Idarubicin (hydrochloride)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idarubicin (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idarubicin (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.072155
ZFAND3 zinc finger, AN1-type domain 3 0.0708398
GREB1L growth regulation by estrogen in breast cancer-like 0.0677227
MKI67 marker of proliferation Ki-67 0.0661675
PCLO piccolo presynaptic cytomatrix protein 0.0649833
PEG10 paternally expressed 10 0.063132
H1-0 H1.0 linker histone 0.0618547
SCAF11 SR-related CTD-associated factor 11 0.0513921
NHSL1 NHS-like 1 0.0508237
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0501784
NSUN6 NOP2/Sun domain family, member 6 0.049864
MED13L mediator complex subunit 13-like 0.0488265
NCAM2 neural cell adhesion molecule 2 0.0486195
VIM vimentin 0.0484035
COL3A1 collagen, type III, alpha 1 0.0469892
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0467181
DST dystonin 0.0458905
RABGAP1L RAB GTPase activating protein 1-like 0.0424343
RPS6 ribosomal protein S6 0.0417018
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0392538
DNAH14 dynein, axonemal, heavy chain 14 0.0389626
SAMD4B sterile alpha motif domain containing 4B 0.0383169
MBD5 methyl-CpG binding domain protein 5 0.0376838
SRRM2 serine/arginine repetitive matrix 2 0.0375055
CCDC88A coiled-coil domain containing 88A 0.0364976
GARS1 glycyl-tRNA synthetase 1 0.0364409
ZC3H12B zinc finger CCCH-type containing 12B 0.0353144
NAP1L1 nucleosome assembly protein 1-like 1 0.0351172
CENPF centromere protein F, 350/400kDa 0.0345664
PROS1 protein S (alpha) 0.0345226
ABI2 abl-interactor 2 0.0344961
TUBA1B tubulin, alpha 1b 0.0344454
ANKRD12 ankyrin repeat domain 12 0.0338516
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0333671
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0329388
ITGAV integrin, alpha V 0.032763
SYNE2 spectrin repeat containing, nuclear envelope 2 0.03262
TENM3 teneurin transmembrane protein 3 0.0326077
MAP4 microtubule-associated protein 4 0.0324985
NBEAL1 neurobeachin-like 1 0.0322673
ATXN1 ataxin 1 0.0321426
GOLIM4 golgi integral membrane protein 4 0.0319655
CDH19 cadherin 19, type 2 0.0318269
HMGB2 high mobility group box 2 0.0315968
BRWD1 bromodomain and WD repeat domain containing 1 0.0313795
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0306515
MYO10 myosin X 0.0306156
PHF3 PHD finger protein 3 0.0302992
PRRC2C proline-rich coiled-coil 2C 0.0301823
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0301541
CUL4B cullin 4B 0.029707
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0296668
BAIAP2L1 BAI1-associated protein 2-like 1 0.0295057
ARHGAP24 Rho GTPase activating protein 24 0.0293537
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0290815
BLTP1 bridge-like lipid transfer protein family member 1 0.0289717
TXNRD1 thioredoxin reductase 1 0.0285567
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0281838
RICTOR RPTOR independent companion of MTOR, complex 2 0.027759
EEF1G eukaryotic translation elongation factor 1 gamma 0.0277497
FAF1 Fas (TNFRSF6) associated factor 1 0.0274877
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0273523
PDS5A PDS5 cohesin associated factor A 0.027284
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0272003
TTC28 tetratricopeptide repeat domain 28 0.0271858
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0269885
BRCA2 breast cancer 2, early onset 0.0269691
RPS2 ribosomal protein S2 0.0268129
SMC1A structural maintenance of chromosomes 1A 0.0267853
TNRC6A trinucleotide repeat containing 6A 0.0266438
COG6 component of oligomeric golgi complex 6 0.0265389
HMGA2 high mobility group AT-hook 2 0.0265072
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0259636
BBX bobby sox homolog (Drosophila) 0.0259524
BRCA1 breast cancer 1, early onset 0.0258588
FOXP2 forkhead box P2 0.0257285
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 0.0253737
NDC80 NDC80 kinetochore complex component 0.0251504
TAS2R14 taste receptor, type 2, member 14 0.0250643
GSE1 Gse1 coiled-coil protein 0.0248721
BPTF bromodomain PHD finger transcription factor 0.0248367
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0247758
PNISR PNN-interacting serine/arginine-rich protein 0.0247531
KIF18B kinesin family member 18B 0.0247168
RFPL4B ret finger protein-like 4B 0.0244617
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0244455
CCDC102B coiled-coil domain containing 102B 0.0244296
SPAG9 sperm associated antigen 9 0.024421
EIF1 eukaryotic translation initiation factor 1 0.0243805
PARD3 par-3 family cell polarity regulator 0.0243205
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.0241352
NFE2L2 nuclear factor, erythroid 2-like 2 0.0241019
NBEA neurobeachin 0.0240341
MAML2 mastermind-like 2 (Drosophila) 0.0238799
WASL Wiskott-Aldrich syndrome-like 0.0238313
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0237294
THOC1 THO complex 1 0.0237079
MCTP1 multiple C2 domains, transmembrane 1 0.0236893
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0236387
N4BP2L2 NEDD4 binding protein 2-like 2 0.0235942

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.196611
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.142799
HDAC9 histone deacetylase 9 -0.137623
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.131069
COL11A1 collagen, type XI, alpha 1 -0.124225
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.118008
LRRC4C leucine rich repeat containing 4C -0.0776305
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0723363
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0712616
TRPS1 trichorhinophalangeal syndrome I -0.0630666
CSMD3 CUB and Sushi multiple domains 3 -0.0622523
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.061536
POTEF POTE ankyrin domain family, member F -0.061009
PGAP1 post-GPI attachment to proteins 1 -0.0609391
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.06014
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0579196
ADGRL2 adhesion G protein-coupled receptor L2 -0.0559355
PDIA3 protein disulfide isomerase family A, member 3 -0.0540542
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0534796
TUT4 terminal uridylyl transferase 4 -0.0530225
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0528361
ADGRL3 adhesion G protein-coupled receptor L3 -0.0499538
MEIS2 Meis homeobox 2 -0.049549
TSC22D2 TSC22 domain family, member 2 -0.0493722
USP9X ubiquitin specific peptidase 9, X-linked -0.0480828
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0473239
ADGRV1 adhesion G protein-coupled receptor V1 -0.0467237
PCDH9 protocadherin 9 -0.0459758
INTS6 integrator complex subunit 6 -0.045139
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0448985
MRPS6 mitochondrial ribosomal protein S6 -0.0446904
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0445235
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.04299
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0429448
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0413637
CADM2 cell adhesion molecule 2 -0.0409182
TFRC transferrin receptor -0.0407578
GLS2 glutaminase 2 (liver, mitochondrial) -0.0395507
ZEB2 zinc finger E-box binding homeobox 2 -0.0390337
MACF1 microtubule-actin crosslinking factor 1 -0.0385674
ANKRD33B ankyrin repeat domain 33B -0.0382812
ANXA1 annexin A1 -0.0382143
RBM20 RNA binding motif protein 20 -0.0375737
EMP1 epithelial membrane protein 1 -0.0370561
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0364798
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.036363
JARID2 jumonji, AT rich interactive domain 2 -0.0362139
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0360393
ADAM9 ADAM metallopeptidase domain 9 -0.0360125
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.0356761
RAD21 RAD21 homolog (S. pombe) -0.0356211
TMSB4X thymosin beta 4, X-linked -0.0351931
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0348793
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0347703
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0346778
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0336656
NRG1 neuregulin 1 -0.0336333
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0335514
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0333836
RPL11 ribosomal protein L11 -0.0332667
ZFPM2 zinc finger protein, FOG family member 2 -0.0332378
SCFD1 sec1 family domain containing 1 -0.0329875
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0328633
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0327624
CAMTA1 calmodulin binding transcription activator 1 -0.0325903
PBX3 pre-B-cell leukemia homeobox 3 -0.0325793
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0322998
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0322775
TNRC6B trinucleotide repeat containing 6B -0.0322734
ATXN2 ataxin 2 -0.0320874
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0316958
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0316153
SRP72 signal recognition particle 72kDa -0.0315451
ZNF608 zinc finger protein 608 -0.031036
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0307559
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0307187
IGF2 insulin-like growth factor 2 -0.0307117
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0307106
TENM2 teneurin transmembrane protein 2 -0.0306536
ACTG1 actin gamma 1 -0.0305723
PARD3B par-3 family cell polarity regulator beta -0.0305441
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0302319
KDM3A lysine (K)-specific demethylase 3A -0.030163
VCL vinculin -0.0301607
RPS24 ribosomal protein S24 -0.0301564
SLIT2 slit homolog 2 (Drosophila) -0.0300766
APP amyloid beta (A4) precursor protein -0.02986
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0298107
STRN3 striatin, calmodulin binding protein 3 -0.029772
PLPP1 phospholipid phosphatase 1 -0.0297194
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0293272
ZMYM2 zinc finger, MYM-type 2 -0.0292985
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0292733
CDK13 cyclin-dependent kinase 13 -0.0292619
HMGA1 high mobility group AT-hook 1 -0.0292221
KDM5B lysine (K)-specific demethylase 5B -0.0290919
ANK2 ankyrin 2, neuronal -0.0290389
PTK2 protein tyrosine kinase 2 -0.0287887
SYT1 synaptotagmin I -0.0284715
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.028466