Idoxuridine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.123566
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.099688
LMO7 LIM domain 7 0.0944665
ASPH aspartate beta-hydroxylase 0.0841102
LAMC2 laminin, gamma 2 0.0775044
LDHA lactate dehydrogenase A 0.0754999
PGK1 phosphoglycerate kinase 1 0.0595889
PKM pyruvate kinase, muscle 0.0579347
ENO1 enolase 1, (alpha) 0.0552844
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0536847
NAMPT nicotinamide phosphoribosyltransferase 0.0530914
UBC ubiquitin C 0.0493114
AHNAK AHNAK nucleoprotein 0.0477495
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0467363
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0457854
DSCAM Down syndrome cell adhesion molecule 0.0454202
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0433077
RAB27B RAB27B, member RAS oncogene family 0.0423728
PCBP2 poly(rC) binding protein 2 0.04151
CAV1 caveolin 1, caveolae protein, 22kDa 0.0413968
SPAG9 sperm associated antigen 9 0.0413789
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0413123
LAMA4 laminin, alpha 4 0.0398866
PRRC2C proline-rich coiled-coil 2C 0.0394368
SOD2 superoxide dismutase 2, mitochondrial 0.0384331
ERRFI1 ERBB receptor feedback inhibitor 1 0.0383214
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0372031
DSPP dentin sialophosphoprotein 0.0370584
FAM13A family with sequence similarity 13, member A 0.0368005
TOP1 topoisomerase (DNA) I 0.0353094
RICTOR RPTOR independent companion of MTOR, complex 2 0.0351332
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0347216
NDRG1 N-myc downstream regulated 1 0.0346005
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0345914
BZW1 basic leucine zipper and W2 domains 1 0.0344002
STC1 stanniocalcin 1 0.0330773
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0326316
SEC31A SEC31 homolog A (S. cerevisiae) 0.0324588
CXCL8 chemokine (C-X-C motif) ligand 8 0.0321228
PTMA prothymosin, alpha 0.0314028
LAMB3 laminin, beta 3 0.0313132
KRT18 keratin 18, type I 0.0311913
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0311216
ANXA2 annexin A2 0.0310133
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0307469
CANX calnexin 0.0306946
ZC3H11A zinc finger CCCH-type containing 11A 0.0303483
ACTG1 actin gamma 1 0.030333
TES testin LIM domain protein 0.0296299
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0292819
OSMR oncostatin M receptor 0.0292304
H1-0 H1.0 linker histone 0.028254
GSK3B glycogen synthase kinase 3 beta 0.0281676
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0281229
CPE carboxypeptidase E 0.0276961
HDLBP high density lipoprotein binding protein 0.0275665
TPD52 tumor protein D52 0.0269339
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0260676
USP34 ubiquitin specific peptidase 34 0.0259442
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.025793
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0254472
OGA O-GlcNAcase 0.0253727
JMJD1C jumonji domain containing 1C 0.0250425
MYH9 myosin, heavy chain 9, non-muscle 0.0249317
NGLY1 N-glycanase 1 0.0246627
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0242505
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0240808
JAK1 Janus kinase 1 0.0236802
HOOK2 hook microtubule-tethering protein 2 0.0235262
MCL1 myeloid cell leukemia 1 0.0234683
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0234254
AKR1C1 aldo-keto reductase family 1, member C1 0.0233377
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0230929
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0230881
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0226808
KDM3A lysine (K)-specific demethylase 3A 0.022342
S100A10 S100 calcium binding protein A10 0.0223085
CTNND1 catenin (cadherin-associated protein), delta 1 0.022212
USP9X ubiquitin specific peptidase 9, X-linked 0.0221158
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0220807
DOCK5 dedicator of cytokinesis 5 0.0219857
ATP13A3 ATPase type 13A3 0.0219107
MACF1 microtubule-actin crosslinking factor 1 0.0215847
NSUN6 NOP2/Sun domain family, member 6 0.021313
ARRDC3 arrestin domain containing 3 0.0212757
PTPRM protein tyrosine phosphatase, receptor type, M 0.0210906
GCLC glutamate-cysteine ligase, catalytic subunit 0.02109
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0209242
SLC38A1 solute carrier family 38, member 1 0.02092
EIF4A2 eukaryotic translation initiation factor 4A2 0.0208597
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0208351
YTHDC1 YTH domain containing 1 0.0207901
CES1 carboxylesterase 1 0.0207219
RBM39 RNA binding motif protein 39 0.0205267
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0204282
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0203399
ARHGAP32 Rho GTPase activating protein 32 0.020329
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0202731
ANO6 anoctamin 6 0.0202208
PATJ PATJ crumbs cell polarity complex component 0.0200422

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.033819
INTS6 integrator complex subunit 6 -0.0315086
RPLP1 ribosomal protein, large, P1 -0.0255401
RPS3 ribosomal protein S3 -0.0198001
RPS12 ribosomal protein S12 -0.0179059
RPS27 ribosomal protein S27 -0.0174333
S100P S100 calcium binding protein P -0.0161204
RPL37A ribosomal protein L37a -0.0147349
RPS25 ribosomal protein S25 -0.0143033
RPS17 ribosomal protein S17 -0.012792
RPS19 ribosomal protein S19 -0.0120494
RPL36 ribosomal protein L36 -0.011814
RPL35A ribosomal protein L35a -0.0114825
HOMER1 homer scaffolding protein 1 -0.0111761
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0108268
CEMIP cell migration inducing protein, hyaluronan binding -0.0108208
RPLP2 ribosomal protein, large, P2 -0.0107814
RPS23 ribosomal protein S23 -0.0105767
LRRC23 leucine rich repeat containing 23 -0.00958407
KRT86 keratin 86, type II -0.00943357
RPS6 ribosomal protein S6 -0.0094313
ZSWIM6 zinc finger, SWIM-type containing 6 -0.00937317
RACK1 receptor for activated C kinase 1 -0.00896884
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.00887058
RPS8 ribosomal protein S8 -0.00872886
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.00833184
RPS29 ribosomal protein S29 -0.00812696
RPL31 ribosomal protein L31 -0.00803587
CATSPERB catsper channel auxiliary subunit beta -0.00800831
ANKRD37 ankyrin repeat domain 37 -0.00799427
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.00785264
ARMH4 armadillo like helical domain containing 4 -0.00773187
FTL ferritin, light polypeptide -0.0076582
RPL34 ribosomal protein L34 -0.00763184
RPL32 ribosomal protein L32 -0.00735286
RPS20 ribosomal protein S20 -0.0073361
RPL5 ribosomal protein L5 -0.00696832
GUK1 guanylate kinase 1 -0.00694399
KDM3B lysine (K)-specific demethylase 3B -0.00693137
RPL28 ribosomal protein L28 -0.00691608
RPS10 ribosomal protein S10 -0.00684955
SMOC1 SPARC related modular calcium binding 1 -0.00684792
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.00665595
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00664015
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.00663897
RPL12 ribosomal protein L12 -0.00634955
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.00627762
IRS2 insulin receptor substrate 2 -0.00627571
LRP12 low density lipoprotein receptor-related protein 12 -0.00613944
WDPCP WD repeat containing planar cell polarity effector -0.00604948
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.00600662
DISC1 disrupted in schizophrenia 1 -0.00600151
PER3 period circadian clock 3 -0.00593081
RAD51B RAD51 paralog B -0.00583573
AEBP2 AE binding protein 2 -0.0057876
NACA nascent polypeptide-associated complex alpha subunit -0.00574639
SERTAD2 SERTA domain containing 2 -0.0056685
RPL13A ribosomal protein L13a -0.00562582
RPL23 ribosomal protein L23 -0.00555654
CCSER1 coiled-coil serine-rich protein 1 -0.00554768
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.00553509
RPS16 ribosomal protein S16 -0.0055185
TMEM184B transmembrane protein 184B -0.00551317
WNT2B wingless-type MMTV integration site family, member 2B -0.0055117
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.00545138
GTF2B general transcription factor IIB -0.0054083
BANP BTG3 associated nuclear protein -0.00537234
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.00534995
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -0.00533281
CFAP96 cilia and flagella associated protein 96 -0.00531213
SRP19 signal recognition particle 19kDa -0.00530254
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.00527477
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.00522653
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00522424
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.00522386
FANK1 fibronectin type III and ankyrin repeat domains 1 -0.00521907
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00517728
MTERF1 mitochondrial transcription termination factor 1 -0.00516949
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -0.00516261
BCL2L11 BCL2-like 11 (apoptosis facilitator) -0.00516068
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.00515106
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.00510404
ERI2 ERI1 exoribonuclease family member 2 -0.00508252
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -0.00504562
PLSCR2 phospholipid scramblase 2 -0.00502114
SHB Src homology 2 domain containing adaptor protein B -0.00501769
LGMN legumain -0.00497
RPL19 ribosomal protein L19 -0.00496044
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.00495617
RPS13 ribosomal protein S13 -0.00486709
IFRD1 interferon-related developmental regulator 1 -0.00484919
PTPRD protein tyrosine phosphatase, receptor type, D -0.00483338
MIPOL1 mirror-image polydactyly 1 -0.0048092
RPL11 ribosomal protein L11 -0.0047901
PEAK1 pseudopodium-enriched atypical kinase 1 -0.00478134
TRAM1 translocation associated membrane protein 1 -0.00470959
DNASE1 deoxyribonuclease I -0.00468174
MICU1 mitochondrial calcium uptake 1 -0.00466975
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.00465939
GTDC1 glycosyltransferase-like domain containing 1 -0.00462003