Idoxuridine_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.302145
COL6A3 collagen, type VI, alpha 3 0.154915
AHNAK AHNAK nucleoprotein 0.103076
EXT1 exostosin glycosyltransferase 1 0.102668
COL1A1 collagen, type I, alpha 1 0.0981272
TRIO trio Rho guanine nucleotide exchange factor 0.0948273
PSD3 pleckstrin and Sec7 domain containing 3 0.0929059
LDHA lactate dehydrogenase A 0.0836238
FBN1 fibrillin 1 0.0828203
ASPH aspartate beta-hydroxylase 0.0701293
COL5A1 collagen, type V, alpha 1 0.0666487
ATP13A3 ATPase type 13A3 0.0588255
CDH13 cadherin 13 0.0583844
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0566046
MYH9 myosin, heavy chain 9, non-muscle 0.0539888
NDRG1 N-myc downstream regulated 1 0.0515656
LOX lysyl oxidase 0.0504725
APP amyloid beta (A4) precursor protein 0.0491238
HMGA2 high mobility group AT-hook 2 0.0487898
PTK2 protein tyrosine kinase 2 0.0481087
FNDC3B fibronectin type III domain containing 3B 0.0476194
CANX calnexin 0.0464501
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0462152
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0442603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0436195
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0420948
NAV2 neuron navigator 2 0.0418506
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0412498
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0411976
JARID2 jumonji, AT rich interactive domain 2 0.0411067
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0404414
ZBTB20 zinc finger and BTB domain containing 20 0.0395959
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0391945
SPAG9 sperm associated antigen 9 0.0391645
PDE10A phosphodiesterase 10A 0.0391448
DOCK5 dedicator of cytokinesis 5 0.0389985
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0388311
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0385364
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0378238
ERRFI1 ERBB receptor feedback inhibitor 1 0.0374644
MACF1 microtubule-actin crosslinking factor 1 0.0372141
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0355643
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0350813
WWTR1 WW domain containing transcription regulator 1 0.0350578
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0347983
KMT2C lysine (K)-specific methyltransferase 2C 0.034354
TM4SF1 transmembrane 4 L six family member 1 0.0339247
UBC ubiquitin C 0.0332403
CALU calumenin 0.0327268
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0324559
LPP LIM domain containing preferred translocation partner in lipoma 0.0318537
DLG1 discs, large homolog 1 (Drosophila) 0.0303152
DST dystonin 0.0301095
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0297346
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0297172
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0296648
ANKRD11 ankyrin repeat domain 11 0.0296353
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0292143
PICALM phosphatidylinositol binding clathrin assembly protein 0.0291956
GRB10 growth factor receptor-bound protein 10 0.0289494
LIMS1 LIM and senescent cell antigen-like domains 1 0.0288847
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.028654
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0285041
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0284259
USP34 ubiquitin specific peptidase 34 0.0281363
ENO1 enolase 1, (alpha) 0.0279824
ZEB1 zinc finger E-box binding homeobox 1 0.0279526
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0275333
PTPRG protein tyrosine phosphatase, receptor type, G 0.0275251
CLIC4 chloride intracellular channel 4 0.0272613
CAMTA1 calmodulin binding transcription activator 1 0.0270833
FNIP1 folliculin interacting protein 1 0.0268364
COL1A2 collagen, type I, alpha 2 0.0266421
ATXN1 ataxin 1 0.0263977
PRELID2 PRELI domain containing 2 0.0261433
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0261004
PLEC plectin 0.0259565
MED13L mediator complex subunit 13-like 0.0259081
FMNL2 formin-like 2 0.0258186
MTDH metadherin 0.0254815
EIF4A1 eukaryotic translation initiation factor 4A1 0.0254335
HOOK3 hook microtubule-tethering protein 3 0.0254055
SMYD3 SET and MYND domain containing 3 0.0253687
MYO10 myosin X 0.0252245
RB1CC1 RB1-inducible coiled-coil 1 0.0251316
IGFBP3 insulin-like growth factor binding protein 3 0.0249931
ZFAND3 zinc finger, AN1-type domain 3 0.024706
VMP1 vacuole membrane protein 1 0.0244519
RND3 Rho family GTPase 3 0.0243025
NOTCH2 notch 2 0.0239206
IQGAP1 IQ motif containing GTPase activating protein 1 0.0238574
NAV1 neuron navigator 1 0.0238212
OGA O-GlcNAcase 0.0237678
BIRC6 baculoviral IAP repeat containing 6 0.0237618
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0237194
FAM107B family with sequence similarity 107, member B 0.0235525
ZCCHC7 zinc finger, CCHC domain containing 7 0.0235498
HIPK2 homeodomain interacting protein kinase 2 0.0233964
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0230251
SEC31A SEC31 homolog A (S. cerevisiae) 0.0229925

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.111696
MT2A metallothionein 2A -0.0970871
RPS8 ribosomal protein S8 -0.0532503
RPL35A ribosomal protein L35a -0.0517288
FTL ferritin, light polypeptide -0.0419263
RPS19 ribosomal protein S19 -0.040547
PTMA prothymosin, alpha -0.0387654
S100A9 S100 calcium binding protein A9 -0.0373975
RPS6 ribosomal protein S6 -0.0339902
RPS3 ribosomal protein S3 -0.0324584
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0303387
RPL36 ribosomal protein L36 -0.0269448
RPS20 ribosomal protein S20 -0.0269258
RPLP2 ribosomal protein, large, P2 -0.0258581
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0252057
RPL28 ribosomal protein L28 -0.0246958
HMGA1 high mobility group AT-hook 1 -0.0222418
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0214616
CYB5R3 cytochrome b5 reductase 3 -0.0214036
RPLP1 ribosomal protein, large, P1 -0.0213185
TMSB4X thymosin beta 4, X-linked -0.0204882
IER3 immediate early response 3 -0.0200604
RPL5 ribosomal protein L5 -0.0200548
RPL19 ribosomal protein L19 -0.0198223
RPL37A ribosomal protein L37a -0.0193711
B2M beta-2-microglobulin -0.0192557
RPS14 ribosomal protein S14 -0.0189318
RPS2 ribosomal protein S2 -0.0185352
RACK1 receptor for activated C kinase 1 -0.0183992
NAMPT nicotinamide phosphoribosyltransferase -0.0183754
HILPDA hypoxia inducible lipid droplet-associated -0.0179841
RPL11 ribosomal protein L11 -0.0174599
RPS12 ribosomal protein S12 -0.0172374
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0168822
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0162981
DSTN destrin (actin depolymerizing factor) -0.0162938
BHLHE40 basic helix-loop-helix family, member e40 -0.0161246
RPL18 ribosomal protein L18 -0.0159298
GPX4 glutathione peroxidase 4 -0.0158621
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0157587
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0156101
S100A10 S100 calcium binding protein A10 -0.0155427
EGR1 early growth response 1 -0.0153744
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0152852
RPL30 ribosomal protein L30 -0.015252
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0148954
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0148469
RPL12 ribosomal protein L12 -0.0146101
RPS15 ribosomal protein S15 -0.0143986
FTH1 ferritin, heavy polypeptide 1 -0.0143826
RPS16 ribosomal protein S16 -0.0143279
HMGB1 high mobility group box 1 -0.0140884
CSF1 colony stimulating factor 1 (macrophage) -0.0139881
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0138245
DDIT4 DNA-damage-inducible transcript 4 -0.0135047
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0134182
RPL13A ribosomal protein L13a -0.013402
RPS29 ribosomal protein S29 -0.0131345
EMP3 epithelial membrane protein 3 -0.0130994
CAV1 caveolin 1, caveolae protein, 22kDa -0.013077
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0130739
OAZ1 ornithine decarboxylase antizyme 1 -0.0129219
TPM1 tropomyosin 1 (alpha) -0.0128214
RPS13 ribosomal protein S13 -0.0128186
RPL23 ribosomal protein L23 -0.0127569
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0127476
SRGN serglycin -0.0123961
DEPP1 DEPP autophagy regulator 1 -0.0122716
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0119389
RPL34 ribosomal protein L34 -0.0116887
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0116316
RIPK2 receptor-interacting serine-threonine kinase 2 -0.011452
RPL32 ribosomal protein L32 -0.0113872
PFN1 profilin 1 -0.0113242
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0112223
RPS21 ribosomal protein S21 -0.0111697
ATP5F1E ATP synthase F1 subunit epsilon -0.0110854
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0110305
RPS5 ribosomal protein S5 -0.0108816
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0104847
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0104656
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -0.0102826
RPS11 ribosomal protein S11 -0.0102445
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0102201
RPL9 ribosomal protein L9 -0.0102189
RPL15 ribosomal protein L15 -0.0101595
COX6C cytochrome c oxidase subunit VIc -0.0100787
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0100719
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -0.00998666
CADM1 cell adhesion molecule 1 -0.00992453
RPL38 ribosomal protein L38 -0.00984033
RPL14 ribosomal protein L14 -0.00982186
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.009757
KIAA1217 KIAA1217 -0.00972677
YBX1 Y box binding protein 1 -0.00972649
RPL7A ribosomal protein L7a -0.00967906
CD70 CD70 molecule -0.00963657
ISG15 ISG15 ubiquitin-like modifier -0.00963135
GSTP1 glutathione S-transferase pi 1 -0.00962561
RPL27 ribosomal protein L27 -0.00961202