Idiopathic Osteoarthritis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description disease cluster belonging to disease group metabolic (Genetic Association Database)
External Link https://www.disgenet.org/browser/0/1/0/C0409952
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Genes

61 genes associated with the disease Idiopathic Osteoarthritis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
BID BH3 interacting domain death agonist
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
CALCA calcitonin-related polypeptide alpha
CCL8 chemokine (C-C motif) ligand 8
CLU clusterin
CNGB1 cyclic nucleotide gated channel beta 1
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL9A1 collagen, type IX, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DNASE1L3 deoxyribonuclease I-like 3
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
FRZB frizzled-related protein
GDF5 growth differentiation factor 5
GH1 growth hormone 1
GHR growth hormone receptor
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRAP2 GRB2-related adaptor protein 2
HCK HCK proto-oncogene, Src family tyrosine kinase
HFE hemochromatosis
HLA-B major histocompatibility complex, class I, B
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
LRRC32 leucine rich repeat containing 32
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MEFV Mediterranean fever
MGP matrix Gla protein
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
NAMPT nicotinamide phosphoribosyltransferase
NOTCH1 notch 1
PHB prohibitin
PITX1 paired-like homeodomain 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PTH2R parathyroid hormone 2 receptor
PTK2B protein tyrosine kinase 2 beta
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROM1 retinal outer segment membrane protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
SMAD3 SMAD family member 3
SPP1 secreted phosphoprotein 1
TLR10 toll-like receptor 10
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPSG1 tryptase gamma 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A