Idoxuridine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Idoxuridine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Idoxuridine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.094794
NAMPT nicotinamide phosphoribosyltransferase 0.0579113
EXT1 exostosin glycosyltransferase 1 0.0533024
AHR aryl hydrocarbon receptor 0.0506529
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0496705
OSMR oncostatin M receptor 0.0447315
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0431677
FNDC3B fibronectin type III domain containing 3B 0.0425446
ITGA1 integrin, alpha 1 0.039812
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0368039
CD109 CD109 molecule 0.0358566
FN1 fibronectin 1 0.0346589
TMEM156 transmembrane protein 156 0.0344856
MCTP2 multiple C2 domains, transmembrane 2 0.0331112
CAB39 calcium binding protein 39 0.0326333
HIPK2 homeodomain interacting protein kinase 2 0.0320233
NRIP1 nuclear receptor interacting protein 1 0.0318779
DST dystonin 0.031007
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.030594
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0303623
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0298114
RUNX2 runt-related transcription factor 2 0.0290373
NRP1 neuropilin 1 0.0288073
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0280866
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0277429
SMOX spermine oxidase 0.0275698
ASPH aspartate beta-hydroxylase 0.0274388
OGA O-GlcNAcase 0.0272817
HMGA2 high mobility group AT-hook 2 0.0269975
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0262329
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.026087
EFNA5 ephrin-A5 0.0260791
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0259814
DOCK5 dedicator of cytokinesis 5 0.0257739
ETV6 ets variant 6 0.0254703
SMYD3 SET and MYND domain containing 3 0.0227782
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0226873
CDC73 cell division cycle 73 0.0225007
TPR translocated promoter region, nuclear basket protein 0.022363
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0222521
MYH9 myosin, heavy chain 9, non-muscle 0.0220033
PTK2 protein tyrosine kinase 2 0.0218333
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0214856
APP amyloid beta (A4) precursor protein 0.020747
ADD3 adducin 3 (gamma) 0.0206421
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0205673
LIFR leukemia inhibitory factor receptor alpha 0.0204059
ZC3H11A zinc finger CCCH-type containing 11A 0.0203445
CLTC clathrin, heavy chain (Hc) 0.020242
ETNK1 ethanolamine kinase 1 0.0200115
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0198801
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.019876
FOXP1 forkhead box P1 0.0195927
AOPEP aminopeptidase O (putative) 0.0193871
SMAD3 SMAD family member 3 0.0193407
KMT2C lysine (K)-specific methyltransferase 2C 0.0192509
SEC23A Sec23 homolog A (S. cerevisiae) 0.0186201
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0185709
NPAS2 neuronal PAS domain protein 2 0.0183708
ANKRD28 ankyrin repeat domain 28 0.0183136
CD44 CD44 molecule (Indian blood group) 0.0181947
AFDN afadin, adherens junction formation factor 0.0181821
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0180249
IL6ST interleukin 6 signal transducer 0.0179487
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.017888
SYNJ2 synaptojanin 2 0.0177703
TRIO trio Rho guanine nucleotide exchange factor 0.0176442
AHNAK AHNAK nucleoprotein 0.0175985
PELO pelota homolog (Drosophila) 0.0174608
WDR26 WD repeat domain 26 0.0173444
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.017333
COPA coatomer protein complex, subunit alpha 0.0171898
FBXW11 F-box and WD repeat domain containing 11 0.0170806
PRRC2C proline-rich coiled-coil 2C 0.0168821
EPS8 epidermal growth factor receptor pathway substrate 8 0.0168235
RICTOR RPTOR independent companion of MTOR, complex 2 0.0167749
RB1CC1 RB1-inducible coiled-coil 1 0.0167283
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0165914
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.016584
TXNIP thioredoxin interacting protein 0.0164463
SPATS2L spermatogenesis associated, serine-rich 2-like 0.016446
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0159493
FAM20C family with sequence similarity 20, member C 0.015791
PTBP3 polypyrimidine tract binding protein 3 0.0156206
SPRED1 sprouty-related, EVH1 domain containing 1 0.0155904
SPRED2 sprouty-related, EVH1 domain containing 2 0.0155329
FRY furry homolog (Drosophila) 0.0154626
FNBP1 formin binding protein 1 0.0154364
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0153416
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0153248
AKAP9 A kinase (PRKA) anchor protein 9 0.0153137
HOMER2 homer scaffolding protein 2 0.0149335
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.014798
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0147143
TXNRD1 thioredoxin reductase 1 0.0146781
WWTR1 WW domain containing transcription regulator 1 0.014632
SPAG9 sperm associated antigen 9 0.0146193
RAB31 RAB31, member RAS oncogene family 0.0146153
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0144536
BIRC6 baculoviral IAP repeat containing 6 0.0143299

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.139479
FTL ferritin, light polypeptide -0.11596
TMSB10 thymosin beta 10 -0.112241
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0899484
MT2A metallothionein 2A -0.0856464
TPT1 tumor protein, translationally-controlled 1 -0.0682497
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0658611
IFI27 interferon, alpha-inducible protein 27 -0.0604382
B2M beta-2-microglobulin -0.0583395
RPS6 ribosomal protein S6 -0.0563433
RPL35A ribosomal protein L35a -0.0548259
HLA-B major histocompatibility complex, class I, B -0.053588
RPL37A ribosomal protein L37a -0.0527456
RPL31 ribosomal protein L31 -0.0518753
VIM vimentin -0.0508306
RPLP1 ribosomal protein, large, P1 -0.0502142
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0494742
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0479706
RPS27 ribosomal protein S27 -0.046654
RPS12 ribosomal protein S12 -0.0462282
RPL37 ribosomal protein L37 -0.04567
RPS8 ribosomal protein S8 -0.0453222
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0442477
RPS19 ribosomal protein S19 -0.0431192
RPL23 ribosomal protein L23 -0.0426366
RPS29 ribosomal protein S29 -0.0425598
NRG1 neuregulin 1 -0.0408634
RPS16 ribosomal protein S16 -0.0394167
NDRG1 N-myc downstream regulated 1 -0.0388108
RPS3 ribosomal protein S3 -0.0379401
EIF1 eukaryotic translation initiation factor 1 -0.0377481
RACK1 receptor for activated C kinase 1 -0.0375627
RPS27A ribosomal protein S27a -0.03644
SQSTM1 sequestosome 1 -0.036405
S100A6 S100 calcium binding protein A6 -0.036312
RPS25 ribosomal protein S25 -0.0356314
INTS6 integrator complex subunit 6 -0.0352534
RPL9 ribosomal protein L9 -0.0331451
STC2 stanniocalcin 2 -0.0324683
RPLP2 ribosomal protein, large, P2 -0.0321788
RPL12 ribosomal protein L12 -0.0321211
ACTG1 actin gamma 1 -0.0321202
ENO2 enolase 2 (gamma, neuronal) -0.0318185
RPL36 ribosomal protein L36 -0.0315572
S100A9 S100 calcium binding protein A9 -0.0315164
RPL11 ribosomal protein L11 -0.031249
RPL34 ribosomal protein L34 -0.0308033
RPL19 ribosomal protein L19 -0.0304132
IFI6 interferon, alpha-inducible protein 6 -0.0298088
RPS20 ribosomal protein S20 -0.0290815
IER3 immediate early response 3 -0.0288995
RPL38 ribosomal protein L38 -0.028883
HILPDA hypoxia inducible lipid droplet-associated -0.0287236
TMSB4X thymosin beta 4, X-linked -0.0280861
RPS24 ribosomal protein S24 -0.0279683
RPL28 ribosomal protein L28 -0.0275901
HMGA1 high mobility group AT-hook 1 -0.0272359
S100A10 S100 calcium binding protein A10 -0.0267588
RPS21 ribosomal protein S21 -0.026706
RPL13A ribosomal protein L13a -0.0263214
GNAS GNAS complex locus -0.0259718
HLA-A major histocompatibility complex, class I, A -0.0256048
LRRC23 leucine rich repeat containing 23 -0.024599
RPS5 ribosomal protein S5 -0.024518
LOC102724023 ES1 protein homolog, mitochondrial -0.0244686
RPS11 ribosomal protein S11 -0.023849
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0238164
ENO1 enolase 1, (alpha) -0.0238149
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0237161
RPS13 ribosomal protein S13 -0.0237122
RPS23 ribosomal protein S23 -0.0233888
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0227448
CALR calreticulin -0.0224102
EGR1 early growth response 1 -0.0218404
EIF5B eukaryotic translation initiation factor 5B -0.0218095
RPL26 ribosomal protein L26 -0.0215112
RPL5 ribosomal protein L5 -0.0211291
RAB7A RAB7A, member RAS oncogene family -0.0211142
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0208354
LMNA lamin A/C -0.0208305
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0205937
RPS17 ribosomal protein S17 -0.0202234
RPL8 ribosomal protein L8 -0.0201604
RPS14 ribosomal protein S14 -0.020082
MRPS6 mitochondrial ribosomal protein S6 -0.0200413
PKM pyruvate kinase, muscle -0.0185977
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0185848
IFITM3 interferon induced transmembrane protein 3 -0.0184314
CTSD cathepsin D -0.0184059
SERF2 small EDRK-rich factor 2 -0.0183702
RPL18 ribosomal protein L18 -0.0182763
TPI1 triosephosphate isomerase 1 -0.0182246
RPL27A ribosomal protein L27a -0.0181766
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0179898
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.017947
RPS10 ribosomal protein S10 -0.0174985
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0174187
RPL32 ribosomal protein L32 -0.0173377
NAP1L1 nucleosome assembly protein 1-like 1 -0.0172668
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0172095