Idoxuridine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.174016
RBM39 RNA binding motif protein 39 0.0833394
PCBP2 poly(rC) binding protein 2 0.079382
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0761574
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0674356
KDM3A lysine (K)-specific demethylase 3A 0.0673387
GOLGA4 golgin A4 0.0658984
APP amyloid beta (A4) precursor protein 0.0589337
SOD2 superoxide dismutase 2, mitochondrial 0.0569764
FNDC3B fibronectin type III domain containing 3B 0.0559944
RICTOR RPTOR independent companion of MTOR, complex 2 0.0542596
DSCAM Down syndrome cell adhesion molecule 0.0537798
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0537214
CD44 CD44 molecule (Indian blood group) 0.0500969
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0496809
KDM2A lysine (K)-specific demethylase 2A 0.0492447
ATP13A3 ATPase type 13A3 0.0462586
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0455133
ZFAND3 zinc finger, AN1-type domain 3 0.0442211
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0442096
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0438344
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0423291
ARHGAP5 Rho GTPase activating protein 5 0.0421037
ELL2 elongation factor, RNA polymerase II, 2 0.0406165
WAC WW domain containing adaptor with coiled-coil 0.0402524
KMT2C lysine (K)-specific methyltransferase 2C 0.0397102
USP34 ubiquitin specific peptidase 34 0.0396128
SMAD3 SMAD family member 3 0.0388134
UBE2H ubiquitin-conjugating enzyme E2H 0.0377614
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0364981
OSMR oncostatin M receptor 0.0362317
PRRC2C proline-rich coiled-coil 2C 0.0358544
CHD1 chromodomain helicase DNA binding protein 1 0.0354886
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0335756
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0319177
SIK3 SIK family kinase 3 0.0315099
OGA O-GlcNAcase 0.0313396
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0312579
CANX calnexin 0.0304476
YTHDC1 YTH domain containing 1 0.0300655
SPRED2 sprouty-related, EVH1 domain containing 2 0.0299887
CSDE1 cold shock domain containing E1, RNA-binding 0.02967
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0296573
BACE2 beta-site APP-cleaving enzyme 2 0.0293605
TJP1 tight junction protein 1 0.0291809
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.029145
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0288102
PDIA3 protein disulfide isomerase family A, member 3 0.0286387
FAM20C family with sequence similarity 20, member C 0.0286294
BZW1 basic leucine zipper and W2 domains 1 0.0283938
AGFG1 ArfGAP with FG repeats 1 0.0281694
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0280146
PICALM phosphatidylinositol binding clathrin assembly protein 0.0278609
RBM25 RNA binding motif protein 25 0.0274248
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0273599
TPR translocated promoter region, nuclear basket protein 0.0272073
SEC23A Sec23 homolog A (S. cerevisiae) 0.0270617
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0269622
EIF4H eukaryotic translation initiation factor 4H 0.0268259
ELP2 elongator acetyltransferase complex subunit 2 0.0266469
NPC1 Niemann-Pick disease, type C1 0.0265811
MARCHF6 membrane associated ring-CH-type finger 6 0.0260727
HAS2 hyaluronan synthase 2 0.0259524
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0254787
CEP95 centrosomal protein 95kDa 0.0254714
AKAP12 A kinase (PRKA) anchor protein 12 0.0254377
SREBF2 sterol regulatory element binding transcription factor 2 0.0254309
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0253919
USP3 ubiquitin specific peptidase 3 0.0253669
MARS1 methionyl-tRNA synthetase 1 0.0253258
MAPK8 mitogen-activated protein kinase 8 0.0251433
STRN3 striatin, calmodulin binding protein 3 0.0250916
SUCO SUN domain containing ossification factor 0.024967
COPA coatomer protein complex, subunit alpha 0.0249212
BIRC3 baculoviral IAP repeat containing 3 0.0249064
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0249039
CLTC clathrin, heavy chain (Hc) 0.0248867
RAB1A RAB1A, member RAS oncogene family 0.0248699
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0246769
SRP54 signal recognition particle 54kDa 0.0244981
RUNX1 runt-related transcription factor 1 0.0244288
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0236492
PELI1 pellino E3 ubiquitin protein ligase 1 0.023573
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0235236
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0235035
TRIO trio Rho guanine nucleotide exchange factor 0.0234439
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0232828
PTBP2 polypyrimidine tract binding protein 2 0.0231726
APLP2 amyloid beta (A4) precursor-like protein 2 0.0231686
PDE8A phosphodiesterase 8A 0.0230582
ITCH itchy E3 ubiquitin protein ligase 0.0230575
RERE arginine-glutamic acid dipeptide (RE) repeats 0.02296
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0229274
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0229224
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.022852
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0228441
RNF24 ring finger protein 24 0.0228284
RLF rearranged L-myc fusion 0.022778
ANKRD11 ankyrin repeat domain 11 0.0227451
DENND4A DENN/MADD domain containing 4A 0.0226902

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.147699
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147043
TMSB10 thymosin beta 10 -0.143486
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.101751
FN1 fibronectin 1 -0.0958894
CDH13 cadherin 13 -0.0910493
FTL ferritin, light polypeptide -0.0788788
HMGA2 high mobility group AT-hook 2 -0.0760284
PDE4D phosphodiesterase 4D, cAMP-specific -0.0748179
RPLP1 ribosomal protein, large, P1 -0.0669536
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0639673
DPYD dihydropyrimidine dehydrogenase -0.0631034
LOX lysyl oxidase -0.0612477
PSD3 pleckstrin and Sec7 domain containing 3 -0.0596834
RPS8 ribosomal protein S8 -0.0578172
RPS19 ribosomal protein S19 -0.0572169
IGFBP3 insulin-like growth factor binding protein 3 -0.0553433
SDK1 sidekick cell adhesion molecule 1 -0.0526388
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0525472
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0523853
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0496354
NDRG1 N-myc downstream regulated 1 -0.048443
NRG1 neuregulin 1 -0.0440442
S100A6 S100 calcium binding protein A6 -0.0434735
EGR1 early growth response 1 -0.0426111
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0422736
RPS6 ribosomal protein S6 -0.0414268
TGFB1 transforming growth factor, beta 1 -0.0399883
RPL36 ribosomal protein L36 -0.0393806
OXR1 oxidation resistance 1 -0.0385014
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0383112
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0381622
MSRB3 methionine sulfoxide reductase B3 -0.0373227
RPS25 ribosomal protein S25 -0.0372336
MTSS1 metastasis suppressor 1 -0.0366218
ZFP36L1 ZFP36 ring finger protein-like 1 -0.036208
PLIN2 perilipin 2 -0.0356432
MAML3 mastermind-like 3 (Drosophila) -0.03561
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0356091
MT2A metallothionein 2A -0.0355431
RPS29 ribosomal protein S29 -0.0354629
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0352079
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0350993
GNAS GNAS complex locus -0.0349209
PKM pyruvate kinase, muscle -0.0344675
RPS27 ribosomal protein S27 -0.0344147
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0340035
RPL28 ribosomal protein L28 -0.0338025
SYT1 synaptotagmin I -0.0337817
DST dystonin -0.0336769
RPL34 ribosomal protein L34 -0.0334476
MEF2A myocyte enhancer factor 2A -0.0334351
ASPH aspartate beta-hydroxylase -0.0331126
RPS17 ribosomal protein S17 -0.0320252
RPL35A ribosomal protein L35a -0.0312525
LGALS1 lectin, galactoside-binding, soluble, 1 -0.031222
SUMF1 sulfatase modifying factor 1 -0.0311883
TFPI2 tissue factor pathway inhibitor 2 -0.0305922
RPL31 ribosomal protein L31 -0.0305675
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0300704
RPL37A ribosomal protein L37a -0.0297988
RPL18 ribosomal protein L18 -0.0297875
DDIT3 DNA-damage-inducible transcript 3 -0.029617
NPAS2 neuronal PAS domain protein 2 -0.0295667
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0292834
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0286415
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0282676
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0279888
RPS12 ribosomal protein S12 -0.0277452
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.027394
HIPK2 homeodomain interacting protein kinase 2 -0.0269296
PRKCA protein kinase C, alpha -0.0268185
RPLP0 ribosomal protein, large, P0 -0.0267663
GPC6 glypican 6 -0.0262191
RACK1 receptor for activated C kinase 1 -0.0260185
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.025404
RASAL2 RAS protein activator like 2 -0.0252453
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0252346
FLNB filamin B, beta -0.0248715
DIAPH2 diaphanous-related formin 2 -0.0247547
RPL11 ribosomal protein L11 -0.0247289
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0247261
RPL7A ribosomal protein L7a -0.0240342
FTH1 ferritin, heavy polypeptide 1 -0.0238115
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0236506
SAMD9 sterile alpha motif domain containing 9 -0.0234674
NAV1 neuron navigator 1 -0.0229119
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0227966
CLMP CXADR-like membrane protein -0.0225629
EXOC4 exocyst complex component 4 -0.0225048
ZNF804A zinc finger protein 804A -0.0222649
MECOM MDS1 and EVI1 complex locus -0.0222633
TMSB4X thymosin beta 4, X-linked -0.0221326
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0221245
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0219987
TPI1 triosephosphate isomerase 1 -0.0218725
AADAC arylacetamide deacetylase -0.0218417
RPL12 ribosomal protein L12 -0.0217217
PTMA prothymosin, alpha -0.0215729
LOC112694756 uncharaterized LOC112694756 -0.0215425