Idoxuridine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.103009
AHNAK AHNAK nucleoprotein 0.0910356
LOX lysyl oxidase 0.0814189
PODXL podocalyxin-like 0.0704303
NAV1 neuron navigator 1 0.0686024
PLAT plasminogen activator, tissue 0.0645042
SAMD9 sterile alpha motif domain containing 9 0.0581414
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0505628
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.050472
AKAP12 A kinase (PRKA) anchor protein 12 0.0484464
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0465785
DST dystonin 0.0424591
CAVIN1 caveolae associated protein 1 0.0397617
PRSS23 protease, serine, 23 0.0386447
THBS2 thrombospondin 2 0.0370435
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0345052
FNDC3B fibronectin type III domain containing 3B 0.0336569
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0336039
FBN1 fibrillin 1 0.0328384
PSD3 pleckstrin and Sec7 domain containing 3 0.0326224
COL3A1 collagen, type III, alpha 1 0.0317491
ZBTB20 zinc finger and BTB domain containing 20 0.0305174
IFIH1 interferon induced with helicase C domain 1 0.030182
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0300547
ABI3BP ABI family, member 3 (NESH) binding protein 0.0292844
TRIO trio Rho guanine nucleotide exchange factor 0.0292109
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0289437
HLA-B major histocompatibility complex, class I, B 0.0288895
COL8A1 collagen, type VIII, alpha 1 0.0283479
IFI16 interferon, gamma-inducible protein 16 0.0279837
RIGI RNA sensor RIG-I 0.0278072
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0273575
CD44 CD44 molecule (Indian blood group) 0.0270554
ASPH aspartate beta-hydroxylase 0.026827
LDHA lactate dehydrogenase A 0.0258425
DLG1 discs, large homolog 1 (Drosophila) 0.0255624
AHNAK2 AHNAK nucleoprotein 2 0.0254437
GLIS3 GLIS family zinc finger 3 0.025328
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0252882
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0251709
EXT1 exostosin glycosyltransferase 1 0.0244214
LRRC17 leucine rich repeat containing 17 0.0241445
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0239607
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.023939
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0238419
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0236327
FN1 fibronectin 1 0.0234568
VCL vinculin 0.0232185
ERRFI1 ERBB receptor feedback inhibitor 1 0.0231698
MYL12B myosin, light chain 12B, regulatory 0.0231123
CD59 CD59 molecule, complement regulatory protein 0.0229847
IQGAP1 IQ motif containing GTPase activating protein 1 0.0227703
COL1A2 collagen, type I, alpha 2 0.0223266
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.021505
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.021466
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0209822
COL5A1 collagen, type V, alpha 1 0.020739
APP amyloid beta (A4) precursor protein 0.020646
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0203968
EHBP1 EH domain binding protein 1 0.0203828
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.01992
ITPRID2 ITPR interacting domain containing 2 0.0198736
LPP LIM domain containing preferred translocation partner in lipoma 0.019252
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0191996
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0189443
FRMD4A FERM domain containing 4A 0.0188373
IFI6 interferon, alpha-inducible protein 6 0.0185959
MACF1 microtubule-actin crosslinking factor 1 0.0184175
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.018319
ANO6 anoctamin 6 0.0181682
PRELID2 PRELI domain containing 2 0.0181604
MAP1B microtubule-associated protein 1B 0.0179969
ZNF217 zinc finger protein 217 0.0178509
HLA-C major histocompatibility complex, class I, C 0.0177278
BZW1 basic leucine zipper and W2 domains 1 0.0175457
ANXA2 annexin A2 0.0174833
MYOF myoferlin 0.0174284
COPB1 coatomer protein complex, subunit beta 1 0.0173213
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0171327
RASAL2 RAS protein activator like 2 0.0171324
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0170767
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.016619
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0165391
TM4SF1 transmembrane 4 L six family member 1 0.0164505
SAR1A secretion associated, Ras related GTPase 1A 0.0160864
SMYD3 SET and MYND domain containing 3 0.0158491
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0157904
ALCAM activated leukocyte cell adhesion molecule 0.015746
RNF144A ring finger protein 144A 0.0157328
CYTH3 cytohesin 3 0.015581
ANKRD36 ankyrin repeat domain 36 0.0155732
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0153214
TUBB4B tubulin, beta 4B class IVb 0.015175
DNAAF9 dynein axonemal assembly factor 9 0.0149479
PGK1 phosphoglycerate kinase 1 0.0148753
DOCK5 dedicator of cytokinesis 5 0.0147924
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0147795
ELL2 elongation factor, RNA polymerase II, 2 0.0147462
TDRD7 tudor domain containing 7 0.0147432
TMSB4X thymosin beta 4, X-linked 0.0141702

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.173345
IGFBP3 insulin-like growth factor binding protein 3 -0.126403
TMSB10 thymosin beta 10 -0.0866536
VIM vimentin -0.0611586
NDRG1 N-myc downstream regulated 1 -0.0602405
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0510148
PTMA prothymosin, alpha -0.0450143
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.043887
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0420684
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0359049
PDIA3 protein disulfide isomerase family A, member 3 -0.0349646
PKM pyruvate kinase, muscle -0.0300297
FTL ferritin, light polypeptide -0.027795
VEGFA vascular endothelial growth factor A -0.0258522
RPS6 ribosomal protein S6 -0.0251309
LOC112694756 uncharaterized LOC112694756 -0.0227713
BSG basigin (Ok blood group) -0.0225907
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0225233
RUNX1 runt-related transcription factor 1 -0.0222943
RPS19 ribosomal protein S19 -0.0222503
WSB1 WD repeat and SOCS box containing 1 -0.0221741
CALR calreticulin -0.0214703
EEF2 eukaryotic translation elongation factor 2 -0.0213729
FTH1 ferritin, heavy polypeptide 1 -0.0211972
MT2A metallothionein 2A -0.0211816
PDIA6 protein disulfide isomerase family A, member 6 -0.0209251
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0204655
PFN1 profilin 1 -0.0201473
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0196585
ADM adrenomedullin -0.0192056
LOXL2 lysyl oxidase-like 2 -0.0191255
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0191186
INSIG1 insulin induced gene 1 -0.0186446
RPS3 ribosomal protein S3 -0.018591
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0185636
FOSL1 FOS-like antigen 1 -0.0184917
MXI1 MAX interactor 1, dimerization protein -0.0184825
GDF15 growth differentiation factor 15 -0.0182409
RPL28 ribosomal protein L28 -0.0179379
MSN moesin -0.0179176
SQSTM1 sequestosome 1 -0.017875
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0178509
DDIT4 DNA-damage-inducible transcript 4 -0.0173983
RPS27 ribosomal protein S27 -0.0172255
BBX bobby sox homolog (Drosophila) -0.0170833
MEIS2 Meis homeobox 2 -0.0169133
RHOBTB3 Rho-related BTB domain containing 3 -0.0165358
RNMT RNA (guanine-7-) methyltransferase -0.0164236
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0159617
MNT MAX network transcriptional repressor -0.0157249
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0156157
RND3 Rho family GTPase 3 -0.015536
TPM4 tropomyosin 4 -0.0155349
SMIM44 small integral membrane protein 44 -0.0154342
TPM1 tropomyosin 1 (alpha) -0.0153035
HELZ helicase with zinc finger -0.0150142
CD99 CD99 molecule -0.0148377
RPLP2 ribosomal protein, large, P2 -0.0147714
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0146492
RHOA ras homolog family member A -0.0146434
MSI2 musashi RNA-binding protein 2 -0.014555
S100A9 S100 calcium binding protein A9 -0.0145249
KMT2E lysine (K)-specific methyltransferase 2E -0.0142779
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0142504
HLA-A major histocompatibility complex, class I, A -0.0139162
COL5A2 collagen, type V, alpha 2 -0.0137637
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0137171
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0136129
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.013489
FADS2 fatty acid desaturase 2 -0.0134431
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.013442
BHLHE40 basic helix-loop-helix family, member e40 -0.0134155
LOC102724023 ES1 protein homolog, mitochondrial -0.0133085
PCBP2 poly(rC) binding protein 2 -0.0132579
CXXC5 CXXC finger protein 5 -0.0132443
GOLGA4 golgin A4 -0.0131679
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0130978
MEF2D myocyte enhancer factor 2D -0.0130686
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0130396
SEPTIN9 septin 9 -0.0128639
DEPP1 DEPP autophagy regulator 1 -0.0127557
TGFB1 transforming growth factor, beta 1 -0.0124963
CLU clusterin -0.0123922
HSPB1 heat shock 27kDa protein 1 -0.0123848
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0123703
EPAS1 endothelial PAS domain protein 1 -0.0123214
FAM107B family with sequence similarity 107, member B -0.0122303
MIMS1 mitochondrial inner membrane scaffold 1 -0.01223
GARS1 glycyl-tRNA synthetase 1 -0.0121601
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0121161
ADAM9 ADAM metallopeptidase domain 9 -0.0120937
RPL35 ribosomal protein L35 -0.0119757
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0118306
UGCG UDP-glucose ceramide glucosyltransferase -0.011779
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.011726
HILPDA hypoxia inducible lipid droplet-associated -0.0116531
TAPBP TAP binding protein (tapasin) -0.0116123
MMP12 matrix metallopeptidase 12 -0.0115781
GSE1 Gse1 coiled-coil protein -0.0115662
MBNL2 muscleblind-like splicing regulator 2 -0.0114951