Idoxuridine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.179473
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.147458
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0971098
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0912962
TXNRD1 thioredoxin reductase 1 0.0890638
PCBP2 poly(rC) binding protein 2 0.0883275
ERRFI1 ERBB receptor feedback inhibitor 1 0.0855954
AHNAK AHNAK nucleoprotein 0.0837217
RAD51B RAD51 paralog B 0.0750528
KTN1 kinectin 1 (kinesin receptor) 0.0743997
TRIO trio Rho guanine nucleotide exchange factor 0.0742175
TPM3 tropomyosin 3 0.0713995
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0671719
XPO1 exportin 1 0.0649222
GRAMD1B GRAM domain containing 1B 0.0631767
CSDE1 cold shock domain containing E1, RNA-binding 0.0615059
KDM2A lysine (K)-specific demethylase 2A 0.0606498
COPA coatomer protein complex, subunit alpha 0.0552
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0522567
ZCCHC7 zinc finger, CCHC domain containing 7 0.0512356
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0504237
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0485305
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0474943
UBC ubiquitin C 0.0453022
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0451111
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0446084
USP34 ubiquitin specific peptidase 34 0.0442084
MORF4L2 mortality factor 4 like 2 0.0429
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0426104
EEF2 eukaryotic translation elongation factor 2 0.0422205
OGA O-GlcNAcase 0.0415455
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0415274
MYH9 myosin, heavy chain 9, non-muscle 0.0410934
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0405898
CANX calnexin 0.0402134
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0396655
RBM39 RNA binding motif protein 39 0.0394933
JMJD1C jumonji domain containing 1C 0.0387067
SMAD3 SMAD family member 3 0.0386297
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0382186
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0382139
EIF4B eukaryotic translation initiation factor 4B 0.0381133
CSNK1A1 casein kinase 1, alpha 1 0.0380534
SET SET nuclear proto-oncogene 0.0371985
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0370439
UBE2H ubiquitin-conjugating enzyme E2H 0.0365577
PGK1 phosphoglycerate kinase 1 0.0359636
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0359617
MACF1 microtubule-actin crosslinking factor 1 0.0358958
APP amyloid beta (A4) precursor protein 0.0358365
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0345013
PTK2 protein tyrosine kinase 2 0.0344602
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0343303
SPAG9 sperm associated antigen 9 0.0339703
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0334568
ANO6 anoctamin 6 0.0333303
RPL3 ribosomal protein L3 0.0331562
RPL4 ribosomal protein L4 0.032921
PUM2 pumilio RNA-binding family member 2 0.0328286
NCAPD2 non-SMC condensin I complex, subunit D2 0.0326932
CLTC clathrin, heavy chain (Hc) 0.03232
BIRC6 baculoviral IAP repeat containing 6 0.0323069
FMNL2 formin-like 2 0.0321088
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0318153
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.031581
ANKRD36 ankyrin repeat domain 36 0.0309917
LDHA lactate dehydrogenase A 0.0308203
VMP1 vacuole membrane protein 1 0.0301731
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0298602
SFPQ splicing factor proline/glutamine-rich 0.0295048
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0288981
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0287542
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0287493
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0285097
FXR1 fragile X mental retardation, autosomal homolog 1 0.0283752
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0283
ADAR adenosine deaminase, RNA-specific 0.0282779
USP9X ubiquitin specific peptidase 9, X-linked 0.0277781
ENO1 enolase 1, (alpha) 0.0276423
RSF1 remodeling and spacing factor 1 0.0276338
ANXA5 annexin A5 0.0276205
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0274404
NUP58 nucleoporin 58 0.0273238
KDM3A lysine (K)-specific demethylase 3A 0.0269183
ZNF292 zinc finger protein 292 0.0268997
TLN1 talin 1 0.0267204
CKAP5 cytoskeleton associated protein 5 0.0263029
RBM25 RNA binding motif protein 25 0.0262532
RTN4 reticulon 4 0.0261735
ZNF638 zinc finger protein 638 0.0259771
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0257944
HELZ helicase with zinc finger 0.0257846
ACTN1 actinin, alpha 1 0.025373
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0253123
KMT2C lysine (K)-specific methyltransferase 2C 0.0252698
ITCH itchy E3 ubiquitin protein ligase 0.0250677
ATP13A3 ATPase type 13A3 0.0250071
CEP192 centrosomal protein 192kDa 0.0249711
GDI2 GDP dissociation inhibitor 2 0.0248494
XPOT exportin, tRNA 0.0248263

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.325034
TMSB10 thymosin beta 10 -0.122874
TFPI2 tissue factor pathway inhibitor 2 -0.104699
EGR1 early growth response 1 -0.0908883
RPL35A ribosomal protein L35a -0.0767718
RPLP1 ribosomal protein, large, P1 -0.0606961
RPS15 ribosomal protein S15 -0.0590408
RPS29 ribosomal protein S29 -0.0544058
RPL37A ribosomal protein L37a -0.0499422
RPS21 ribosomal protein S21 -0.0499006
RPS10 ribosomal protein S10 -0.0468947
RPL34 ribosomal protein L34 -0.0444647
RPL19 ribosomal protein L19 -0.0436668
MT2A metallothionein 2A -0.043562
RPLP2 ribosomal protein, large, P2 -0.0433751
RPS8 ribosomal protein S8 -0.0432994
RPS19 ribosomal protein S19 -0.0398935
RPS6 ribosomal protein S6 -0.0385908
PTMA prothymosin, alpha -0.0380818
MYL12B myosin, light chain 12B, regulatory -0.0375847
RPL37 ribosomal protein L37 -0.0367027
FTL ferritin, light polypeptide -0.034993
S100A11 S100 calcium binding protein A11 -0.0337246
TPT1 tumor protein, translationally-controlled 1 -0.0337068
RPL38 ribosomal protein L38 -0.0333693
RPL36 ribosomal protein L36 -0.0327464
RPS23 ribosomal protein S23 -0.0319604
HLA-B major histocompatibility complex, class I, B -0.0319291
RPLP0 ribosomal protein, large, P0 -0.0318298
RPL32 ribosomal protein L32 -0.030532
PFN1 profilin 1 -0.0304802
RPS13 ribosomal protein S13 -0.0294248
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0293661
RPL9 ribosomal protein L9 -0.0292498
RPL23 ribosomal protein L23 -0.0288827
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.028837
RPS25 ribosomal protein S25 -0.0286405
RPS27 ribosomal protein S27 -0.0277513
RPL31 ribosomal protein L31 -0.0276235
IER3 immediate early response 3 -0.0265597
RPL28 ribosomal protein L28 -0.0251229
ATP5F1E ATP synthase F1 subunit epsilon -0.0247784
RPS27A ribosomal protein S27a -0.0247532
IGF2 insulin-like growth factor 2 -0.0244971
RPL8 ribosomal protein L8 -0.0234207
RPS24 ribosomal protein S24 -0.0230144
RPL36A ribosomal protein L36a -0.0228056
RPL26 ribosomal protein L26 -0.0222577
RPS14 ribosomal protein S14 -0.0220383
IFI6 interferon, alpha-inducible protein 6 -0.0217623
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0213717
RPL12 ribosomal protein L12 -0.0211003
RPL11 ribosomal protein L11 -0.0203848
FUS FUS RNA binding protein -0.020277
RPS16 ribosomal protein S16 -0.0201475
RPS17 ribosomal protein S17 -0.0201159
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0201121
GSTP1 glutathione S-transferase pi 1 -0.0199967
EIF1 eukaryotic translation initiation factor 1 -0.0193073
RPL35 ribosomal protein L35 -0.0193047
RPS20 ribosomal protein S20 -0.0192813
VDAC1 voltage-dependent anion channel 1 -0.0190676
PRH1 proline-rich protein HaeIII subfamily 1 -0.0182366
SEC61G Sec61 gamma subunit -0.0182252
ACTG1 actin gamma 1 -0.0182204
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0181543
HMGB1 high mobility group box 1 -0.0179768
EIF5B eukaryotic translation initiation factor 5B -0.0179102
RACK1 receptor for activated C kinase 1 -0.0176605
RPL13A ribosomal protein L13a -0.0172965
RPL30 ribosomal protein L30 -0.0170319
UBB ubiquitin B -0.0170264
RPL5 ribosomal protein L5 -0.0160773
CCND1 cyclin D1 -0.0159949
RPS3 ribosomal protein S3 -0.0156211
GNAS GNAS complex locus -0.0154833
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0153455
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0151887
TAPBP TAP binding protein (tapasin) -0.0151656
WNT2B wingless-type MMTV integration site family, member 2B -0.0150546
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0149361
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0149302
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0146171
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0146063
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.014391
S100A10 S100 calcium binding protein A10 -0.0142812
COX5B cytochrome c oxidase subunit Vb -0.0140466
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0140292
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0138558
FAM162A family with sequence similarity 162, member A -0.0138358
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.0136853
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0133572
RPL7A ribosomal protein L7a -0.013162
CCNI cyclin I -0.0129989
ASTN2 astrotactin 2 -0.0127053
RPS2 ribosomal protein S2 -0.0125979
TBCA tubulin folding cofactor A -0.0125252
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0120826
RPS26 ribosomal protein S26 -0.0120606
NDUFA4 NDUFA4, mitochondrial complex associated -0.0120437