Idarubicin (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idarubicin (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idarubicin (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.103139
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0928797
SAMD4A sterile alpha motif domain containing 4A 0.08807
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0724217
PRRC2B proline-rich coiled-coil 2B 0.0697664
PTPRG protein tyrosine phosphatase, receptor type, G 0.0680595
FRMD6 FERM domain containing 6 0.0662675
APLP2 amyloid beta (A4) precursor-like protein 2 0.0658461
ZSWIM6 zinc finger, SWIM-type containing 6 0.0618571
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0617269
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.060913
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0606367
COL27A1 collagen, type XXVII, alpha 1 0.0595891
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0567285
RPS6 ribosomal protein S6 0.0560046
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0450092
TLN1 talin 1 0.0444716
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0432684
SERINC5 serine incorporator 5 0.0419208
NSUN6 NOP2/Sun domain family, member 6 0.0408288
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0400019
FRMD4A FERM domain containing 4A 0.0400013
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0394751
MKI67 marker of proliferation Ki-67 0.0390746
EXT1 exostosin glycosyltransferase 1 0.0388238
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0387869
GOLGB1 golgin B1 0.0386812
TEX14 testis expressed 14 0.0384236
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0382786
KLHL29 kelch-like family member 29 0.0377105
WNK1 WNK lysine deficient protein kinase 1 0.0376951
NABP1 nucleic acid binding protein 1 0.036007
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0359018
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0358182
TPM3 tropomyosin 3 0.035692
GPHN gephyrin 0.0351678
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0348754
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0346993
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0340833
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0339861
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0336545
ARHGAP21 Rho GTPase activating protein 21 0.0331147
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0330607
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0327839
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0325779
RBBP6 retinoblastoma binding protein 6 0.0322602
ARL15 ADP-ribosylation factor-like 15 0.0322552
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0313341
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0312286
UTRN utrophin 0.0309345
MCTP1 multiple C2 domains, transmembrane 1 0.0304624
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0301309
TCF12 transcription factor 12 0.0300382
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0297886
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0297176
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0297071
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0296012
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0295068
TRIP12 thyroid hormone receptor interactor 12 0.0293416
SND1 staphylococcal nuclease and tudor domain containing 1 0.0287189
SATB2 SATB homeobox 2 0.0278196
NFE2L1 nuclear factor, erythroid 2-like 1 0.0276021
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0270684
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0268832
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0267723
GPATCH2L G patch domain containing 2-like 0.0266856
RPL13A ribosomal protein L13a 0.0266845
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0265148
RPS2 ribosomal protein S2 0.0263643
CFLAR CASP8 and FADD-like apoptosis regulator 0.0263618
PTPRK protein tyrosine phosphatase, receptor type, K 0.026082
FER fer (fps/fes related) tyrosine kinase 0.0259072
GNAS GNAS complex locus 0.0258302
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.025518
INTS6 integrator complex subunit 6 0.0252676
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.025265
NCOA2 nuclear receptor coactivator 2 0.0250122
LARP4B La ribonucleoprotein domain family, member 4B 0.0248728
CUX1 cut-like homeobox 1 0.0248408
IRF3 interferon regulatory factor 3 0.024829
KDM5B lysine (K)-specific demethylase 5B 0.0246875
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0246607
RCOR1 REST corepressor 1 0.0246475
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0245574
ITFG1 integrin alpha FG-GAP repeat containing 1 0.024534
EXOC4 exocyst complex component 4 0.024446
ITSN1 intersectin 1 (SH3 domain protein) 0.0239929
RPS12 ribosomal protein S12 0.023968
TMEM117 transmembrane protein 117 0.0239616
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0238867
LRRC23 leucine rich repeat containing 23 0.0236653
RPL4 ribosomal protein L4 0.0235588
CDK6 cyclin-dependent kinase 6 0.0232814
CEMIP2 cell migration inducing hyaluronidase 2 0.0232703
ALCAM activated leukocyte cell adhesion molecule 0.0231691
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0229776
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0229267
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0228895
TULP4 tubby like protein 4 0.0227975
IGF2 insulin-like growth factor 2 0.0227352

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.243038
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.124161
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.123146
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121764
STC1 stanniocalcin 1 -0.121016
POTEF POTE ankyrin domain family, member F -0.120183
ACTG1 actin gamma 1 -0.108846
HMGA1 high mobility group AT-hook 1 -0.0818835
LDHA lactate dehydrogenase A -0.0750648
FTL ferritin, light polypeptide -0.0748321
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0741976
DLC1 DLC1 Rho GTPase activating protein -0.0664544
RAD21 RAD21 homolog (S. pombe) -0.0596005
ZNF292 zinc finger protein 292 -0.0594206
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0577108
LOC112694756 uncharaterized LOC112694756 -0.0574622
S100A2 S100 calcium binding protein A2 -0.055076
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0540161
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0540099
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0526642
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0525313
TPD52 tumor protein D52 -0.0472998
UPP1 uridine phosphorylase 1 -0.0466846
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0466072
PGK1 phosphoglycerate kinase 1 -0.045828
C2CD2 C2 calcium-dependent domain containing 2 -0.045462
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0439124
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0431007
NUP58 nucleoporin 58 -0.0430394
ENO1 enolase 1, (alpha) -0.0421408
PUM2 pumilio RNA-binding family member 2 -0.0416236
ADAM9 ADAM metallopeptidase domain 9 -0.0399176
RLF rearranged L-myc fusion -0.0387767
FOSL1 FOS-like antigen 1 -0.0382781
PTK2 protein tyrosine kinase 2 -0.0381676
TMSB10 thymosin beta 10 -0.0379993
IFI16 interferon, gamma-inducible protein 16 -0.037442
USP3 ubiquitin specific peptidase 3 -0.0365132
TPM4 tropomyosin 4 -0.036426
RPL35A ribosomal protein L35a -0.0356837
NDRG1 N-myc downstream regulated 1 -0.0356275
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0346883
PKM pyruvate kinase, muscle -0.034419
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0342543
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0342293
UBC ubiquitin C -0.0341536
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0334416
PFN1 profilin 1 -0.03339
OLA1 Obg-like ATPase 1 -0.0333806
GLRX glutaredoxin (thioltransferase) -0.0333702
PTMA prothymosin, alpha -0.0331853
RBM39 RNA binding motif protein 39 -0.0328447
WDR45B WD repeat domain 45B -0.0322747
S100A9 S100 calcium binding protein A9 -0.0321915
WDR43 WD repeat domain 43 -0.0317732
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0315389
RPL7 ribosomal protein L7 -0.0311302
G0S2 G0/G1 switch 2 -0.0311294
PTBP2 polypyrimidine tract binding protein 2 -0.0310715
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0310096
CALR calreticulin -0.0308906
RNF145 ring finger protein 145 -0.0305698
HLA-B major histocompatibility complex, class I, B -0.0304123
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0299339
IFI6 interferon, alpha-inducible protein 6 -0.0296175
PIAS2 protein inhibitor of activated STAT, 2 -0.0292342
CDC27 cell division cycle 27 -0.0290268
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0287209
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0284264
TRAM1 translocation associated membrane protein 1 -0.0284077
TMEM87A transmembrane protein 87A -0.0283698
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0280738
RPLP0 ribosomal protein, large, P0 -0.0277727
TSC22D2 TSC22 domain family, member 2 -0.0277721
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0276215
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.027479
ZMYM2 zinc finger, MYM-type 2 -0.0272775
UGCG UDP-glucose ceramide glucosyltransferase -0.0271524
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0271294
NEMF nuclear export mediator factor -0.0270141
PNISR PNN-interacting serine/arginine-rich protein -0.0264972
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0263048
ELL2 elongation factor, RNA polymerase II, 2 -0.0262898
RPL9 ribosomal protein L9 -0.026248
MYL12B myosin, light chain 12B, regulatory -0.0262429
RTN4 reticulon 4 -0.0261625
SBF2 SET binding factor 2 -0.0260753
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0260712
XPO1 exportin 1 -0.0255238
BHLHE40 basic helix-loop-helix family, member e40 -0.0254976
KMT2C lysine (K)-specific methyltransferase 2C -0.025449
MARCHF6 membrane associated ring-CH-type finger 6 -0.0253513
B2M beta-2-microglobulin -0.0252508
ANXA2 annexin A2 -0.0249673
SMYD3 SET and MYND domain containing 3 -0.0249492
WAC WW domain containing adaptor with coiled-coil -0.0246708
TFRC transferrin receptor -0.0245739
MATR3 matrin 3 -0.0242824
MCL1 myeloid cell leukemia 1 -0.02372
FOXO3 forkhead box O3 -0.0234866