3 -0.073728
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0734031
CDH13 cadherin 13 -0.073196
FNDC3A fibronectin type III domain containing 3A -0.0707697
NAMPT nicotinamide phosphoribosyltransferase -0.0685789
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0671765
CANX calnexin -0.0662793
NAV2 neuron navigator 2 -0.0660412
WSB1 WD repeat and SOCS box containing 1 -0.0633355
PSD3 pleckstrin and Sec7 domain containing 3 -0.0592772
PDE10A phosphodiesterase 10A -0.0573724
PTMA prothymosin, alpha -0.0494915
PTPRM protein tyrosine phosphatase, receptor type, M -0.0489633
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0485861
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0459487
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0433821
OGA O-GlcNAcase -0.0433307
DOCK4 dedicator of cytokinesis 4 -0.0430208
FN1 fibronectin 1 -0.0429118
EIF1 eukaryotic translation initiation factor 1 -0.0412044
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0382723
SAMD4A sterile alpha motif domain containing 4A -0.0382098
DST dystonin -0.0362829
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.035955
PDLIM5 PDZ and LIM domain 5 -0.0327979
CUX1 cut-like homeobox 1 -0.0321852
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0321036
IGF2 insulin-like growth factor 2 -0.029401
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0279327
VIM vimentin -0.0273283
B2M beta-2-microglobulin -0.0272588
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0262898
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0241258
TPT1 tumor protein, translationally-controlled 1 -0.0225544
PARD3 par-3 family cell polarity regulator -0.0218519
MAML3 mastermind-like 3 (Drosophila) -0.0218321
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0213612
EXT1 exostosin glycosyltransferase 1 -0.0209629
PRKCA protein kinase C, alpha -0.0205779
SEC31A SEC31 homolog A (S. cerevisiae) -0.0203597
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0195424
THSD4 thrombospondin, type I, domain containing 4 -0.0179627
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0177486
SETD5 SET domain containing 5 -0.0175683
TBC1D22A TBC1 domain family, member 22A -0.0165317
VCL vinculin -0.0134372
MYOF myoferlin -0.0130528
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0121318
KMT2C lysine (K)-specific methyltransferase 2C -0.0111355
ATXN1 ataxin 1 -0.0108417
BPTF bromodomain PHD finger transcription factor -0.0104932
MT2A metallothionein 2A -0.0102062
NAP1L1 nucleosome assembly protein 1-like 1 -0.00956461
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00698892
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.00630464
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.00625073
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00619644
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.00502157
RAD51B RAD51 paralog B -0.00394465
SMAD3 SMAD family member 3 -0.00382479
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0017066
PCBP3 poly(rC) binding protein 3 -9.34644E-4
RPS6 ribosomal protein S6 -4.85949E-4
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.7196E-4