Idoxuridine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.145888
EFNA5 ephrin-A5 0.137537
ASPH aspartate beta-hydroxylase 0.127662
GDA guanine deaminase 0.0933297
TRIO trio Rho guanine nucleotide exchange factor 0.0789365
NAMPT nicotinamide phosphoribosyltransferase 0.0777487
GRAMD1B GRAM domain containing 1B 0.0661164
TXNRD1 thioredoxin reductase 1 0.0653423
NEK7 NIMA-related kinase 7 0.0626383
DST dystonin 0.0620707
KYNU kynureninase 0.0593709
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.058287
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0579787
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0528814
MYOF myoferlin 0.0497485
LIMCH1 LIM and calponin homology domains 1 0.0485409
COL8A1 collagen, type VIII, alpha 1 0.048055
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.047493
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0461258
SAMD4A sterile alpha motif domain containing 4A 0.0458284
PSD3 pleckstrin and Sec7 domain containing 3 0.0439156
CXCL8 chemokine (C-X-C motif) ligand 8 0.0438203
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0413703
FNDC3B fibronectin type III domain containing 3B 0.0389032
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0385889
TFPI2 tissue factor pathway inhibitor 2 0.0381466
ELL2 elongation factor, RNA polymerase II, 2 0.0379891
MFF mitochondrial fission factor 0.0378445
TGFBR1 transforming growth factor, beta receptor 1 0.0376677
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0376288
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0367312
PDE10A phosphodiesterase 10A 0.0367041
RTN4 reticulon 4 0.0363621
AHNAK AHNAK nucleoprotein 0.0363034
PCBP2 poly(rC) binding protein 2 0.0362355
TM4SF1 transmembrane 4 L six family member 1 0.0361267
LDHA lactate dehydrogenase A 0.0360561
DOCK4 dedicator of cytokinesis 4 0.0355874
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0355362
PDLIM5 PDZ and LIM domain 5 0.0351086
FLNB filamin B, beta 0.0347261
NRCAM neuronal cell adhesion molecule 0.0344182
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0343051
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0340548
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0338697
OGA O-GlcNAcase 0.0322236
CTSC cathepsin C 0.032045
PGK1 phosphoglycerate kinase 1 0.0318456
BCAR3 breast cancer anti-estrogen resistance 3 0.0317395
BZW1 basic leucine zipper and W2 domains 1 0.03136
PM20D1 peptidase M20 domain containing 1 0.0313372
ITPRID2 ITPR interacting domain containing 2 0.0310352
COL4A5 collagen, type IV, alpha 5 0.0309267
TNPO1 transportin 1 0.0300278
ENAH enabled homolog (Drosophila) 0.0297802
CANX calnexin 0.0294593
NPAS2 neuronal PAS domain protein 2 0.0292707
CD109 CD109 molecule 0.0290191
SFPQ splicing factor proline/glutamine-rich 0.0284195
PCBP3 poly(rC) binding protein 3 0.0283642
RAB3B RAB3B, member RAS oncogene family 0.027718
ARHGAP29 Rho GTPase activating protein 29 0.0274718
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0273934
CARD16 caspase recruitment domain family, member 16 0.027185
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0266591
PRRC2C proline-rich coiled-coil 2C 0.0265782
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0262447
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0258003
RPL4 ribosomal protein L4 0.0256399
EIF4A1 eukaryotic translation initiation factor 4A1 0.0252719
USP9X ubiquitin specific peptidase 9, X-linked 0.0250635
RBM39 RNA binding motif protein 39 0.0249248
CENPF centromere protein F, 350/400kDa 0.0248132
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0246919
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0243731
TBXT T-box transcription factor T 0.0243333
APP amyloid beta (A4) precursor protein 0.0242083
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0241514
MAML3 mastermind-like 3 (Drosophila) 0.0240948
ANKRD28 ankyrin repeat domain 28 0.0239434
PTEN phosphatase and tensin homolog 0.0239315
ERRFI1 ERBB receptor feedback inhibitor 1 0.0238538
COL4A6 collagen, type IV, alpha 6 0.023708
PHF20 PHD finger protein 20 0.0234063
MCL1 myeloid cell leukemia 1 0.0234037
TRIP12 thyroid hormone receptor interactor 12 0.023233
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0231161
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0230763
AGFG1 ArfGAP with FG repeats 1 0.0229842
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0229711
ATP13A3 ATPase type 13A3 0.0225928
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0220738
BIRC6 baculoviral IAP repeat containing 6 0.0220566
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0219236
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0210391
SLF1 SMC5-SMC6 complex localization factor 1 0.0209933
JMJD1C jumonji domain containing 1C 0.0208615
APLP2 amyloid beta (A4) precursor-like protein 2 0.0208467
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0207322
PUM2 pumilio RNA-binding family member 2 0.0207193

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.101143
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0501958
TMSB10 thymosin beta 10 -0.0486499
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0378427
RPLP1 ribosomal protein, large, P1 -0.0369297
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0365267
RPS6 ribosomal protein S6 -0.0346581
TPT1 tumor protein, translationally-controlled 1 -0.0344147
RPL35A ribosomal protein L35a -0.0308059
WARS1 tryptophanyl-tRNA synthetase 1 -0.0304661
P4HB prolyl 4-hydroxylase, beta polypeptide -0.026963
CDH13 cadherin 13 -0.0251689
FTL ferritin, light polypeptide -0.0230627
VIM vimentin -0.0223732
RPS19 ribosomal protein S19 -0.0222629
LSAMP limbic system-associated membrane protein -0.0219566
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.021066
RPL37A ribosomal protein L37a -0.0206305
FTH1 ferritin, heavy polypeptide 1 -0.0202949
EGR1 early growth response 1 -0.019229
IGFBP3 insulin-like growth factor binding protein 3 -0.0175115
CAMTA1 calmodulin binding transcription activator 1 -0.0168704
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.016855
RPS23 ribosomal protein S23 -0.0168208
PDIA3 protein disulfide isomerase family A, member 3 -0.0165503
IFIH1 interferon induced with helicase C domain 1 -0.016528
RPL31 ribosomal protein L31 -0.0165001
RPL34 ribosomal protein L34 -0.0164907
RPS27 ribosomal protein S27 -0.0163921
OASL 2'-5'-oligoadenylate synthetase-like -0.0161571
RPS29 ribosomal protein S29 -0.0158959
MAP7 microtubule-associated protein 7 -0.0156599
AUTS2 autism susceptibility candidate 2 -0.0152748
LAMA5 laminin, alpha 5 -0.0152716
SQSTM1 sequestosome 1 -0.0151942
RPS8 ribosomal protein S8 -0.0151532
TTC28 tetratricopeptide repeat domain 28 -0.0151057
HLA-A major histocompatibility complex, class I, A -0.0148649
RPS14 ribosomal protein S14 -0.0148453
IL6 interleukin 6 -0.014502
HILPDA hypoxia inducible lipid droplet-associated -0.0144111
HLA-B major histocompatibility complex, class I, B -0.0142709
LOC102724023 ES1 protein homolog, mitochondrial -0.0142243
RPS25 ribosomal protein S25 -0.0140358
NALF1 NALCN channel auxiliary factor 1 -0.0140314
PTMA prothymosin, alpha -0.013826
RPL36A ribosomal protein L36a -0.0136838
NCKAP5 NCK-associated protein 5 -0.0136616
RPL36 ribosomal protein L36 -0.0133931
NBEAL1 neurobeachin-like 1 -0.013391
TENM2 teneurin transmembrane protein 2 -0.0132015
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0129272
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0126172
RPL9 ribosomal protein L9 -0.0125146
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0123417
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0122805
SOX6 SRY (sex determining region Y)-box 6 -0.0121236
RPL37 ribosomal protein L37 -0.0120662
CTSL cathepsin L -0.0119143
NDRG1 N-myc downstream regulated 1 -0.0118198
GRB10 growth factor receptor-bound protein 10 -0.0116227
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0115822
RPS13 ribosomal protein S13 -0.011576
IER3 immediate early response 3 -0.0115578
AGR2 anterior gradient 2 -0.0114881
RPL38 ribosomal protein L38 -0.0114479
XYLT1 xylosyltransferase I -0.0114122
ENO2 enolase 2 (gamma, neuronal) -0.0111675
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0110718
RPLP2 ribosomal protein, large, P2 -0.0108919
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0107531
PRKN parkin RBR E3 ubiquitin protein ligase -0.0107413
PKM pyruvate kinase, muscle -0.0103847
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0095238
NCOR2 nuclear receptor corepressor 2 -0.00951212
CTBP2 C-terminal binding protein 2 -0.00942475
RPS10 ribosomal protein S10 -0.00940795
RPS17 ribosomal protein S17 -0.00938037
ESM1 endothelial cell-specific molecule 1 -0.00936416
ISG15 ISG15 ubiquitin-like modifier -0.00928096
LMNA lamin A/C -0.00927603
RPL28 ribosomal protein L28 -0.00924607
RPS16 ribosomal protein S16 -0.00913411
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.00900248
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00893629
GNAS GNAS complex locus -0.00891077
CA12 carbonic anhydrase XII -0.00886218
RPS3 ribosomal protein S3 -0.00878495
BTG1 B-cell translocation gene 1, anti-proliferative -0.00877922
RPS24 ribosomal protein S24 -0.00870303
RPS21 ribosomal protein S21 -0.00863877
SOX4 SRY (sex determining region Y)-box 4 -0.00837075
TENM3 teneurin transmembrane protein 3 -0.00828006
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.00821727
RAD51B RAD51 paralog B -0.00814024
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.00808953
C9ORF153 chromosome 9 open reading frame 153 -0.00801464
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.00797148
BASP1 brain abundant, membrane attached signal protein 1 -0.00783932
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.00778602