Iga Glomerulonephritis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A chronic form of glomerulonephritis characterized by deposits of predominantly immunoglobulin A in the mesangial area (glomerular mesangium). Deposits of complement C3 and immunoglobulin G are also often found. Clinical features may progress from asymptomatic hematuria to end-stage kidney disease. (Experimental Factor Ontology, EFO_0004194)
External Link https://www.disgenet.org/browser/0/1/0/C0017661
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Genes

418 genes associated with the disease Iga Glomerulonephritis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACACA acetyl-CoA carboxylase alpha
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACOXL acyl-CoA oxidase-like
ACTB actin, beta
ACTN4 actinin, alpha 4
ACYP2 acylphosphatase 2, muscle type
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
AGBL2 ATP/GTP binding protein-like 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AICDA activation-induced cytidine deaminase
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
ANGPT2 angiopoietin 2
ANKRD16 ankyrin repeat domain 16
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
APOM apolipoprotein M
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATR ATR serine/threonine kinase
AURKB aurora kinase B
AVP arginine vasopressin
AZU1 azurocidin 1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCR breakpoint cluster region
BDNF brain-derived neurotrophic factor
BEST1 bestrophin 1
BGN biglycan
BID BH3 interacting domain death agonist
BLK BLK proto-oncogene, Src family tyrosine kinase
BLNK B-cell linker
BMS1 BMS1 ribosome biogenesis factor
BSG basigin (Ok blood group)
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C1GALT1C1 C1GALT1-specific chaperone 1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C2 complement component 2
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
C4BPB complement component 4 binding protein, beta
C5 complement component 5
C5AR1 complement component 5a receptor 1
CABIN1 calcineurin binding protein 1
CARD9 caspase recruitment domain family, member 9
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCDC132 coiled-coil domain containing 132
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCL27 chemokine (C-C motif) ligand 27
CCL5 chemokine (C-C motif) ligand 5
CCN2 cellular communication network factor 2
CCND1 cyclin D1
CCR10 chemokine (C-C motif) receptor 10
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD14 CD14 molecule
CD163 CD163 molecule
CD19 CD19 molecule
CD27 CD27 molecule
CD2AP CD2-associated protein
CD37 CD37 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD63 CD63 molecule
CD68 CD68 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD80 CD80 molecule
CD86 CD86 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFH complement factor H
CFHR1 complement factor H-related 1
CFHR3 complement factor H-related 3
CFHR5 complement factor H-related 5
CHGA chromogranin A
CHPF chondroitin polymerizing factor
CIB1 calcium and integrin binding 1 (calmyrin)
CIB2 calcium and integrin binding family member 2
CLEC14A C-type lectin domain family 14, member A
CLU clusterin
CMA1 chymase 1, mast cell
CNR1 cannabinoid receptor 1 (brain)
COL4A2 collagen, type IV, alpha 2
COL4A5 collagen, type IV, alpha 5
CORO1C coronin, actin binding protein, 1C
CP ceruloplasmin (ferroxidase)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
DCN decorin
DDN dendrin
DDR1 discoidin domain receptor tyrosine kinase 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFA5 defensin, alpha 5, Paneth cell-specific
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNMT1 DNA (cytosine-5-)-methyltransferase 1
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELANE elastase, neutrophil expressed
ELL2 elongation factor, RNA polymerase II, 2
ENAH enabled homolog (Drosophila)
EPHB2 EPH receptor B2
EPHX2 epoxide hydrolase 2, cytoplasmic
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP1 fatty acid binding protein 1, liver
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FCAR Fc fragment of IgA receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCRL3 Fc receptor-like 3
FCRLB Fc receptor-like B
FDCSP follicular dendritic cell secreted protein
FDX1 ferredoxin 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXM1 forkhead box M1
FOXP3 forkhead box P3
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GATA3 GATA binding protein 3
GDE1 glycerophosphodiester phosphodiesterase 1
GDF15 growth differentiation factor 15
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GOLGA2 golgin A2
GORASP1 golgi reassembly stacking protein 1, 65kDa
GPR183 G protein-coupled receptor 183
GRAP2 GRB2-related adaptor protein 2
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HELT helt bHLH transcription factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HORMAD2 HORMA domain containing 2
HPSE heparanase
HSPG2 heparan sulfate proteoglycan 2
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGHMBP2 immunoglobulin mu binding protein 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL16 interleukin 16
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL23R interleukin 23 receptor
IL4 interleukin 4
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
INS insulin
IRF5 interferon regulatory factor 5
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
JAG1 jagged 1
JAK3 Janus kinase 3
JCHAIN joining chain of multimeric IgA and IgM
KIF15 kinesin family member 15
KL klotho
KLF6 Kruppel-like factor 6
KRT20 keratin 20, type I
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LHFPL2 lipoma HMGIC fusion partner-like 2
LMAN1 lectin, mannose-binding, 1
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LPA lipoprotein, Lp(a)
LPP LIM domain containing preferred translocation partner in lipoma
LRP2 low density lipoprotein receptor-related protein 2
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP6 microtubule-associated protein 6
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MBL2 mannose-binding lectin (protein C) 2, soluble
MBP myelin basic protein
MEFV Mediterranean fever
MERTK MER proto-oncogene, tyrosine kinase
MEST mesoderm specific transcript
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPDU1 mannose-P-dolichol utilization defect 1
MPG N-methylpurine-DNA glycosylase
MPV17 MpV17 mitochondrial inner membrane protein
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT-ATP6 ATP synthase F0 subunit 6
MTM1 myotubularin 1
MTMR3 myotubularin related protein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC1 mucin 1, cell surface associated
MUC20 mucin 20, cell surface associated
MX1 MX dynamin-like GTPase 1
MYCT1 myc target 1
MYD88 myeloid differentiation primary response 88
MYH9 myosin, heavy chain 9, non-muscle
MYOM2 myomesin 2
NEU1 sialidase 1 (lysosomal sialidase)
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NLRC5 NLR family, CARD domain containing 5
NLRP3 NLR family, pyrin domain containing 3
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH3 notch 3
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPPC natriuretic peptide C
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTN4 netrin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OPTN optineurin
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDE5A phosphodiesterase 5A, cGMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PEBP4 phosphatidylethanolamine-binding protein 4
PER2 period circadian clock 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIGR polymeric immunoglobulin receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAU plasminogen activator, urokinase
PLB1 phospholipase B1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POMC proopiomelanocortin
PON1 paraoxonase 1
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRC1 protein regulator of cytokinesis 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTEN phosphatase and tensin homolog
PTH parathyroid hormone
PTPRC protein tyrosine phosphatase, receptor type, C
PTX3 pentraxin 3, long
PXK PX domain containing serine/threonine kinase
QTRT1 queuine tRNA-ribosyltransferase 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM45 RNA binding motif protein 45
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RGS1 regulator of G-protein signaling 1
RHO rhodopsin
RHOA ras homolog family member A
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELE selectin E
SELL selectin L
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC43A3 solute carrier family 43, member 3
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMN1 survival of motor neuron 1, telomeric
SMN2 survival of motor neuron 2, centromeric
SNED1 sushi, nidogen and EGF-like domains 1
SOCS1 suppressor of cytokine signaling 1
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPN sialophorin
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SYK spleen tyrosine kinase
SYNPO synaptopodin
SYT1 synaptotagmin I
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TIMELESS timeless circadian clock
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR1 toll-like receptor 1
TLR10 toll-like receptor 10
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNC tenascin C
TNF tumor necrosis factor
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNS3 tensin 3
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRAF1 TNF receptor-associated factor 1
TSLP thymic stromal lymphopoietin
TXN thioredoxin
UBC ubiquitin C
UBE2K ubiquitin-conjugating enzyme E2K
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBL4A ubiquitin-like 4A
UMOD uromodulin
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP2 ubiquitin specific peptidase 2
VAV3 vav 3 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WAS Wiskott-Aldrich syndrome
WNK1 WNK lysine deficient protein kinase 1
XCL1 chemokine (C motif) ligand 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta