Idoxuridine_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 0.140723
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.117433
AKAP12 A kinase (PRKA) anchor protein 12 0.103291
ZFAND3 zinc finger, AN1-type domain 3 0.0930438
RBM39 RNA binding motif protein 39 0.0913933
APP amyloid beta (A4) precursor protein 0.087434
PARD3 par-3 family cell polarity regulator 0.0853491
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0798739
VIM vimentin 0.0793347
GRAMD1B GRAM domain containing 1B 0.071623
LDHA lactate dehydrogenase A 0.0705223
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0690541
AHNAK AHNAK nucleoprotein 0.0678834
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0676173
TXNRD1 thioredoxin reductase 1 0.0667906
DSCAM Down syndrome cell adhesion molecule 0.065279
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0613557
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0610315
RICTOR RPTOR independent companion of MTOR, complex 2 0.0582657
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0563673
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0560618
FMNL2 formin-like 2 0.0557835
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0555228
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0547301
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0547064
KTN1 kinectin 1 (kinesin receptor) 0.0540633
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0522766
LPP LIM domain containing preferred translocation partner in lipoma 0.0521517
TPD52 tumor protein D52 0.0519519
WDR43 WD repeat domain 43 0.0516705
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0504344
CXCL8 chemokine (C-X-C motif) ligand 8 0.0503645
ANKRD11 ankyrin repeat domain 11 0.048706
EIF4A1 eukaryotic translation initiation factor 4A1 0.0484992
PTK2 protein tyrosine kinase 2 0.0469955
RPL4 ribosomal protein L4 0.0467894
S100A6 S100 calcium binding protein A6 0.0466902
RASAL2 RAS protein activator like 2 0.0465534
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0462768
ERBIN erbb2 interacting protein 0.0461489
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0459268
UBASH3B ubiquitin associated and SH3 domain containing B 0.0458978
SAMD4A sterile alpha motif domain containing 4A 0.0455674
AKAP13 A kinase (PRKA) anchor protein 13 0.0452302
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0452149
MACF1 microtubule-actin crosslinking factor 1 0.0450882
TRIO trio Rho guanine nucleotide exchange factor 0.0450203
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0434505
PUM1 pumilio RNA-binding family member 1 0.043376
KDM3A lysine (K)-specific demethylase 3A 0.0428266
HDAC9 histone deacetylase 9 0.0426563
GLG1 golgi glycoprotein 1 0.0425509
NOP58 NOP58 ribonucleoprotein 0.0417382
COPA coatomer protein complex, subunit alpha 0.0416475
PCBP2 poly(rC) binding protein 2 0.041279
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0412054
ERRFI1 ERBB receptor feedback inhibitor 1 0.0409511
EIF1 eukaryotic translation initiation factor 1 0.0408726
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0404698
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0396556
FLNB filamin B, beta 0.0396252
PDLIM5 PDZ and LIM domain 5 0.0395393
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0394373
FNDC3B fibronectin type III domain containing 3B 0.0389972
ZNF207 zinc finger protein 207 0.0386374
EXT1 exostosin glycosyltransferase 1 0.0384338
WAC WW domain containing adaptor with coiled-coil 0.0381001
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0376266
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0374077
RAD21 RAD21 homolog (S. pombe) 0.0368447
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0366105
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0358381
CAVIN1 caveolae associated protein 1 0.0358175
TM4SF1 transmembrane 4 L six family member 1 0.0356133
KYNU kynureninase 0.0355437
SIK3 SIK family kinase 3 0.0352698
THSD4 thrombospondin, type I, domain containing 4 0.0351915
ASPH aspartate beta-hydroxylase 0.0350716
FAM107B family with sequence similarity 107, member B 0.0350528
EWSR1 EWS RNA-binding protein 1 0.0349086
IER3 immediate early response 3 0.0348146
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0347377
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0347354
COG5 component of oligomeric golgi complex 5 0.03467
SEPTIN7 septin 7 0.0344404
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0339365
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0338011
RHEB Ras homolog enriched in brain 0.0337702
SBF2 SET binding factor 2 0.0334852
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0334715
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0334485
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0333151
PTPRM protein tyrosine phosphatase, receptor type, M 0.0331757
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0331374
WIPF2 WAS/WASL interacting protein family, member 2 0.0330546
UBAP2L ubiquitin associated protein 2-like 0.0329322
YBX3 Y box binding protein 3 0.0328825
MARCHF6 membrane associated ring-CH-type finger 6 0.0328298
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0327267
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0327004

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.104827
FTH1 ferritin, heavy polypeptide 1 -0.0688324
IGF2 insulin-like growth factor 2 -0.0574243
PDE4D phosphodiesterase 4D, cAMP-specific -0.0404845
PM20D1 peptidase M20 domain containing 1 -0.0357929
RPLP1 ribosomal protein, large, P1 -0.0325578
RPS8 ribosomal protein S8 -0.0256563
BIRC3 baculoviral IAP repeat containing 3 -0.0249836
HMGA1 high mobility group AT-hook 1 -0.0230664
PFN1 profilin 1 -0.0224003
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.021197
RPL36 ribosomal protein L36 -0.0204258
S100A11 S100 calcium binding protein A11 -0.0189947
RPS29 ribosomal protein S29 -0.0188903
EGR1 early growth response 1 -0.0182556
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0181516
RPS19 ribosomal protein S19 -0.0180701
KIAA0319 KIAA0319 -0.017677
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0169251
RPS12 ribosomal protein S12 -0.0167377
WWOX WW domain containing oxidoreductase -0.016674
RPS2 ribosomal protein S2 -0.0162327
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0155374
ROMO1 reactive oxygen species modulator 1 -0.0152593
RPL19 ribosomal protein L19 -0.0151417
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0147848
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0144671
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0142729
RPL23 ribosomal protein L23 -0.013431
RPL28 ribosomal protein L28 -0.0133431
CNRIP1 cannabinoid receptor interacting protein 1 -0.0130814
RPL9 ribosomal protein L9 -0.0129124
S100A9 S100 calcium binding protein A9 -0.0120883
RPLP2 ribosomal protein, large, P2 -0.0116604
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0115297
CCSER1 coiled-coil serine-rich protein 1 -0.0114588
ACLY ATP citrate lyase -0.0110656
RPS6 ribosomal protein S6 -0.0109156
ISG15 ISG15 ubiquitin-like modifier -0.0108683
RSPO3 R-spondin 3 -0.0107723
KIFC3 kinesin family member C3 -0.0107266
NFIA nuclear factor I/A -0.0106729
RPS25 ribosomal protein S25 -0.0105768
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.0105214
HMGB1 high mobility group box 1 -0.0104233
CYB5R3 cytochrome b5 reductase 3 -0.0103622
LDHB lactate dehydrogenase B -0.0103127
TBK1 TANK-binding kinase 1 -0.0102077
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0100673
LRMDA leucine rich melanocyte differentiation associated -0.00988089
MKI67 marker of proliferation Ki-67 -0.00986369
FOSL1 FOS-like antigen 1 -0.00977137
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00941503
SAMD12 sterile alpha motif domain containing 12 -0.00925995
ATP5MG ATP synthase membrane subunit g -0.00897046
DSE dermatan sulfate epimerase -0.00896743
RPS20 ribosomal protein S20 -0.00895721
BMP5 bone morphogenetic protein 5 -0.00895511
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.00891118
NNMT nicotinamide N-methyltransferase -0.00873375
RPL37A ribosomal protein L37a -0.00856217
RHOBTB3 Rho-related BTB domain containing 3 -0.00852461
EPGN epithelial mitogen -0.00838295
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -0.00835419
ATN1 atrophin 1 -0.00829759
LAMA5 laminin, alpha 5 -0.00828073
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.0082419
CISD1 CDGSH iron sulfur domain 1 -0.00814385
NCEH1 neutral cholesterol ester hydrolase 1 -0.00804428
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.00800475
CKLF chemokine-like factor -0.00797629
HDGF hepatoma-derived growth factor -0.00795326
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -0.00789628
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.00787422
EIF3K eukaryotic translation initiation factor 3, subunit K -0.00787106
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -0.00785981
RIGI RNA sensor RIG-I -0.00766404
RPS27L ribosomal protein S27-like -0.00755775
HEXIM1 hexamethylene bis-acetamide inducible 1 -0.0075396
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.00739158
CCDC68 coiled-coil domain containing 68 -0.00734688
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.00733717
TSLIG2 tRNA splicing ligase complex subunit 2 -0.00733591
FHIT fragile histidine triad -0.00731199
KIAA1328 KIAA1328 -0.00715339
MRPL13 mitochondrial ribosomal protein L13 -0.00713561
HSPE1 heat shock 10kDa protein 1 -0.00709948
ATP5F1E ATP synthase F1 subunit epsilon -0.0070994
FGFR2 fibroblast growth factor receptor 2 -0.0070805
GOLM2 golgi membrane protein 2 -0.0070744
PEA15 phosphoprotein enriched in astrocytes 15 -0.0070335
CHMP1B charged multivesicular body protein 1B -0.00702622
ACYP2 acylphosphatase 2, muscle type -0.0070195
B2M beta-2-microglobulin -0.00698982
GSTP1 glutathione S-transferase pi 1 -0.00697911
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.00691636
TUSC3 tumor suppressor candidate 3 -0.00690585
R3HDM1 R3H domain containing 1 -0.00690166
ATP5MF ATP synthase membrane subunit f -0.00685805
FKBP11 FK506 binding protein 11, 19 kDa -0.00684436