Idoxuridine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.161918
NAMPT nicotinamide phosphoribosyltransferase 0.138384
MYH9 myosin, heavy chain 9, non-muscle 0.135429
AKAP12 A kinase (PRKA) anchor protein 12 0.103923
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0879954
FNDC3B fibronectin type III domain containing 3B 0.0842577
AHNAK AHNAK nucleoprotein 0.0832717
RB1CC1 RB1-inducible coiled-coil 1 0.0733002
TRIO trio Rho guanine nucleotide exchange factor 0.0712338
CD44 CD44 molecule (Indian blood group) 0.0702084
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0666989
SOD2 superoxide dismutase 2, mitochondrial 0.0663603
UGCG UDP-glucose ceramide glucosyltransferase 0.0657993
PABPC1 poly(A) binding protein, cytoplasmic 1 0.059164
NAV2 neuron navigator 2 0.0585482
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0568728
CDK19 cyclin-dependent kinase 19 0.0534541
FLNB filamin B, beta 0.0525479
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0505691
ELL2 elongation factor, RNA polymerase II, 2 0.0505135
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0503705
JMJD1C jumonji domain containing 1C 0.0486879
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0481428
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0470645
APLP2 amyloid beta (A4) precursor-like protein 2 0.0455397
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0452212
USP9X ubiquitin specific peptidase 9, X-linked 0.04519
NDRG1 N-myc downstream regulated 1 0.0447861
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0444855
UBA6 ubiquitin-like modifier activating enzyme 6 0.0443716
APP amyloid beta (A4) precursor protein 0.0439285
PGK1 phosphoglycerate kinase 1 0.0433688
LDHA lactate dehydrogenase A 0.0421149
DSCAM Down syndrome cell adhesion molecule 0.0408629
SFTPA2 surfactant protein A2 0.0406103
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0405265
ARRDC3 arrestin domain containing 3 0.0402997
ANLN anillin, actin binding protein 0.0394622
ATP13A3 ATPase type 13A3 0.0393503
PCBP2 poly(rC) binding protein 2 0.0385208
MSN moesin 0.0376038
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0368061
STC1 stanniocalcin 1 0.0367922
VIM vimentin 0.0365702
AKAP13 A kinase (PRKA) anchor protein 13 0.0362576
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0359922
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0345812
TENT5A terminal nucleotidyltransferase 5A 0.0343099
VEGFA vascular endothelial growth factor A 0.0342532
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0331948
TNS3 tensin 3 0.0320426
IQGAP1 IQ motif containing GTPase activating protein 1 0.0312131
RTN4 reticulon 4 0.0305213
SPAG9 sperm associated antigen 9 0.03009
SDK1 sidekick cell adhesion molecule 1 0.0293333
DLG1 discs, large homolog 1 (Drosophila) 0.0290304
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0280664
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0278653
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0275174
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0273149
COL6A3 collagen, type VI, alpha 3 0.027312
CKAP5 cytoskeleton associated protein 5 0.0267643
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0264478
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0263908
UBC ubiquitin C 0.0262751
CDCP1 CUB domain containing protein 1 0.0258774
ARFGEF3 ARFGEF family member 3 0.025791
ACTN1 actinin, alpha 1 0.0257253
CD99 CD99 molecule 0.0256177
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0255961
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0255271
TUBB tubulin, beta class I 0.0254918
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0251947
MARCHF6 membrane associated ring-CH-type finger 6 0.0251799
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0251684
OGA O-GlcNAcase 0.0249319
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0246998
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0246884
NIPBL Nipped-B homolog (Drosophila) 0.0244779
FNIP1 folliculin interacting protein 1 0.0243392
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0239554
IL1RAP interleukin 1 receptor accessory protein 0.0238862
TXNIP thioredoxin interacting protein 0.0238634
SDC4 syndecan 4 0.0238426
KIF4A kinesin family member 4A 0.0237513
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0235114
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0234935
CSDE1 cold shock domain containing E1, RNA-binding 0.0233705
DST dystonin 0.0231667
FMNL2 formin-like 2 0.0229066
FAM3C family with sequence similarity 3, member C 0.0229021
AFDN afadin, adherens junction formation factor 0.022813
PRELID2 PRELI domain containing 2 0.022379
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0222816
KTN1 kinectin 1 (kinesin receptor) 0.0220985
CLTC clathrin, heavy chain (Hc) 0.0218439
MYOF myoferlin 0.021841
PPARD peroxisome proliferator-activated receptor delta 0.0215501
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0215232
PDE10A phosphodiesterase 10A 0.0214352

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.0819881
IER3 immediate early response 3 -0.0815737
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0619215
RPS6 ribosomal protein S6 -0.0610737
TMSB10 thymosin beta 10 -0.0582539
RPS8 ribosomal protein S8 -0.0551424
RPL37A ribosomal protein L37a -0.0513136
IGFBP3 insulin-like growth factor binding protein 3 -0.0481312
RPLP1 ribosomal protein, large, P1 -0.0453394
RPS24 ribosomal protein S24 -0.0447332
TPT1 tumor protein, translationally-controlled 1 -0.0426252
RPLP2 ribosomal protein, large, P2 -0.0395278
RPL23 ribosomal protein L23 -0.0378891
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0373745
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0356842
BICC1 BicC family RNA binding protein 1 -0.0347582
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0341404
RPS19 ribosomal protein S19 -0.0341285
RPS25 ribosomal protein S25 -0.0334988
INTS6 integrator complex subunit 6 -0.0321394
RPL12 ribosomal protein L12 -0.0315588
RPL35A ribosomal protein L35a -0.0314883
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0311978
MT2A metallothionein 2A -0.0311836
FRMPD4 FERM and PDZ domain containing 4 -0.0303147
RPL32 ribosomal protein L32 -0.029104
RPL35 ribosomal protein L35 -0.0286384
RPS13 ribosomal protein S13 -0.0274716
TMSB4X thymosin beta 4, X-linked -0.0267418
RPL36 ribosomal protein L36 -0.0258066
RPS3 ribosomal protein S3 -0.0257279
GNAS GNAS complex locus -0.0253053
RPL19 ribosomal protein L19 -0.0245672
RPS21 ribosomal protein S21 -0.0241429
RPL9 ribosomal protein L9 -0.0240739
PTPRK protein tyrosine phosphatase, receptor type, K -0.0240348
RPS12 ribosomal protein S12 -0.0236565
VCAN versican -0.0236406
CDH13 cadherin 13 -0.0234905
RPS2 ribosomal protein S2 -0.0231965
RPS20 ribosomal protein S20 -0.0228494
RPL39 ribosomal protein L39 -0.0224142
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0223921
RPL36A ribosomal protein L36a -0.022186
RPS4X ribosomal protein S4, X-linked -0.0219301
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0216971
RPS17 ribosomal protein S17 -0.0216613
RPS29 ribosomal protein S29 -0.0216252
RPL38 ribosomal protein L38 -0.0215709
RPS27A ribosomal protein S27a -0.0214088
RPL28 ribosomal protein L28 -0.0213353
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0212678
RPS10 ribosomal protein S10 -0.0207596
WSB1 WD repeat and SOCS box containing 1 -0.0205274
RPL13A ribosomal protein L13a -0.0204747
S100A9 S100 calcium binding protein A9 -0.0201648
ASTN2 astrotactin 2 -0.0201061
RPL27A ribosomal protein L27a -0.0200923
RPL15 ribosomal protein L15 -0.0200605
RPS27 ribosomal protein S27 -0.0197183
NACA nascent polypeptide-associated complex alpha subunit -0.0183849
IARS1 isoleucyl-tRNA synthetase 1 -0.0183121
ISG15 ISG15 ubiquitin-like modifier -0.0179471
GLIS3 GLIS family zinc finger 3 -0.0178663
IFITM3 interferon induced transmembrane protein 3 -0.0178156
TPM4 tropomyosin 4 -0.0177909
RAI14 retinoic acid induced 14 -0.0176095
RTN3 reticulon 3 -0.0175031
RPL31 ribosomal protein L31 -0.0174183
RPS14 ribosomal protein S14 -0.0173499
RPL18 ribosomal protein L18 -0.0173094
RACK1 receptor for activated C kinase 1 -0.0168899
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0167998
RPL34 ribosomal protein L34 -0.0162952
HILPDA hypoxia inducible lipid droplet-associated -0.0161231
RPL8 ribosomal protein L8 -0.0155262
TMEM178B transmembrane protein 178B -0.0152771
RPL7A ribosomal protein L7a -0.0152742
SQSTM1 sequestosome 1 -0.0152534
RPL5 ribosomal protein L5 -0.0151707
AHI1 Abelson helper integration site 1 -0.015059
RPL10A ribosomal protein L10a -0.0150419
WTAP Wilms tumor 1 associated protein -0.0149442
RPS23 ribosomal protein S23 -0.014575
KYNU kynureninase -0.0140016
TKT transketolase -0.0139833
PALLD palladin, cytoskeletal associated protein -0.0138986
RPL30 ribosomal protein L30 -0.0138702
RPL11 ribosomal protein L11 -0.013864
SLC35F3 solute carrier family 35, member F3 -0.0136744
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0135822
RPLP0 ribosomal protein, large, P0 -0.0134947
UBB ubiquitin B -0.0134862
NCOA7 nuclear receptor coactivator 7 -0.0134099
RPL26 ribosomal protein L26 -0.0133685
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0132669
LOC112694756 uncharaterized LOC112694756 -0.0131854
ATF4 activating transcription factor 4 -0.0130331
TTC3 tetratricopeptide repeat domain 3 -0.0129331
RPS15 ribosomal protein S15 -0.0127528