IgSF CAM signaling Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Immunoglobulin superfamily cell adhesion molecules (IgSF CAMs) are cell surface proteins that mediate calcium-independent adhesion via their Ig-like domains. These extracellular regions commonly form homophilic interactions with similar molecules on adjacent cells but can also bind heterophilically to various other molecular partners. Their intracellular tails associate with cytoskeletal and adaptor proteins, linking external adhesion events to intracellular signaling. Through these mechanisms, IgSF CAMs play key roles in both normal physiological regulation and disease processes such as cancer development. (Kyoto Encyclopedia of Genes and Genomes, hsa04517)
External Link https://www.kegg.jp/entry/hsa04517
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Genes

294 proteins participating in the IgSF CAM signaling pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACTR3C ARP3 actin-related protein 3 homolog C (yeast)
AFDN afadin, adherens junction formation factor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APP amyloid beta (A4) precursor protein
ARF6 ADP-ribosylation factor 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4-TTLL3 ARPC4-TTLL3 readthrough
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARPC5L actin related protein 2/3 complex, subunit 5-like
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
BUB1B-PAK6 BUB1B-PAK6 readthrough
CABLES1 Cdk5 and Abl enzyme substrate 1
CABLES2 Cdk5 and Abl enzyme substrate 2
CADM1 cell adhesion molecule 1
CADM2 cell adhesion molecule 2
CADM3 cell adhesion molecule 3
CADM4 cell adhesion molecule 4
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASKIN1 CASK interacting protein 1
CASKIN2 CASK interacting protein 2
CD2 CD2 molecule
CD209 CD209 molecule
CD226 CD226 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD28 CD28 molecule
CD2AP CD2-associated protein
CD48 CD48 molecule
CD80 CD80 molecule
CD84 CD84 molecule
CD86 CD86 molecule
CD96 CD96 molecule
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLEC4M C-type lectin domain family 4, member M
CLMP CXADR-like membrane protein
CLSTN1 calsyntenin 1
CNKSR3 CNKSR family member 3
CNTN1 contactin 1
CNTN2 contactin 2 (axonal)
CNTNAP1 contactin associated protein 1
CNTNAP2 contactin associated protein-like 2
CRTAM cytotoxic and regulatory T cell molecule
CSK c-src tyrosine kinase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXADR coxsackie virus and adenovirus receptor
DCC DCC netrin 1 receptor
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERC1 ELKS/RAB6-interacting/CAST family member 1
ESAM endothelial cell adhesion molecule
EZR ezrin
F11R F11 receptor
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR1 fibroblast growth factor receptor 1
FGG fibrinogen gamma chain
FOXO1 forkhead box O1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLDN gliomedin
GRB2 growth factor receptor-bound protein 2
GRIP2 glutamate receptor interacting protein 2
GSK3B glycogen synthase kinase 3 beta
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
ICAM3 intercellular adhesion molecule 3
IGSF5 immunoglobulin superfamily, member 5
IL1RAP interleukin 1 receptor accessory protein
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
JAML junction adhesion molecule like
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KDR kinase insert domain receptor
KIRREL1 kirre like nephrin family adhesion molecule 1
KIRREL2 kin of IRRE like 2 (Drosophila)
KIRREL3 kin of IRRE like 3 (Drosophila)
L1CAM L1 cell adhesion molecule
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS12 lectin, galactoside-binding, soluble, 12
LMO7 LIM domain 7
LNCEGFL7OS lncRNA EGFL7 opposite strand
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRFN5 leucine rich repeat and fibronectin type III domain containing 5
LRRC4B leucine rich repeat containing 4B
LRRC4C leucine rich repeat containing 4C
LRRTM4 leucine rich repeat transmembrane neuronal 4
LY9 lymphocyte antigen 9
LYN LYN proto-oncogene, Src family tyrosine kinase
MAG myelin associated glycoprotein
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
METAP2 methionyl aminopeptidase 2
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MPZ myelin protein zero
MSN moesin
MTSS1 metastasis suppressor 1
MTSS2 MTSS I-BAR domain containing 2
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYH14 myosin, heavy chain 14, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
MYLK2 myosin light chain kinase 2
MYLK3 myosin light chain kinase 3
MYLK4 myosin light chain kinase family, member 4
NCAM1 neural cell adhesion molecule 1
NCAM2 neural cell adhesion molecule 2
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NECTIN1 nectin cell adhesion molecule 1
NECTIN2 nectin cell adhesion molecule 2
NECTIN3 nectin cell adhesion molecule 3
NECTIN4 nectin cell adhesion molecule 4
NFASC neurofascin
NLGN1 neuroligin 1
NLGN2 neuroligin 2
NLGN3 neuroligin 3
NLGN4X neuroligin 4, X-linked
NLGN4Y neuroligin 4, Y-linked
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NRCAM neuronal cell adhesion molecule
NRP1 neuropilin 1
NRP2 neuropilin 2
NTN1 netrin 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PALS2 protein associated with LIN7 2, MAGUK p55 family member
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKN1 protein kinase N1
PKN2 protein kinase N2
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLXNA1 plexin A1
PLXNA2 plexin A2
PLXNA3 plexin A3
PLXNA4 plexin A4
PMP2 peripheral myelin protein 2
POTEF POTE ankyrin domain family, member F
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRS protein tyrosine phosphatase, receptor type, S
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PVR poliovirus receptor
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RDX radixin
RHOA ras homolog family member A
RIMS1 regulating synaptic membrane exocytosis 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SH2D1A SH2 domain containing 1A
SH2D1B SH2 domain containing 1B
SLAMF1 signaling lymphocytic activation molecule family member 1
SLAMF6 SLAM family member 6
SLAMF7 SLAM family member 7
SLIT2 slit homolog 2 (Drosophila)
SLIT3 slit homolog 3 (Drosophila)
SLITRK1 SLIT and NTRK-like family, member 1
SLITRK2 SLIT and NTRK-like family, member 2
SLITRK3 SLIT and NTRK-like family, member 3
SLITRK4 SLIT and NTRK-like family, member 4
SLITRK5 SLIT and NTRK-like family, member 5
SLITRK6 SLIT and NTRK-like family, member 6
SORBS1 sorbin and SH3 domain containing 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SPTBN4 spectrin, beta, non-erythrocytic 4
SPTBN5 spectrin, beta, non-erythrocytic 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
SYNGAP1 synaptic Ras GTPase activating protein 1
TIGIT T cell immunoreceptor with Ig and ITIM domains
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIO trio Rho guanine nucleotide exchange factor
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
TUBA3E tubulin, alpha 3e
TUBA4A tubulin, alpha 4a
TUBA8 tubulin, alpha 8
TUBAL3 tubulin, alpha-like 3
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TUBB8B tubulin beta 8B
UNC5A unc-5 homolog A (C. elegans)
UNC5B unc-5 homolog B (C. elegans)
UNC5C unc-5 homolog C (C. elegans)
UNC5D unc-5 homolog D (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VCL vinculin
WASL Wiskott-Aldrich syndrome-like