Idoxuridine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.09254
FNDC3B fibronectin type III domain containing 3B 0.0468496
ADAM10 ADAM metallopeptidase domain 10 0.0465755
EXT1 exostosin glycosyltransferase 1 0.0434904
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.037809
TJP1 tight junction protein 1 0.0343691
RPL9 ribosomal protein L9 0.033778
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0319109
ENO2 enolase 2 (gamma, neuronal) 0.031246
INTS6 integrator complex subunit 6 0.031089
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0300404
FLNB filamin B, beta 0.0290042
EGFR epidermal growth factor receptor 0.0287209
RAB27B RAB27B, member RAS oncogene family 0.0282537
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278719
SAMD4A sterile alpha motif domain containing 4A 0.0274939
INO80 INO80 complex subunit 0.0268955
COG5 component of oligomeric golgi complex 5 0.0263962
KANK1 KN motif and ankyrin repeat domains 1 0.0263635
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0262467
ANKRD17 ankyrin repeat domain 17 0.0260446
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0258612
EFNA5 ephrin-A5 0.0252426
PDGFC platelet derived growth factor C 0.0250206
PSD3 pleckstrin and Sec7 domain containing 3 0.0249031
ANK2 ankyrin 2, neuronal 0.0247156
MON2 MON2 homolog (S. cerevisiae) 0.0243939
AKAP9 A kinase (PRKA) anchor protein 9 0.0242929
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0241388
CCNY cyclin Y 0.0239938
ANKRD36 ankyrin repeat domain 36 0.0239917
ANKRD12 ankyrin repeat domain 12 0.0239223
CREBBP CREB binding protein 0.0237157
CSNK1A1 casein kinase 1, alpha 1 0.0237068
VMP1 vacuole membrane protein 1 0.0229813
METTL15 methyltransferase like 15 0.0229004
PDE4D phosphodiesterase 4D, cAMP-specific 0.0225926
NBAS neuroblastoma amplified sequence 0.0222415
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0217683
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0212023
PATJ PATJ crumbs cell polarity complex component 0.0210531
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0209904
ASPH aspartate beta-hydroxylase 0.0209688
RHBDD1 rhomboid domain containing 1 0.0209474
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.020821
ZCCHC7 zinc finger, CCHC domain containing 7 0.0206305
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0201767
SMYD3 SET and MYND domain containing 3 0.0200587
CAMTA1 calmodulin binding transcription activator 1 0.0196343
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0195576
ATM ATM serine/threonine kinase 0.0193828
PCNX4 pecanex 4 0.0190785
FNIP1 folliculin interacting protein 1 0.0188905
UBC ubiquitin C 0.0188771
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0186574
ZNF608 zinc finger protein 608 0.0186509
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0185804
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0185367
ANXA3 annexin A3 0.0183411
SCFD1 sec1 family domain containing 1 0.0183078
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0182603
STAG2 stromal antigen 2 0.0180775
DENND4A DENN/MADD domain containing 4A 0.018022
ERRFI1 ERBB receptor feedback inhibitor 1 0.0178816
RPS23 ribosomal protein S23 0.0178545
FNBP4 formin binding protein 4 0.0177884
PTEN phosphatase and tensin homolog 0.0177335
ANKRD11 ankyrin repeat domain 11 0.0176897
ARHGAP25 Rho GTPase activating protein 25 0.0176105
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0176031
NCEH1 neutral cholesterol ester hydrolase 1 0.017592
PLXNA1 plexin A1 0.017117
ACBD6 acyl-CoA binding domain containing 6 0.0170813
DIDO1 death inducer-obliterator 1 0.0169954
HDLBP high density lipoprotein binding protein 0.0168606
PDIA5 protein disulfide isomerase family A, member 5 0.0167889
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0167411
ZBTB20 zinc finger and BTB domain containing 20 0.0164102
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0164038
ATRN attractin 0.0163842
PRPF39 pre-mRNA processing factor 39 0.0161838
DSCAM Down syndrome cell adhesion molecule 0.0161769
UBE3A ubiquitin protein ligase E3A 0.0160902
MAPK8 mitogen-activated protein kinase 8 0.0160119
SEC31A SEC31 homolog A (S. cerevisiae) 0.0159723
DYM dymeclin 0.0159672
CLIC4 chloride intracellular channel 4 0.015917
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0158946
MCTP1 multiple C2 domains, transmembrane 1 0.0158164
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0158031
HEG1 heart development protein with EGF-like domains 1 0.0157233
CARS1 cysteinyl-tRNA synthetase 1 0.0154755
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.015464
HDAC8 histone deacetylase 8 0.0153459
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0152837
WDFY3 WD repeat and FYVE domain containing 3 0.0152775
ARHGAP12 Rho GTPase activating protein 12 0.0152756
ADIPOR2 adiponectin receptor 2 0.0152561
ANXA2 annexin A2 0.0150201
ARL15 ADP-ribosylation factor-like 15 0.0149611

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.158206
TMSB4X thymosin beta 4, X-linked -0.130409
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.105821
SOX6 SRY (sex determining region Y)-box 6 -0.088112
MKI67 marker of proliferation Ki-67 -0.0837228
B2M beta-2-microglobulin -0.0739246
AHNAK AHNAK nucleoprotein -0.0735917
RPS8 ribosomal protein S8 -0.07168
GLI3 GLI family zinc finger 3 -0.0649421
PFN1 profilin 1 -0.0636265
SSBP2 single-stranded DNA binding protein 2 -0.0628264
BMP10 bone morphogenetic protein 10 -0.0627733
PDE4B phosphodiesterase 4B, cAMP-specific -0.0606387
DIAPH3 diaphanous-related formin 3 -0.0591139
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0560099
BMP2K BMP2 inducible kinase -0.0556791
S100A6 S100 calcium binding protein A6 -0.0554342
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0546504
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0530125
MT2A metallothionein 2A -0.0517211
PARD3 par-3 family cell polarity regulator -0.0506427
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0505341
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0503366
RPS6 ribosomal protein S6 -0.047997
S100A4 S100 calcium binding protein A4 -0.0473138
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0454906
SMC4 structural maintenance of chromosomes 4 -0.0451591
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0446858
NAV2 neuron navigator 2 -0.043376
TMSB10 thymosin beta 10 -0.0433402
ENO1 enolase 1, (alpha) -0.041917
RPS19 ribosomal protein S19 -0.0410922
KIF5B kinesin family member 5B -0.0410802
MYO5C myosin VC -0.0405179
CENPF centromere protein F, 350/400kDa -0.0397028
HJURP Holliday junction recognition protein -0.0377678
RPL23 ribosomal protein L23 -0.0370673
RPLP1 ribosomal protein, large, P1 -0.036999
EZR ezrin -0.0367809
PKM pyruvate kinase, muscle -0.0364511
SEPTIN11 septin 11 -0.0358178
CSDE1 cold shock domain containing E1, RNA-binding -0.0354847
ARL4C ADP-ribosylation factor-like 4C -0.0352528
PKP4 plakophilin 4 -0.0351536
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0346576
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0346069
RPL36 ribosomal protein L36 -0.0343401
DLG1 discs, large homolog 1 (Drosophila) -0.0339706
CAMKMT calmodulin-lysine N-methyltransferase -0.0339208
TPI1 triosephosphate isomerase 1 -0.0332927
VCL vinculin -0.0331667
ECT2 epithelial cell transforming 2 -0.0324457
RPS11 ribosomal protein S11 -0.0322627
RPLP2 ribosomal protein, large, P2 -0.0322233
RPL35A ribosomal protein L35a -0.0317849
RPS14 ribosomal protein S14 -0.0314935
SMIM44 small integral membrane protein 44 -0.0314829
RPL12 ribosomal protein L12 -0.0314022
MATR3 matrin 3 -0.0312575
SCLT1 sodium channel and clathrin linker 1 -0.0310936
RPL37A ribosomal protein L37a -0.0309297
RPL18 ribosomal protein L18 -0.0298541
EBNA1BP2 EBNA1 binding protein 2 -0.0297426
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0293219
EEF1G eukaryotic translation elongation factor 1 gamma -0.0292731
SET SET nuclear proto-oncogene -0.0290293
GCLM glutamate-cysteine ligase, modifier subunit -0.0288852
HDAC9 histone deacetylase 9 -0.0287257
LOC112694756 uncharaterized LOC112694756 -0.0286791
HMGB2 high mobility group box 2 -0.0285238
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0283109
RACK1 receptor for activated C kinase 1 -0.0279902
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0279838
GNAS GNAS complex locus -0.0274593
GOLGA4 golgin A4 -0.027204
LCORL ligand dependent nuclear receptor corepressor-like -0.0270697
DUSP6 dual specificity phosphatase 6 -0.0269059
RPS3 ribosomal protein S3 -0.0268862
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0265885
DDIT4 DNA-damage-inducible transcript 4 -0.0265879
TRIO trio Rho guanine nucleotide exchange factor -0.0264382
SMC3 structural maintenance of chromosomes 3 -0.0262709
FOXP1 forkhead box P1 -0.0259513
DPYD dihydropyrimidine dehydrogenase -0.025936
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0259082
S100A9 S100 calcium binding protein A9 -0.025877
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0255724
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0255207
SRRM1 serine/arginine repetitive matrix 1 -0.025516
SERBP1 SERPINE1 mRNA binding protein 1 -0.0254968
TPR translocated promoter region, nuclear basket protein -0.025038
ZNF638 zinc finger protein 638 -0.0249395
FAF1 Fas (TNFRSF6) associated factor 1 -0.0245338
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0244479
PHIP pleckstrin homology domain interacting protein -0.0241258
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0240625
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0238106
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0237306
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0236366
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0235359