Idoxuridine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.140497
GRB10 growth factor receptor-bound protein 10 0.0921817
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0914216
AKAP9 A kinase (PRKA) anchor protein 9 0.0802141
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0788643
CEMIP cell migration inducing protein, hyaluronan binding 0.0738599
LAMC2 laminin, gamma 2 0.0590017
KYNU kynureninase 0.0577938
GOLGA4 golgin A4 0.0563293
USP9X ubiquitin specific peptidase 9, X-linked 0.0548188
FTL ferritin, light polypeptide 0.0528755
KDM3A lysine (K)-specific demethylase 3A 0.0522746
FNDC3B fibronectin type III domain containing 3B 0.0484614
BZW1 basic leucine zipper and W2 domains 1 0.0483285
PLAUR plasminogen activator, urokinase receptor 0.0481906
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0481252
HOOK2 hook microtubule-tethering protein 2 0.047692
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0470775
TPT1 tumor protein, translationally-controlled 1 0.0465309
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0449469
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0439279
ESYT2 extended synaptotagmin-like protein 2 0.0438385
SEC31A SEC31 homolog A (S. cerevisiae) 0.0435018
PCBP2 poly(rC) binding protein 2 0.0429529
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0424506
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0412575
CANX calnexin 0.040848
ZMYM2 zinc finger, MYM-type 2 0.0397145
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0392714
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0377607
RNF149 ring finger protein 149 0.0377544
ZNF292 zinc finger protein 292 0.0374772
KDM2A lysine (K)-specific demethylase 2A 0.0373873
PTMA prothymosin, alpha 0.0370185
ERRFI1 ERBB receptor feedback inhibitor 1 0.0365265
KDM6A lysine (K)-specific demethylase 6A 0.0364673
FRY furry homolog (Drosophila) 0.0358144
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0351127
ABI1 abl-interactor 1 0.0346638
ITCH itchy E3 ubiquitin protein ligase 0.0341203
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0340662
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0337233
PDIA6 protein disulfide isomerase family A, member 6 0.033064
DSCAM Down syndrome cell adhesion molecule 0.0328698
EIF1 eukaryotic translation initiation factor 1 0.0326772
RPS16 ribosomal protein S16 0.0319638
RYBP RING1 and YY1 binding protein 0.0316599
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0315136
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0314297
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0312544
NAMPT nicotinamide phosphoribosyltransferase 0.0312463
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0308054
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0305356
ARHGAP21 Rho GTPase activating protein 21 0.030486
SCFD1 sec1 family domain containing 1 0.0302988
UBC ubiquitin C 0.0302093
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0296072
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0295903
RPLP2 ribosomal protein, large, P2 0.0295725
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0294458
ZMYND8 zinc finger, MYND-type containing 8 0.0291566
ANTXR2 anthrax toxin receptor 2 0.0289067
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0286656
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0285302
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.027863
RPS13 ribosomal protein S13 0.027849
RPLP1 ribosomal protein, large, P1 0.0277569
ANXA1 annexin A1 0.0277087
MYOF myoferlin 0.0274697
KRT17 keratin 17, type I 0.0272431
S100A6 S100 calcium binding protein A6 0.027064
DSPP dentin sialophosphoprotein 0.0269181
HLA-A major histocompatibility complex, class I, A 0.0267922
DDIT4 DNA-damage-inducible transcript 4 0.026767
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0267613
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0266883
H3-3B H3.3 histone B 0.0266351
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0266272
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0266194
PEAK1 pseudopodium-enriched atypical kinase 1 0.0261771
ATP13A3 ATPase type 13A3 0.0260465
SHB Src homology 2 domain containing adaptor protein B 0.0260218
ZCCHC7 zinc finger, CCHC domain containing 7 0.0260146
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0258627
FBL fibrillarin 0.0258598
RPL26 ribosomal protein L26 0.0257375
RPL37A ribosomal protein L37a 0.0257019
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0256611
RPS3 ribosomal protein S3 0.0254436
SPAG9 sperm associated antigen 9 0.0253867
F3 coagulation factor III (thromboplastin, tissue factor) 0.0253081
GCC2 GRIP and coiled-coil domain containing 2 0.02523
F11R F11 receptor 0.0251519
ABHD17C abhydrolase domain containing 17C 0.0250298
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.024895
PPARD peroxisome proliferator-activated receptor delta 0.0248795
MYH9 myosin, heavy chain 9, non-muscle 0.024817
RPL12 ribosomal protein L12 0.0245064
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0243585
STK24 serine/threonine kinase 24 0.0243299

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.12161
LMO7 LIM domain 7 -0.110305
SLTM SAFB-like, transcription modulator -0.0687186
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0664335
DPYD dihydropyrimidine dehydrogenase -0.0622624
COL6A3 collagen, type VI, alpha 3 -0.057583
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.053735
FN1 fibronectin 1 -0.0529986
HMGA2 high mobility group AT-hook 2 -0.0521854
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.049479
AKAP12 A kinase (PRKA) anchor protein 12 -0.0480649
VIM vimentin -0.0456901
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0450721
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0446284
PDE4D phosphodiesterase 4D, cAMP-specific -0.0443347
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0433087
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0428831
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0423463
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0415487
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0413379
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0397472
DENND5B DENN/MADD domain containing 5B -0.0389716
VCL vinculin -0.0367999
TTC3 tetratricopeptide repeat domain 3 -0.0366778
ZNFX1 zinc finger, NFX1-type containing 1 -0.0358021
CALD1 caldesmon 1 -0.03559
RUNX1 runt-related transcription factor 1 -0.0354856
NALF1 NALCN channel auxiliary factor 1 -0.0353316
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0352808
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0350542
NPAS2 neuronal PAS domain protein 2 -0.0350473
STC1 stanniocalcin 1 -0.0342723
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0342666
MYO9A myosin IXA -0.0336945
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0328748
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0327879
OSBPL8 oxysterol binding protein-like 8 -0.0321212
INHBA inhibin, beta A -0.0315592
RNF216 ring finger protein 216 -0.0315162
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0313576
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0313085
FRMD5 FERM domain containing 5 -0.031194
NABP1 nucleic acid binding protein 1 -0.031131
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.030862
NSD3 nuclear receptor binding SET domain protein 3 -0.0307771
NHSL1 NHS-like 1 -0.0306861
RBM25 RNA binding motif protein 25 -0.030663
RRBP1 ribosome binding protein 1 -0.0305268
MAML2 mastermind-like 2 (Drosophila) -0.03048
TXNRD1 thioredoxin reductase 1 -0.0304169
TXNIP thioredoxin interacting protein -0.0302899
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0298837
JAK1 Janus kinase 1 -0.0298619
MACC1 metastasis associated in colon cancer 1 -0.0297992
TNRC6B trinucleotide repeat containing 6B -0.0296152
AHI1 Abelson helper integration site 1 -0.0295581
STK17A serine/threonine kinase 17a -0.0294087
TULP4 tubby like protein 4 -0.0292698
JMJD1C jumonji domain containing 1C -0.0290556
KATNBL1 katanin p80 subunit B-like 1 -0.0288321
THSD4 thrombospondin, type I, domain containing 4 -0.0286853
EPS8 epidermal growth factor receptor pathway substrate 8 -0.02856
MYO1B myosin IB -0.0285273
RANBP2 RAN binding protein 2 -0.0284869
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0280826
MICU1 mitochondrial calcium uptake 1 -0.0279721
BPTF bromodomain PHD finger transcription factor -0.0278909
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0278598
PDS5B PDS5 cohesin associated factor B -0.0277134
CUL5 cullin 5 -0.0276161
ZBTB38 zinc finger and BTB domain containing 38 -0.0275955
CCDC6 coiled-coil domain containing 6 -0.0274985
PKM pyruvate kinase, muscle -0.0274635
MAML3 mastermind-like 3 (Drosophila) -0.0273609
ACTN1 actinin, alpha 1 -0.0273259
RAB7A RAB7A, member RAS oncogene family -0.0273213
SOS1 son of sevenless homolog 1 (Drosophila) -0.0268351
FAM204A family with sequence similarity 204, member A -0.0263926
ECPAS Ecm29 proteasome adaptor and scaffold -0.0263057
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0262949
SYT1 synaptotagmin I -0.0262536
PRKG1 protein kinase, cGMP-dependent, type I -0.0262246
CD44 CD44 molecule (Indian blood group) -0.0261098
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.026057
LRP12 low density lipoprotein receptor-related protein 12 -0.0259849
BRWD1 bromodomain and WD repeat domain containing 1 -0.0257204
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0256705
TMEM165 transmembrane protein 165 -0.0256328
PDE8A phosphodiesterase 8A -0.0255604
TBC1D5 TBC1 domain family, member 5 -0.0255422
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0254278
RPS12 ribosomal protein S12 -0.0254002
BIN3 bridging integrator 3 -0.025285
SP100 SP100 nuclear antigen -0.0252135
MEIS1 Meis homeobox 1 -0.0251788
PEG10 paternally expressed 10 -0.0246975
ARFGEF3 ARFGEF family member 3 -0.0245732
USP24 ubiquitin specific peptidase 24 -0.0243228
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.0242662
NPC1 Niemann-Pick disease, type C1 -0.0240707