Idarubicin (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idarubicin (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idarubicin (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0537517
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0380486
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0377999
HSPA8 heat shock 70kDa protein 8 0.035367
LAMC2 laminin, gamma 2 0.0259789
RPS2 ribosomal protein S2 0.0255948
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0201135
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0200254
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0177769
LMO7 LIM domain 7 0.0161773
KDM6A lysine (K)-specific demethylase 6A 0.014283
ZMAT3 zinc finger, matrin-type 3 0.013743
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0132031
XPC xeroderma pigmentosum, complementation group C 0.0122701
OSBPL3 oxysterol binding protein-like 3 0.0120797
GDF15 growth differentiation factor 15 0.0119613
EPHA4 EPH receptor A4 0.0115012
KDM4B lysine (K)-specific demethylase 4B 0.0113339
CASZ1 castor zinc finger 1 0.0111287
CDPF1 cysteine-rich, DPF motif domain containing 1 0.01112
TSC22D2 TSC22 domain family, member 2 0.010461
FLNA filamin A, alpha 0.0103393
IGF2 insulin-like growth factor 2 0.0100896
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0100278
SRP54 signal recognition particle 54kDa 0.00996757
MYO6 myosin VI 0.00984778
KDM5B lysine (K)-specific demethylase 5B 0.00955897
RPL4 ribosomal protein L4 0.00954573
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.00951428
PNPLA8 patatin-like phospholipase domain containing 8 0.00948093
NUP58 nucleoporin 58 0.00946335
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.00939108
ZMIZ1 zinc finger, MIZ-type containing 1 0.00884409
EP300 E1A binding protein p300 0.00883686
ARL15 ADP-ribosylation factor-like 15 0.00874212
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.00869118
FHL2 four and a half LIM domains 2 0.00868537
EGLN1 egl-9 family hypoxia-inducible factor 1 0.00862324
SCYL2 SCY1-like 2 (S. cerevisiae) 0.00839218
RNF145 ring finger protein 145 0.0083518
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00832169
SOX4 SRY (sex determining region Y)-box 4 0.00831828
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.00830994
MARK4 MAP/microtubule affinity-regulating kinase 4 0.00802679
ATOSA atos homolog A 0.00797822
ITFG1 integrin alpha FG-GAP repeat containing 1 0.00794732
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.0079366
USP3 ubiquitin specific peptidase 3 0.00793182
TLN1 talin 1 0.00777704
MLEC malectin 0.00776238
TAFA2 TAFA chemokine like family member 2 0.00775952
FBXL20 F-box and leucine-rich repeat protein 20 0.00752705
SPATS2L spermatogenesis associated, serine-rich 2-like 0.00748904
EIF4H eukaryotic translation initiation factor 4H 0.00747583
BHLHE40 basic helix-loop-helix family, member e40 0.00741665
THRB thyroid hormone receptor, beta 0.007276
ARL8B ADP-ribosylation factor-like 8B 0.00727585
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00719443
ATF3 activating transcription factor 3 0.00716858
TAC4 tachykinin 4 (hemokinin) 0.00715767
PRDM1 PR domain containing 1, with ZNF domain 0.00710776
HDAC3 histone deacetylase 3 0.00710371
MPZL3 myelin protein zero-like 3 0.00707633
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00702785
SLFN5 schlafen family member 5 0.00696598
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.00695365
MIDEAS mitotic deacetylase associated SANT domain protein 0.00694749
POLH polymerase (DNA directed), eta 0.00677607
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.00675598
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.00670276
BSDC1 BSD domain containing 1 0.00665541
CLU clusterin 0.00664178
SULF2 sulfatase 2 0.00659617
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.00655528
TMF1 TATA element modulatory factor 1 0.00654306
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.00650947
HEXIM1 hexamethylene bis-acetamide inducible 1 0.00646875
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0064577
ALG11 ALG11, alpha-1,2-mannosyltransferase 0.00639181
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.00634082
FOXJ3 forkhead box J3 0.00633385
TTC6 tetratricopeptide repeat domain 6 0.0062898
PLK2 polo-like kinase 2 0.00621364
DPF3 D4, zinc and double PHD fingers, family 3 0.0061698
TPM3 tropomyosin 3 0.00615497
CSNK1G1 casein kinase 1, gamma 1 0.00614992
CREBRF CREB3 regulatory factor 0.00614484
FAM169A family with sequence similarity 169, member A 0.00610865
SFTPA2 surfactant protein A2 0.00608688
FYN FYN proto-oncogene, Src family tyrosine kinase 0.00608186
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 0.0060394
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.00602907
TET2 tet methylcytosine dioxygenase 2 0.00602341
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.00598677
UBQLN1 ubiquilin 1 0.00593851
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.00593388
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00591953
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 0.00590917
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.00588388
OSBP oxysterol binding protein 0.00587935

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.283203
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.141821
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.132514
ACTG1 actin gamma 1 -0.132135
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.130999
RAD51B RAD51 paralog B -0.11263
RPL35A ribosomal protein L35a -0.103237
HMGA2 high mobility group AT-hook 2 -0.102779
TMSB10 thymosin beta 10 -0.0974427
IER3 immediate early response 3 -0.0945208
FHIT fragile histidine triad -0.0838624
EGR1 early growth response 1 -0.0796626
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0759988
LOC102724023 ES1 protein homolog, mitochondrial -0.0750403
EGFR epidermal growth factor receptor -0.0693625
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0684567
RPS24 ribosomal protein S24 -0.0635218
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0621951
CD36 CD36 molecule (thrombospondin receptor) -0.0614221
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0597075
RPL37A ribosomal protein L37a -0.0596927
LDHA lactate dehydrogenase A -0.0593676
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0581567
GPHN gephyrin -0.0572976
EZR ezrin -0.0570275
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0561605
FLOT1 flotillin 1 -0.0551406
RCOR1 REST corepressor 1 -0.0550042
CCSER1 coiled-coil serine-rich protein 1 -0.0547827
FERMT1 fermitin family member 1 -0.0534944
TPT1 tumor protein, translationally-controlled 1 -0.052972
VCL vinculin -0.0528074
RPL23 ribosomal protein L23 -0.0522355
RPLP1 ribosomal protein, large, P1 -0.0504402
ANXA2 annexin A2 -0.0504256
RPL31 ribosomal protein L31 -0.0491074
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.048932
RPL34 ribosomal protein L34 -0.0488487
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0485422
RPS8 ribosomal protein S8 -0.0460262
RPS29 ribosomal protein S29 -0.0449783
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0446285
S100A6 S100 calcium binding protein A6 -0.0423497
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0420709
ATXN1 ataxin 1 -0.0415353
CUX1 cut-like homeobox 1 -0.0411769
CENPF centromere protein F, 350/400kDa -0.0410802
RPS25 ribosomal protein S25 -0.0407962
MKI67 marker of proliferation Ki-67 -0.040745
CD9 CD9 molecule -0.040553
HDAC2 histone deacetylase 2 -0.0404753
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0403579
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0403339
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0396971
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0392909
FOSL1 FOS-like antigen 1 -0.0390723
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0386748
DIAPH2 diaphanous-related formin 2 -0.0384206
RPS3 ribosomal protein S3 -0.0380457
ENO1 enolase 1, (alpha) -0.0380374
ITPKC inositol-trisphosphate 3-kinase C -0.0374064
EXOC4 exocyst complex component 4 -0.0373074
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0368378
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0364207
RPS14 ribosomal protein S14 -0.0364154
ACTN4 actinin, alpha 4 -0.0362052
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0358726
SMYD3 SET and MYND domain containing 3 -0.0354184
RPL26 ribosomal protein L26 -0.0353906
DEK DEK proto-oncogene -0.0353741
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0353221
AREG amphiregulin -0.0347009
RPL9 ribosomal protein L9 -0.034534
RPLP2 ribosomal protein, large, P2 -0.0342225
TPM4 tropomyosin 4 -0.0339775
S100A10 S100 calcium binding protein A10 -0.0337033
RPS21 ribosomal protein S21 -0.0331468
RPS13 ribosomal protein S13 -0.0329826
RPS19 ribosomal protein S19 -0.0329382
RPL11 ribosomal protein L11 -0.0329262
RPS27A ribosomal protein S27a -0.0327924
RPL12 ribosomal protein L12 -0.0327456
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0327262
RPS6 ribosomal protein S6 -0.0326394
TRAF3 TNF receptor-associated factor 3 -0.0324283
KPNB1 karyopherin (importin) beta 1 -0.0323812
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0322129
RPS23 ribosomal protein S23 -0.0320067
EHBP1 EH domain binding protein 1 -0.0317531
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0316475
PARD3 par-3 family cell polarity regulator -0.0314241
RPS17 ribosomal protein S17 -0.0313289
RPLP0 ribosomal protein, large, P0 -0.0307228
PHF14 PHD finger protein 14 -0.0307216
BMP4 bone morphogenetic protein 4 -0.0304964
RPL5 ribosomal protein L5 -0.0304659
PKM pyruvate kinase, muscle -0.0303453
RPL7A ribosomal protein L7a -0.0302802
RBM25 RNA binding motif protein 25 -0.0302583
ANKRD17 ankyrin repeat domain 17 -0.0299117