Idoxuridine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.113562
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0808543
FMN1 formin 1 0.0768261
VIM vimentin 0.0700685
NRG1 neuregulin 1 0.0692569
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0592093
PLAT plasminogen activator, tissue 0.0556667
PRKCA protein kinase C, alpha 0.0555423
DST dystonin 0.0545866
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.05407
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0515255
FNDC3B fibronectin type III domain containing 3B 0.0513044
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0511777
NALF1 NALCN channel auxiliary factor 1 0.0511136
LIMCH1 LIM and calponin homology domains 1 0.0508531
DSCAM Down syndrome cell adhesion molecule 0.04983
PCBP2 poly(rC) binding protein 2 0.0480043
EXT1 exostosin glycosyltransferase 1 0.0475856
VCL vinculin 0.0451309
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0439069
PTPRD protein tyrosine phosphatase, receptor type, D 0.0437833
SOS1 son of sevenless homolog 1 (Drosophila) 0.042846
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0423974
ITPRID2 ITPR interacting domain containing 2 0.042093
MAP1B microtubule-associated protein 1B 0.0420057
PSD3 pleckstrin and Sec7 domain containing 3 0.0399371
AHNAK AHNAK nucleoprotein 0.0375807
PGK1 phosphoglycerate kinase 1 0.036637
ASPH aspartate beta-hydroxylase 0.0355401
SPTBN1 spectrin, beta, non-erythrocytic 1 0.035188
TLE4 transducin-like enhancer of split 4 0.03518
FNDC3A fibronectin type III domain containing 3A 0.0335625
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0329231
FAM13A family with sequence similarity 13, member A 0.0320172
APP amyloid beta (A4) precursor protein 0.0309657
EFNA5 ephrin-A5 0.030772
CANX calnexin 0.0306548
B2M beta-2-microglobulin 0.0305863
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0300825
AHR aryl hydrocarbon receptor 0.0299803
TPST1 tyrosylprotein sulfotransferase 1 0.0291185
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0290348
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0284552
BPTF bromodomain PHD finger transcription factor 0.028374
FN1 fibronectin 1 0.0283241
PTPRM protein tyrosine phosphatase, receptor type, M 0.0283186
MEIS2 Meis homeobox 2 0.0269984
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0269601
SPAG9 sperm associated antigen 9 0.0268545
NF1 neurofibromin 1 0.0266553
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0266364
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0266011
LPIN1 lipin 1 0.0264284
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0259575
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0258305
MYO6 myosin VI 0.025714
AEBP2 AE binding protein 2 0.0252966
EEF2 eukaryotic translation elongation factor 2 0.0250831
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0250175
CSDE1 cold shock domain containing E1, RNA-binding 0.0249756
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0248985
AUTS2 autism susceptibility candidate 2 0.0247864
ZFC3H1 zinc finger, C3H1-type containing 0.0246921
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0246714
PRRC2C proline-rich coiled-coil 2C 0.0243117
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0241978
PCBP3 poly(rC) binding protein 3 0.0241887
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0240845
LSAMP limbic system-associated membrane protein 0.0235546
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0232249
NBEA neurobeachin 0.0230005
SIK2 salt-inducible kinase 2 0.0226142
YEATS2 YEATS domain containing 2 0.0221952
ANTXR1 anthrax toxin receptor 1 0.0220086
EIF4A2 eukaryotic translation initiation factor 4A2 0.021927
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0219074
WDR45B WD repeat domain 45B 0.0219001
IGF1R insulin-like growth factor 1 receptor 0.0216364
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0214737
ENO1 enolase 1, (alpha) 0.0214032
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0211264
LINGO2 leucine rich repeat and Ig domain containing 2 0.0210227
CALD1 caldesmon 1 0.0209374
FRMD4A FERM domain containing 4A 0.0209179
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0206261
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0206078
OGA O-GlcNAcase 0.0202333
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0200465
PCM1 pericentriolar material 1 0.0199944
NAP1L1 nucleosome assembly protein 1-like 1 0.0199895
MSI2 musashi RNA-binding protein 2 0.0199885
COL4A1 collagen, type IV, alpha 1 0.0198807
CALU calumenin 0.0197348
HDLBP high density lipoprotein binding protein 0.0196642
USP34 ubiquitin specific peptidase 34 0.0196165
ERRFI1 ERBB receptor feedback inhibitor 1 0.0195651
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0194238
TAS2R14 taste receptor, type 2, member 14 0.0192704
KTN1 kinectin 1 (kinesin receptor) 0.0192497
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.019225

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.113805
RPLP1 ribosomal protein, large, P1 -0.0332896
RPL35A ribosomal protein L35a -0.0329382
RPL34 ribosomal protein L34 -0.0273807
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0182976
PCDH9 protocadherin 9 -0.0182819
LMNA lamin A/C -0.0162586
ACBD3 acyl-CoA binding domain containing 3 -0.0162383
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0151554
CDC27 cell division cycle 27 -0.014994
TSC22D2 TSC22 domain family, member 2 -0.0146797
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0144827
HMGB1 high mobility group box 1 -0.0144569
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0142538
RPS24 ribosomal protein S24 -0.0139066
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0138624
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0136438
ZFAND5 zinc finger, AN1-type domain 5 -0.0136252
RPL36 ribosomal protein L36 -0.0134425
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0133258
FOXN2 forkhead box N2 -0.0132423
TRA2A transformer 2 alpha homolog (Drosophila) -0.0127162
KCNIP4 Kv channel interacting protein 4 -0.0126076
SUMF1 sulfatase modifying factor 1 -0.0124895
CDK8 cyclin-dependent kinase 8 -0.0123795
HMGA1 high mobility group AT-hook 1 -0.0123361
FDPS farnesyl diphosphate synthase -0.0122928
MAPK8 mitogen-activated protein kinase 8 -0.0122431
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0120296
RPS10 ribosomal protein S10 -0.0118688
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0117696
PCDH10 protocadherin 10 -0.011725
NRIP1 nuclear receptor interacting protein 1 -0.0117181
SLMAP sarcolemma associated protein -0.0117094
MXD1 MAX dimerization protein 1 -0.0116383
NKTR natural killer cell triggering receptor -0.0115954
ARID4A AT rich interactive domain 4A (RBP1-like) -0.0115671
GATA3 GATA binding protein 3 -0.0113273
POTEF POTE ankyrin domain family, member F -0.0113177
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0112608
FOXK2 forkhead box K2 -0.0112133
ITGA1 integrin, alpha 1 -0.0111761
NRF1 nuclear respiratory factor 1 -0.0111593
S100A9 S100 calcium binding protein A9 -0.0111492
RAD23B RAD23 homolog B (S. cerevisiae) -0.0109723
MRTFA myocardin related transcription factor A -0.0109466
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0109216
RPL22L1 ribosomal protein L22-like 1 -0.0109121
TMSB4X thymosin beta 4, X-linked -0.0108794
OAZ1 ornithine decarboxylase antizyme 1 -0.0108486
YLPM1 YLP motif containing 1 -0.0107916
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0107251
LRRC23 leucine rich repeat containing 23 -0.0107237
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0105966
RNF150 ring finger protein 150 -0.0105439
CA5B carbonic anhydrase VB, mitochondrial -0.0105164
RPL27A ribosomal protein L27a -0.0104805
RPL23 ribosomal protein L23 -0.0103462
UBL5 ubiquitin-like 5 -0.0100151
SSBP2 single-stranded DNA binding protein 2 -0.00993979
BLZF1 basic leucine zipper nuclear factor 1 -0.0098679
TBK1 TANK-binding kinase 1 -0.00985977
RPS25 ribosomal protein S25 -0.00984072
RBM8A RNA binding motif protein 8A -0.00983231
MED26 mediator complex subunit 26 -0.00979957
THRA thyroid hormone receptor, alpha -0.00977415
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.00970491
RPS21 ribosomal protein S21 -0.00970451
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.00968065
GOLIM4 golgi integral membrane protein 4 -0.00965232
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.00964752
GTF2A2 general transcription factor IIA, 2, 12kDa -0.009625
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.00962105
RPL35 ribosomal protein L35 -0.0096061
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.00959525
RPS6 ribosomal protein S6 -0.00953784
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.00953575
TNRC6C trinucleotide repeat containing 6C -0.00951053
SAP130 Sin3A-associated protein, 130kDa -0.00948738
JMJD1C jumonji domain containing 1C -0.00945473
UNC13B unc-13 homolog B (C. elegans) -0.00939757
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.00938283
MX1 MX dynamin-like GTPase 1 -0.00914379
ZCCHC8 zinc finger, CCHC domain containing 8 -0.00913301
FAM168A family with sequence similarity 168, member A -0.00912823
YARS1 tyrosyl-tRNA synthetase 1 -0.00911936
HLA-A major histocompatibility complex, class I, A -0.00909978
PI4KB phosphatidylinositol 4-kinase, catalytic, beta -0.00909422
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.00900995
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast) -0.00900287
ACIN1 apoptotic chromatin condensation inducer 1 -0.00893268
ATP5F1B ATP synthase F1 subunit beta -0.00892239
PDCD7 programmed cell death 7 -0.00890668
COLEC11 collectin sub-family member 11 -0.00885029
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.00884748
RPL19 ribosomal protein L19 -0.00884006
ASTN2 astrotactin 2 -0.0088214
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -0.00879918
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.00879759
AFTPH aftiphilin -0.00875645