Imiquimod (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Imiquimod (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Imiquimod (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.125557
EEF2 eukaryotic translation elongation factor 2 0.107858
SPTBN1 spectrin, beta, non-erythrocytic 1 0.104168
SMAD3 SMAD family member 3 0.0930639
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0890193
GRB10 growth factor receptor-bound protein 10 0.0860472
NDRG1 N-myc downstream regulated 1 0.0835058
AKAP12 A kinase (PRKA) anchor protein 12 0.0801376
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0764008
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0657142
USP3 ubiquitin specific peptidase 3 0.0616591
SPAG9 sperm associated antigen 9 0.0608717
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0605206
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0603695
ANKRD11 ankyrin repeat domain 11 0.0578752
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0562623
CA12 carbonic anhydrase XII 0.0562197
RPL4 ribosomal protein L4 0.0556826
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0544441
MCL1 myeloid cell leukemia 1 0.0543803
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0537811
HELZ helicase with zinc finger 0.0528088
KDM3A lysine (K)-specific demethylase 3A 0.0527268
SOD2 superoxide dismutase 2, mitochondrial 0.0492138
FLNA filamin A, alpha 0.0480398
FMNL2 formin-like 2 0.0480058
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0476375
TNIP1 TNFAIP3 interacting protein 1 0.0461496
RPL3 ribosomal protein L3 0.0453959
ANXA2 annexin A2 0.0449839
PKM pyruvate kinase, muscle 0.0435155
NUP58 nucleoporin 58 0.0429195
FTH1 ferritin, heavy polypeptide 1 0.0426474
ADAM17 ADAM metallopeptidase domain 17 0.0413093
FAM13A family with sequence similarity 13, member A 0.0409015
SHB Src homology 2 domain containing adaptor protein B 0.0397464
PGK1 phosphoglycerate kinase 1 0.0397002
WAC WW domain containing adaptor with coiled-coil 0.0383258
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0379971
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0352172
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0351446
SRRM2 serine/arginine repetitive matrix 2 0.0351321
PCBP2 poly(rC) binding protein 2 0.0350453
HDLBP high density lipoprotein binding protein 0.0348272
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0343198
TFG TRK-fused gene 0.033728
LTBP4 latent transforming growth factor beta binding protein 4 0.0335448
KMT2C lysine (K)-specific methyltransferase 2C 0.0331417
TNS1 tensin 1 0.0328249
ACTN4 actinin, alpha 4 0.0327762
LOXL2 lysyl oxidase-like 2 0.0327165
PDLIM5 PDZ and LIM domain 5 0.0323884
EPAS1 endothelial PAS domain protein 1 0.0322053
PLEC plectin 0.0316008
UBC ubiquitin C 0.0313195
KCTD9 potassium channel tetramerization domain containing 9 0.030986
DHFR dihydrofolate reductase 0.0308623
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0305126
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0304917
TBC1D22A TBC1 domain family, member 22A 0.0304187
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.030005
DAPK1 death-associated protein kinase 1 0.0299524
COPA coatomer protein complex, subunit alpha 0.0299223
FLNB filamin B, beta 0.0296887
MYOF myoferlin 0.0288178
UBE2O ubiquitin-conjugating enzyme E2O 0.0287475
CCNY cyclin Y 0.0285653
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0284222
TRA2A transformer 2 alpha homolog (Drosophila) 0.0279397
RHCG Rh family, C glycoprotein 0.0278518
HIPK2 homeodomain interacting protein kinase 2 0.0276876
PTPRF protein tyrosine phosphatase, receptor type, F 0.0276692
C1D C1D nuclear receptor corepressor 0.0276669
CTBP2 C-terminal binding protein 2 0.0275998
CASC3 cancer susceptibility candidate 3 0.0274794
HILPDA hypoxia inducible lipid droplet-associated 0.0272571
BHLHE40 basic helix-loop-helix family, member e40 0.0271452
DDIT4 DNA-damage-inducible transcript 4 0.0271311
AUTS2 autism susceptibility candidate 2 0.0266293
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0265091
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0264424
WDR43 WD repeat domain 43 0.0262415
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.025869
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0255061
MYO1E myosin IE 0.0254907
CALU calumenin 0.0253541
DGKD diacylglycerol kinase, delta 130kDa 0.025306
IQGAP1 IQ motif containing GTPase activating protein 1 0.025289
AHNAK AHNAK nucleoprotein 0.0252139
NAV2 neuron navigator 2 0.0251125
MYH9 myosin, heavy chain 9, non-muscle 0.0250308
DENND5A DENN/MADD domain containing 5A 0.0245025
ARL5B ADP-ribosylation factor-like 5B 0.0244957
QKI QKI, KH domain containing, RNA binding 0.024383
OLA1 Obg-like ATPase 1 0.0242924
ECT2 epithelial cell transforming 2 0.0242644
IGF1R insulin-like growth factor 1 receptor 0.02425
TPM4 tropomyosin 4 0.0241277
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0237641
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0234248

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125983
MT2A metallothionein 2A -0.117227
RPS6 ribosomal protein S6 -0.102931
TMSB10 thymosin beta 10 -0.079341
ASPH aspartate beta-hydroxylase -0.0634848
KYNU kynureninase -0.0634189
RPS2 ribosomal protein S2 -0.0628273
RPLP1 ribosomal protein, large, P1 -0.0622582
ACTG1 actin gamma 1 -0.05919
RPS19 ribosomal protein S19 -0.0567791
ARHGAP26 Rho GTPase activating protein 26 -0.0532904
TPT1 tumor protein, translationally-controlled 1 -0.0526881
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.052419
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0512629
RPL19 ribosomal protein L19 -0.0471897
TM4SF1 transmembrane 4 L six family member 1 -0.0466785
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0442975
RPL9 ribosomal protein L9 -0.0430831
VIM vimentin -0.0430183
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0410069
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0395945
FTL ferritin, light polypeptide -0.0394759
RPL37A ribosomal protein L37a -0.0381157
RPS16 ribosomal protein S16 -0.0374104
RPS27A ribosomal protein S27a -0.0364938
RPL12 ribosomal protein L12 -0.0361123
RPS12 ribosomal protein S12 -0.0348931
KRT81 keratin 81, type II -0.0348353
RPL38 ribosomal protein L38 -0.0345266
RPL26 ribosomal protein L26 -0.0333869
RPS23 ribosomal protein S23 -0.0322031
RPS8 ribosomal protein S8 -0.0317107
RPS29 ribosomal protein S29 -0.0315339
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.031193
NRIP1 nuclear receptor interacting protein 1 -0.029729
RPL28 ribosomal protein L28 -0.0291064
ZBTB20 zinc finger and BTB domain containing 20 -0.0289272
EIF1 eukaryotic translation initiation factor 1 -0.0288597
RPS13 ribosomal protein S13 -0.0282474
RPL31 ribosomal protein L31 -0.0279044
RPS17 ribosomal protein S17 -0.0278356
SLC38A2 solute carrier family 38, member 2 -0.0276581
RPLP2 ribosomal protein, large, P2 -0.0275205
TXNRD1 thioredoxin reductase 1 -0.0273041
NRG1 neuregulin 1 -0.0270983
RPS3 ribosomal protein S3 -0.0270637
BMERB1 bMERB domain containing 1 -0.026659
RPS11 ribosomal protein S11 -0.0256649
RPS5 ribosomal protein S5 -0.0254981
OSMR oncostatin M receptor -0.025101
PDE10A phosphodiesterase 10A -0.024424
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0241872
RPL32 ribosomal protein L32 -0.0232741
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0226604
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0225984
SMYD3 SET and MYND domain containing 3 -0.0223557
THSD4 thrombospondin, type I, domain containing 4 -0.022063
RPL35A ribosomal protein L35a -0.0217953
FAM107B family with sequence similarity 107, member B -0.0212566
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0211579
RPS27 ribosomal protein S27 -0.0211306
SSH2 slingshot protein phosphatase 2 -0.0210845
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0209423
S100A6 S100 calcium binding protein A6 -0.0207784
GRAMD1B GRAM domain containing 1B -0.0204853
PFN1 profilin 1 -0.0202776
PTMA prothymosin, alpha -0.0200895
RPL35 ribosomal protein L35 -0.0199816
BICC1 BicC family RNA binding protein 1 -0.0199686
RPL34 ribosomal protein L34 -0.0196311
RPL36 ribosomal protein L36 -0.0195387
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0194048
RPS21 ribosomal protein S21 -0.019379
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0193367
PTBP3 polypyrimidine tract binding protein 3 -0.019263
RPS25 ribosomal protein S25 -0.0192417
SOS1 son of sevenless homolog 1 (Drosophila) -0.0189562
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0188324
ANXA4 annexin A4 -0.0188096
CENPF centromere protein F, 350/400kDa -0.0188002
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0187897
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0187075
RPL7A ribosomal protein L7a -0.0179127
LIMCH1 LIM and calponin homology domains 1 -0.0177539
MBD5 methyl-CpG binding domain protein 5 -0.0176334
RPL18 ribosomal protein L18 -0.017616
ZFAND6 zinc finger, AN1-type domain 6 -0.0172387
MT1X metallothionein 1X -0.0171984
WWOX WW domain containing oxidoreductase -0.0171379
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0170435
RSPO3 R-spondin 3 -0.0167049
BCL2L1 BCL2-like 1 -0.0166668
EIF5B eukaryotic translation initiation factor 5B -0.0165059
MAML3 mastermind-like 3 (Drosophila) -0.0164143
DSCAM Down syndrome cell adhesion molecule -0.0162379
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0162337
RPS10 ribosomal protein S10 -0.0159023
RPS14 ribosomal protein S14 -0.0157808
RPS15 ribosomal protein S15 -0.015778
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0157293