Idoxuridine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.1313
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.118885
TM4SF1 transmembrane 4 L six family member 1 0.113511
CAPRIN2 caprin family member 2 0.0817038
POTEF POTE ankyrin domain family, member F 0.0726249
AHNAK AHNAK nucleoprotein 0.061447
UBC ubiquitin C 0.0610872
VIM vimentin 0.0596508
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0591501
LDHA lactate dehydrogenase A 0.0541947
TXNRD1 thioredoxin reductase 1 0.051206
KMT2E lysine (K)-specific methyltransferase 2E 0.0496747
DST dystonin 0.0481623
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0472186
APLP2 amyloid beta (A4) precursor-like protein 2 0.0438716
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0433031
EREG epiregulin 0.0430742
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0395744
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0392131
PRELID2 PRELI domain containing 2 0.0385067
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0384129
SDK1 sidekick cell adhesion molecule 1 0.0381955
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0380994
ADAM17 ADAM metallopeptidase domain 17 0.0374741
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0370704
BZW1 basic leucine zipper and W2 domains 1 0.0357613
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0355398
MACF1 microtubule-actin crosslinking factor 1 0.0350984
HLA-B major histocompatibility complex, class I, B 0.0350094
SPAG9 sperm associated antigen 9 0.0347001
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.033861
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0333734
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0328155
HOOK2 hook microtubule-tethering protein 2 0.0324527
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0323954
NIBAN2 niban apoptosis regulator 2 0.0318609
TRIP12 thyroid hormone receptor interactor 12 0.0318402
FTH1 ferritin, heavy polypeptide 1 0.0318027
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0314492
JUN jun proto-oncogene 0.0306503
JMJD1C jumonji domain containing 1C 0.03033
SRRM2 serine/arginine repetitive matrix 2 0.0299309
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0298114
ANXA1 annexin A1 0.0284595
UPP1 uridine phosphorylase 1 0.0282425
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0276814
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0273247
USP9X ubiquitin specific peptidase 9, X-linked 0.0269144
MYH9 myosin, heavy chain 9, non-muscle 0.0268803
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0267131
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0263571
ZSWIM6 zinc finger, SWIM-type containing 6 0.0263255
EEF2 eukaryotic translation elongation factor 2 0.026264
EMP1 epithelial membrane protein 1 0.0262459
WWTR1 WW domain containing transcription regulator 1 0.0258487
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0258258
RRM2 ribonucleotide reductase M2 0.0257485
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0256741
CXCL8 chemokine (C-X-C motif) ligand 8 0.0254205
ANGPTL4 angiopoietin-like 4 0.0249181
EIF4A2 eukaryotic translation initiation factor 4A2 0.0247032
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0243897
PYGL phosphorylase, glycogen, liver 0.0243631
ARRDC3 arrestin domain containing 3 0.0243392
MCL1 myeloid cell leukemia 1 0.024185
TPM3 tropomyosin 3 0.024154
PGK1 phosphoglycerate kinase 1 0.0241443
USP12 ubiquitin specific peptidase 12 0.0238335
CSNK1A1 casein kinase 1, alpha 1 0.0238194
CORO1C coronin, actin binding protein, 1C 0.0237089
ECE1 endothelin converting enzyme 1 0.0230727
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0229836
LOXL2 lysyl oxidase-like 2 0.0229755
KDM4C lysine (K)-specific demethylase 4C 0.0228774
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0228369
DIAPH1 diaphanous-related formin 1 0.0220477
ARFGEF3 ARFGEF family member 3 0.0214498
PCBP2 poly(rC) binding protein 2 0.0214441
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0213096
BIRC3 baculoviral IAP repeat containing 3 0.0213039
RTN4 reticulon 4 0.0210573
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.020949
NAV2 neuron navigator 2 0.0208708
SQSTM1 sequestosome 1 0.0207818
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0205567
DSCAM Down syndrome cell adhesion molecule 0.0204264
AREG amphiregulin 0.0203435
SDC4 syndecan 4 0.0203169
FLNB filamin B, beta 0.0202796
ZEB1 zinc finger E-box binding homeobox 1 0.0202157
SOD2 superoxide dismutase 2, mitochondrial 0.020179
SMAD3 SMAD family member 3 0.0199331
VCL vinculin 0.0195122
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0194232
USP34 ubiquitin specific peptidase 34 0.0194014
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0193586
RASA2 RAS p21 protein activator 2 0.0191933
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0191166
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.018997
EZR ezrin 0.0189576

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.184622
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.119462
TMSB4X thymosin beta 4, X-linked -0.117908
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0874488
DLG1 discs, large homolog 1 (Drosophila) -0.0851692
FTL ferritin, light polypeptide -0.0805842
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0796731
PTMA prothymosin, alpha -0.0733343
CFAP299 cilia and flagella associated protein 299 -0.0668637
TP63 tumor protein p63 -0.0660754
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0607908
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.060573
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0582798
DPYD dihydropyrimidine dehydrogenase -0.0581271
RPS8 ribosomal protein S8 -0.0564173
EHBP1 EH domain binding protein 1 -0.0554676
RIGI RNA sensor RIG-I -0.0526923
RPL35A ribosomal protein L35a -0.0526816
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0508283
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0499269
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.046833
RPL23 ribosomal protein L23 -0.0433689
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0420482
EPHA4 EPH receptor A4 -0.0396504
GOLGA4 golgin A4 -0.0390829
RPS3 ribosomal protein S3 -0.0377335
S100A9 S100 calcium binding protein A9 -0.035886
CD44 CD44 molecule (Indian blood group) -0.035819
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0351842
RPL19 ribosomal protein L19 -0.0338882
GNAS GNAS complex locus -0.0335485
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0329945
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0320122
RPS29 ribosomal protein S29 -0.031684
RACK1 receptor for activated C kinase 1 -0.0315127
RPL36 ribosomal protein L36 -0.0313543
SDCCAG8 serologically defined colon cancer antigen 8 -0.0308367
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0301271
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0297601
TAS2R14 taste receptor, type 2, member 14 -0.0287221
CALR calreticulin -0.0278
RPS6 ribosomal protein S6 -0.0275884
TPI1 triosephosphate isomerase 1 -0.0273148
TTC28 tetratricopeptide repeat domain 28 -0.0271244
EIF1 eukaryotic translation initiation factor 1 -0.0263629
RPL37A ribosomal protein L37a -0.0263555
THOC2 THO complex 2 -0.0263474
RPL18 ribosomal protein L18 -0.0260387
SYT1 synaptotagmin I -0.0260298
FAF1 Fas (TNFRSF6) associated factor 1 -0.0257122
EXOC4 exocyst complex component 4 -0.0256693
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0256005
EPB41 erythrocyte membrane protein band 4.1 -0.025527
RPL5 ribosomal protein L5 -0.0255214
CADM2 cell adhesion molecule 2 -0.0254629
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0251361
EFNA5 ephrin-A5 -0.0248683
RPS19 ribosomal protein S19 -0.0245774
PTPRF protein tyrosine phosphatase, receptor type, F -0.0244538
ACACA acetyl-CoA carboxylase alpha -0.0242989
RPL28 ribosomal protein L28 -0.0240884
RPL35 ribosomal protein L35 -0.0240611
GPBP1 GC-rich promoter binding protein 1 -0.0238786
ADGRG6 adhesion G protein-coupled receptor G6 -0.0238263
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0235042
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0225661
BCAS3 breast carcinoma amplified sequence 3 -0.0225497
THSD4 thrombospondin, type I, domain containing 4 -0.0219862
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0217856
TOP1 topoisomerase (DNA) I -0.0207553
ZNF609 zinc finger protein 609 -0.0206903
AMBRA1 autophagy/beclin-1 regulator 1 -0.0205391
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0204545
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0204494
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0200344
GARS1 glycyl-tRNA synthetase 1 -0.0199113
TNRC6B trinucleotide repeat containing 6B -0.0198389
ZFR zinc finger RNA binding protein -0.01975
MBTD1 mbt domain containing 1 -0.0197343
RPL32 ribosomal protein L32 -0.0195179
TTC3 tetratricopeptide repeat domain 3 -0.0194691
GTF2I general transcription factor IIi -0.0192998
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0191473
RPL13A ribosomal protein L13a -0.019014
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.018973
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0189567
BPTF bromodomain PHD finger transcription factor -0.0188958
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0188765
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.018855
RPLP2 ribosomal protein, large, P2 -0.0187705
RPS20 ribosomal protein S20 -0.0184584
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0184228
ADNP activity-dependent neuroprotector homeobox -0.0183729
DPH6 diphthamine biosynthesis 6 -0.0183303
PATJ PATJ crumbs cell polarity complex component -0.0182226
ANKRD28 ankyrin repeat domain 28 -0.0178874
HDAC8 histone deacetylase 8 -0.0178469
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0176963
FNDC3B fibronectin type III domain containing 3B -0.0175524
BSG basigin (Ok blood group) -0.0174804