Idoxuridine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.167335
GPC6 glypican 6 0.141341
KMT2E lysine (K)-specific methyltransferase 2E 0.13283
NDRG1 N-myc downstream regulated 1 0.114755
FN1 fibronectin 1 0.100697
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0991962
AKAP12 A kinase (PRKA) anchor protein 12 0.0971935
GLG1 golgi glycoprotein 1 0.0918495
VIM vimentin 0.0874266
EXT1 exostosin glycosyltransferase 1 0.0859133
ITCH itchy E3 ubiquitin protein ligase 0.0852179
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0812838
DST dystonin 0.0745696
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0709036
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0677374
RPL11 ribosomal protein L11 0.0637708
OSMR oncostatin M receptor 0.0612438
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0581241
PKM pyruvate kinase, muscle 0.0564354
BAIAP2L1 BAI1-associated protein 2-like 1 0.0556477
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0546217
ESYT2 extended synaptotagmin-like protein 2 0.0539442
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0526149
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0522174
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0507573
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0486601
HMGA2 high mobility group AT-hook 2 0.0486299
RAD51B RAD51 paralog B 0.0461348
BPTF bromodomain PHD finger transcription factor 0.045988
RICTOR RPTOR independent companion of MTOR, complex 2 0.0452986
FNDC3B fibronectin type III domain containing 3B 0.04359
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0429956
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0427779
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0425692
PDE10A phosphodiesterase 10A 0.0420049
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0408317
DGKD diacylglycerol kinase, delta 130kDa 0.0401571
ITGA6 integrin, alpha 6 0.0398608
STC1 stanniocalcin 1 0.0395959
PTK2 protein tyrosine kinase 2 0.0393892
H3-3B H3.3 histone B 0.0392395
ASPH aspartate beta-hydroxylase 0.0384386
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0371271
TPT1 tumor protein, translationally-controlled 1 0.036007
TBC1D22A TBC1 domain family, member 22A 0.0359922
ARID4B AT rich interactive domain 4B (RBP1-like) 0.035588
CAMTA1 calmodulin binding transcription activator 1 0.0355714
ZFAND3 zinc finger, AN1-type domain 3 0.0352566
SEPTIN2 septin 2 0.034935
LPP LIM domain containing preferred translocation partner in lipoma 0.0347298
DLG1 discs, large homolog 1 (Drosophila) 0.0346857
SPAG9 sperm associated antigen 9 0.0342346
MARCHF6 membrane associated ring-CH-type finger 6 0.0342002
USP9X ubiquitin specific peptidase 9, X-linked 0.0340629
WAC WW domain containing adaptor with coiled-coil 0.0334292
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0333732
KDM3A lysine (K)-specific demethylase 3A 0.032698
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0324932
JMJD1C jumonji domain containing 1C 0.0320443
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0320117
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0289775
ERRFI1 ERBB receptor feedback inhibitor 1 0.0278635
GOLGA4 golgin A4 0.0272384
RAD21 RAD21 homolog (S. pombe) 0.0271421
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0269625
NAMPT nicotinamide phosphoribosyltransferase 0.0260968
KPNB1 karyopherin (importin) beta 1 0.0256549
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0244372
RPL34 ribosomal protein L34 0.0240423
HDLBP high density lipoprotein binding protein 0.0239901
OGA O-GlcNAcase 0.0229043
GCLC glutamate-cysteine ligase, catalytic subunit 0.0201316
TJP1 tight junction protein 1 0.0197869
SRPK2 SRSF protein kinase 2 0.0195859
SAMD4A sterile alpha motif domain containing 4A 0.0188073
RBM39 RNA binding motif protein 39 0.0181368
ZNF292 zinc finger protein 292 0.0180461
NIPBL Nipped-B homolog (Drosophila) 0.017609
CXCL8 chemokine (C-X-C motif) ligand 8 0.0168188
KMT2C lysine (K)-specific methyltransferase 2C 0.0166816
ZCCHC7 zinc finger, CCHC domain containing 7 0.0163057
RPS16 ribosomal protein S16 0.0162622
GPHN gephyrin 0.0152412
NAP1L1 nucleosome assembly protein 1-like 1 0.0149013
DSCAM Down syndrome cell adhesion molecule 0.0148667
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0147323
MED13L mediator complex subunit 13-like 0.0147294
EIF1 eukaryotic translation initiation factor 1 0.0145607
CD44 CD44 molecule (Indian blood group) 0.0143074
PTMA prothymosin, alpha 0.0141869
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0137905
RPL23 ribosomal protein L23 0.013432
PRELID2 PRELI domain containing 2 0.0121354
LAMB3 laminin, beta 3 0.0117545
PGK1 phosphoglycerate kinase 1 0.0107896
PCBP2 poly(rC) binding protein 2 0.0106054
NCOA3 nuclear receptor coactivator 3 0.00970764
SMYD3 SET and MYND domain containing 3 0.00966108
SQSTM1 sequestosome 1 0.00918551
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.00902762

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.109452
RPS6 ribosomal protein S6 -0.0831004
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.080825
ZBTB20 zinc finger and BTB domain containing 20 -0.078774
LMO7 LIM domain 7 -0.0756577
NCOR1 nuclear receptor corepressor 1 -0.0739287
EGFR epidermal growth factor receptor -0.0716219
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.070001
RPL7 ribosomal protein L7 -0.0670712
LDHA lactate dehydrogenase A -0.0664252
RPL37A ribosomal protein L37a -0.0660118
RPS8 ribosomal protein S8 -0.0649924
MYO1E myosin IE -0.0633675
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0630137
NF1 neurofibromin 1 -0.0629767
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0623079
GMDS GDP-mannose 4,6-dehydratase -0.0617533
SBF2 SET binding factor 2 -0.0589073
RPL31 ribosomal protein L31 -0.055915
POTEF POTE ankyrin domain family, member F -0.0537887
ACTG1 actin gamma 1 -0.0534151
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0524197
IGFBP3 insulin-like growth factor binding protein 3 -0.0521711
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.050737
PIAS1 protein inhibitor of activated STAT, 1 -0.0501532
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.048567
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0471277
RPS3 ribosomal protein S3 -0.0448465
FOXO3 forkhead box O3 -0.0440825
RPS27A ribosomal protein S27a -0.0427929
EFNA5 ephrin-A5 -0.0415768
MYOF myoferlin -0.0405834
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0404235
TMSB10 thymosin beta 10 -0.0400391
ANKRD12 ankyrin repeat domain 12 -0.0384591
YBX3 Y box binding protein 3 -0.0383263
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0382329
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0373607
TXNRD1 thioredoxin reductase 1 -0.0356716
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0353993
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0352924
VMP1 vacuole membrane protein 1 -0.0350829
CANX calnexin -0.0349369
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0341191
KTN1 kinectin 1 (kinesin receptor) -0.0340465
HDAC9 histone deacetylase 9 -0.0335658
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0329872
EEF2 eukaryotic translation elongation factor 2 -0.0328575
PDIA3 protein disulfide isomerase family A, member 3 -0.0325057
TPM4 tropomyosin 4 -0.0324247
UBE2K ubiquitin-conjugating enzyme E2K -0.0323213
MYO6 myosin VI -0.0317084
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0302394
FHIT fragile histidine triad -0.0299535
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0296643
CSDE1 cold shock domain containing E1, RNA-binding -0.0293708
RPL26 ribosomal protein L26 -0.0283922
TRA2A transformer 2 alpha homolog (Drosophila) -0.0270041
RNF149 ring finger protein 149 -0.0267261
PRKCA protein kinase C, alpha -0.026647
SLTM SAFB-like, transcription modulator -0.0256945
RPLP1 ribosomal protein, large, P1 -0.0249887
FTL ferritin, light polypeptide -0.0248478
ARRDC3 arrestin domain containing 3 -0.024772
HDAC2 histone deacetylase 2 -0.0247099
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0245784
RPS12 ribosomal protein S12 -0.0243608
FMNL2 formin-like 2 -0.0242687
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0240107
RPLP0 ribosomal protein, large, P0 -0.0234647
VCL vinculin -0.02272
MAP4 microtubule-associated protein 4 -0.0226065
RORA RAR-related orphan receptor A -0.022565
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0222146
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0214755
PDE8A phosphodiesterase 8A -0.0209095
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0205958
RPL32 ribosomal protein L32 -0.0204054
RPL12 ribosomal protein L12 -0.0204001
ELL2 elongation factor, RNA polymerase II, 2 -0.0200953
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0200055
ANXA2 annexin A2 -0.0197174
MACF1 microtubule-actin crosslinking factor 1 -0.0187357
PHF3 PHD finger protein 3 -0.0180342
ANKRD11 ankyrin repeat domain 11 -0.0176584
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0172859
B2M beta-2-microglobulin -0.016061
GOLGB1 golgin B1 -0.0151817
RAB7A RAB7A, member RAS oncogene family -0.0147183
TSC22D2 TSC22 domain family, member 2 -0.0146406
MT2A metallothionein 2A -0.0146399
LIMCH1 LIM and calponin homology domains 1 -0.0144302
COL6A3 collagen, type VI, alpha 3 -0.0137019
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0136861
EZR ezrin -0.012951
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0127215
ARHGAP32 Rho GTPase activating protein 32 -0.0121178
RPS13 ribosomal protein S13 -0.0113288
HELZ helicase with zinc finger -0.0109938
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0106173