| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5311181 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Iloprost relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SYT17 | synaptotagmin XVII | 1.97 |
| ANGPTL4 | angiopoietin-like 4 | 1.57 |
| PIP | prolactin-induced protein | 1.52 |
| AXIN2 | axin 2 | 1.4 |
| DNAH12 | dynein, axonemal, heavy chain 12 | 1.19 |
| RPL26 | ribosomal protein L26 | 1.15 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | 1.14 |
| HIST2H2AB | histone cluster 2, H2ab | 1.14 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.13 |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 0.94 |
| MRPL57 | mitochondrial ribosomal protein L57 | 0.88 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.77 |
| GSTO1 | glutathione S-transferase omega 1 | 0.77 |
| RPL17 | ribosomal protein L17 | 0.76 |
| MYH16 | myosin, heavy chain 16 pseudogene | 0.72 |
| PWWP2B | PWWP domain containing 2B | 0.62 |
| GID8 | GID complex subunit 8 | 0.62 |
| SEPTIN4 | septin 4 | 0.61 |
| C12ORF60 | chromosome 12 open reading frame 60 | 0.61 |
| S100A6 | S100 calcium binding protein A6 | 0.61 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | 0.61 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | 0.61 |
| HSPA8 | heat shock 70kDa protein 8 | 0.59 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.58 |
| MDH2 | malate dehydrogenase 2, NAD (mitochondrial) | 0.58 |
| RPL3L | ribosomal protein L3-like | 0.56 |
| E2F7 | E2F transcription factor 7 | 0.56 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | 0.56 |
| ANKRD13B | ankyrin repeat domain 13B | 0.53 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | 0.52 |
| RPS23 | ribosomal protein S23 | 0.52 |
| HMGA1 | high mobility group AT-hook 1 | 0.51 |
| H1-4 | H1.4 linker histone, cluster member | 0.51 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.5 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.5 |
| SET | SET nuclear proto-oncogene | 0.5 |
| SP100 | SP100 nuclear antigen | 0.49 |
| PRDX1 | peroxiredoxin 1 | 0.48 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.48 |
| CCDC91 | coiled-coil domain containing 91 | 0.48 |
| SPTBN4 | spectrin, beta, non-erythrocytic 4 | 0.47 |
| RPL10 | ribosomal protein L10 | 0.47 |
| ZNF700 | zinc finger protein 700 | 0.47 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.46 |
| RHOC | ras homolog family member C | 0.46 |
| ENO1 | enolase 1, (alpha) | 0.45 |
| EZR | ezrin | 0.45 |
| CCDC9B | coiled-coil domain containing 9B | 0.44 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | 0.44 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.44 |
| ACAA2 | acetyl-CoA acyltransferase 2 | 0.44 |
| EEF1A1P5 | eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 | 0.44 |
| PCNP | PEST proteolytic signal containing nuclear protein | 0.43 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.43 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.43 |
| BRMS1 | breast cancer metastasis suppressor 1 | 0.42 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.42 |
| DOCK3 | dedicator of cytokinesis 3 | 0.42 |
| BANF1 | barrier to autointegration factor 1 | 0.42 |
| RPS19 | ribosomal protein S19 | 0.41 |
| RPL34 | ribosomal protein L34 | 0.41 |
| RPL4 | ribosomal protein L4 | 0.41 |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.4 |
| TPM3 | tropomyosin 3 | 0.4 |
| MIEF1 | mitochondrial elongation factor 1 | 0.39 |
| RPS10 | ribosomal protein S10 | 0.39 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.39 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.39 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.38 |
| SASH1 | SAM and SH3 domain containing 1 | 0.38 |
| PRMT1 | protein arginine methyltransferase 1 | 0.37 |
| RPS17 | ribosomal protein S17 | 0.37 |
| ILF2 | interleukin enhancer binding factor 2 | 0.37 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.37 |
| RPL23 | ribosomal protein L23 | 0.37 |
| SDF2 | stromal cell-derived factor 2 | 0.36 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.36 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.36 |
| RPS18 | ribosomal protein S18 | 0.35 |
| ZNF721 | zinc finger protein 721 | 0.35 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.35 |
| HDAC5 | histone deacetylase 5 | 0.35 |
| GAPDHS | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 0.35 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.35 |
| H2AZ1 | H2A.Z variant histone 1 | 0.34 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.34 |
| PRG4 | proteoglycan 4 | 0.34 |
| NPHP4 | nephronophthisis 4 | 0.34 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.33 |
| TLL2 | tolloid-like 2 | 0.33 |
| ZSCAN20 | zinc finger and SCAN domain containing 20 | 0.33 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.33 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.33 |
| CFL1 | cofilin 1 (non-muscle) | 0.33 |
| MRPL34 | mitochondrial ribosomal protein L34 | 0.33 |
| DYNLL2 | dynein, light chain, LC8-type 2 | 0.33 |
| MIDN | midnolin | 0.32 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.32 |
| DCTPP1 | dCTP pyrophosphatase 1 | 0.32 |
| BOLA2 | bolA family member 2 | 0.32 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MED12L | mediator complex subunit 12-like | -1.47 |
| TRIB3 | tribbles pseudokinase 3 | -1.36 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -1.01 |
| PEX7 | peroxisomal biogenesis factor 7 | -0.97 |
| ABHD2 | abhydrolase domain containing 2 | -0.72 |
| TMEM248 | transmembrane protein 248 | -0.7 |
| IL10RB | interleukin 10 receptor, beta | -0.69 |
| TSPAN3 | tetraspanin 3 | -0.65 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.6 |
| SYN1 | synapsin I | -0.57 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.52 |
| METTL22 | methyltransferase like 22 | -0.51 |
| TRIM35 | tripartite motif containing 35 | -0.5 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.5 |
| HBA1 | hemoglobin, alpha 1 | -0.49 |
| ZNF197 | zinc finger protein 197 | -0.46 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -0.46 |
| PALB2 | partner and localizer of BRCA2 | -0.45 |
| ARG2 | arginase 2 | -0.45 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.45 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -0.44 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.44 |
| TRMO | tRNA methyltransferase O | -0.43 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.42 |
| FN1 | fibronectin 1 | -0.41 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.41 |
| COPS4 | COP9 signalosome subunit 4 | -0.4 |
| ZNF445 | zinc finger protein 445 | -0.4 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.4 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.4 |
| PHF1 | PHD finger protein 1 | -0.4 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.4 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.4 |
| NRP1 | neuropilin 1 | -0.39 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.38 |
| THBS1 | thrombospondin 1 | -0.38 |
| ZNF428 | zinc finger protein 428 | -0.38 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.38 |
| MIS12 | MIS12 kinetochore complex component | -0.38 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | -0.37 |
| ARSG | arylsulfatase G | -0.37 |
| CDC26 | cell division cycle 26 | -0.37 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -0.37 |
| CD63 | CD63 molecule | -0.36 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | -0.36 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.36 |
| LIX1L | Lix1 homolog (chicken) like | -0.35 |
| DMD | dystrophin | -0.35 |
| ZMYM6 | zinc finger, MYM-type 6 | -0.35 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.35 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | -0.35 |
| TNNI3 | troponin I type 3 (cardiac) | -0.35 |
| EXT1 | exostosin glycosyltransferase 1 | -0.35 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.35 |
| CCDC158 | coiled-coil domain containing 158 | -0.34 |
| GPATCH2L | G patch domain containing 2-like | -0.34 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.34 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.34 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.34 |
| BOK | BCL2-related ovarian killer | -0.34 |
| STARD5 | StAR-related lipid transfer (START) domain containing 5 | -0.34 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -0.33 |
| IFRD1 | interferon-related developmental regulator 1 | -0.33 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.33 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.33 |
| CCDC167 | coiled-coil domain containing 167 | -0.33 |
| IL6ST | interleukin 6 signal transducer | -0.33 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.33 |
| GTPBP2 | GTP binding protein 2 | -0.33 |
| ADCY6 | adenylate cyclase 6 | -0.32 |
| ZBTB4 | zinc finger and BTB domain containing 4 | -0.32 |
| MSANTD4 | Myb/SANT-like DNA-binding domain containing 4 with coiled-coils | -0.32 |
| NOP16 | NOP16 nucleolar protein | -0.32 |
| ATE1 | arginyltransferase 1 | -0.31 |
| SERINC5 | serine incorporator 5 | -0.31 |
| ZNF526 | zinc finger protein 526 | -0.31 |
| CCDC102A | coiled-coil domain containing 102A | -0.31 |
| NRXN3 | neurexin 3 | -0.31 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | -0.3 |
| NPEPL1 | aminopeptidase-like 1 | -0.3 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.3 |
| RNF111 | ring finger protein 111 | -0.3 |
| ABHD3 | abhydrolase domain containing 3 | -0.3 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.3 |
| ATF6B | activating transcription factor 6 beta | -0.3 |
| CCDC90B | coiled-coil domain containing 90B | -0.3 |
| CHPF | chondroitin polymerizing factor | -0.3 |
| UPP1 | uridine phosphorylase 1 | -0.3 |
| CA13 | carbonic anhydrase XIII | -0.3 |
| KIAA1210 | KIAA1210 | -0.3 |
| ABHD18 | abhydrolase domain containing 18 | -0.29 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.29 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.29 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.29 |
| FLNB | filamin B, beta | -0.29 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | -0.29 |
| TBC1D13 | TBC1 domain family, member 13 | -0.29 |
| TSPAN5 | tetraspanin 5 | -0.29 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.29 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | -0.29 |
