Idoxuridine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.210083
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.160297
NDRG1 N-myc downstream regulated 1 0.138357
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.109912
ASPH aspartate beta-hydroxylase 0.100018
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0980137
POTEF POTE ankyrin domain family, member F 0.0850758
UBC ubiquitin C 0.0839547
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0793099
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.072769
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0639808
SDC4 syndecan 4 0.0599102
TXNRD1 thioredoxin reductase 1 0.0561191
ADAM9 ADAM metallopeptidase domain 9 0.0517052
LAMC2 laminin, gamma 2 0.0508907
PGK1 phosphoglycerate kinase 1 0.0492317
LDHA lactate dehydrogenase A 0.045374
TFG TRK-fused gene 0.0445127
LAMB3 laminin, beta 3 0.0444506
MARCHF6 membrane associated ring-CH-type finger 6 0.044063
ELL2 elongation factor, RNA polymerase II, 2 0.0435974
AHNAK AHNAK nucleoprotein 0.0425415
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0422166
TACSTD2 tumor-associated calcium signal transducer 2 0.0413946
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0407066
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0393376
NAMPT nicotinamide phosphoribosyltransferase 0.038598
ATP13A3 ATPase type 13A3 0.0367046
UBA6 ubiquitin-like modifier activating enzyme 6 0.0362031
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0346364
RICTOR RPTOR independent companion of MTOR, complex 2 0.034558
UPP1 uridine phosphorylase 1 0.0341855
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0340751
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0328966
ARHGAP29 Rho GTPase activating protein 29 0.0326175
NCKAP1 NCK-associated protein 1 0.0322116
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0307863
IQGAP1 IQ motif containing GTPase activating protein 1 0.0300439
ANXA1 annexin A1 0.0297383
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0295224
APLP2 amyloid beta (A4) precursor-like protein 2 0.0294492
ANXA5 annexin A5 0.0290188
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.028825
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0282702
RYBP RING1 and YY1 binding protein 0.0282222
DSCAM Down syndrome cell adhesion molecule 0.0280955
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0280654
SLC38A1 solute carrier family 38, member 1 0.027994
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0278379
S100A6 S100 calcium binding protein A6 0.0278307
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0277905
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.02762
NAP1L1 nucleosome assembly protein 1-like 1 0.027157
EZR ezrin 0.0270665
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0269255
RBM39 RNA binding motif protein 39 0.0266999
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0265733
UGCG UDP-glucose ceramide glucosyltransferase 0.0264959
ABI1 abl-interactor 1 0.0263694
ARRDC3 arrestin domain containing 3 0.0261002
DSPP dentin sialophosphoprotein 0.026016
TOP1 topoisomerase (DNA) I 0.0260074
APP amyloid beta (A4) precursor protein 0.0259775
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0258359
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0257828
USP3 ubiquitin specific peptidase 3 0.0257261
G0S2 G0/G1 switch 2 0.0253063
RNF145 ring finger protein 145 0.0245339
SEPTIN7 septin 7 0.0244105
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0241382
RASA2 RAS p21 protein activator 2 0.0238884
SNX9 sorting nexin 9 0.0237995
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0237294
DSG2 desmoglein 2 0.0237201
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0236123
EIF4A2 eukaryotic translation initiation factor 4A2 0.023472
MATR3 matrin 3 0.0232653
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0230749
NUP58 nucleoporin 58 0.0230034
ECT2 epithelial cell transforming 2 0.022486
SFTPA2 surfactant protein A2 0.0220448
HMGA1 high mobility group AT-hook 1 0.0219631
YTHDC1 YTH domain containing 1 0.0219419
CCNL1 cyclin L1 0.0219347
EIF4A1 eukaryotic translation initiation factor 4A1 0.0219181
TNPO1 transportin 1 0.0216707
CDK17 cyclin-dependent kinase 17 0.0213377
AZIN1 antizyme inhibitor 1 0.021335
MYO5B myosin VB 0.0209327
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0206371
RPS23 ribosomal protein S23 0.020566
SGMS2 sphingomyelin synthase 2 0.0205205
PCBP2 poly(rC) binding protein 2 0.0202987
EMP1 epithelial membrane protein 1 0.0202379
SPAG9 sperm associated antigen 9 0.0202239
IRF6 interferon regulatory factor 6 0.0201068
DIAPH1 diaphanous-related formin 1 0.0199534
RAD23B RAD23 homolog B (S. cerevisiae) 0.0199042
RAD21 RAD21 homolog (S. pombe) 0.019872
TM4SF1 transmembrane 4 L six family member 1 0.0198638

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.135976
FTL ferritin, light polypeptide -0.129322
PTMA prothymosin, alpha -0.117974
LPP LIM domain containing preferred translocation partner in lipoma -0.0986165
SAMD4A sterile alpha motif domain containing 4A -0.0881669
EXT1 exostosin glycosyltransferase 1 -0.0771913
LIMCH1 LIM and calponin homology domains 1 -0.0747545
RPL35A ribosomal protein L35a -0.0702678
TMSB4X thymosin beta 4, X-linked -0.0612562
RPS3 ribosomal protein S3 -0.0567523
RPL37A ribosomal protein L37a -0.0560441
ISG15 ISG15 ubiquitin-like modifier -0.0522431
PDLIM5 PDZ and LIM domain 5 -0.0514363
EFNA5 ephrin-A5 -0.0494477
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0488651
RPS12 ribosomal protein S12 -0.0484083
RPL36 ribosomal protein L36 -0.0467037
VCL vinculin -0.0466639
ACTG1 actin gamma 1 -0.0464521
RPL34 ribosomal protein L34 -0.0463205
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0425891
RPS8 ribosomal protein S8 -0.0422297
CSTB cystatin B (stefin B) -0.0417983
IFITM3 interferon induced transmembrane protein 3 -0.0388294
FBXO34 F-box protein 34 -0.038075
WSB1 WD repeat and SOCS box containing 1 -0.0377228
RPL19 ribosomal protein L19 -0.0376888
RPS25 ribosomal protein S25 -0.037327
FBXO32 F-box protein 32 -0.0365781
RPS17 ribosomal protein S17 -0.0362461
GNAS GNAS complex locus -0.0355006
RPL37 ribosomal protein L37 -0.0351555
FNIP1 folliculin interacting protein 1 -0.0338389
S100A9 S100 calcium binding protein A9 -0.0335874
RPS29 ribosomal protein S29 -0.0331399
RPLP1 ribosomal protein, large, P1 -0.0328767
ARHGAP20 Rho GTPase activating protein 20 -0.0325637
PALLD palladin, cytoskeletal associated protein -0.0322695
RPS27 ribosomal protein S27 -0.0319863
RPS6 ribosomal protein S6 -0.0318898
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0316865
GOLGB1 golgin B1 -0.0315318
RAI14 retinoic acid induced 14 -0.0312371
RPS19 ribosomal protein S19 -0.0308652
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0307583
IFI27 interferon, alpha-inducible protein 27 -0.0297322
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0294818
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0294714
ARID4B AT rich interactive domain 4B (RBP1-like) -0.029364
MYO1E myosin IE -0.0293256
RPLP2 ribosomal protein, large, P2 -0.0291932
GPX4 glutathione peroxidase 4 -0.0290506
TPM4 tropomyosin 4 -0.0288685
RPL12 ribosomal protein L12 -0.0288527
TMEM165 transmembrane protein 165 -0.0287925
RAB7A RAB7A, member RAS oncogene family -0.0286792
INTS6 integrator complex subunit 6 -0.0276722
MCU mitochondrial calcium uniporter -0.0276292
RPL35 ribosomal protein L35 -0.0273496
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0270495
TPI1 triosephosphate isomerase 1 -0.0262903
ZBTB20 zinc finger and BTB domain containing 20 -0.0261104
IFI6 interferon, alpha-inducible protein 6 -0.0259463
CDK13 cyclin-dependent kinase 13 -0.0255397
RPS13 ribosomal protein S13 -0.0253597
HSPB1 heat shock 27kDa protein 1 -0.0253171
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0252335
SOX4 SRY (sex determining region Y)-box 4 -0.0252054
GRB10 growth factor receptor-bound protein 10 -0.0252005
C15ORF48 chromosome 15 open reading frame 48 -0.0251194
TTC3 tetratricopeptide repeat domain 3 -0.0247281
CTBP2 C-terminal binding protein 2 -0.024605
RPS27A ribosomal protein S27a -0.0245128
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0241616
RPS20 ribosomal protein S20 -0.0241326
RACK1 receptor for activated C kinase 1 -0.0241315
RPL9 ribosomal protein L9 -0.0240617
RPL23 ribosomal protein L23 -0.0239646
AFF1 AF4/FMR2 family, member 1 -0.023572
RPS16 ribosomal protein S16 -0.0232658
IFI16 interferon, gamma-inducible protein 16 -0.0231469
RPL31 ribosomal protein L31 -0.022402
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0223488
RPL27A ribosomal protein L27a -0.022333
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0221089
RAD51B RAD51 paralog B -0.0219126
ETV6 ets variant 6 -0.0218711
CAVIN1 caveolae associated protein 1 -0.0218598
BBX bobby sox homolog (Drosophila) -0.0217997
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.021796
CD2AP CD2-associated protein -0.021678
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0214352
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0211415
BASP1 brain abundant, membrane attached signal protein 1 -0.0209236
RPL15 ribosomal protein L15 -0.0208256
FAM114A1 family with sequence similarity 114, member A1 -0.0207273
FAM13A family with sequence similarity 13, member A -0.0207234
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0207111
KMT2C lysine (K)-specific methyltransferase 2C -0.0205127
OSBPL3 oxysterol binding protein-like 3 -0.020343