Idoxuridine_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0838141
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0784206
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0766451
ASPH aspartate beta-hydroxylase 0.0730431
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0706306
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0693098
ANXA1 annexin A1 0.068971
AHNAK AHNAK nucleoprotein 0.0639909
EHBP1 EH domain binding protein 1 0.0592531
DST dystonin 0.0590002
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0579287
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0518315
PCBP2 poly(rC) binding protein 2 0.0512753
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0474479
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0468282
MMP12 matrix metallopeptidase 12 0.045319
NHSL1 NHS-like 1 0.0411718
ECT2 epithelial cell transforming 2 0.0410361
FXR1 fragile X mental retardation, autosomal homolog 1 0.0408189
HMGA2 high mobility group AT-hook 2 0.0396563
ERRFI1 ERBB receptor feedback inhibitor 1 0.039381
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0375504
NLGN1 neuroligin 1 0.036532
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0355595
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0352576
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0352532
JMJD1C jumonji domain containing 1C 0.0345387
NAP1L1 nucleosome assembly protein 1-like 1 0.0344499
MACF1 microtubule-actin crosslinking factor 1 0.0328443
LDHA lactate dehydrogenase A 0.0323228
LMO7 LIM domain 7 0.0317892
PCDH7 protocadherin 7 0.0316985
NEBL nebulette 0.0316878
AKAP12 A kinase (PRKA) anchor protein 12 0.0314487
CKAP5 cytoskeleton associated protein 5 0.0307806
YAP1 Yes-associated protein 1 0.0299992
MED13L mediator complex subunit 13-like 0.0297308
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0294435
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0292174
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0289015
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0280468
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0278516
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0275883
EIF4B eukaryotic translation initiation factor 4B 0.0274388
TPM3 tropomyosin 3 0.0272912
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0270524
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.02666
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0264704
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0259054
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0258805
IFIH1 interferon induced with helicase C domain 1 0.0253018
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0246618
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0245007
VMP1 vacuole membrane protein 1 0.0240975
GSK3B glycogen synthase kinase 3 beta 0.0237472
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0235734
FGFR1 fibroblast growth factor receptor 1 0.0235663
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0232563
TRIO trio Rho guanine nucleotide exchange factor 0.0230475
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0229693
OSBPL8 oxysterol binding protein-like 8 0.0227621
ADIPOR2 adiponectin receptor 2 0.0227225
RASAL2 RAS protein activator like 2 0.0225763
SPATS2 spermatogenesis associated, serine-rich 2 0.0224638
CLDN1 claudin 1 0.0223816
LPP LIM domain containing preferred translocation partner in lipoma 0.021985
INTS6 integrator complex subunit 6 0.0213482
CANX calnexin 0.021334
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0213298
BIRC6 baculoviral IAP repeat containing 6 0.0213214
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0207821
CUX1 cut-like homeobox 1 0.0205408
USP34 ubiquitin specific peptidase 34 0.0204576
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0203857
GJA1 gap junction protein, alpha 1, 43kDa 0.0202449
RPL4 ribosomal protein L4 0.0196455
FAT1 FAT atypical cadherin 1 0.0194808
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.019446
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0193726
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0191334
CLTC clathrin, heavy chain (Hc) 0.0191049
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0190037
ENO1 enolase 1, (alpha) 0.0189887
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0189311
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0189083
RAB10 RAB10, member RAS oncogene family 0.018797
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0187436
ZFAND3 zinc finger, AN1-type domain 3 0.0186042
PCDH9 protocadherin 9 0.0185344
HSPA8 heat shock 70kDa protein 8 0.018526
CNOT1 CCR4-NOT transcription complex, subunit 1 0.018485
CSNK1A1 casein kinase 1, alpha 1 0.0184531
RRM2 ribonucleotide reductase M2 0.0183668
ZNF217 zinc finger protein 217 0.0183307
STIP1 stress-induced phosphoprotein 1 0.0182055
RBM39 RNA binding motif protein 39 0.0181622
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0180429
UBC ubiquitin C 0.0179528
IPO7 importin 7 0.0177411
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0176467

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.263983
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.220896
FTL ferritin, light polypeptide -0.118818
AREG amphiregulin -0.0991741
VIM vimentin -0.095483
RPL35A ribosomal protein L35a -0.0745216
RPLP1 ribosomal protein, large, P1 -0.0707929
CNRIP1 cannabinoid receptor interacting protein 1 -0.0631496
RPL19 ribosomal protein L19 -0.0601203
RPS23 ribosomal protein S23 -0.0584237
RPS19 ribosomal protein S19 -0.0571323
RPL23 ribosomal protein L23 -0.0569516
RPLP2 ribosomal protein, large, P2 -0.0509686
RPL12 ribosomal protein L12 -0.0508747
RPS8 ribosomal protein S8 -0.0484989
RPL36 ribosomal protein L36 -0.0477083
RPS6 ribosomal protein S6 -0.0473966
RPS29 ribosomal protein S29 -0.0450055
EIF1 eukaryotic translation initiation factor 1 -0.0439389
RPS21 ribosomal protein S21 -0.0413089
RPL32 ribosomal protein L32 -0.040433
RPS12 ribosomal protein S12 -0.0398071
RPL34 ribosomal protein L34 -0.0371353
RPL31 ribosomal protein L31 -0.0341307
RPL28 ribosomal protein L28 -0.0336633
RPS13 ribosomal protein S13 -0.0331835
ATP5F1E ATP synthase F1 subunit epsilon -0.033084
RPS15 ribosomal protein S15 -0.0329309
RPS5 ribosomal protein S5 -0.0327717
RPL37A ribosomal protein L37a -0.0326282
RPL8 ribosomal protein L8 -0.032594
RPL11 ribosomal protein L11 -0.0325658
PFN1 profilin 1 -0.0324135
RPS27 ribosomal protein S27 -0.0311525
ATP5F1B ATP synthase F1 subunit beta -0.0310566
RPL5 ribosomal protein L5 -0.0293425
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0285444
RPLP0 ribosomal protein, large, P0 -0.0281884
RPS14 ribosomal protein S14 -0.0280804
RPS16 ribosomal protein S16 -0.026783
RPL38 ribosomal protein L38 -0.026117
RPS4X ribosomal protein S4, X-linked -0.0257581
HMGA1 high mobility group AT-hook 1 -0.0252527
RPL37 ribosomal protein L37 -0.0249368
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0239278
HSPB1 heat shock 27kDa protein 1 -0.0235815
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0234239
RPS26 ribosomal protein S26 -0.0234233
NDUFA4 NDUFA4, mitochondrial complex associated -0.0231462
RPS10 ribosomal protein S10 -0.0230856
GNAS GNAS complex locus -0.0229519
VDAC1 voltage-dependent anion channel 1 -0.0226034
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0222247
RPL9 ribosomal protein L9 -0.0217782
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0215473
RPS25 ribosomal protein S25 -0.0214531
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.0214193
S100A9 S100 calcium binding protein A9 -0.0214027
RAB7A RAB7A, member RAS oncogene family -0.0213436
RPS20 ribosomal protein S20 -0.0202051
FTH1 ferritin, heavy polypeptide 1 -0.0199591
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0198665
RACK1 receptor for activated C kinase 1 -0.0194163
RPL35 ribosomal protein L35 -0.019187
RPL26 ribosomal protein L26 -0.0178379
ZBTB20 zinc finger and BTB domain containing 20 -0.0174267
MYL12B myosin, light chain 12B, regulatory -0.0171772
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.017044
BTG3 BTG family, member 3 -0.0170318
PNISR PNN-interacting serine/arginine-rich protein -0.0163798
ATF4 activating transcription factor 4 -0.0163278
RPL36A ribosomal protein L36a -0.0161262
RPL27 ribosomal protein L27 -0.016082
RPS27A ribosomal protein S27a -0.016074
RPL7 ribosomal protein L7 -0.0160585
HMGB1 high mobility group box 1 -0.0158147
RPS2 ribosomal protein S2 -0.0158088
RPL18 ribosomal protein L18 -0.0157549
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0155061
SEC62 SEC62 homolog (S. cerevisiae) -0.0154892
GSTP1 glutathione S-transferase pi 1 -0.015177
GPX1 glutathione peroxidase 1 -0.0149675
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0149245
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0147292
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0146096
CPOX coproporphyrinogen oxidase -0.0145392
ATP5MJ ATP synthase membrane subunit j -0.0144255
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.0142794
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0142158
UQCRH ubiquinol-cytochrome c reductase hinge protein -0.0141467
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0138726
COX6C cytochrome c oxidase subunit VIc -0.0137838
CCDC88A coiled-coil domain containing 88A -0.0134473
H2AZ1 H2A.Z variant histone 1 -0.013377
ROMO1 reactive oxygen species modulator 1 -0.0133605
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -0.013278
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0131746
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0131613
MT2A metallothionein 2A -0.0129995
TPT1 tumor protein, translationally-controlled 1 -0.0125579