Idoxuridine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.171923
TOP2A topoisomerase (DNA) II alpha 170kDa 0.120458
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.11325
ADGRL2 adhesion G protein-coupled receptor L2 0.105949
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0988231
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0963661
COL11A1 collagen, type XI, alpha 1 0.0955917
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.085026
ITGAV integrin, alpha V 0.0841181
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0817647
VIM vimentin 0.08114
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0764523
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0712201
ADGRV1 adhesion G protein-coupled receptor V1 0.0704682
AHNAK AHNAK nucleoprotein 0.0697813
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0667618
MKI67 marker of proliferation Ki-67 0.0651109
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0612991
APP amyloid beta (A4) precursor protein 0.0606188
THBS1 thrombospondin 1 0.0591701
DST dystonin 0.0589824
FNDC3B fibronectin type III domain containing 3B 0.0586718
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0582433
COL5A2 collagen, type V, alpha 2 0.0569099
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0568547
COL1A2 collagen, type I, alpha 2 0.0566508
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.056531
RAD21 RAD21 homolog (S. pombe) 0.0559446
MACF1 microtubule-actin crosslinking factor 1 0.0556694
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0548152
LDHA lactate dehydrogenase A 0.0515655
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0511226
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0506717
CKAP5 cytoskeleton associated protein 5 0.0503276
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0491566
CALR calreticulin 0.0481476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0471683
ANXA1 annexin A1 0.0468104
COL3A1 collagen, type III, alpha 1 0.0465376
HMGB2 high mobility group box 2 0.0464113
ADGRG6 adhesion G protein-coupled receptor G6 0.0462283
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0453661
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0452838
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0444965
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0442621
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0442327
TMSB4X thymosin beta 4, X-linked 0.0441662
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0438889
EMP1 epithelial membrane protein 1 0.0438595
TPX2 TPX2, microtubule-associated 0.043117
ACTG1 actin gamma 1 0.0430235
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.042592
BIRC6 baculoviral IAP repeat containing 6 0.0424085
BZW1 basic leucine zipper and W2 domains 1 0.0423776
ATAD2 ATPase family, AAA domain containing 2 0.0423115
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0417846
SFPQ splicing factor proline/glutamine-rich 0.0415683
TEX11 testis expressed 11 0.0415524
RPL4 ribosomal protein L4 0.0411394
MYH9 myosin, heavy chain 9, non-muscle 0.0410359
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0410176
CKAP2 cytoskeleton associated protein 2 0.0405125
KDM3A lysine (K)-specific demethylase 3A 0.0404481
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0403417
CANX calnexin 0.0401499
CDK6 cyclin-dependent kinase 6 0.0398097
SET SET nuclear proto-oncogene 0.0397823
TPM3 tropomyosin 3 0.0396544
GPC3 glypican 3 0.0390316
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0390087
ANXA2 annexin A2 0.0389445
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0386423
PCDH9 protocadherin 9 0.0382339
ENO1 enolase 1, (alpha) 0.0372453
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0366383
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0366348
LYPLA1 lysophospholipase I 0.0366097
CALU calumenin 0.0361402
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0360354
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0358709
UTRN utrophin 0.0356681
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0356483
PCBP2 poly(rC) binding protein 2 0.0355456
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0352077
PDGFC platelet derived growth factor C 0.0345063
CSDE1 cold shock domain containing E1, RNA-binding 0.0339248
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0336694
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0334548
XPO1 exportin 1 0.0328427
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0324575
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0321419
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0320869
PEG10 paternally expressed 10 0.0317333
TXNRD1 thioredoxin reductase 1 0.0312387
KIF4A kinesin family member 4A 0.0309828
NUSAP1 nucleolar and spindle associated protein 1 0.0309398
MYOF myoferlin 0.0309235
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.0307827
HP1BP3 heterochromatin protein 1, binding protein 3 0.0302591
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0301275

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0913805
TSC22D2 TSC22 domain family, member 2 -0.0710801
RPS6 ribosomal protein S6 -0.0621228
WSB1 WD repeat and SOCS box containing 1 -0.0608774
PFN1 profilin 1 -0.0595913
TMSB10 thymosin beta 10 -0.0498102
CDH10 cadherin 10, type 2 (T2-cadherin) -0.04762
RPL11 ribosomal protein L11 -0.0450032
RPLP1 ribosomal protein, large, P1 -0.0392417
RPS21 ribosomal protein S21 -0.0366232
GNAS GNAS complex locus -0.035302
RPS3 ribosomal protein S3 -0.0348551
LRRC4C leucine rich repeat containing 4C -0.034635
ADNP activity-dependent neuroprotector homeobox -0.0343547
RPS8 ribosomal protein S8 -0.033458
RPS23 ribosomal protein S23 -0.0333896
RAB7A RAB7A, member RAS oncogene family -0.0331549
RPL28 ribosomal protein L28 -0.0314285
PRTG protogenin -0.0303203
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0302946
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.030216
FNDC3A fibronectin type III domain containing 3A -0.0298133
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0292317
RACK1 receptor for activated C kinase 1 -0.0291612
EIF1 eukaryotic translation initiation factor 1 -0.0287032
PHIP pleckstrin homology domain interacting protein -0.028069
RPS19 ribosomal protein S19 -0.0278655
RCC1 regulator of chromosome condensation 1 -0.027295
WASF2 WAS protein family, member 2 -0.0272423
JMJD1C jumonji domain containing 1C -0.0271487
MED13 mediator complex subunit 13 -0.0267951
RPS13 ribosomal protein S13 -0.0267358
PRR16 proline rich 16 -0.0263246
MEIS2 Meis homeobox 2 -0.0254924
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0248209
SYT1 synaptotagmin I -0.0243965
MBD5 methyl-CpG binding domain protein 5 -0.0239984
FIGN fidgetin -0.0239666
MYL12B myosin, light chain 12B, regulatory -0.0238861
S100A10 S100 calcium binding protein A10 -0.0237744
RPLP2 ribosomal protein, large, P2 -0.0233392
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0232747
MDK midkine (neurite growth-promoting factor 2) -0.0232553
RPL12 ribosomal protein L12 -0.0231843
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0228577
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0225612
RPL19 ribosomal protein L19 -0.0223673
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.022347
DSTN destrin (actin depolymerizing factor) -0.0223364
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0220664
RASAL2 RAS protein activator like 2 -0.0217766
TNRC6B trinucleotide repeat containing 6B -0.0214581
RPS17 ribosomal protein S17 -0.0212703
NFIA nuclear factor I/A -0.0212101
VDAC1 voltage-dependent anion channel 1 -0.0211932
HBS1L HBS1-like translational GTPase -0.0210464
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0210442
RPL34 ribosomal protein L34 -0.0207464
RPL35A ribosomal protein L35a -0.020504
ASXL2 additional sex combs like transcriptional regulator 2 -0.0204737
RPL10A ribosomal protein L10a -0.020412
RPS4X ribosomal protein S4, X-linked -0.020359
NPR2 natriuretic peptide receptor 2 -0.0202557
LOC112694756 uncharaterized LOC112694756 -0.0201053
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0200622
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0200584
RPAP3 RNA polymerase II associated protein 3 -0.0199689
TUT4 terminal uridylyl transferase 4 -0.0198925
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0198691
SNX3 sorting nexin 3 -0.0196866
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0194929
RPL32 ribosomal protein L32 -0.0194785
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.019446
FTL ferritin, light polypeptide -0.0190939
ZNF217 zinc finger protein 217 -0.0190819
EAPP E2F-associated phosphoprotein -0.019079
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0190667
RPL9 ribosomal protein L9 -0.0190298
MEF2A myocyte enhancer factor 2A -0.0190204
MED12L mediator complex subunit 12-like -0.0189208
ADM adrenomedullin -0.0187825
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0187728
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0187198
SLC39A9 solute carrier family 39, member 9 -0.0185725
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0185476
EIF5B eukaryotic translation initiation factor 5B -0.0185261
SESN2 sestrin 2 -0.0184494
STRN3 striatin, calmodulin binding protein 3 -0.0183807
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0181443
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0181376
NCOA2 nuclear receptor coactivator 2 -0.0180717
RPL23 ribosomal protein L23 -0.0180358
RPL35 ribosomal protein L35 -0.0179832
GLO1 glyoxalase I -0.0177416
PARD3B par-3 family cell polarity regulator beta -0.0176276
LOXL2 lysyl oxidase-like 2 -0.0176218
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.017616
ACVR1 activin A receptor, type I -0.0175692
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0174604
IRF2BPL interferon regulatory factor 2 binding protein-like -0.0174584