Idoxuridine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.133289
LMO7 LIM domain 7 0.110092
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.102913
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0972775
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.076225
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0738719
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0737693
MACC1 metastasis associated in colon cancer 1 0.0728846
PTBP3 polypyrimidine tract binding protein 3 0.072439
FNIP1 folliculin interacting protein 1 0.064715
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0637956
DSPP dentin sialophosphoprotein 0.0625832
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0567107
PRELID2 PRELI domain containing 2 0.0548072
IFNGR1 interferon gamma receptor 1 0.0535362
BTBD9 BTB (POZ) domain containing 9 0.053109
AHNAK AHNAK nucleoprotein 0.0508696
CLTC clathrin, heavy chain (Hc) 0.0500985
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.047511
SBF2 SET binding factor 2 0.0474673
RHOBTB3 Rho-related BTB domain containing 3 0.0473978
STK24 serine/threonine kinase 24 0.0463019
MEIS2 Meis homeobox 2 0.0453616
PTEN phosphatase and tensin homolog 0.0451431
BCLAF1 BCL2-associated transcription factor 1 0.0432512
EPS8 epidermal growth factor receptor pathway substrate 8 0.0411877
SERINC5 serine incorporator 5 0.0410904
ERRFI1 ERBB receptor feedback inhibitor 1 0.0410727
UBC ubiquitin C 0.0410638
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0401197
PGK1 phosphoglycerate kinase 1 0.0399446
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0398221
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0391979
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0387754
ABHD2 abhydrolase domain containing 2 0.0385868
TMEM51 transmembrane protein 51 0.0381375
ANLN anillin, actin binding protein 0.0375448
KMT2C lysine (K)-specific methyltransferase 2C 0.0374621
NAMPT nicotinamide phosphoribosyltransferase 0.0370974
RNF43 ring finger protein 43 0.0355532
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0354061
CUL3 cullin 3 0.0353351
KLF5 Kruppel-like factor 5 (intestinal) 0.0348674
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0346798
SREBF2 sterol regulatory element binding transcription factor 2 0.0346591
FAT1 FAT atypical cadherin 1 0.0340543
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0338826
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0330052
AKAP13 A kinase (PRKA) anchor protein 13 0.0321724
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0319334
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0319264
HELZ helicase with zinc finger 0.0315831
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0315581
USP9X ubiquitin specific peptidase 9, X-linked 0.0314099
TMPRSS4 transmembrane protease, serine 4 0.0307885
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0307601
SMYD3 SET and MYND domain containing 3 0.0307161
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0306936
NRIP1 nuclear receptor interacting protein 1 0.0305301
GLG1 golgi glycoprotein 1 0.0302653
CENPF centromere protein F, 350/400kDa 0.0300091
SCFD1 sec1 family domain containing 1 0.0298473
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0297984
PDZD8 PDZ domain containing 8 0.0297217
PICALM phosphatidylinositol binding clathrin assembly protein 0.0293787
FNDC3A fibronectin type III domain containing 3A 0.028898
DSCAM Down syndrome cell adhesion molecule 0.0288968
PDIA3 protein disulfide isomerase family A, member 3 0.0287983
ERBB3 erb-b2 receptor tyrosine kinase 3 0.0287836
ESRP1 epithelial splicing regulatory protein 1 0.0283514
AKAP11 A kinase (PRKA) anchor protein 11 0.02831
KDM3A lysine (K)-specific demethylase 3A 0.0282428
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.028189
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0280793
TBPL1 TBP-like 1 0.027933
MARCHF6 membrane associated ring-CH-type finger 6 0.0275439
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0274564
YTHDC1 YTH domain containing 1 0.027279
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0272121
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0271616
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0269557
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0269023
UBE2H ubiquitin-conjugating enzyme E2H 0.0268971
PDE8A phosphodiesterase 8A 0.0268844
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.0268789
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0268023
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0267463
CCNL1 cyclin L1 0.0267249
TAOK1 TAO kinase 1 0.0266449
HYOU1 hypoxia up-regulated 1 0.0265912
ANO6 anoctamin 6 0.0264836
NCOR1 nuclear receptor corepressor 1 0.0264088
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.026376
TJP2 tight junction protein 2 0.0262781
MKI67 marker of proliferation Ki-67 0.0262775
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.0262152
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0261852
EREG epiregulin 0.0260104
JUN jun proto-oncogene 0.026007
FNDC3B fibronectin type III domain containing 3B 0.0259476

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.141016
B2M beta-2-microglobulin -0.106819
LCN2 lipocalin 2 -0.0928764
EPSTI1 epithelial stromal interaction 1 (breast) -0.0746947
RNF213 ring finger protein 213 -0.0704238
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0682285
LYZ lysozyme -0.0677739
TMSB10 thymosin beta 10 -0.0665054
FTL ferritin, light polypeptide -0.0655688
MX2 MX dynamin-like GTPase 2 -0.0651116
GMDS GDP-mannose 4,6-dehydratase -0.0644485
GCLC glutamate-cysteine ligase, catalytic subunit -0.0634093
SP100 SP100 nuclear antigen -0.0609355
RPL34 ribosomal protein L34 -0.0608772
RPL35A ribosomal protein L35a -0.0602939
EGR1 early growth response 1 -0.0595114
INTS6 integrator complex subunit 6 -0.0591292
PTMA prothymosin, alpha -0.0585955
RPL23 ribosomal protein L23 -0.0566161
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0557433
RABGAP1L RAB GTPase activating protein 1-like -0.0556021
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0545308
ACTG1 actin gamma 1 -0.0540793
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0515028
IFI27 interferon, alpha-inducible protein 27 -0.0514122
RIGI RNA sensor RIG-I -0.05037
NPSR1 neuropeptide S receptor 1 -0.0481674
XAF1 XIAP associated factor 1 -0.0454956
MPHOSPH8 M-phase phosphoprotein 8 -0.0445784
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0422523
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0417992
IGFBP3 insulin-like growth factor binding protein 3 -0.0402575
IFI6 interferon, alpha-inducible protein 6 -0.0393939
RPS19 ribosomal protein S19 -0.0392906
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0388872
RPLP1 ribosomal protein, large, P1 -0.0384102
RPS8 ribosomal protein S8 -0.0381116
ANXA2 annexin A2 -0.0377408
RPS27 ribosomal protein S27 -0.0374602
MX1 MX dynamin-like GTPase 1 -0.0363846
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0362449
MT2A metallothionein 2A -0.035968
RPS6 ribosomal protein S6 -0.0354631
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0346739
RPS12 ribosomal protein S12 -0.0346482
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.033474
RPL13A ribosomal protein L13a -0.0334522
CSTB cystatin B (stefin B) -0.0331466
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0327812
STS steroid sulfatase (microsomal), isozyme S -0.0325434
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0321928
PLSCR1 phospholipid scramblase 1 -0.0318787
RPL30 ribosomal protein L30 -0.0317078
RPS24 ribosomal protein S24 -0.0317019
TSHZ2 teashirt zinc finger homeobox 2 -0.0313993
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.031387
RPS3 ribosomal protein S3 -0.0313139
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0311413
RACK1 receptor for activated C kinase 1 -0.0309817
ATF4 activating transcription factor 4 -0.0301007
RPS29 ribosomal protein S29 -0.0300788
SSH2 slingshot protein phosphatase 2 -0.0299215
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0297982
RPL28 ribosomal protein L28 -0.0295785
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0290719
MAML2 mastermind-like 2 (Drosophila) -0.0289983
IFITM3 interferon induced transmembrane protein 3 -0.0289774
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0287285
PTPRF protein tyrosine phosphatase, receptor type, F -0.0284222
RPL19 ribosomal protein L19 -0.028379
RPL36A ribosomal protein L36a -0.0282962
RPS17 ribosomal protein S17 -0.0277825
SAMD9 sterile alpha motif domain containing 9 -0.0276453
MUC20 mucin 20, cell surface associated -0.0276046
IER3 immediate early response 3 -0.0270925
FDPS farnesyl diphosphate synthase -0.0270321
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0266808
C6ORF132 chromosome 6 open reading frame 132 -0.0265842
IRS2 insulin receptor substrate 2 -0.026257
S100A9 S100 calcium binding protein A9 -0.0261629
TAOK3 TAO kinase 3 -0.0261359
RPS14 ribosomal protein S14 -0.0259811
PLSCR2 phospholipid scramblase 2 -0.0257325
PDLIM5 PDZ and LIM domain 5 -0.0257267
TPI1 triosephosphate isomerase 1 -0.0254983
RPS25 ribosomal protein S25 -0.0253576
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0251548
TRIM56 tripartite motif containing 56 -0.0249692
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0248399
FOSL1 FOS-like antigen 1 -0.024561
POMP proteasome maturation protein -0.0244922
RPL38 ribosomal protein L38 -0.0243392
RPS21 ribosomal protein S21 -0.0240387
GOLGB1 golgin B1 -0.0238702
CST3 cystatin C -0.0238529
SCARB1 scavenger receptor class B, member 1 -0.0237359
TBC1D22A TBC1 domain family, member 22A -0.0236978
HMGB1 high mobility group box 1 -0.0231793
LAP3 leucine aminopeptidase 3 -0.0231322
S100A11 S100 calcium binding protein A11 -0.023086